Putative KU80 protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

KU80 protein, putative

Species:

Leishmania mexicana

UniProt:

E9B0F8_LEIMU

TriTrypDb:

LmxM.29.0340

Length:

798

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0005694	chromosome	5	1
GO:0032991	protein-containing complex	1	12
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0043564	Ku70:Ku80 complex	3	12
GO:0110165	cellular anatomical entity	1	1
GO:0140513	nuclear protein-containing complex	2	12

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Expansion

Sequence features

E9B0F8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B0F8

Function

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Biological processes
Term	Name	Level	Count
GO:0000723	telomere maintenance	5	12
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006259	DNA metabolic process	4	12
GO:0006281	DNA repair	5	12
GO:0006302	double-strand break repair	6	12
GO:0006303	double-strand break repair via nonhomologous end joining	7	12
GO:0006310	DNA recombination	5	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0006950	response to stress	2	12

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Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003676	nucleic acid binding	3	12
GO:0003677	DNA binding	4	12
GO:0003684	damaged DNA binding	5	12
GO:0003824	catalytic activity	1	12
GO:0004386	helicase activity	2	12
GO:0005488	binding	1	12
GO:0005524	ATP binding	5	12
GO:0016787	hydrolase activity	2	12
GO:0017076	purine nucleotide binding	4	12

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	111	115	PF00656	0.559
CLV_C14_Caspase3-7	154	158	PF00656	0.351
CLV_C14_Caspase3-7	277	281	PF00656	0.476
CLV_C14_Caspase3-7	452	456	PF00656	0.535
CLV_C14_Caspase3-7	549	553	PF00656	0.635
CLV_C14_Caspase3-7	687	691	PF00656	0.469
CLV_C14_Caspase3-7	743	747	PF00656	0.562
CLV_NRD_NRD_1	103	105	PF00675	0.207
CLV_NRD_NRD_1	201	203	PF00675	0.564
CLV_NRD_NRD_1	239	241	PF00675	0.446

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HUA9	Leptomonas seymouri	56%	100%
A0A0S4JHV4	Bodo saltans	28%	97%
A0A1X0P2Y5	Trypanosomatidae	31%	95%
A0A3Q8IRQ2	Leishmania donovani	91%	100%
A0A422NMK3	Trypanosoma rangeli	36%	100%
A4HHY1	Leishmania braziliensis	78%	100%
A4I561	Leishmania infantum	91%	100%
C9ZQI7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
Q4Q7S5	Leishmania major	90%	100%
Q54LY5	Dictyostelium discoideum	22%	100%

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