Hydrolase_4 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Alpha/beta hydrolase family, putative

Species:

Leishmania mexicana

UniProt:

E9B0G4_LEIMU

TriTrypDb:

LmxM.29.0400

Length:

480

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B0G4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B0G4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0016787	hydrolase activity	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	148	152	PF00656	0.360
CLV_C14_Caspase3-7	16	20	PF00656	0.348
CLV_C14_Caspase3-7	231	235	PF00656	0.424
CLV_C14_Caspase3-7	3	7	PF00656	0.543
CLV_C14_Caspase3-7	455	459	PF00656	0.523
CLV_NRD_NRD_1	218	220	PF00675	0.366
CLV_NRD_NRD_1	477	479	PF00675	0.611
CLV_NRD_NRD_1	79	81	PF00675	0.389
CLV_PCSK_KEX2_1	220	222	PF00082	0.380
CLV_PCSK_KEX2_1	224	226	PF00082	0.391
CLV_PCSK_KEX2_1	477	479	PF00082	0.611
CLV_PCSK_KEX2_1	79	81	PF00082	0.389
CLV_PCSK_PC1ET2_1	220	222	PF00082	0.380
CLV_PCSK_PC1ET2_1	224	226	PF00082	0.391
CLV_PCSK_SKI1_1	221	225	PF00082	0.433
CLV_PCSK_SKI1_1	237	241	PF00082	0.435
CLV_PCSK_SKI1_1	266	270	PF00082	0.444
CLV_PCSK_SKI1_1	295	299	PF00082	0.386
CLV_PCSK_SKI1_1	337	341	PF00082	0.595
DEG_APCC_DBOX_1	132	140	PF00400	0.300
DEG_Nend_Nbox_1	1	3	PF02207	0.552
DEG_SPOP_SBC_1	379	383	PF00917	0.677
DEG_SPOP_SBC_1	391	395	PF00917	0.672
DOC_CKS1_1	276	281	PF01111	0.488
DOC_CYCLIN_RxL_1	310	323	PF00134	0.522
DOC_CYCLIN_yCln2_LP_2	354	357	PF00134	0.574
DOC_MAPK_DCC_7	201	211	PF00069	0.328
DOC_MAPK_DCC_7	240	249	PF00069	0.398
DOC_MAPK_gen_1	201	211	PF00069	0.385
DOC_MAPK_gen_1	292	302	PF00069	0.249
DOC_MAPK_gen_1	466	476	PF00069	0.519
DOC_MAPK_MEF2A_6	204	211	PF00069	0.352
DOC_MAPK_MEF2A_6	240	249	PF00069	0.398
DOC_MAPK_MEF2A_6	295	302	PF00069	0.406
DOC_MAPK_NFAT4_5	295	303	PF00069	0.381
DOC_PP1_RVXF_1	62	69	PF00149	0.408
DOC_PP2B_LxvP_1	354	357	PF13499	0.574
DOC_PP2B_PxIxI_1	206	212	PF00149	0.328
DOC_PP4_FxxP_1	256	259	PF00568	0.416
DOC_PP4_FxxP_1	269	272	PF00568	0.465
DOC_USP7_MATH_1	183	187	PF00917	0.360
DOC_USP7_MATH_1	338	342	PF00917	0.537
DOC_USP7_MATH_1	377	381	PF00917	0.685
DOC_USP7_MATH_1	387	391	PF00917	0.603
DOC_USP7_MATH_1	447	451	PF00917	0.537
DOC_USP7_UBL2_3	220	224	PF12436	0.371
DOC_WW_Pin1_4	179	184	PF00397	0.328
DOC_WW_Pin1_4	255	260	PF00397	0.498
DOC_WW_Pin1_4	275	280	PF00397	0.518
DOC_WW_Pin1_4	322	327	PF00397	0.521
DOC_WW_Pin1_4	370	375	PF00397	0.700
DOC_WW_Pin1_4	383	388	PF00397	0.655
DOC_WW_Pin1_4	400	405	PF00397	0.688
DOC_WW_Pin1_4	417	422	PF00397	0.549
DOC_WW_Pin1_4	428	433	PF00397	0.556
LIG_14-3-3_CanoR_1	27	35	PF00244	0.463
LIG_14-3-3_CanoR_1	446	456	PF00244	0.655
LIG_14-3-3_CanoR_1	67	73	PF00244	0.380
LIG_14-3-3_CterR_2	477	480	PF00244	0.503
LIG_AP2alpha_2	172	174	PF02296	0.336
LIG_BIR_III_2	267	271	PF00653	0.448
LIG_BRCT_BRCA1_1	126	130	PF00533	0.300
LIG_BRCT_BRCA1_1	393	397	PF00533	0.619
LIG_Clathr_ClatBox_1	110	114	PF01394	0.360
LIG_eIF4E_1	131	137	PF01652	0.376
LIG_EVH1_2	432	436	PF00568	0.489
LIG_FHA_1	200	206	PF00498	0.470
LIG_FHA_1	30	36	PF00498	0.418
LIG_FHA_1	365	371	PF00498	0.735
LIG_FHA_1	417	423	PF00498	0.516
LIG_FHA_1	451	457	PF00498	0.581
LIG_FHA_1	469	475	PF00498	0.500
LIG_FHA_2	258	264	PF00498	0.390
LIG_FHA_2	393	399	PF00498	0.597
LIG_FHA_2	453	459	PF00498	0.510
LIG_LIR_Apic_2	253	259	PF02991	0.432
LIG_LIR_Apic_2	267	272	PF02991	0.458
LIG_LIR_Apic_2	71	75	PF02991	0.278
LIG_LIR_Gen_1	106	115	PF02991	0.417
LIG_LIR_Gen_1	122	131	PF02991	0.236
LIG_LIR_Gen_1	141	150	PF02991	0.300
LIG_LIR_Gen_1	181	191	PF02991	0.300
LIG_LIR_Nem_3	106	111	PF02991	0.417
LIG_LIR_Nem_3	122	128	PF02991	0.236
LIG_LIR_Nem_3	141	145	PF02991	0.300
LIG_LIR_Nem_3	181	187	PF02991	0.300
LIG_LIR_Nem_3	71	76	PF02991	0.380
LIG_PCNA_PIPBox_1	291	300	PF02747	0.332
LIG_PCNA_yPIPBox_3	286	298	PF02747	0.344
LIG_Pex14_1	72	76	PF04695	0.383
LIG_Pex14_2	111	115	PF04695	0.360
LIG_Pex14_2	68	72	PF04695	0.373
LIG_PTAP_UEV_1	342	347	PF05743	0.507
LIG_SH2_PTP2	125	128	PF00017	0.360
LIG_SH2_STAT3	131	134	PF00017	0.300
LIG_SH2_STAT5	125	128	PF00017	0.347
LIG_SH2_STAT5	301	304	PF00017	0.359
LIG_SH2_STAT5	411	414	PF00017	0.397
LIG_SH2_STAT5	86	89	PF00017	0.312
LIG_SH3_3	340	346	PF00018	0.634
LIG_SUMO_SIM_anti_2	135	141	PF11976	0.376
LIG_SUMO_SIM_par_1	135	141	PF11976	0.376
LIG_WRPW_2	73	76	PF00400	0.331
LIG_WW_3	27	31	PF00397	0.445
MOD_CDC14_SPxK_1	420	423	PF00782	0.502
MOD_CDK_SPxK_1	417	423	PF00069	0.486
MOD_CDK_SPxxK_3	400	407	PF00069	0.565
MOD_CK1_1	118	124	PF00069	0.300
MOD_CK1_1	13	19	PF00069	0.478
MOD_CK1_1	341	347	PF00069	0.642
MOD_CK1_1	372	378	PF00069	0.663
MOD_CK1_1	380	386	PF00069	0.731
MOD_CK1_1	390	396	PF00069	0.765
MOD_CK1_1	400	406	PF00069	0.412
MOD_CK1_1	415	421	PF00069	0.572
MOD_CK1_1	438	444	PF00069	0.574
MOD_CK1_1	450	456	PF00069	0.638
MOD_CK2_1	118	124	PF00069	0.300
MOD_CK2_1	257	263	PF00069	0.371
MOD_CK2_1	28	34	PF00069	0.448
MOD_GlcNHglycan	117	120	PF01048	0.300
MOD_GlcNHglycan	12	15	PF01048	0.558
MOD_GlcNHglycan	2	5	PF01048	0.538
MOD_GlcNHglycan	343	346	PF01048	0.750
MOD_GlcNHglycan	375	378	PF01048	0.678
MOD_GlcNHglycan	389	392	PF01048	0.655
MOD_GlcNHglycan	442	445	PF01048	0.563
MOD_GlcNHglycan	449	452	PF01048	0.539
MOD_GSK3_1	179	186	PF00069	0.304
MOD_GSK3_1	333	340	PF00069	0.573
MOD_GSK3_1	364	371	PF00069	0.682
MOD_GSK3_1	373	380	PF00069	0.582
MOD_GSK3_1	381	388	PF00069	0.648
MOD_GSK3_1	389	396	PF00069	0.755
MOD_GSK3_1	412	419	PF00069	0.671
MOD_GSK3_1	424	431	PF00069	0.630
MOD_GSK3_1	434	441	PF00069	0.680
MOD_GSK3_1	464	471	PF00069	0.621
MOD_GSK3_1	472	479	PF00069	0.529
MOD_GSK3_1	9	16	PF00069	0.517
MOD_NEK2_1	115	120	PF00069	0.360
MOD_NEK2_1	320	325	PF00069	0.493
MOD_NEK2_1	369	374	PF00069	0.638
MOD_NEK2_1	397	402	PF00069	0.523
MOD_NEK2_1	435	440	PF00069	0.565
MOD_NEK2_1	68	73	PF00069	0.372
MOD_NEK2_1	9	14	PF00069	0.570
MOD_NEK2_2	183	188	PF00069	0.300
MOD_NEK2_2	472	477	PF00069	0.514
MOD_PIKK_1	338	344	PF00454	0.528
MOD_PKA_2	29	35	PF00069	0.464
MOD_PKA_2	415	421	PF00069	0.536
MOD_PKA_2	439	445	PF00069	0.621
MOD_PKA_2	447	453	PF00069	0.639
MOD_PKA_2	468	474	PF00069	0.532
MOD_Plk_1	397	403	PF00069	0.551
MOD_Plk_4	13	19	PF00069	0.478
MOD_Plk_4	397	403	PF00069	0.464
MOD_Plk_4	68	74	PF00069	0.314
MOD_ProDKin_1	179	185	PF00069	0.328
MOD_ProDKin_1	255	261	PF00069	0.493
MOD_ProDKin_1	275	281	PF00069	0.518
MOD_ProDKin_1	322	328	PF00069	0.526
MOD_ProDKin_1	370	376	PF00069	0.703
MOD_ProDKin_1	383	389	PF00069	0.655
MOD_ProDKin_1	400	406	PF00069	0.685
MOD_ProDKin_1	417	423	PF00069	0.555
MOD_ProDKin_1	428	434	PF00069	0.554
TRG_DiLeu_BaEn_1	132	137	PF01217	0.376
TRG_DiLeu_BaEn_1	99	104	PF01217	0.336
TRG_DiLeu_BaLyEn_6	185	190	PF01217	0.398
TRG_DiLeu_BaLyEn_6	289	294	PF01217	0.268
TRG_ENDOCYTIC_2	125	128	PF00928	0.360
TRG_ENDOCYTIC_2	95	98	PF00928	0.360
TRG_ER_diArg_1	218	221	PF00400	0.370
TRG_ER_diArg_1	446	449	PF00400	0.546
TRG_ER_diArg_1	476	478	PF00400	0.522
TRG_ER_diArg_1	79	81	PF00400	0.393
TRG_NES_CRM1_1	134	149	PF08389	0.360
TRG_NES_CRM1_1	288	304	PF08389	0.366
TRG_NES_CRM1_1	99	114	PF08389	0.300
TRG_NLS_MonoExtN_4	217	223	PF00514	0.372
TRG_Pf-PMV_PEXEL_1	188	192	PF00026	0.309
TRG_Pf-PMV_PEXEL_1	212	216	PF00026	0.321
TRG_Pf-PMV_PEXEL_1	64	69	PF00026	0.406

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HRJ3	Leptomonas seymouri	76%	100%
A0A0S4JBE5	Bodo saltans	48%	100%
A0A3S5H7M3	Leishmania donovani	85%	97%
A4HHZ0	Leishmania braziliensis	81%	100%
A4I567	Leishmania infantum	86%	97%
Q4Q7R9	Leishmania major	88%	100%