Dolichyldiphosphatase

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

PAP2 family protein, putative

Species:

Leishmania mexicana

UniProt:

E9B0G5_LEIMU

TriTrypDb:

LmxM.29.0405

Length:

252

Annotations

LeishMANIAdb annotations

Involved in N-glycan biogenesis, conserved eukaryotic protein.. Localization: ER (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	4
GO:0110165	cellular anatomical entity	1	4

Expansion

Sequence features

E9B0G5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B0G5

Function

Biological processes
Term	Name	Level	Count
GO:0006486	protein glycosylation	4	6
GO:0006487	protein N-linked glycosylation	5	6
GO:0006807	nitrogen compound metabolic process	2	6
GO:0008152	metabolic process	1	9
GO:0019538	protein metabolic process	3	6
GO:0036211	protein modification process	4	6
GO:0043170	macromolecule metabolic process	3	6
GO:0043412	macromolecule modification	4	6
GO:0043413	macromolecule glycosylation	3	6
GO:0044238	primary metabolic process	2	9
GO:0070085	glycosylation	2	6
GO:0071704	organic substance metabolic process	2	9
GO:1901564	organonitrogen compound metabolic process	3	6
GO:0006629	lipid metabolic process	3	1
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0009987	cellular process	1	1
GO:0016311	dephosphorylation	5	1
GO:0030258	lipid modification	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044255	cellular lipid metabolic process	3	1
GO:0046839	phospholipid dephosphorylation	5	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	9
GO:0016462	pyrophosphatase activity	5	6
GO:0016787	hydrolase activity	2	9
GO:0016817	hydrolase activity, acting on acid anhydrides	3	6
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	6
GO:0047874	dolichyldiphosphatase activity	6	6
GO:0016788	hydrolase activity, acting on ester bonds	3	4
GO:0016791	phosphatase activity	5	4
GO:0042392	sphingosine-1-phosphate phosphatase activity	7	1
GO:0042577	lipid phosphatase activity	6	1
GO:0042578	phosphoric ester hydrolase activity	4	4
GO:0008195	phosphatidate phosphatase activity	6	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	141	143	PF00675	0.269
CLV_NRD_NRD_1	147	149	PF00675	0.283
CLV_NRD_NRD_1	153	155	PF00675	0.289
CLV_NRD_NRD_1	79	81	PF00675	0.378
CLV_PCSK_FUR_1	77	81	PF00082	0.391
CLV_PCSK_KEX2_1	141	143	PF00082	0.293
CLV_PCSK_KEX2_1	147	149	PF00082	0.305
CLV_PCSK_KEX2_1	153	155	PF00082	0.309
CLV_PCSK_KEX2_1	79	81	PF00082	0.378
CLV_PCSK_SKI1_1	227	231	PF00082	0.373
DEG_Nend_UBRbox_1	1	4	PF02207	0.339
DOC_CYCLIN_yClb5_NLxxxL_5	81	90	PF00134	0.532
DOC_MAPK_gen_1	77	86	PF00069	0.538
DOC_MAPK_MEF2A_6	235	242	PF00069	0.551
DOC_MAPK_MEF2A_6	79	88	PF00069	0.504
DOC_PP1_RVXF_1	225	232	PF00149	0.454
DOC_USP7_MATH_1	165	169	PF00917	0.515
DOC_USP7_MATH_1	22	26	PF00917	0.534
DOC_WW_Pin1_4	103	108	PF00397	0.298
DOC_WW_Pin1_4	172	177	PF00397	0.570
DOC_WW_Pin1_4	24	29	PF00397	0.456
LIG_14-3-3_CanoR_1	147	156	PF00244	0.504
LIG_14-3-3_CanoR_1	227	232	PF00244	0.577
LIG_Actin_WH2_2	85	103	PF00022	0.465
LIG_BRCT_BRCA1_1	50	54	PF00533	0.341
LIG_EH1_1	53	61	PF00400	0.387
LIG_eIF4E_1	178	184	PF01652	0.465
LIG_eIF4E_1	44	50	PF01652	0.396
LIG_FHA_1	186	192	PF00498	0.417
LIG_FHA_1	220	226	PF00498	0.368
LIG_FHA_1	246	252	PF00498	0.572
LIG_FHA_1	38	44	PF00498	0.417
LIG_FHA_2	18	24	PF00498	0.544
LIG_FHA_2	25	31	PF00498	0.400
LIG_GBD_Chelix_1	181	189	PF00786	0.290
LIG_LIR_Apic_2	119	125	PF02991	0.315
LIG_LIR_Gen_1	175	186	PF02991	0.522
LIG_LIR_Nem_3	175	181	PF02991	0.497
LIG_LIR_Nem_3	188	193	PF02991	0.239
LIG_LYPXL_SIV_4	177	185	PF13949	0.515
LIG_NRBOX	179	185	PF00104	0.465
LIG_Pex14_2	131	135	PF04695	0.330
LIG_Pex14_2	186	190	PF04695	0.368
LIG_RPA_C_Fungi	7	19	PF08784	0.676
LIG_SH2_CRK	118	122	PF00017	0.361
LIG_SH2_CRK	178	182	PF00017	0.429
LIG_SH2_CRK	200	204	PF00017	0.352
LIG_SH2_NCK_1	118	122	PF00017	0.387
LIG_SH2_NCK_1	178	182	PF00017	0.465
LIG_SH2_STAP1	118	122	PF00017	0.387
LIG_SH2_STAP1	178	182	PF00017	0.401
LIG_SH2_STAT5	118	121	PF00017	0.363
LIG_SH2_STAT5	138	141	PF00017	0.411
LIG_SH2_STAT5	89	92	PF00017	0.383
LIG_SH3_3	101	107	PF00018	0.344
LIG_SH3_3	25	31	PF00018	0.698
LIG_TYR_ITIM	116	121	PF00017	0.242
LIG_TYR_ITIM	87	92	PF00017	0.411
MOD_CDK_SPK_2	103	108	PF00069	0.363
MOD_CK2_1	17	23	PF00069	0.703
MOD_CK2_1	24	30	PF00069	0.519
MOD_CMANNOS	34	37	PF00535	0.473
MOD_GlcNHglycan	163	166	PF01048	0.407
MOD_GlcNHglycan	167	170	PF01048	0.451
MOD_GlcNHglycan	72	75	PF01048	0.427
MOD_GSK3_1	161	168	PF00069	0.446
MOD_GSK3_1	17	24	PF00069	0.706
MOD_GSK3_1	33	40	PF00069	0.397
MOD_NEK2_1	171	176	PF00069	0.400
MOD_NEK2_1	185	190	PF00069	0.265
MOD_NEK2_1	218	223	PF00069	0.411
MOD_NEK2_1	242	247	PF00069	0.512
MOD_NEK2_1	54	59	PF00069	0.363
MOD_NEK2_1	90	95	PF00069	0.411
MOD_NEK2_2	117	122	PF00069	0.174
MOD_NEK2_2	133	138	PF00069	0.465
MOD_PKA_2	161	167	PF00069	0.259
MOD_Plk_1	22	28	PF00069	0.529
MOD_Plk_4	117	123	PF00069	0.290
MOD_Plk_4	185	191	PF00069	0.376
MOD_Plk_4	227	233	PF00069	0.380
MOD_Plk_4	242	248	PF00069	0.501
MOD_Plk_4	55	61	PF00069	0.355
MOD_ProDKin_1	103	109	PF00069	0.363
MOD_ProDKin_1	172	178	PF00069	0.464
MOD_ProDKin_1	24	30	PF00069	0.578
TRG_ENDOCYTIC_2	118	121	PF00928	0.389
TRG_ENDOCYTIC_2	156	159	PF00928	0.290
TRG_ENDOCYTIC_2	178	181	PF00928	0.364
TRG_ENDOCYTIC_2	200	203	PF00928	0.352
TRG_ENDOCYTIC_2	89	92	PF00928	0.411
TRG_ER_diArg_1	140	142	PF00400	0.354
TRG_ER_diArg_1	147	150	PF00400	0.372
TRG_ER_diArg_1	79	81	PF00400	0.475

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IGH8	Leptomonas seymouri	61%	94%
A0A1X0P264	Trypanosomatidae	34%	100%
A0A3S7X373	Leishmania donovani	90%	93%
A0A422NMI8	Trypanosoma rangeli	34%	100%
A4HHZ1	Leishmania braziliensis	80%	100%
A4I568	Leishmania infantum	91%	93%
B0CM95	Papio anubis	32%	100%
B0KWE9	Callithrix jacchus	32%	100%
B1MTH4	Plecturocebus moloch	32%	100%
B2KI79	Rhinolophus ferrumequinum	32%	100%
C9ZQJ4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
P53223	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	29%	100%
Q4Q7R8	Leishmania major	88%	100%
Q86IX2	Dictyostelium discoideum	27%	100%
Q86YN1	Homo sapiens	32%	100%
Q9JMF7	Mus musculus	31%	100%