Transmembrane 9 superfamily member

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

endosomal integral membrane protein, putative

Species:

Leishmania mexicana

UniProt:

E9B0G0_LEIMU

TriTrypDb:

LmxM.29.0360

Length:

658

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 7, no: 4
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	12
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

E9B0G0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B0G0

Function

Biological processes
Term	Name	Level	Count
GO:0008104	protein localization	4	1
GO:0009987	cellular process	1	1
GO:0033036	macromolecule localization	2	1
GO:0051179	localization	1	1
GO:0051641	cellular localization	2	1
GO:0051668	localization within membrane	3	1
GO:0070727	cellular macromolecule localization	3	1
GO:0072657	protein localization to membrane	4	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	109	111	PF00675	0.420
CLV_NRD_NRD_1	182	184	PF00675	0.458
CLV_NRD_NRD_1	19	21	PF00675	0.547
CLV_NRD_NRD_1	424	426	PF00675	0.311
CLV_PCSK_KEX2_1	109	111	PF00082	0.500
CLV_PCSK_KEX2_1	154	156	PF00082	0.480
CLV_PCSK_KEX2_1	182	184	PF00082	0.459
CLV_PCSK_KEX2_1	19	21	PF00082	0.507
CLV_PCSK_KEX2_1	423	425	PF00082	0.311
CLV_PCSK_PC1ET2_1	154	156	PF00082	0.480
CLV_PCSK_SKI1_1	135	139	PF00082	0.466
CLV_PCSK_SKI1_1	154	158	PF00082	0.523
CLV_PCSK_SKI1_1	195	199	PF00082	0.419
CLV_PCSK_SKI1_1	20	24	PF00082	0.377
CLV_PCSK_SKI1_1	34	38	PF00082	0.283
CLV_PCSK_SKI1_1	393	397	PF00082	0.422
CLV_PCSK_SKI1_1	514	518	PF00082	0.311
CLV_PCSK_SKI1_1	586	590	PF00082	0.218
CLV_PCSK_SKI1_1	613	617	PF00082	0.516
CLV_PCSK_SKI1_1	649	653	PF00082	0.260
CLV_PCSK_SKI1_1	77	81	PF00082	0.596
DEG_APCC_DBOX_1	19	27	PF00400	0.689
DEG_APCC_DBOX_1	33	41	PF00400	0.366
DEG_APCC_DBOX_1	392	400	PF00400	0.311
DEG_MDM2_SWIB_1	538	545	PF02201	0.249
DEG_SCF_FBW7_1	257	264	PF00400	0.183
DEG_SCF_FBW7_1	275	282	PF00400	0.253
DEG_SCF_TRCP1_1	123	129	PF00400	0.188
DEG_SPOP_SBC_1	216	220	PF00917	0.175
DEG_SPOP_SBC_1	274	278	PF00917	0.306
DOC_CDC14_PxL_1	166	174	PF14671	0.253
DOC_CKS1_1	258	263	PF01111	0.183
DOC_CYCLIN_RxL_1	646	654	PF00134	0.427
DOC_MAPK_gen_1	159	166	PF00069	0.231
DOC_MAPK_gen_1	354	364	PF00069	0.431
DOC_MAPK_gen_1	423	432	PF00069	0.418
DOC_MAPK_MEF2A_6	34	43	PF00069	0.356
DOC_MAPK_MEF2A_6	357	366	PF00069	0.449
DOC_MAPK_MEF2A_6	613	622	PF00069	0.356
DOC_PP1_RVXF_1	224	231	PF00149	0.218
DOC_PP1_RVXF_1	647	653	PF00149	0.452
DOC_PP2B_LxvP_1	172	175	PF13499	0.222
DOC_PP4_FxxP_1	353	356	PF00568	0.407
DOC_USP7_MATH_1	216	220	PF00917	0.225
DOC_USP7_MATH_1	261	265	PF00917	0.214
DOC_WW_Pin1_4	257	262	PF00397	0.310
DOC_WW_Pin1_4	275	280	PF00397	0.291
DOC_WW_Pin1_4	5	10	PF00397	0.714
LIG_14-3-3_CanoR_1	12	17	PF00244	0.553
LIG_14-3-3_CanoR_1	127	131	PF00244	0.162
LIG_14-3-3_CanoR_1	143	152	PF00244	0.209
LIG_14-3-3_CanoR_1	195	200	PF00244	0.175
LIG_14-3-3_CanoR_1	266	272	PF00244	0.295
LIG_14-3-3_CanoR_1	423	428	PF00244	0.474
LIG_14-3-3_CanoR_1	548	553	PF00244	0.253
LIG_14-3-3_CanoR_1	89	94	PF00244	0.372
LIG_Actin_WH2_1	19	36	PF00022	0.488
LIG_BRCT_BRCA1_1	263	267	PF00533	0.222
LIG_BRCT_BRCA1_1	378	382	PF00533	0.366
LIG_BRCT_BRCA1_1	54	58	PF00533	0.394
LIG_BRCT_BRCA1_1	567	571	PF00533	0.227
LIG_BRCT_BRCA1_1	643	647	PF00533	0.299
LIG_BRCT_BRCA1_1	90	94	PF00533	0.269
LIG_deltaCOP1_diTrp_1	272	280	PF00928	0.324
LIG_EH1_1	381	389	PF00400	0.252
LIG_eIF4E_1	331	337	PF01652	0.511
LIG_eIF4E_1	445	451	PF01652	0.354
LIG_eIF4E_1	573	579	PF01652	0.511
LIG_FHA_1	11	17	PF00498	0.545
LIG_FHA_1	238	244	PF00498	0.324
LIG_FHA_1	246	252	PF00498	0.240
LIG_FHA_1	28	34	PF00498	0.413
LIG_FHA_1	413	419	PF00498	0.274
LIG_FHA_1	445	451	PF00498	0.276
LIG_FHA_1	49	55	PF00498	0.443
LIG_FHA_1	497	503	PF00498	0.357
LIG_FHA_1	629	635	PF00498	0.253
LIG_FHA_1	69	75	PF00498	0.404
LIG_FHA_2	118	124	PF00498	0.230
LIG_FHA_2	216	222	PF00498	0.222
LIG_FHA_2	258	264	PF00498	0.311
LIG_FHA_2	280	286	PF00498	0.210
LIG_LIR_Apic_2	285	290	PF02991	0.136
LIG_LIR_Apic_2	351	356	PF02991	0.407
LIG_LIR_Apic_2	518	522	PF02991	0.142
LIG_LIR_Gen_1	198	208	PF02991	0.296
LIG_LIR_Gen_1	426	435	PF02991	0.531
LIG_LIR_Gen_1	460	471	PF02991	0.255
LIG_LIR_Gen_1	530	538	PF02991	0.292
LIG_LIR_Gen_1	572	581	PF02991	0.278
LIG_LIR_Gen_1	644	655	PF02991	0.328
LIG_LIR_Nem_3	198	204	PF02991	0.269
LIG_LIR_Nem_3	213	217	PF02991	0.191
LIG_LIR_Nem_3	282	287	PF02991	0.237
LIG_LIR_Nem_3	342	348	PF02991	0.438
LIG_LIR_Nem_3	426	430	PF02991	0.423
LIG_LIR_Nem_3	460	466	PF02991	0.255
LIG_LIR_Nem_3	530	534	PF02991	0.236
LIG_LIR_Nem_3	536	541	PF02991	0.175
LIG_LIR_Nem_3	546	550	PF02991	0.193
LIG_LIR_Nem_3	568	573	PF02991	0.262
LIG_LIR_Nem_3	644	650	PF02991	0.310
LIG_LIR_Nem_3	91	97	PF02991	0.195
LIG_MAD2	226	234	PF02301	0.274
LIG_MLH1_MIPbox_1	567	571	PF16413	0.227
LIG_MYND_3	169	173	PF01753	0.311
LIG_NRBOX	395	401	PF00104	0.411
LIG_NRBOX	465	471	PF00104	0.249
LIG_Pex14_1	427	431	PF04695	0.415
LIG_Pex14_1	584	588	PF04695	0.407
LIG_Pex14_1	597	601	PF04695	0.240
LIG_Pex14_1	90	94	PF04695	0.355
LIG_Pex14_2	538	542	PF04695	0.219
LIG_SH2_CRK	300	304	PF00017	0.240
LIG_SH2_CRK	573	577	PF00017	0.422
LIG_SH2_CRK	601	605	PF00017	0.374
LIG_SH2_CRK	624	628	PF00017	0.423
LIG_SH2_NCK_1	300	304	PF00017	0.197
LIG_SH2_PTP2	287	290	PF00017	0.136
LIG_SH2_PTP2	318	321	PF00017	0.301
LIG_SH2_PTP2	519	522	PF00017	0.377
LIG_SH2_PTP2	531	534	PF00017	0.404
LIG_SH2_SRC	287	290	PF00017	0.167
LIG_SH2_STAP1	152	156	PF00017	0.245
LIG_SH2_STAP1	269	273	PF00017	0.211
LIG_SH2_STAT5	287	290	PF00017	0.274
LIG_SH2_STAT5	318	321	PF00017	0.275
LIG_SH2_STAT5	445	448	PF00017	0.241
LIG_SH2_STAT5	468	471	PF00017	0.387
LIG_SH2_STAT5	519	522	PF00017	0.259
LIG_SH2_STAT5	531	534	PF00017	0.322
LIG_SH2_STAT5	601	604	PF00017	0.274
LIG_SH3_1	504	510	PF00018	0.418
LIG_SH3_3	1	7	PF00018	0.568
LIG_SH3_3	249	255	PF00018	0.322
LIG_SH3_3	349	355	PF00018	0.480
LIG_SH3_3	473	479	PF00018	0.257
LIG_SH3_3	504	510	PF00018	0.415
LIG_SUMO_SIM_anti_2	307	313	PF11976	0.283
LIG_SUMO_SIM_anti_2	398	403	PF11976	0.262
LIG_SUMO_SIM_anti_2	631	636	PF11976	0.306
LIG_SUMO_SIM_par_1	307	313	PF11976	0.407
LIG_TYR_ITIM	212	217	PF00017	0.249
LIG_TYR_ITIM	316	321	PF00017	0.275
LIG_TYR_ITIM	443	448	PF00017	0.270
LIG_TYR_ITIM	604	609	PF00017	0.303
LIG_WRC_WIRS_1	549	554	PF05994	0.339
LIG_WW_3	354	358	PF00397	0.511
MOD_CDK_SPxK_1	275	281	PF00069	0.253
MOD_CDK_SPxxK_3	5	12	PF00069	0.553
MOD_CK1_1	108	114	PF00069	0.298
MOD_CK1_1	176	182	PF00069	0.269
MOD_CK1_1	292	298	PF00069	0.304
MOD_CK1_1	389	395	PF00069	0.210
MOD_CK1_1	48	54	PF00069	0.322
MOD_CK1_1	78	84	PF00069	0.264
MOD_CK2_1	108	114	PF00069	0.207
MOD_CK2_1	142	148	PF00069	0.219
MOD_CK2_1	257	263	PF00069	0.343
MOD_CK2_1	327	333	PF00069	0.526
MOD_CK2_1	527	533	PF00069	0.301
MOD_CK2_1	64	70	PF00069	0.369
MOD_Cter_Amidation	17	20	PF01082	0.484
MOD_GlcNHglycan	122	126	PF01048	0.475
MOD_GlcNHglycan	341	345	PF01048	0.312
MOD_GlcNHglycan	590	593	PF01048	0.244
MOD_GSK3_1	101	108	PF00069	0.420
MOD_GSK3_1	117	124	PF00069	0.355
MOD_GSK3_1	138	145	PF00069	0.200
MOD_GSK3_1	191	198	PF00069	0.299
MOD_GSK3_1	233	240	PF00069	0.253
MOD_GSK3_1	257	264	PF00069	0.281
MOD_GSK3_1	275	282	PF00069	0.294
MOD_GSK3_1	452	459	PF00069	0.248
MOD_GSK3_1	48	55	PF00069	0.421
MOD_GSK3_1	487	494	PF00069	0.289
MOD_GSK3_1	533	540	PF00069	0.390
MOD_GSK3_1	565	572	PF00069	0.301
MOD_GSK3_1	584	591	PF00069	0.338
MOD_GSK3_1	64	71	PF00069	0.303
MOD_LATS_1	181	187	PF00433	0.183
MOD_N-GLC_1	191	196	PF02516	0.453
MOD_N-GLC_1	491	496	PF02516	0.298
MOD_NEK2_1	100	105	PF00069	0.356
MOD_NEK2_1	121	126	PF00069	0.236
MOD_NEK2_1	138	143	PF00069	0.249
MOD_NEK2_1	210	215	PF00069	0.224
MOD_NEK2_1	310	315	PF00069	0.258
MOD_NEK2_1	320	325	PF00069	0.244
MOD_NEK2_1	395	400	PF00069	0.359
MOD_NEK2_1	406	411	PF00069	0.241
MOD_NEK2_1	431	436	PF00069	0.277
MOD_NEK2_1	474	479	PF00069	0.297
MOD_NEK2_1	527	532	PF00069	0.280
MOD_NEK2_1	543	548	PF00069	0.209
MOD_NEK2_1	565	570	PF00069	0.198
MOD_NEK2_1	588	593	PF00069	0.253
MOD_NEK2_1	64	69	PF00069	0.406
MOD_NEK2_1	641	646	PF00069	0.265
MOD_NEK2_1	651	656	PF00069	0.491
MOD_NEK2_1	75	80	PF00069	0.324
MOD_NEK2_1	88	93	PF00069	0.310
MOD_NEK2_2	261	266	PF00069	0.250
MOD_NEK2_2	584	589	PF00069	0.548
MOD_PIKK_1	64	70	PF00454	0.317
MOD_PK_1	12	18	PF00069	0.536
MOD_PK_1	89	95	PF00069	0.274
MOD_PKA_1	423	429	PF00069	0.511
MOD_PKA_2	108	114	PF00069	0.120
MOD_PKA_2	126	132	PF00069	0.130
MOD_PKA_2	142	148	PF00069	0.162
MOD_PKA_2	265	271	PF00069	0.315
MOD_PKA_2	292	298	PF00069	0.247
MOD_PKA_2	423	429	PF00069	0.511
MOD_PKA_2	88	94	PF00069	0.410
MOD_Plk_1	326	332	PF00069	0.419
MOD_Plk_1	491	497	PF00069	0.473
MOD_Plk_2-3	173	179	PF00069	0.222
MOD_Plk_2-3	327	333	PF00069	0.511
MOD_Plk_4	126	132	PF00069	0.168
MOD_Plk_4	210	216	PF00069	0.315
MOD_Plk_4	28	34	PF00069	0.380
MOD_Plk_4	298	304	PF00069	0.240
MOD_Plk_4	310	316	PF00069	0.205
MOD_Plk_4	360	366	PF00069	0.470
MOD_Plk_4	376	382	PF00069	0.210
MOD_Plk_4	395	401	PF00069	0.139
MOD_Plk_4	414	420	PF00069	0.230
MOD_Plk_4	515	521	PF00069	0.278
MOD_Plk_4	527	533	PF00069	0.262
MOD_Plk_4	537	543	PF00069	0.181
MOD_Plk_4	565	571	PF00069	0.271
MOD_Plk_4	574	580	PF00069	0.427
MOD_Plk_4	641	647	PF00069	0.308
MOD_Plk_4	89	95	PF00069	0.274
MOD_ProDKin_1	257	263	PF00069	0.310
MOD_ProDKin_1	275	281	PF00069	0.291
MOD_ProDKin_1	5	11	PF00069	0.714
MOD_SUMO_rev_2	289	297	PF00179	0.300
TRG_DiLeu_BaLyEn_6	96	101	PF01217	0.342
TRG_ENDOCYTIC_2	205	208	PF00928	0.274
TRG_ENDOCYTIC_2	214	217	PF00928	0.212
TRG_ENDOCYTIC_2	300	303	PF00928	0.416
TRG_ENDOCYTIC_2	318	321	PF00928	0.208
TRG_ENDOCYTIC_2	445	448	PF00928	0.241
TRG_ENDOCYTIC_2	531	534	PF00928	0.301
TRG_ENDOCYTIC_2	547	550	PF00928	0.148
TRG_ENDOCYTIC_2	573	576	PF00928	0.415
TRG_ENDOCYTIC_2	601	604	PF00928	0.246
TRG_ENDOCYTIC_2	605	608	PF00928	0.237
TRG_ENDOCYTIC_2	624	627	PF00928	0.155
TRG_ER_diArg_1	182	185	PF00400	0.274
TRG_ER_diArg_1	422	425	PF00400	0.474
TRG_Pf-PMV_PEXEL_1	110	114	PF00026	0.440

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P948	Leptomonas seymouri	29%	99%
A0A0N1I2B1	Leptomonas seymouri	57%	100%
A0A0N1I6Y7	Leptomonas seymouri	26%	100%
A0A0N1IME8	Leptomonas seymouri	22%	100%
A0A0S4IV41	Bodo saltans	33%	100%
A0A0S4J9X2	Bodo saltans	30%	100%
A0A0S4JBB1	Bodo saltans	38%	100%
A0A0S4JCH7	Bodo saltans	30%	96%
A0A0S4JEU5	Bodo saltans	31%	100%
A0A0S4JIF4	Bodo saltans	35%	100%
A0A0S4JWZ9	Bodo saltans	28%	100%
A0A0S4JZ31	Bodo saltans	29%	100%
A0A1X0NJN3	Trypanosomatidae	24%	100%
A0A1X0NK64	Trypanosomatidae	33%	100%
A0A1X0NZX5	Trypanosomatidae	31%	100%
A0A1X0P2G3	Trypanosomatidae	45%	100%
A0A1X0PA12	Trypanosomatidae	33%	100%
A0A3Q8IBT4	Leishmania donovani	26%	100%
A0A3Q8IFM1	Leishmania donovani	89%	100%
A0A3Q8IHT3	Leishmania donovani	27%	100%
A0A3R7MBZ3	Trypanosoma rangeli	32%	100%
A0A3S7X2L7	Leishmania donovani	30%	97%
A0A422NED2	Trypanosoma rangeli	30%	100%
A0A422NMS9	Trypanosoma rangeli	46%	100%
A0A422P482	Trypanosoma rangeli	24%	100%
A4H7C1	Leishmania braziliensis	22%	95%
A4HB85	Leishmania braziliensis	29%	100%
A4HHH4	Leishmania braziliensis	30%	100%
A4HHY3	Leishmania braziliensis	76%	100%
A4HVR6	Leishmania infantum	24%	100%
A4I4M3	Leishmania infantum	30%	97%
A4I563	Leishmania infantum	89%	100%
A4IAD3	Leishmania infantum	27%	100%
A4IFE9	Bos taurus	28%	100%
A5D7E2	Bos taurus	33%	100%
C9ZLB0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	90%
C9ZLW2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
C9ZUX0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
D0A6H3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
E9AE21	Leishmania major	30%	100%
E9ALR2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
E9APG2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	22%	96%
E9B5F7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
F4HW17	Arabidopsis thaliana	26%	100%
F4JRE0	Arabidopsis thaliana	31%	100%
F4KIB2	Arabidopsis thaliana	32%	100%
O15321	Homo sapiens	28%	100%
P32802	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	30%	99%
P40071	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	25%	93%
P58021	Mus musculus	32%	99%
Q04562	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	31%	98%
Q4KLL4	Rattus norvegicus	33%	100%
Q4Q2H8	Leishmania major	27%	100%
Q4Q7S3	Leishmania major	90%	100%
Q4QG16	Leishmania major	21%	95%
Q54ZW0	Dictyostelium discoideum	27%	100%
Q55FP0	Dictyostelium discoideum	31%	100%
Q5R8F1	Pongo abelii	29%	100%
Q5R8Y6	Pongo abelii	32%	99%
Q5RDY2	Pongo abelii	33%	100%
Q66HF2	Rattus norvegicus	29%	100%
Q66HG5	Rattus norvegicus	32%	99%
Q7YTA6	Dictyostelium discoideum	26%	100%
Q8BH24	Mus musculus	33%	100%
Q8RWW1	Arabidopsis thaliana	33%	100%
Q92544	Homo sapiens	33%	100%
Q940G0	Arabidopsis thaliana	29%	100%
Q940S0	Arabidopsis thaliana	29%	100%
Q99805	Homo sapiens	32%	99%
Q9C5N2	Arabidopsis thaliana	32%	100%
Q9C720	Arabidopsis thaliana	33%	100%
Q9DBU0	Mus musculus	29%	100%
Q9ET30	Mus musculus	27%	100%
Q9FHT4	Arabidopsis thaliana	28%	100%
Q9FYQ8	Arabidopsis thaliana	32%	100%
Q9HD45	Homo sapiens	27%	100%
Q9LIC2	Arabidopsis thaliana	32%	100%
Q9Y819	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	34%	100%
Q9ZPS7	Arabidopsis thaliana	28%	100%
V5BCD5	Trypanosoma cruzi	46%	100%
V5BHS7	Trypanosoma cruzi	33%	100%
V5D9U0	Trypanosoma cruzi	30%	100%
V5DII3	Trypanosoma cruzi	24%	100%