Type III endosome membrane protein TEMP

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9B0G3_LEIMU

TriTrypDb:

LmxM.29.0390

Length:

266

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 4
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

E9B0G3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B0G3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	163	167	PF00656	0.620
CLV_C14_Caspase3-7	202	206	PF00656	0.733
CLV_C14_Caspase3-7	236	240	PF00656	0.682
CLV_NRD_NRD_1	258	260	PF00675	0.501
CLV_NRD_NRD_1	262	264	PF00675	0.471
CLV_NRD_NRD_1	36	38	PF00675	0.215
CLV_PCSK_FUR_1	256	260	PF00082	0.412
CLV_PCSK_KEX2_1	258	260	PF00082	0.501
CLV_PCSK_KEX2_1	36	38	PF00082	0.240
CLV_PCSK_SKI1_1	16	20	PF00082	0.386
CLV_PCSK_SKI1_1	32	36	PF00082	0.406
DEG_SCF_FBW7_1	231	238	PF00400	0.712
DEG_SCF_TRCP1_1	84	90	PF00400	0.492
DOC_CKS1_1	177	182	PF01111	0.695
DOC_CYCLIN_RxL_1	13	24	PF00134	0.570
DOC_CYCLIN_yCln2_LP_2	19	22	PF00134	0.559
DOC_MAPK_gen_1	36	42	PF00069	0.415
DOC_MAPK_MEF2A_6	27	35	PF00069	0.597
DOC_PP2B_LxvP_1	18	21	PF13499	0.547
DOC_PP2B_LxvP_1	3	6	PF13499	0.581
DOC_PP4_MxPP_1	185	188	PF00568	0.682
DOC_USP7_MATH_1	65	69	PF00917	0.465
DOC_USP7_MATH_1	89	93	PF00917	0.411
DOC_WW_Pin1_4	176	181	PF00397	0.714
DOC_WW_Pin1_4	231	236	PF00397	0.709
DOC_WW_Pin1_4	87	92	PF00397	0.528
LIG_14-3-3_CanoR_1	251	255	PF00244	0.779
LIG_Actin_WH2_2	22	38	PF00022	0.599
LIG_BIR_II_1	1	5	PF00653	0.596
LIG_BRCT_BRCA1_1	222	226	PF00533	0.792
LIG_deltaCOP1_diTrp_1	101	112	PF00928	0.427
LIG_FHA_1	148	154	PF00498	0.717
LIG_FHA_1	15	21	PF00498	0.565
LIG_FHA_1	193	199	PF00498	0.786
LIG_FHA_1	232	238	PF00498	0.626
LIG_FHA_2	142	148	PF00498	0.750
LIG_LIR_Gen_1	102	113	PF02991	0.444
LIG_LIR_Gen_1	127	135	PF02991	0.221
LIG_LIR_Gen_1	223	231	PF02991	0.801
LIG_LIR_LC3C_4	225	229	PF02991	0.622
LIG_LIR_Nem_3	102	108	PF02991	0.487
LIG_LIR_Nem_3	109	115	PF02991	0.374
LIG_LIR_Nem_3	127	131	PF02991	0.295
LIG_LIR_Nem_3	138	142	PF02991	0.648
LIG_LIR_Nem_3	223	229	PF02991	0.800
LIG_NRP_CendR_1	263	266	PF00754	0.492
LIG_Pex14_2	112	116	PF04695	0.442
LIG_SH2_PTP2	177	180	PF00017	0.652
LIG_SH2_SRC	200	203	PF00017	0.630
LIG_SH2_STAT5	135	138	PF00017	0.684
LIG_SH2_STAT5	177	180	PF00017	0.652
LIG_SH3_3	225	231	PF00018	0.622
LIG_SH3_3	88	94	PF00018	0.525
LIG_SUMO_SIM_anti_2	127	133	PF11976	0.221
LIG_SUMO_SIM_anti_2	225	234	PF11976	0.622
LIG_SUMO_SIM_par_1	225	234	PF11976	0.622
LIG_SUMO_SIM_par_1	49	54	PF11976	0.385
LIG_TRAF2_1	199	202	PF00917	0.800
LIG_UBA3_1	28	32	PF00899	0.584
LIG_WRC_WIRS_1	125	130	PF05994	0.221
MOD_CDK_SPK_2	176	181	PF00069	0.697
MOD_CDK_SPxxK_3	176	183	PF00069	0.692
MOD_CK1_1	145	151	PF00069	0.707
MOD_CK1_1	152	158	PF00069	0.681
MOD_CK1_1	159	165	PF00069	0.644
MOD_CK1_1	167	173	PF00069	0.631
MOD_CK1_1	220	226	PF00069	0.729
MOD_CK1_1	238	244	PF00069	0.629
MOD_CK1_1	250	256	PF00069	0.694
MOD_CK1_1	54	60	PF00069	0.479
MOD_CK1_1	63	69	PF00069	0.447
MOD_CK1_1	74	80	PF00069	0.385
MOD_CK1_1	82	88	PF00069	0.415
MOD_CK1_1	92	98	PF00069	0.429
MOD_CK2_1	145	151	PF00069	0.734
MOD_CK2_1	167	173	PF00069	0.701
MOD_GlcNHglycan	117	120	PF01048	0.224
MOD_GlcNHglycan	163	166	PF01048	0.540
MOD_GlcNHglycan	53	56	PF01048	0.648
MOD_GlcNHglycan	63	66	PF01048	0.627
MOD_GlcNHglycan	71	74	PF01048	0.623
MOD_GlcNHglycan	78	81	PF01048	0.685
MOD_GlcNHglycan	84	87	PF01048	0.701
MOD_GSK3_1	1	8	PF00069	0.590
MOD_GSK3_1	141	148	PF00069	0.692
MOD_GSK3_1	152	159	PF00069	0.656
MOD_GSK3_1	160	167	PF00069	0.611
MOD_GSK3_1	231	238	PF00069	0.729
MOD_GSK3_1	250	257	PF00069	0.822
MOD_GSK3_1	51	58	PF00069	0.673
MOD_GSK3_1	60	67	PF00069	0.492
MOD_GSK3_1	89	96	PF00069	0.424
MOD_N-GLC_1	106	111	PF02516	0.613
MOD_N-GLC_1	220	225	PF02516	0.526
MOD_NEK2_1	1	6	PF00069	0.585
MOD_NEK2_1	254	259	PF00069	0.693
MOD_NEK2_1	60	65	PF00069	0.535
MOD_NEK2_2	106	111	PF00069	0.374
MOD_PIKK_1	156	162	PF00454	0.701
MOD_PIKK_1	215	221	PF00454	0.734
MOD_PKA_2	155	161	PF00069	0.723
MOD_PKA_2	250	256	PF00069	0.725
MOD_Plk_1	106	112	PF00069	0.515
MOD_Plk_2-3	168	174	PF00069	0.686
MOD_Plk_4	124	130	PF00069	0.221
MOD_ProDKin_1	176	182	PF00069	0.711
MOD_ProDKin_1	231	237	PF00069	0.711
MOD_ProDKin_1	87	93	PF00069	0.529
TRG_DiLeu_BaEn_2	221	227	PF01217	0.699
TRG_DiLeu_BaLyEn_6	24	29	PF01217	0.612
TRG_ENDOCYTIC_2	139	142	PF00928	0.666
TRG_ER_diArg_1	180	183	PF00400	0.684
TRG_ER_diArg_1	256	259	PF00400	0.632
TRG_ER_diArg_1	35	37	PF00400	0.572

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X330	Leishmania donovani	80%	100%
A4HHY6	Leishmania braziliensis	57%	100%
A4I566	Leishmania infantum	80%	100%
Q4Q7S0	Leishmania major	76%	100%