Sulfhydryl oxidase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Sulfhydryl oxidase

Gene product:

quiescin sulfhydryl oxidase, putative

Species:

Leishmania mexicana

UniProt:

E9B0G8_LEIMU

TriTrypDb:

LmxM.29.0430

Length:

561

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 9, no: 1
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	11
GO:0005615	extracellular space	2	1

Expansion

Sequence features

E9B0G8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B0G8

Function

Biological processes
Term	Name	Level	Count
GO:0006457	protein folding	2	1
GO:0009987	cellular process	1	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0015035	protein-disulfide reductase activity	3	11
GO:0015036	disulfide oxidoreductase activity	4	11
GO:0016491	oxidoreductase activity	2	11
GO:0016667	oxidoreductase activity, acting on a sulfur group of donors	3	11
GO:0016670	oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor	4	11
GO:0016971	flavin-linked sulfhydryl oxidase activity	4	11
GO:0016972	thiol oxidase activity	5	11
GO:0140096	catalytic activity, acting on a protein	2	11
GO:0003756	protein disulfide isomerase activity	3	1
GO:0016853	isomerase activity	2	1
GO:0016860	intramolecular oxidoreductase activity	3	1
GO:0016864	intramolecular oxidoreductase activity, transposing S-S bonds	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	179	181	PF00675	0.631
CLV_NRD_NRD_1	265	267	PF00675	0.586
CLV_NRD_NRD_1	295	297	PF00675	0.586
CLV_NRD_NRD_1	427	429	PF00675	0.548
CLV_NRD_NRD_1	541	543	PF00675	0.396
CLV_NRD_NRD_1	551	553	PF00675	0.423
CLV_PCSK_KEX2_1	265	267	PF00082	0.585
CLV_PCSK_KEX2_1	295	297	PF00082	0.586
CLV_PCSK_KEX2_1	427	429	PF00082	0.522
CLV_PCSK_KEX2_1	442	444	PF00082	0.476
CLV_PCSK_KEX2_1	500	502	PF00082	0.761
CLV_PCSK_KEX2_1	541	543	PF00082	0.387
CLV_PCSK_KEX2_1	549	551	PF00082	0.439
CLV_PCSK_PC1ET2_1	442	444	PF00082	0.541
CLV_PCSK_PC1ET2_1	500	502	PF00082	0.715
CLV_PCSK_PC1ET2_1	549	551	PF00082	0.544
CLV_PCSK_SKI1_1	265	269	PF00082	0.511
CLV_PCSK_SKI1_1	317	321	PF00082	0.577
CLV_PCSK_SKI1_1	33	37	PF00082	0.547
CLV_PCSK_SKI1_1	392	396	PF00082	0.482
CLV_PCSK_SKI1_1	428	432	PF00082	0.423
CLV_PCSK_SKI1_1	442	446	PF00082	0.581
CLV_PCSK_SKI1_1	552	556	PF00082	0.573
DEG_APCC_DBOX_1	36	44	PF00400	0.283
DOC_CKS1_1	327	332	PF01111	0.348
DOC_MAPK_FxFP_2	126	129	PF00069	0.336
DOC_MAPK_gen_1	549	557	PF00069	0.734
DOC_MAPK_MEF2A_6	514	523	PF00069	0.335
DOC_MAPK_MEF2A_6	549	557	PF00069	0.709
DOC_PP1_RVXF_1	329	336	PF00149	0.348
DOC_PP2B_PxIxI_1	60	66	PF00149	0.399
DOC_PP4_FxxP_1	126	129	PF00568	0.256
DOC_USP7_MATH_1	300	304	PF00917	0.472
DOC_USP7_MATH_1	376	380	PF00917	0.172
DOC_WW_Pin1_4	326	331	PF00397	0.353
LIG_14-3-3_CanoR_1	331	336	PF00244	0.369
LIG_14-3-3_CanoR_1	427	433	PF00244	0.297
LIG_14-3-3_CanoR_1	514	520	PF00244	0.315
LIG_14-3-3_CanoR_1	75	79	PF00244	0.314
LIG_BIR_II_1	1	5	PF00653	0.595
LIG_BRCT_BRCA1_1	122	126	PF00533	0.336
LIG_EH_1	514	518	PF12763	0.325
LIG_FHA_1	14	20	PF00498	0.445
LIG_FHA_1	234	240	PF00498	0.339
LIG_FHA_1	361	367	PF00498	0.279
LIG_FHA_1	370	376	PF00498	0.272
LIG_FHA_1	379	385	PF00498	0.268
LIG_FHA_1	400	406	PF00498	0.375
LIG_FHA_1	489	495	PF00498	0.580
LIG_FHA_1	507	513	PF00498	0.559
LIG_FHA_1	522	528	PF00498	0.345
LIG_FHA_2	192	198	PF00498	0.445
LIG_FHA_2	429	435	PF00498	0.237
LIG_FHA_2	500	506	PF00498	0.391
LIG_FHA_2	86	92	PF00498	0.298
LIG_LIR_Apic_2	123	129	PF02991	0.336
LIG_LIR_Gen_1	248	259	PF02991	0.287
LIG_LIR_Gen_1	305	312	PF02991	0.415
LIG_LIR_Gen_1	314	322	PF02991	0.394
LIG_LIR_Gen_1	382	391	PF02991	0.357
LIG_LIR_Gen_1	402	409	PF02991	0.150
LIG_LIR_Gen_1	520	530	PF02991	0.269
LIG_LIR_Nem_3	123	128	PF02991	0.348
LIG_LIR_Nem_3	248	254	PF02991	0.278
LIG_LIR_Nem_3	305	310	PF02991	0.423
LIG_LIR_Nem_3	314	318	PF02991	0.394
LIG_LIR_Nem_3	342	348	PF02991	0.316
LIG_LIR_Nem_3	382	388	PF02991	0.357
LIG_LIR_Nem_3	402	407	PF02991	0.150
LIG_LIR_Nem_3	520	525	PF02991	0.269
LIG_MLH1_MIPbox_1	122	126	PF16413	0.297
LIG_Pex14_2	124	128	PF04695	0.297
LIG_Pex14_2	247	251	PF04695	0.329
LIG_PTB_Apo_2	142	149	PF02174	0.230
LIG_PTB_Apo_2	241	248	PF02174	0.347
LIG_SH2_CRK	356	360	PF00017	0.290
LIG_SH2_SRC	67	70	PF00017	0.240
LIG_SH2_STAP1	289	293	PF00017	0.409
LIG_SH2_STAP1	390	394	PF00017	0.342
LIG_SH2_STAT5	125	128	PF00017	0.389
LIG_SH2_STAT5	205	208	PF00017	0.375
LIG_SH2_STAT5	21	24	PF00017	0.649
LIG_SH2_STAT5	475	478	PF00017	0.363
LIG_SH2_STAT5	538	541	PF00017	0.522
LIG_SH2_STAT5	67	70	PF00017	0.297
LIG_SH3_1	550	556	PF00018	0.724
LIG_SH3_2	438	443	PF14604	0.329
LIG_SH3_2	553	558	PF14604	0.723
LIG_SH3_3	116	122	PF00018	0.297
LIG_SH3_3	435	441	PF00018	0.322
LIG_SH3_3	550	556	PF00018	0.724
LIG_SUMO_SIM_anti_2	524	530	PF11976	0.420
LIG_SUMO_SIM_par_1	41	49	PF11976	0.355
LIG_TRFH_1	125	129	PF08558	0.348
LIG_TYR_ITIM	354	359	PF00017	0.290
LIG_WRC_WIRS_1	121	126	PF05994	0.336
LIG_WRC_WIRS_1	307	312	PF05994	0.304
LIG_WRC_WIRS_1	429	434	PF05994	0.172
MOD_CDK_SPK_2	326	331	PF00069	0.353
MOD_CK1_1	209	215	PF00069	0.453
MOD_CK1_1	334	340	PF00069	0.361
MOD_CK2_1	191	197	PF00069	0.375
MOD_CK2_1	376	382	PF00069	0.220
MOD_CK2_1	428	434	PF00069	0.297
MOD_CK2_1	46	52	PF00069	0.369
MOD_GlcNHglycan	186	189	PF01048	0.546
MOD_GlcNHglycan	223	226	PF01048	0.565
MOD_GlcNHglycan	320	323	PF01048	0.565
MOD_GlcNHglycan	545	548	PF01048	0.489
MOD_GlcNHglycan	55	58	PF01048	0.518
MOD_GlcNHglycan	76	79	PF01048	0.550
MOD_GlcNHglycan	90	94	PF01048	0.388
MOD_GSK3_1	221	228	PF00069	0.442
MOD_GSK3_1	27	34	PF00069	0.568
MOD_GSK3_1	334	341	PF00069	0.303
MOD_GSK3_1	488	495	PF00069	0.499
MOD_GSK3_1	85	92	PF00069	0.352
MOD_N-GLC_1	134	139	PF02516	0.640
MOD_N-GLC_1	45	50	PF02516	0.530
MOD_NEK2_1	184	189	PF00069	0.414
MOD_NEK2_1	246	251	PF00069	0.326
MOD_NEK2_1	259	264	PF00069	0.354
MOD_NEK2_1	287	292	PF00069	0.429
MOD_NEK2_1	29	34	PF00069	0.461
MOD_NEK2_1	318	323	PF00069	0.340
MOD_NEK2_1	355	360	PF00069	0.274
MOD_NEK2_1	470	475	PF00069	0.387
MOD_NEK2_1	53	58	PF00069	0.345
MOD_PKA_2	206	212	PF00069	0.433
MOD_PKA_2	74	80	PF00069	0.324
MOD_Plk_1	106	112	PF00069	0.346
MOD_Plk_1	134	140	PF00069	0.497
MOD_Plk_1	232	238	PF00069	0.407
MOD_Plk_1	45	51	PF00069	0.320
MOD_Plk_1	85	91	PF00069	0.272
MOD_Plk_1	97	103	PF00069	0.346
MOD_Plk_2-3	107	113	PF00069	0.218
MOD_Plk_4	120	126	PF00069	0.348
MOD_Plk_4	246	252	PF00069	0.309
MOD_Plk_4	411	417	PF00069	0.172
MOD_Plk_4	521	527	PF00069	0.333
MOD_ProDKin_1	326	332	PF00069	0.353
MOD_SUMO_rev_2	150	159	PF00179	0.448
TRG_AP2beta_CARGO_1	382	392	PF09066	0.342
TRG_DiLeu_BaEn_2	462	468	PF01217	0.384
TRG_ENDOCYTIC_2	125	128	PF00928	0.386
TRG_ENDOCYTIC_2	345	348	PF00928	0.300
TRG_ENDOCYTIC_2	356	359	PF00928	0.235
TRG_ER_diArg_1	295	297	PF00400	0.386
TRG_ER_diArg_1	427	429	PF00400	0.348
TRG_ER_diArg_1	476	479	PF00400	0.316
TRG_ER_diArg_1	540	542	PF00400	0.569
TRG_ER_diArg_1	550	552	PF00400	0.636
TRG_ER_diArg_1	557	560	PF00400	0.721
TRG_NLS_MonoCore_2	548	553	PF00514	0.712
TRG_NLS_MonoExtC_3	548	553	PF00514	0.718
TRG_Pf-PMV_PEXEL_1	163	168	PF00026	0.571
TRG_Pf-PMV_PEXEL_1	33	38	PF00026	0.553
TRG_Pf-PMV_PEXEL_1	501	505	PF00026	0.718
TRG_Pf-PMV_PEXEL_1	51	55	PF00026	0.497

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2H4	Leptomonas seymouri	47%	97%
A0A0S4ILW1	Bodo saltans	31%	72%
A0A1X0P2E7	Trypanosomatidae	34%	100%
A0A3S7X306	Leishmania donovani	86%	100%
A0A422NMK4	Trypanosoma rangeli	36%	100%
A4HHZ4	Leishmania braziliensis	66%	99%
A4I571	Leishmania infantum	86%	100%
C9ZQJ7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
Q4Q7R5	Leishmania major	84%	98%