Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B0H2_LEIMU

TriTrypDb:

LmxM.29.0470

Length:

666

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 21
NetGPI	no	yes: 0, no: 21

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B0H2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B0H2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	269	273	PF00656	0.391
CLV_C14_Caspase3-7	428	432	PF00656	0.723
CLV_C14_Caspase3-7	494	498	PF00656	0.419
CLV_NRD_NRD_1	314	316	PF00675	0.390
CLV_NRD_NRD_1	373	375	PF00675	0.447
CLV_NRD_NRD_1	41	43	PF00675	0.501
CLV_NRD_NRD_1	542	544	PF00675	0.433
CLV_NRD_NRD_1	581	583	PF00675	0.441
CLV_NRD_NRD_1	625	627	PF00675	0.473
CLV_NRD_NRD_1	638	640	PF00675	0.547
CLV_NRD_NRD_1	64	66	PF00675	0.490
CLV_NRD_NRD_1	646	648	PF00675	0.623
CLV_NRD_NRD_1	72	74	PF00675	0.534
CLV_PCSK_FUR_1	311	315	PF00082	0.393
CLV_PCSK_KEX2_1	313	315	PF00082	0.387
CLV_PCSK_KEX2_1	342	344	PF00082	0.526
CLV_PCSK_KEX2_1	372	374	PF00082	0.493
CLV_PCSK_KEX2_1	41	43	PF00082	0.501
CLV_PCSK_KEX2_1	542	544	PF00082	0.433
CLV_PCSK_KEX2_1	581	583	PF00082	0.390
CLV_PCSK_KEX2_1	625	627	PF00082	0.429
CLV_PCSK_KEX2_1	638	640	PF00082	0.501
CLV_PCSK_KEX2_1	64	66	PF00082	0.481
CLV_PCSK_KEX2_1	645	647	PF00082	0.409
CLV_PCSK_KEX2_1	72	74	PF00082	0.520
CLV_PCSK_PC1ET2_1	342	344	PF00082	0.526
CLV_PCSK_PC1ET2_1	372	374	PF00082	0.484
CLV_PCSK_PC1ET2_1	645	647	PF00082	0.697
CLV_PCSK_SKI1_1	234	238	PF00082	0.538
CLV_PCSK_SKI1_1	642	646	PF00082	0.448
CLV_PCSK_SKI1_1	72	76	PF00082	0.654
DEG_Nend_Nbox_1	1	3	PF02207	0.597
DEG_ODPH_VHL_1	515	528	PF01847	0.525
DEG_SCF_FBW7_2	354	361	PF00400	0.382
DEG_SPOP_SBC_1	43	47	PF00917	0.428
DOC_CKS1_1	236	241	PF01111	0.564
DOC_CKS1_1	468	473	PF01111	0.655
DOC_CYCLIN_RxL_1	231	238	PF00134	0.528
DOC_CYCLIN_RxL_1	486	497	PF00134	0.390
DOC_CYCLIN_yCln2_LP_2	237	243	PF00134	0.526
DOC_MAPK_DCC_7	314	324	PF00069	0.410
DOC_MAPK_DCC_7	496	506	PF00069	0.540
DOC_MAPK_gen_1	247	256	PF00069	0.534
DOC_MAPK_gen_1	581	589	PF00069	0.482
DOC_PP1_RVXF_1	159	166	PF00149	0.363
DOC_PP2B_LxvP_1	132	135	PF13499	0.327
DOC_PP2B_LxvP_1	237	240	PF13499	0.531
DOC_PP2B_LxvP_1	75	78	PF13499	0.573
DOC_PP2B_LxvP_1	93	96	PF13499	0.569
DOC_PP4_FxxP_1	74	77	PF00568	0.446
DOC_PP4_FxxP_1	92	95	PF00568	0.433
DOC_USP7_MATH_1	429	433	PF00917	0.763
DOC_USP7_MATH_1	435	439	PF00917	0.776
DOC_USP7_MATH_1	458	462	PF00917	0.644
DOC_USP7_MATH_1	566	570	PF00917	0.422
DOC_USP7_MATH_1	98	102	PF00917	0.671
DOC_USP7_MATH_2	123	129	PF00917	0.284
DOC_USP7_UBL2_3	368	372	PF12436	0.390
DOC_WW_Pin1_4	102	107	PF00397	0.518
DOC_WW_Pin1_4	119	124	PF00397	0.457
DOC_WW_Pin1_4	235	240	PF00397	0.594
DOC_WW_Pin1_4	329	334	PF00397	0.406
DOC_WW_Pin1_4	354	359	PF00397	0.373
DOC_WW_Pin1_4	405	410	PF00397	0.656
DOC_WW_Pin1_4	433	438	PF00397	0.640
DOC_WW_Pin1_4	451	456	PF00397	0.520
DOC_WW_Pin1_4	467	472	PF00397	0.586
DOC_WW_Pin1_4	562	567	PF00397	0.439
DOC_WW_Pin1_4	6	11	PF00397	0.567
LIG_14-3-3_CanoR_1	259	264	PF00244	0.488
LIG_14-3-3_CanoR_1	373	379	PF00244	0.501
LIG_14-3-3_CanoR_1	542	550	PF00244	0.417
LIG_APCC_ABBA_1	185	190	PF00400	0.530
LIG_BRCT_BRCA1_1	526	530	PF00533	0.399
LIG_BRCT_BRCA1_1	70	74	PF00533	0.462
LIG_Clathr_ClatBox_1	501	505	PF01394	0.501
LIG_CtBP_PxDLS_1	503	507	PF00389	0.555
LIG_CtBP_PxDLS_1	549	553	PF00389	0.506
LIG_eIF4E_1	6	12	PF01652	0.425
LIG_EVH1_1	75	79	PF00568	0.611
LIG_EVH1_1	93	97	PF00568	0.457
LIG_FHA_1	127	133	PF00498	0.381
LIG_FHA_1	134	140	PF00498	0.319
LIG_FHA_1	19	25	PF00498	0.657
LIG_FHA_1	210	216	PF00498	0.558
LIG_FHA_1	32	38	PF00498	0.654
LIG_FHA_1	329	335	PF00498	0.470
LIG_FHA_1	391	397	PF00498	0.529
LIG_FHA_1	468	474	PF00498	0.616
LIG_FHA_1	490	496	PF00498	0.437
LIG_FHA_2	267	273	PF00498	0.458
LIG_FHA_2	426	432	PF00498	0.685
LIG_LIR_Apic_2	71	77	PF02991	0.455
LIG_LIR_Apic_2	89	95	PF02991	0.442
LIG_LIR_Gen_1	136	145	PF02991	0.473
LIG_LIR_Gen_1	267	274	PF02991	0.442
LIG_LIR_Gen_1	303	312	PF02991	0.378
LIG_LIR_Gen_1	357	366	PF02991	0.421
LIG_LIR_Gen_1	399	409	PF02991	0.666
LIG_LIR_LC3C_4	174	178	PF02991	0.333
LIG_LIR_Nem_3	128	133	PF02991	0.402
LIG_LIR_Nem_3	136	141	PF02991	0.420
LIG_LIR_Nem_3	267	271	PF02991	0.415
LIG_LIR_Nem_3	281	287	PF02991	0.471
LIG_LIR_Nem_3	303	308	PF02991	0.388
LIG_LIR_Nem_3	357	363	PF02991	0.395
LIG_LIR_Nem_3	377	381	PF02991	0.376
LIG_LIR_Nem_3	399	404	PF02991	0.406
LIG_LIR_Nem_3	485	490	PF02991	0.419
LIG_MAD2	234	242	PF02301	0.531
LIG_MYND_1	317	321	PF01753	0.429
LIG_MYND_1	451	455	PF01753	0.468
LIG_PDZ_Class_1	661	666	PF00595	0.406
LIG_Pex14_1	483	487	PF04695	0.496
LIG_Pex14_2	137	141	PF04695	0.236
LIG_Pex14_2	165	169	PF04695	0.451
LIG_Pex14_2	284	288	PF04695	0.409
LIG_Pex14_2	526	530	PF04695	0.399
LIG_PTB_Apo_2	478	485	PF02174	0.377
LIG_PTB_Phospho_1	478	484	PF10480	0.507
LIG_Rb_LxCxE_1	219	229	PF01857	0.526
LIG_REV1ctd_RIR_1	163	169	PF16727	0.367
LIG_SH2_CRK	490	494	PF00017	0.472
LIG_SH2_CRK	557	561	PF00017	0.478
LIG_SH2_GRB2like	287	290	PF00017	0.400
LIG_SH2_GRB2like	557	560	PF00017	0.269
LIG_SH2_NCK_1	557	561	PF00017	0.412
LIG_SH2_SRC	557	560	PF00017	0.374
LIG_SH2_STAT5	133	136	PF00017	0.414
LIG_SH2_STAT5	138	141	PF00017	0.415
LIG_SH2_STAT5	214	217	PF00017	0.516
LIG_SH2_STAT5	287	290	PF00017	0.418
LIG_SH2_STAT5	474	477	PF00017	0.433
LIG_SH2_STAT5	525	528	PF00017	0.392
LIG_SH3_1	73	79	PF00018	0.626
LIG_SH3_3	212	218	PF00018	0.567
LIG_SH3_3	236	242	PF00018	0.612
LIG_SH3_3	445	451	PF00018	0.705
LIG_SH3_3	465	471	PF00018	0.418
LIG_SH3_3	610	616	PF00018	0.472
LIG_SH3_3	73	79	PF00018	0.573
LIG_SH3_3	91	97	PF00018	0.451
LIG_SUMO_SIM_anti_2	174	180	PF11976	0.395
LIG_SUMO_SIM_par_1	174	180	PF11976	0.395
LIG_SUMO_SIM_par_1	320	326	PF11976	0.419
LIG_SUMO_SIM_par_1	491	497	PF11976	0.328
LIG_TRAF2_1	122	125	PF00917	0.432
LIG_TRAF2_1	273	276	PF00917	0.542
LIG_TRAF2_1	531	534	PF00917	0.633
LIG_UBA3_1	294	300	PF00899	0.449
LIG_WRC_WIRS_1	134	139	PF05994	0.342
LIG_WRC_WIRS_1	375	380	PF05994	0.422
MOD_CK1_1	405	411	PF00069	0.575
MOD_CK1_1	414	420	PF00069	0.570
MOD_CK1_1	433	439	PF00069	0.660
MOD_CK1_1	44	50	PF00069	0.651
MOD_CK1_1	449	455	PF00069	0.517
MOD_CK1_1	462	468	PF00069	0.720
MOD_CK2_1	119	125	PF00069	0.342
MOD_CK2_1	274	280	PF00069	0.453
MOD_GlcNHglycan	100	103	PF01048	0.713
MOD_GlcNHglycan	114	117	PF01048	0.552
MOD_GlcNHglycan	179	182	PF01048	0.450
MOD_GlcNHglycan	413	416	PF01048	0.697
MOD_GlcNHglycan	431	435	PF01048	0.599
MOD_GlcNHglycan	437	440	PF01048	0.627
MOD_GlcNHglycan	461	464	PF01048	0.666
MOD_GlcNHglycan	508	511	PF01048	0.511
MOD_GlcNHglycan	568	571	PF01048	0.431
MOD_GlcNHglycan	57	60	PF01048	0.566
MOD_GlcNHglycan	68	71	PF01048	0.472
MOD_GlcNHglycan	83	86	PF01048	0.611
MOD_GSK3_1	110	117	PF00069	0.669
MOD_GSK3_1	133	140	PF00069	0.541
MOD_GSK3_1	325	332	PF00069	0.423
MOD_GSK3_1	385	392	PF00069	0.398
MOD_GSK3_1	405	412	PF00069	0.400
MOD_GSK3_1	41	48	PF00069	0.707
MOD_GSK3_1	425	432	PF00069	0.474
MOD_GSK3_1	458	465	PF00069	0.731
MOD_GSK3_1	506	513	PF00069	0.521
MOD_GSK3_1	51	58	PF00069	0.596
MOD_GSK3_1	562	569	PF00069	0.581
MOD_GSK3_1	98	105	PF00069	0.714
MOD_NEK2_1	11	16	PF00069	0.620
MOD_NEK2_1	137	142	PF00069	0.517
MOD_NEK2_1	23	28	PF00069	0.507
MOD_NEK2_1	274	279	PF00069	0.514
MOD_NEK2_1	396	401	PF00069	0.482
MOD_NEK2_1	403	408	PF00069	0.613
MOD_NEK2_1	506	511	PF00069	0.504
MOD_NEK2_1	659	664	PF00069	0.525
MOD_NEK2_1	81	86	PF00069	0.453
MOD_NEK2_2	620	625	PF00069	0.400
MOD_PIKK_1	440	446	PF00454	0.788
MOD_PKA_1	41	47	PF00069	0.533
MOD_PKA_1	542	548	PF00069	0.434
MOD_PKA_1	638	644	PF00069	0.691
MOD_PKA_2	41	47	PF00069	0.491
MOD_PKA_2	429	435	PF00069	0.700
MOD_PKA_2	506	512	PF00069	0.441
MOD_PKA_2	542	548	PF00069	0.434
MOD_PKA_2	638	644	PF00069	0.718
MOD_Plk_1	266	272	PF00069	0.507
MOD_Plk_1	274	280	PF00069	0.467
MOD_Plk_1	325	331	PF00069	0.440
MOD_Plk_1	620	626	PF00069	0.325
MOD_Plk_1	659	665	PF00069	0.691
MOD_Plk_2-3	276	282	PF00069	0.373
MOD_Plk_2-3	325	331	PF00069	0.541
MOD_Plk_4	126	132	PF00069	0.360
MOD_Plk_4	133	139	PF00069	0.362
MOD_Plk_4	143	149	PF00069	0.396
MOD_Plk_4	210	216	PF00069	0.670
MOD_Plk_4	396	402	PF00069	0.486
MOD_Plk_4	88	94	PF00069	0.670
MOD_ProDKin_1	102	108	PF00069	0.517
MOD_ProDKin_1	119	125	PF00069	0.447
MOD_ProDKin_1	235	241	PF00069	0.592
MOD_ProDKin_1	329	335	PF00069	0.411
MOD_ProDKin_1	354	360	PF00069	0.377
MOD_ProDKin_1	405	411	PF00069	0.659
MOD_ProDKin_1	433	439	PF00069	0.643
MOD_ProDKin_1	451	457	PF00069	0.521
MOD_ProDKin_1	467	473	PF00069	0.578
MOD_ProDKin_1	562	568	PF00069	0.437
MOD_ProDKin_1	6	12	PF00069	0.569
MOD_SUMO_for_1	216	219	PF00179	0.590
MOD_SUMO_rev_2	634	644	PF00179	0.561
TRG_DiLeu_BaEn_1	336	341	PF01217	0.513
TRG_DiLeu_BaEn_1	585	590	PF01217	0.386
TRG_DiLeu_BaLyEn_6	7	12	PF01217	0.438
TRG_ENDOCYTIC_2	138	141	PF00928	0.379
TRG_ENDOCYTIC_2	360	363	PF00928	0.415
TRG_ENDOCYTIC_2	375	378	PF00928	0.400
TRG_ENDOCYTIC_2	484	487	PF00928	0.429
TRG_ENDOCYTIC_2	490	493	PF00928	0.463
TRG_ENDOCYTIC_2	525	528	PF00928	0.372
TRG_ENDOCYTIC_2	557	560	PF00928	0.403
TRG_ER_diArg_1	159	162	PF00400	0.446
TRG_ER_diArg_1	246	249	PF00400	0.666
TRG_ER_diArg_1	311	314	PF00400	0.409
TRG_ER_diArg_1	373	375	PF00400	0.443
TRG_ER_diArg_1	41	43	PF00400	0.496
TRG_ER_diArg_1	541	543	PF00400	0.415
TRG_ER_diArg_1	580	582	PF00400	0.451
TRG_ER_diArg_1	624	626	PF00400	0.458
TRG_ER_diArg_1	72	74	PF00400	0.566
TRG_NLS_MonoExtC_3	371	376	PF00514	0.438
TRG_Pf-PMV_PEXEL_1	15	20	PF00026	0.452
TRG_Pf-PMV_PEXEL_1	594	598	PF00026	0.443
TRG_Pf-PMV_PEXEL_1	625	629	PF00026	0.479

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7T4	Leptomonas seymouri	56%	100%
A0A0N1PE00	Leptomonas seymouri	25%	94%
A0A0S4IL03	Bodo saltans	40%	100%
A0A1X0NR90	Trypanosomatidae	29%	93%
A0A1X0P2A9	Trypanosomatidae	44%	100%
A0A3S7X1J9	Leishmania donovani	26%	89%
A0A3S7X313	Leishmania donovani	92%	100%
A0A422N566	Trypanosoma rangeli	45%	100%
A0A422NYX8	Trypanosoma rangeli	28%	98%
A4HGM0	Leishmania braziliensis	26%	100%
A4HHZ8	Leishmania braziliensis	83%	100%
A4I3P5	Leishmania infantum	26%	89%
A4I575	Leishmania infantum	92%	100%
C9ZQK1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
D0A8B9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E9AZY6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	83%
Q4Q7R1	Leishmania major	90%	100%
Q4Q899	Leishmania major	26%	89%
V5B7S2	Trypanosoma cruzi	48%	100%
V5BJS6	Trypanosoma cruzi	28%	99%