LIM zinc-binding domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B0F2_LEIMU

TriTrypDb:

LmxM.29.0280

Length:

203

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B0F2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B0F2

PDB structure(s): 7aih_Ax , 7am2_Ax , 7ane_Ax

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	10
GO:0043167	ion binding	2	10
GO:0043169	cation binding	3	10
GO:0046872	metal ion binding	4	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	167	169	PF00675	0.396
CLV_NRD_NRD_1	48	50	PF00675	0.518
CLV_PCSK_KEX2_1	167	169	PF00082	0.396
CLV_PCSK_KEX2_1	48	50	PF00082	0.504
CLV_PCSK_PC7_1	163	169	PF00082	0.432
CLV_PCSK_SKI1_1	128	132	PF00082	0.423
CLV_PCSK_SKI1_1	57	61	PF00082	0.431
DEG_Nend_UBRbox_3	1	3	PF02207	0.519
DOC_CYCLIN_RxL_1	2	13	PF00134	0.439
DOC_MAPK_gen_1	190	197	PF00069	0.465
DOC_PP2B_LxvP_1	25	28	PF13499	0.670
DOC_PP2B_LxvP_1	7	10	PF13499	0.433
DOC_USP7_MATH_1	10	14	PF00917	0.683
DOC_WW_Pin1_4	197	202	PF00397	0.496
LIG_14-3-3_CanoR_1	11	18	PF00244	0.651
LIG_14-3-3_CanoR_1	116	125	PF00244	0.441
LIG_14-3-3_CanoR_1	168	174	PF00244	0.431
LIG_CSL_BTD_1	108	111	PF09270	0.377
LIG_FHA_1	169	175	PF00498	0.432
LIG_FHA_1	20	26	PF00498	0.689
LIG_FHA_1	75	81	PF00498	0.561
LIG_LIR_Gen_1	106	115	PF02991	0.435
LIG_LIR_Nem_3	106	110	PF02991	0.390
LIG_Pex14_1	133	137	PF04695	0.401
LIG_Pex14_1	169	173	PF04695	0.413
LIG_PTB_Apo_2	139	146	PF02174	0.420
LIG_PTB_Phospho_1	139	145	PF10480	0.425
LIG_REV1ctd_RIR_1	122	132	PF16727	0.419
LIG_SH2_CRK	137	141	PF00017	0.488
LIG_SH2_GRB2like	173	176	PF00017	0.426
LIG_SH2_PTP2	107	110	PF00017	0.386
LIG_SH2_STAP1	76	80	PF00017	0.564
LIG_SH2_STAT5	107	110	PF00017	0.386
LIG_SH2_STAT5	123	126	PF00017	0.179
LIG_SH2_STAT5	173	176	PF00017	0.426
LIG_SH2_STAT5	76	79	PF00017	0.552
LIG_SH3_1	68	74	PF00018	0.509
LIG_SH3_3	105	111	PF00018	0.386
LIG_SH3_3	68	74	PF00018	0.508
LIG_SH3_3	77	83	PF00018	0.442
LIG_TRAF2_1	63	66	PF00917	0.628
MOD_CDK_SPK_2	197	202	PF00069	0.496
MOD_CK1_1	181	187	PF00069	0.453
MOD_CK1_1	21	27	PF00069	0.690
MOD_CK2_1	197	203	PF00069	0.568
MOD_GlcNHglycan	111	114	PF01048	0.554
MOD_GlcNHglycan	12	15	PF01048	0.676
MOD_GlcNHglycan	37	40	PF01048	0.671
MOD_GSK3_1	169	176	PF00069	0.429
MOD_GSK3_1	19	26	PF00069	0.681
MOD_LATS_1	33	39	PF00433	0.633
MOD_NEK2_1	18	23	PF00069	0.617
MOD_PIKK_1	117	123	PF00454	0.448
MOD_PIKK_1	41	47	PF00454	0.505
MOD_PKA_2	10	16	PF00069	0.671
MOD_PKA_2	181	187	PF00069	0.431
MOD_Plk_4	103	109	PF00069	0.411
MOD_Plk_4	169	175	PF00069	0.432
MOD_ProDKin_1	197	203	PF00069	0.508
TRG_ENDOCYTIC_2	107	110	PF00928	0.386
TRG_ENDOCYTIC_2	137	140	PF00928	0.391
TRG_ER_diArg_1	167	169	PF00400	0.428
TRG_ER_diArg_1	189	192	PF00400	0.541
TRG_ER_diArg_1	48	50	PF00400	0.519
TRG_ER_diArg_1	68	71	PF00400	0.580

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PF24	Leptomonas seymouri	81%	97%
A0A0S4JZ50	Bodo saltans	63%	92%
A0A1X0P3Q2	Trypanosomatidae	77%	100%
A0A3R7L3B1	Trypanosoma rangeli	73%	100%
A0A3S7X2Y9	Leishmania donovani	95%	94%
A4HHX2	Leishmania braziliensis	92%	100%
A4I522	Leishmania infantum	95%	94%
C9ZQI1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	79%	100%
Q4Q7T1	Leishmania major	95%	100%