Guanine nucleotide-binding protein subunit beta-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

WD-40 repeat protein

Species:

Leishmania mexicana

UniProt:

E9B0G6_LEIMU

TriTrypDb:

LmxM.29.0410

Length:

485

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	11
GO:0005840	ribosome	5	12
GO:0032991	protein-containing complex	1	12
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	11
GO:0043228	non-membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043231	intracellular membrane-bounded organelle	4	11
GO:0043232	intracellular non-membrane-bounded organelle	4	12
GO:0110165	cellular anatomical entity	1	12
GO:1990904	ribonucleoprotein complex	2	12
GO:0005654	nucleoplasm	2	1
GO:0005847	mRNA cleavage and polyadenylation specificity factor complex	4	1
GO:0005849	mRNA cleavage factor complex	3	1
GO:0140513	nuclear protein-containing complex	2	1

Expansion

Sequence features

E9B0G6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B0G6

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006396	RNA processing	6	12
GO:0006397	mRNA processing	7	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0016070	RNA metabolic process	5	12
GO:0016071	mRNA metabolic process	6	12
GO:0031123	RNA 3'-end processing	7	12
GO:0031124	mRNA 3'-end processing	8	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0043170	macromolecule metabolic process	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0046483	heterocycle metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12
GO:0006378	mRNA polyadenylation	7	1
GO:0043631	RNA polyadenylation	6	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	389	393	PF00656	0.482
CLV_NRD_NRD_1	153	155	PF00675	0.382
CLV_NRD_NRD_1	194	196	PF00675	0.559
CLV_NRD_NRD_1	356	358	PF00675	0.574
CLV_NRD_NRD_1	49	51	PF00675	0.710
CLV_NRD_NRD_1	63	65	PF00675	0.479
CLV_NRD_NRD_1	8	10	PF00675	0.746
CLV_PCSK_KEX2_1	153	155	PF00082	0.382
CLV_PCSK_KEX2_1	194	196	PF00082	0.559
CLV_PCSK_KEX2_1	364	366	PF00082	0.553
CLV_PCSK_KEX2_1	48	50	PF00082	0.720
CLV_PCSK_KEX2_1	63	65	PF00082	0.472
CLV_PCSK_KEX2_1	7	9	PF00082	0.745
CLV_PCSK_PC1ET2_1	364	366	PF00082	0.553
CLV_PCSK_PC7_1	3	9	PF00082	0.770
CLV_PCSK_SKI1_1	153	157	PF00082	0.363
CLV_PCSK_SKI1_1	271	275	PF00082	0.356
CLV_PCSK_SKI1_1	340	344	PF00082	0.341
CLV_PCSK_SKI1_1	364	368	PF00082	0.541
CLV_PCSK_SKI1_1	80	84	PF00082	0.456
DEG_APCC_DBOX_1	139	147	PF00400	0.403
DEG_APCC_DBOX_1	79	87	PF00400	0.507
DEG_Nend_UBRbox_2	1	3	PF02207	0.761
DOC_ANK_TNKS_1	333	340	PF00023	0.541
DOC_CKS1_1	139	144	PF01111	0.518
DOC_MAPK_gen_1	194	200	PF00069	0.522
DOC_PP1_RVXF_1	186	193	PF00149	0.369
DOC_PP1_RVXF_1	227	234	PF00149	0.371
DOC_PP1_RVXF_1	373	379	PF00149	0.378
DOC_PP1_RVXF_1	68	75	PF00149	0.483
DOC_PP4_FxxP_1	74	77	PF00568	0.547
DOC_USP7_MATH_1	264	268	PF00917	0.666
DOC_USP7_MATH_1	299	303	PF00917	0.479
DOC_USP7_MATH_1	380	384	PF00917	0.498
DOC_USP7_MATH_1	391	395	PF00917	0.344
DOC_USP7_UBL2_3	427	431	PF12436	0.623
DOC_WW_Pin1_4	138	143	PF00397	0.531
DOC_WW_Pin1_4	146	151	PF00397	0.492
DOC_WW_Pin1_4	438	443	PF00397	0.488
DOC_WW_Pin1_4	73	78	PF00397	0.509
DOC_WW_Pin1_4	88	93	PF00397	0.424
LIG_14-3-3_CanoR_1	154	164	PF00244	0.362
LIG_14-3-3_CanoR_1	357	361	PF00244	0.583
LIG_14-3-3_CanoR_1	49	57	PF00244	0.718
LIG_BRCT_BRCA1_1	382	386	PF00533	0.520
LIG_CSL_BTD_1	439	442	PF09270	0.496
LIG_deltaCOP1_diTrp_1	230	240	PF00928	0.389
LIG_eIF4E_1	102	108	PF01652	0.508
LIG_FHA_1	102	108	PF00498	0.240
LIG_FHA_1	121	127	PF00498	0.228
LIG_FHA_1	252	258	PF00498	0.429
LIG_FHA_1	348	354	PF00498	0.534
LIG_FHA_1	368	374	PF00498	0.238
LIG_FHA_1	406	412	PF00498	0.713
LIG_FHA_1	82	88	PF00498	0.478
LIG_FHA_2	357	363	PF00498	0.574
LIG_FHA_2	379	385	PF00498	0.528
LIG_FHA_2	387	393	PF00498	0.480
LIG_LIR_Apic_2	73	77	PF02991	0.554
LIG_LIR_Gen_1	163	172	PF02991	0.344
LIG_LIR_Gen_1	213	221	PF02991	0.350
LIG_LIR_Nem_3	163	167	PF02991	0.326
LIG_LIR_Nem_3	230	236	PF02991	0.449
LIG_LIR_Nem_3	288	294	PF02991	0.455
LIG_LIR_Nem_3	394	400	PF02991	0.413
LIG_PDZ_Class_2	480	485	PF00595	0.623
LIG_Pex14_1	211	215	PF04695	0.389
LIG_Pex14_2	51	55	PF04695	0.726
LIG_PTB_Apo_2	211	218	PF02174	0.515
LIG_SH2_CRK	294	298	PF00017	0.497
LIG_SH2_STAP1	103	107	PF00017	0.400
LIG_SH2_STAP1	144	148	PF00017	0.513
LIG_SH2_STAT3	144	147	PF00017	0.492
LIG_SH2_STAT5	103	106	PF00017	0.499
LIG_SH3_2	44	49	PF14604	0.735
LIG_SH3_3	32	38	PF00018	0.736
LIG_SH3_3	41	47	PF00018	0.649
LIG_TRAF2_1	464	467	PF00917	0.528
LIG_TYR_ITIM	395	400	PF00017	0.402
MOD_CDK_SPxxK_3	146	153	PF00069	0.487
MOD_CDK_SPxxK_3	73	80	PF00069	0.499
MOD_CK1_1	302	308	PF00069	0.395
MOD_CK1_1	316	322	PF00069	0.373
MOD_CK2_1	356	362	PF00069	0.574
MOD_CK2_1	447	453	PF00069	0.428
MOD_Cter_Amidation	151	154	PF01082	0.400
MOD_Cter_Amidation	192	195	PF01082	0.521
MOD_GlcNHglycan	150	153	PF01048	0.498
MOD_GlcNHglycan	200	203	PF01048	0.345
MOD_GlcNHglycan	246	250	PF01048	0.375
MOD_GlcNHglycan	26	29	PF01048	0.736
MOD_GlcNHglycan	343	346	PF01048	0.317
MOD_GlcNHglycan	449	452	PF01048	0.345
MOD_GSK3_1	106	113	PF00069	0.314
MOD_GSK3_1	116	123	PF00069	0.348
MOD_GSK3_1	216	223	PF00069	0.425
MOD_GSK3_1	260	267	PF00069	0.634
MOD_GSK3_1	324	331	PF00069	0.381
MOD_GSK3_1	343	350	PF00069	0.161
MOD_N-GLC_1	115	120	PF02516	0.488
MOD_N-GLC_1	126	131	PF02516	0.348
MOD_NEK2_1	155	160	PF00069	0.320
MOD_NEK2_1	210	215	PF00069	0.366
MOD_NEK2_1	297	302	PF00069	0.308
MOD_NEK2_1	385	390	PF00069	0.359
MOD_NEK2_1	447	452	PF00069	0.312
MOD_PIKK_1	120	126	PF00454	0.388
MOD_PIKK_1	299	305	PF00454	0.308
MOD_PIKK_1	324	330	PF00454	0.393
MOD_PIKK_1	356	362	PF00454	0.574
MOD_PKA_1	364	370	PF00069	0.564
MOD_PKA_2	316	322	PF00069	0.457
MOD_PKA_2	356	362	PF00069	0.544
MOD_PKA_2	364	370	PF00069	0.540
MOD_PKB_1	48	56	PF00069	0.731
MOD_Plk_1	126	132	PF00069	0.407
MOD_Plk_1	229	235	PF00069	0.378
MOD_Plk_4	391	397	PF00069	0.382
MOD_ProDKin_1	138	144	PF00069	0.527
MOD_ProDKin_1	146	152	PF00069	0.492
MOD_ProDKin_1	438	444	PF00069	0.353
MOD_ProDKin_1	73	79	PF00069	0.511
MOD_ProDKin_1	88	94	PF00069	0.417
MOD_SUMO_for_1	277	280	PF00179	0.436
MOD_SUMO_rev_2	171	179	PF00179	0.437
MOD_SUMO_rev_2	232	240	PF00179	0.463
MOD_SUMO_rev_2	275	279	PF00179	0.431
TRG_DiLeu_BaLyEn_6	151	156	PF01217	0.379
TRG_ENDOCYTIC_2	294	297	PF00928	0.366
TRG_ENDOCYTIC_2	397	400	PF00928	0.397
TRG_ER_diArg_1	153	155	PF00400	0.394
TRG_ER_diArg_1	47	50	PF00400	0.659
TRG_ER_diArg_1	6	9	PF00400	0.762
TRG_ER_diArg_1	62	64	PF00400	0.509
TRG_Pf-PMV_PEXEL_1	64	69	PF00026	0.712

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHN2	Leptomonas seymouri	23%	93%
A0A0N1PBX5	Leptomonas seymouri	89%	100%
A0A0S4J5T5	Bodo saltans	27%	90%
A0A0S4JFE0	Bodo saltans	56%	100%
A0A0S4KJ87	Bodo saltans	25%	81%
A0A1X0NVZ7	Trypanosomatidae	22%	93%
A0A1X0P2X5	Trypanosomatidae	64%	100%
A0A3Q8IE21	Leishmania donovani	96%	100%
A0A3Q8IGC4	Leishmania donovani	23%	93%
A0A3R7N6M9	Trypanosoma rangeli	23%	93%
A0A3R7NRU0	Trypanosoma rangeli	63%	100%
A4HHZ2	Leishmania braziliensis	92%	99%
A4I135	Leishmania infantum	23%	93%
A4I569	Leishmania infantum	96%	100%
B5X212	Salmo salar	22%	100%
B6H7A3	Penicillium rubens (strain ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin 54-1255)	23%	100%
B8AP31	Oryza sativa subsp. indica	24%	100%
C9ZQJ5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	64%	100%
C9ZW72	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	79%
E9AX72	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	100%
O60907	Homo sapiens	21%	84%
O76071	Homo sapiens	23%	100%
P0CS46	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	27%	68%
P0CS47	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	27%	68%
P42841	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	27%	100%
P49177	Arabidopsis thaliana	25%	100%
P49178	Zea mays	23%	100%
Q28DW0	Xenopus tropicalis	24%	100%
Q28I85	Xenopus tropicalis	23%	100%
Q2TZG4	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	31%	80%
Q32PJ6	Bos taurus	23%	100%
Q40687	Oryza sativa subsp. japonica	24%	100%
Q4I7X1	Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)	27%	79%
Q4Q7R7	Leishmania major	96%	98%
Q4QAA4	Leishmania major	24%	100%
Q4R8H1	Macaca fascicularis	21%	85%
Q4V8C4	Rattus norvegicus	22%	100%
Q4X1Y0	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	29%	95%
Q55DA2	Dictyostelium discoideum	20%	100%
Q58D20	Bos taurus	24%	100%
Q59WJ4	Candida albicans (strain SC5314 / ATCC MYA-2876)	29%	89%
Q5AZX0	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	28%	86%
Q5DFU0	Schistosoma japonicum	24%	100%
Q5M7T1	Rattus norvegicus	23%	100%
Q5RD06	Pongo abelii	22%	100%
Q5RE95	Pongo abelii	22%	100%
Q5RFF8	Pongo abelii	24%	100%
Q6BVZ3	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	28%	96%
Q6CGP9	Yarrowia lipolytica (strain CLIB 122 / E 150)	27%	91%
Q6CP71	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	30%	100%
Q6FJS0	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	29%	100%
Q6NLV4	Arabidopsis thaliana	32%	75%
Q75AV4	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	27%	100%
Q7RY68	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	29%	73%
Q7T0P4	Xenopus laevis	23%	100%
Q86VZ2	Homo sapiens	22%	100%
Q8VEJ4	Mus musculus	24%	100%
Q95RJ9	Drosophila melanogaster	24%	69%
Q99KN2	Mus musculus	23%	100%
Q9D7H2	Mus musculus	22%	100%
Q9FLX9	Arabidopsis thaliana	22%	100%
Q9FN19	Arabidopsis thaliana	22%	79%
Q9NVX2	Homo sapiens	24%	100%
Q9QXE7	Mus musculus	22%	92%
Q9UTN4	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	29%	95%
V5BEB2	Trypanosoma cruzi	24%	90%
V5DD51	Trypanosoma cruzi	64%	100%