Kinesin-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

kinesin, putative

Species:

Leishmania mexicana

UniProt:

E9B0F9_LEIMU

TriTrypDb:

LmxM.29.0350

Length:

610

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 7

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005874	microtubule	6	11
GO:0099080	supramolecular complex	2	11
GO:0099081	supramolecular polymer	3	11
GO:0099512	supramolecular fiber	4	11
GO:0099513	polymeric cytoskeletal fiber	5	11
GO:0110165	cellular anatomical entity	1	11
GO:0005737	cytoplasm	2	1
GO:0005871	kinesin complex	3	1
GO:0005875	microtubule associated complex	2	1
GO:0032991	protein-containing complex	1	1

Expansion

Sequence features

E9B0F9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B0F9

Function

Biological processes
Term	Name	Level	Count
GO:0007017	microtubule-based process	2	12
GO:0007018	microtubule-based movement	3	12
GO:0009987	cellular process	1	12
GO:0006810	transport	3	1
GO:0030705	cytoskeleton-dependent intracellular transport	4	1
GO:0046907	intracellular transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003774	cytoskeletal motor activity	1	12
GO:0003777	microtubule motor activity	2	12
GO:0005488	binding	1	12
GO:0005515	protein binding	2	12
GO:0005524	ATP binding	5	12
GO:0008017	microtubule binding	5	12
GO:0008092	cytoskeletal protein binding	3	12
GO:0015631	tubulin binding	4	12
GO:0017076	purine nucleotide binding	4	12
GO:0030554	adenyl nucleotide binding	5	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12
GO:0032559	adenyl ribonucleotide binding	5	12
GO:0035639	purine ribonucleoside triphosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:0140657	ATP-dependent activity	1	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12
GO:0003824	catalytic activity	1	6
GO:0008574	plus-end-directed microtubule motor activity	3	1
GO:0016462	pyrophosphatase activity	5	1
GO:0016787	hydrolase activity	2	6
GO:0016817	hydrolase activity, acting on acid anhydrides	3	1
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	1
GO:0016887	ATP hydrolysis activity	7	1
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	39	43	PF00656	0.365
CLV_C14_Caspase3-7	563	567	PF00656	0.691
CLV_NRD_NRD_1	207	209	PF00675	0.311
CLV_NRD_NRD_1	49	51	PF00675	0.339
CLV_NRD_NRD_1	493	495	PF00675	0.590
CLV_NRD_NRD_1	606	608	PF00675	0.646
CLV_PCSK_KEX2_1	360	362	PF00082	0.428
CLV_PCSK_KEX2_1	493	495	PF00082	0.524
CLV_PCSK_KEX2_1	59	61	PF00082	0.283
CLV_PCSK_PC1ET2_1	360	362	PF00082	0.428
CLV_PCSK_PC1ET2_1	493	495	PF00082	0.524
CLV_PCSK_PC1ET2_1	59	61	PF00082	0.283
CLV_PCSK_SKI1_1	106	110	PF00082	0.351
CLV_PCSK_SKI1_1	131	135	PF00082	0.283
CLV_PCSK_SKI1_1	190	194	PF00082	0.391
CLV_PCSK_SKI1_1	256	260	PF00082	0.381
CLV_PCSK_SKI1_1	286	290	PF00082	0.420
CLV_PCSK_SKI1_1	293	297	PF00082	0.369
CLV_PCSK_SKI1_1	44	48	PF00082	0.384
CLV_PCSK_SKI1_1	484	488	PF00082	0.542
CLV_PCSK_SKI1_1	60	64	PF00082	0.211
DEG_APCC_DBOX_1	255	263	PF00400	0.381
DEG_APCC_DBOX_1	481	489	PF00400	0.479
DOC_CYCLIN_RxL_1	283	290	PF00134	0.420
DOC_MAPK_gen_1	162	171	PF00069	0.317
DOC_MAPK_gen_1	193	201	PF00069	0.270
DOC_MAPK_gen_1	233	242	PF00069	0.319
DOC_MAPK_gen_1	482	489	PF00069	0.463
DOC_MAPK_MEF2A_6	162	169	PF00069	0.348
DOC_MAPK_MEF2A_6	482	489	PF00069	0.503
DOC_MAPK_NFAT4_5	482	490	PF00069	0.575
DOC_USP7_MATH_1	212	216	PF00917	0.410
DOC_USP7_UBL2_3	356	360	PF12436	0.436
DOC_USP7_UBL2_3	51	55	PF12436	0.352
DOC_USP7_UBL2_3	9	13	PF12436	0.504
DOC_WW_Pin1_4	330	335	PF00397	0.307
DOC_WW_Pin1_4	437	442	PF00397	0.643
DOC_WW_Pin1_4	545	550	PF00397	0.625
DOC_WW_Pin1_4	551	556	PF00397	0.593
LIG_14-3-3_CanoR_1	286	292	PF00244	0.397
LIG_14-3-3_CanoR_1	3	12	PF00244	0.630
LIG_14-3-3_CanoR_1	400	405	PF00244	0.578
LIG_14-3-3_CanoR_1	44	49	PF00244	0.355
LIG_14-3-3_CanoR_1	68	77	PF00244	0.365
LIG_Actin_WH2_2	422	437	PF00022	0.597
LIG_APCC_ABBA_1	147	152	PF00400	0.312
LIG_BIR_II_1	1	5	PF00653	0.660
LIG_BIR_III_4	182	186	PF00653	0.163
LIG_BRCT_BRCA1_1	343	347	PF00533	0.163
LIG_BRCT_BRCA1_1	53	57	PF00533	0.292
LIG_BRCT_BRCA1_1	553	557	PF00533	0.477
LIG_BRCT_BRCA1_2	53	59	PF00533	0.163
LIG_FHA_1	105	111	PF00498	0.326
LIG_FHA_1	12	18	PF00498	0.568
LIG_FHA_1	153	159	PF00498	0.321
LIG_FHA_1	226	232	PF00498	0.361
LIG_FHA_1	237	243	PF00498	0.293
LIG_FHA_1	248	254	PF00498	0.364
LIG_FHA_1	311	317	PF00498	0.309
LIG_FHA_1	324	330	PF00498	0.312
LIG_FHA_1	43	49	PF00498	0.298
LIG_FHA_1	523	529	PF00498	0.517
LIG_FHA_1	532	538	PF00498	0.514
LIG_FHA_2	205	211	PF00498	0.376
LIG_FHA_2	269	275	PF00498	0.311
LIG_FHA_2	383	389	PF00498	0.574
LIG_FHA_2	70	76	PF00498	0.386
LIG_Integrin_RGD_1	174	176	PF01839	0.303
LIG_LIR_Gen_1	127	136	PF02991	0.381
LIG_LIR_Gen_1	143	154	PF02991	0.151
LIG_LIR_Gen_1	16	26	PF02991	0.221
LIG_LIR_Gen_1	75	85	PF02991	0.333
LIG_LIR_Nem_3	127	132	PF02991	0.307
LIG_LIR_Nem_3	143	149	PF02991	0.210
LIG_LIR_Nem_3	16	21	PF02991	0.289
LIG_LIR_Nem_3	366	370	PF02991	0.445
LIG_LIR_Nem_3	75	80	PF02991	0.329
LIG_NRBOX	153	159	PF00104	0.307
LIG_PCNA_PIPBox_1	571	580	PF02747	0.353
LIG_PCNA_yPIPBox_3	151	164	PF02747	0.307
LIG_PCNA_yPIPBox_3	419	429	PF02747	0.564
LIG_PCNA_yPIPBox_3	459	468	PF02747	0.600
LIG_PCNA_yPIPBox_3	571	581	PF02747	0.352
LIG_Pex14_2	63	67	PF04695	0.312
LIG_PTB_Apo_2	32	39	PF02174	0.361
LIG_PTB_Apo_2	61	68	PF02174	0.350
LIG_PTB_Phospho_1	32	38	PF10480	0.361
LIG_REV1ctd_RIR_1	199	207	PF16727	0.236
LIG_REV1ctd_RIR_1	345	355	PF16727	0.163
LIG_REV1ctd_RIR_1	60	68	PF16727	0.163
LIG_SH2_CRK	18	22	PF00017	0.411
LIG_SH2_CRK	318	322	PF00017	0.186
LIG_SH2_CRK	367	371	PF00017	0.462
LIG_SH2_NCK_1	38	42	PF00017	0.163
LIG_SH2_PTP2	146	149	PF00017	0.307
LIG_SH2_SRC	38	41	PF00017	0.255
LIG_SH2_SRC	428	431	PF00017	0.543
LIG_SH2_STAP1	140	144	PF00017	0.326
LIG_SH2_STAP1	397	401	PF00017	0.474
LIG_SH2_STAP1	77	81	PF00017	0.326
LIG_SH2_STAT5	146	149	PF00017	0.316
LIG_SH2_STAT5	18	21	PF00017	0.434
LIG_SH2_STAT5	371	374	PF00017	0.455
LIG_SH2_STAT5	428	431	PF00017	0.543
LIG_SH2_STAT5	536	539	PF00017	0.539
LIG_SH2_STAT5	61	64	PF00017	0.407
LIG_SH3_1	20	26	PF00018	0.350
LIG_SH3_3	18	24	PF00018	0.324
LIG_SH3_3	546	552	PF00018	0.725
LIG_SH3_3	63	69	PF00018	0.352
LIG_SH3_5	136	140	PF00018	0.163
LIG_SUMO_SIM_par_1	176	182	PF11976	0.307
LIG_SUMO_SIM_par_1	249	254	PF11976	0.390
LIG_SUMO_SIM_par_1	44	49	PF11976	0.296
LIG_TRAF2_1	385	388	PF00917	0.665
LIG_TRAF2_1	389	392	PF00917	0.627
LIG_TRAF2_1	460	463	PF00917	0.405
LIG_TYR_ITIM	144	149	PF00017	0.307
LIG_TYR_ITIM	316	321	PF00017	0.186
LIG_TYR_ITIM	365	370	PF00017	0.446
LIG_UBA3_1	153	162	PF00899	0.326
LIG_UBA3_1	226	233	PF00899	0.365
LIG_UBA3_1	288	293	PF00899	0.307
LIG_UBA3_1	374	381	PF00899	0.508
LIG_WRC_WIRS_1	503	508	PF05994	0.544
LIG_WRC_WIRS_1	540	545	PF05994	0.685
LIG_WRC_WIRS_1	77	82	PF05994	0.356
MOD_CDK_SPK_2	551	556	PF00069	0.602
MOD_CK1_1	104	110	PF00069	0.294
MOD_CK1_1	181	187	PF00069	0.386
MOD_CK1_1	220	226	PF00069	0.295
MOD_CK1_1	287	293	PF00069	0.395
MOD_CK1_1	310	316	PF00069	0.308
MOD_CK1_1	342	348	PF00069	0.279
MOD_CK1_1	548	554	PF00069	0.637
MOD_CK1_1	7	13	PF00069	0.580
MOD_CK2_1	121	127	PF00069	0.366
MOD_CK2_1	204	210	PF00069	0.287
MOD_CK2_1	268	274	PF00069	0.307
MOD_CK2_1	382	388	PF00069	0.614
MOD_CK2_1	400	406	PF00069	0.375
MOD_GlcNHglycan	103	106	PF01048	0.296
MOD_GlcNHglycan	442	445	PF01048	0.694
MOD_GlcNHglycan	453	456	PF01048	0.431
MOD_GlcNHglycan	51	54	PF01048	0.286
MOD_GlcNHglycan	537	540	PF01048	0.583
MOD_GlcNHglycan	568	571	PF01048	0.612
MOD_GlcNHglycan	9	12	PF01048	0.575
MOD_GSK3_1	104	111	PF00069	0.303
MOD_GSK3_1	138	145	PF00069	0.331
MOD_GSK3_1	212	219	PF00069	0.329
MOD_GSK3_1	243	250	PF00069	0.365
MOD_GSK3_1	262	269	PF00069	0.296
MOD_GSK3_1	332	339	PF00069	0.339
MOD_GSK3_1	42	49	PF00069	0.322
MOD_GSK3_1	523	530	PF00069	0.525
MOD_GSK3_1	531	538	PF00069	0.500
MOD_GSK3_1	539	546	PF00069	0.569
MOD_GSK3_1	7	14	PF00069	0.589
MOD_N-GLC_1	216	221	PF02516	0.307
MOD_N-GLC_1	284	289	PF02516	0.312
MOD_N-GLC_1	324	329	PF02516	0.312
MOD_N-GLC_1	330	335	PF02516	0.300
MOD_N-GLC_1	42	47	PF02516	0.356
MOD_N-GLC_2	230	232	PF02516	0.163
MOD_NEK2_1	121	126	PF00069	0.405
MOD_NEK2_1	158	163	PF00069	0.330
MOD_NEK2_1	211	216	PF00069	0.301
MOD_NEK2_1	307	312	PF00069	0.317
MOD_NEK2_1	316	321	PF00069	0.329
MOD_PIKK_1	350	356	PF00454	0.420
MOD_PIKK_1	515	521	PF00454	0.544
MOD_PIKK_1	69	75	PF00454	0.350
MOD_PK_1	13	19	PF00069	0.310
MOD_PKA_2	266	272	PF00069	0.312
MOD_PKA_2	307	313	PF00069	0.306
MOD_PKA_2	350	356	PF00069	0.420
MOD_PKA_2	399	405	PF00069	0.569
MOD_PKA_2	49	55	PF00069	0.332
MOD_PKA_2	67	73	PF00069	0.350
MOD_Plk_1	279	285	PF00069	0.330
MOD_Plk_1	324	330	PF00069	0.321
MOD_Plk_1	339	345	PF00069	0.266
MOD_Plk_1	382	388	PF00069	0.590
MOD_Plk_1	42	48	PF00069	0.336
MOD_Plk_2-3	274	280	PF00069	0.326
MOD_Plk_2-3	336	342	PF00069	0.326
MOD_Plk_4	142	148	PF00069	0.307
MOD_Plk_4	222	228	PF00069	0.312
MOD_Plk_4	316	322	PF00069	0.329
MOD_Plk_4	324	330	PF00069	0.336
MOD_Plk_4	342	348	PF00069	0.331
MOD_ProDKin_1	330	336	PF00069	0.307
MOD_ProDKin_1	437	443	PF00069	0.648
MOD_ProDKin_1	545	551	PF00069	0.628
MOD_SUMO_for_1	115	118	PF00179	0.236
MOD_SUMO_rev_2	189	198	PF00179	0.422
MOD_SUMO_rev_2	269	278	PF00179	0.327
MOD_SUMO_rev_2	363	370	PF00179	0.440
MOD_SUMO_rev_2	402	411	PF00179	0.597
MOD_SUMO_rev_2	466	475	PF00179	0.463
TRG_DiLeu_BaEn_1	406	411	PF01217	0.530
TRG_DiLeu_BaEn_1	463	468	PF01217	0.315
TRG_DiLeu_BaEn_1	580	585	PF01217	0.528
TRG_DiLeu_BaEn_4	406	412	PF01217	0.602
TRG_ENDOCYTIC_2	146	149	PF00928	0.307
TRG_ENDOCYTIC_2	150	153	PF00928	0.307
TRG_ENDOCYTIC_2	18	21	PF00928	0.434
TRG_ENDOCYTIC_2	318	321	PF00928	0.326
TRG_ENDOCYTIC_2	367	370	PF00928	0.455
TRG_ENDOCYTIC_2	371	374	PF00928	0.466
TRG_ENDOCYTIC_2	77	80	PF00928	0.291
TRG_ER_diArg_1	20	23	PF00400	0.315
TRG_ER_diArg_1	482	485	PF00400	0.568
TRG_NES_CRM1_1	399	414	PF08389	0.573
TRG_Pf-PMV_PEXEL_1	126	130	PF00026	0.216
TRG_Pf-PMV_PEXEL_1	276	280	PF00026	0.326
TRG_Pf-PMV_PEXEL_1	384	388	PF00026	0.693
TRG_Pf-PMV_PEXEL_1	465	469	PF00026	0.545
TRG_Pf-PMV_PEXEL_1	575	580	PF00026	0.539
TRG_Pf-PMV_PEXEL_1	596	601	PF00026	0.545

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P569	Leptomonas seymouri	26%	70%
A0A0N1HY56	Leptomonas seymouri	28%	89%
A0A0N1I0Y5	Leptomonas seymouri	71%	99%
A0A0N1IH46	Leptomonas seymouri	27%	87%
A0A0S4IR67	Bodo saltans	28%	78%
A0A0S4J1I2	Bodo saltans	28%	92%
A0A0S4JEF6	Bodo saltans	50%	91%
A0A1X0NNI2	Trypanosomatidae	34%	67%
A0A1X0NP27	Trypanosomatidae	32%	82%
A0A1X0NPH9	Trypanosomatidae	27%	66%
A0A1X0NQ03	Trypanosomatidae	26%	74%
A0A1X0NWZ8	Trypanosomatidae	28%	82%
A0A1X0P0C2	Trypanosomatidae	29%	74%
A0A1X0P2B6	Trypanosomatidae	56%	99%
A0A1X0P9E3	Trypanosomatidae	31%	100%
A0A1X0P9H3	Trypanosomatidae	32%	71%
A0A1X0P9T0	Trypanosomatidae	32%	100%
A0A3Q8IBS7	Leishmania donovani	87%	100%
A0A3Q8IEL2	Leishmania donovani	30%	100%
A0A3Q8IG88	Leishmania donovani	25%	87%
A0A3Q8IHG6	Leishmania donovani	31%	100%
A0A3R7MDH9	Trypanosoma rangeli	28%	86%
A0A3R7RD86	Trypanosoma rangeli	28%	76%
A0A3S5IRH3	Trypanosoma rangeli	55%	100%
A0A3S7X2P9	Leishmania donovani	30%	100%
A0A3S7X9Y1	Leishmania donovani	26%	100%
A0A422MZ05	Trypanosoma rangeli	26%	90%
A0A422NEQ8	Trypanosoma rangeli	27%	81%
A4H4I4	Leishmania braziliensis	25%	100%
A4HAQ7	Leishmania braziliensis	28%	100%
A4HCA1	Leishmania braziliensis	27%	68%
A4HCT2	Leishmania braziliensis	28%	85%
A4HHN7	Leishmania braziliensis	31%	100%
A4HHN8	Leishmania braziliensis	30%	100%
A4HHY2	Leishmania braziliensis	75%	100%
A4HND6	Leishmania braziliensis	25%	100%
A4HSA6	Leishmania infantum	35%	100%
A4HX45	Leishmania infantum	25%	100%
A4HZT3	Leishmania infantum	25%	69%
A4I4V2	Leishmania infantum	31%	100%
A4I4V3	Leishmania infantum	30%	100%
A4I562	Leishmania infantum	87%	100%
A4IBA7	Leishmania infantum	25%	87%
A4IC09	Leishmania infantum	26%	100%
B9G2X9	Oryza sativa subsp. japonica	30%	100%
C9ZK93	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	82%
C9ZQI8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	97%
C9ZV26	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	81%
E9AEA0	Leishmania major	31%	100%
E9AEA1	Leishmania major	31%	100%
E9AF32	Leishmania major	25%	87%
E9AFU7	Leishmania major	26%	100%
E9AKP6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
E9ALI5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
E9ALI6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
E9AVN8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	69%
E9B687	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	88%
E9B6Z9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
F4I1T9	Arabidopsis thaliana	30%	71%
Q4Q7S4	Leishmania major	84%	100%
Q4R918	Macaca fascicularis	28%	100%
Q75HV1	Oryza sativa subsp. japonica	32%	73%
Q8NI77	Homo sapiens	31%	68%
Q91WD7	Mus musculus	30%	69%
Q965T6	Caenorhabditis elegans	35%	94%
Q96FN5	Homo sapiens	31%	94%
Q9WV04	Mus musculus	32%	77%
V5BK25	Trypanosoma cruzi	28%	85%
V5D733	Trypanosoma cruzi	28%	81%
V5DFA7	Trypanosoma cruzi	30%	100%
V5DMS2	Trypanosoma cruzi	29%	100%
V5DTU1	Trypanosoma cruzi	30%	100%