Putative Zn finger protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Zn finger protein, putative

Species:

Leishmania mexicana

UniProt:

E9B0F0_LEIMU

TriTrypDb:

LmxM.29.0260

Length:

642

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B0F0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B0F0

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006396	RNA processing	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	3
GO:0008270	zinc ion binding	6	1
GO:0043167	ion binding	2	3
GO:0043169	cation binding	3	3
GO:0046872	metal ion binding	4	3
GO:0046914	transition metal ion binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	128	132	PF00656	0.457
CLV_C14_Caspase3-7	324	328	PF00656	0.638
CLV_C14_Caspase3-7	586	590	PF00656	0.550
CLV_NRD_NRD_1	220	222	PF00675	0.551
CLV_NRD_NRD_1	265	267	PF00675	0.587
CLV_NRD_NRD_1	364	366	PF00675	0.483
CLV_NRD_NRD_1	625	627	PF00675	0.641
CLV_NRD_NRD_1	630	632	PF00675	0.647
CLV_PCSK_KEX2_1	220	222	PF00082	0.593
CLV_PCSK_KEX2_1	265	267	PF00082	0.737
CLV_PCSK_KEX2_1	51	53	PF00082	0.318
CLV_PCSK_KEX2_1	513	515	PF00082	0.443
CLV_PCSK_KEX2_1	630	632	PF00082	0.599
CLV_PCSK_PC1ET2_1	51	53	PF00082	0.318
CLV_PCSK_PC1ET2_1	513	515	PF00082	0.443
CLV_PCSK_PC7_1	626	632	PF00082	0.598
CLV_PCSK_SKI1_1	103	107	PF00082	0.461
CLV_PCSK_SKI1_1	130	134	PF00082	0.440
CLV_PCSK_SKI1_1	162	166	PF00082	0.509
CLV_PCSK_SKI1_1	366	370	PF00082	0.575
CLV_PCSK_SKI1_1	46	50	PF00082	0.433
CLV_PCSK_SKI1_1	51	55	PF00082	0.490
CLV_PCSK_SKI1_1	551	555	PF00082	0.419
CLV_PCSK_SKI1_1	576	580	PF00082	0.588
CLV_PCSK_SKI1_1	626	630	PF00082	0.641
CLV_PCSK_SKI1_1	637	641	PF00082	0.630
DEG_APCC_DBOX_1	102	110	PF00400	0.475
DEG_APCC_DBOX_1	575	583	PF00400	0.430
DEG_COP1_1	82	89	PF00400	0.489
DEG_SPOP_SBC_1	339	343	PF00917	0.551
DOC_ANK_TNKS_1	331	338	PF00023	0.599
DOC_CDC14_PxL_1	465	473	PF14671	0.445
DOC_CDC14_PxL_1	516	524	PF14671	0.419
DOC_CKS1_1	578	583	PF01111	0.687
DOC_CKS1_1	92	97	PF01111	0.595
DOC_CYCLIN_RxL_1	525	537	PF00134	0.497
DOC_CYCLIN_yClb5_NLxxxL_5	303	312	PF00134	0.482
DOC_CYCLIN_yCln2_LP_2	92	98	PF00134	0.493
DOC_MAPK_DCC_7	514	524	PF00069	0.368
DOC_MAPK_gen_1	290	299	PF00069	0.307
DOC_MAPK_gen_1	513	524	PF00069	0.616
DOC_MAPK_MEF2A_6	139	146	PF00069	0.494
DOC_MAPK_MEF2A_6	517	526	PF00069	0.404
DOC_MAPK_RevD_3	617	632	PF00069	0.655
DOC_PP1_RVXF_1	121	128	PF00149	0.456
DOC_PP1_RVXF_1	141	147	PF00149	0.359
DOC_PP1_RVXF_1	282	289	PF00149	0.487
DOC_PP4_FxxP_1	381	384	PF00568	0.476
DOC_PP4_FxxP_1	405	408	PF00568	0.365
DOC_PP4_FxxP_1	578	581	PF00568	0.586
DOC_USP7_MATH_1	107	111	PF00917	0.519
DOC_USP7_MATH_1	126	130	PF00917	0.271
DOC_USP7_MATH_1	178	182	PF00917	0.767
DOC_USP7_MATH_1	203	207	PF00917	0.529
DOC_USP7_MATH_1	321	325	PF00917	0.601
DOC_USP7_MATH_1	339	343	PF00917	0.703
DOC_USP7_MATH_1	347	351	PF00917	0.606
DOC_USP7_MATH_1	408	412	PF00917	0.473
DOC_USP7_MATH_1	460	464	PF00917	0.754
DOC_USP7_MATH_1	487	491	PF00917	0.451
DOC_USP7_MATH_1	574	578	PF00917	0.570
DOC_USP7_MATH_1	609	613	PF00917	0.701
DOC_USP7_MATH_1	79	83	PF00917	0.776
DOC_USP7_UBL2_3	139	143	PF12436	0.493
DOC_USP7_UBL2_3	633	637	PF12436	0.585
DOC_WW_Pin1_4	157	162	PF00397	0.458
DOC_WW_Pin1_4	168	173	PF00397	0.614
DOC_WW_Pin1_4	345	350	PF00397	0.775
DOC_WW_Pin1_4	577	582	PF00397	0.602
DOC_WW_Pin1_4	612	617	PF00397	0.634
DOC_WW_Pin1_4	91	96	PF00397	0.600
LIG_14-3-3_CanoR_1	265	272	PF00244	0.537
LIG_14-3-3_CanoR_1	300	309	PF00244	0.556
LIG_14-3-3_CanoR_1	370	379	PF00244	0.516
LIG_14-3-3_CanoR_1	476	482	PF00244	0.273
LIG_BIR_II_1	1	5	PF00653	0.463
LIG_BIR_III_4	426	430	PF00653	0.464
LIG_BIR_III_4	608	612	PF00653	0.627
LIG_BRCT_BRCA1_1	123	127	PF00533	0.486
LIG_BRCT_BRCA1_1	251	255	PF00533	0.468
LIG_BRCT_BRCA1_1	372	376	PF00533	0.396
LIG_BRCT_BRCA1_1	401	405	PF00533	0.627
LIG_FHA_1	13	19	PF00498	0.434
LIG_FHA_1	229	235	PF00498	0.651
LIG_FHA_1	612	618	PF00498	0.599
LIG_FHA_1	71	77	PF00498	0.584
LIG_FHA_2	106	112	PF00498	0.520
LIG_FHA_2	225	231	PF00498	0.730
LIG_FHA_2	28	34	PF00498	0.476
LIG_FHA_2	584	590	PF00498	0.628
LIG_LIR_Apic_2	402	408	PF02991	0.425
LIG_LIR_Apic_2	505	510	PF02991	0.532
LIG_LIR_Apic_2	577	581	PF02991	0.677
LIG_LIR_Gen_1	116	127	PF02991	0.440
LIG_LIR_Gen_1	145	154	PF02991	0.578
LIG_LIR_Gen_1	210	219	PF02991	0.500
LIG_LIR_Gen_1	373	384	PF02991	0.449
LIG_LIR_Gen_1	463	473	PF02991	0.714
LIG_LIR_Gen_1	475	486	PF02991	0.278
LIG_LIR_Nem_3	116	122	PF02991	0.612
LIG_LIR_Nem_3	145	149	PF02991	0.578
LIG_LIR_Nem_3	210	215	PF02991	0.502
LIG_LIR_Nem_3	296	302	PF02991	0.553
LIG_LIR_Nem_3	373	379	PF02991	0.429
LIG_LIR_Nem_3	411	415	PF02991	0.494
LIG_LIR_Nem_3	463	468	PF02991	0.739
LIG_LIR_Nem_3	475	481	PF02991	0.278
LIG_LIR_Nem_3	515	519	PF02991	0.504
LIG_MYND_3	519	523	PF01753	0.414
LIG_SH2_CRK	50	54	PF00017	0.367
LIG_SH2_SRC	414	417	PF00017	0.312
LIG_SH2_STAP1	115	119	PF00017	0.517
LIG_SH2_STAT5	115	118	PF00017	0.464
LIG_SH2_STAT5	414	417	PF00017	0.398
LIG_SH3_2	622	627	PF14604	0.602
LIG_SH3_3	101	107	PF00018	0.696
LIG_SH3_3	150	156	PF00018	0.463
LIG_SH3_3	171	177	PF00018	0.708
LIG_SH3_3	212	218	PF00018	0.595
LIG_SH3_3	541	547	PF00018	0.487
LIG_SH3_3	616	622	PF00018	0.559
LIG_SUMO_SIM_par_1	612	620	PF11976	0.548
LIG_SUMO_SIM_par_1	88	94	PF11976	0.442
LIG_TYR_ITIM	554	559	PF00017	0.466
LIG_UBA3_1	23	32	PF00899	0.515
LIG_UBA3_1	308	315	PF00899	0.531
LIG_WRC_WIRS_1	575	580	PF05994	0.657
MOD_CDK_SPK_2	157	162	PF00069	0.458
MOD_CDK_SPxxK_3	168	175	PF00069	0.613
MOD_CK1_1	160	166	PF00069	0.571
MOD_CK1_1	275	281	PF00069	0.650
MOD_CK1_1	314	320	PF00069	0.563
MOD_CK1_1	340	346	PF00069	0.691
MOD_CK1_1	348	354	PF00069	0.744
MOD_CK1_1	463	469	PF00069	0.662
MOD_CK1_1	498	504	PF00069	0.584
MOD_CK1_1	577	583	PF00069	0.643
MOD_CK1_1	603	609	PF00069	0.615
MOD_CK1_1	610	616	PF00069	0.619
MOD_CK1_1	91	97	PF00069	0.653
MOD_CK2_1	105	111	PF00069	0.523
MOD_CK2_1	27	33	PF00069	0.515
MOD_CK2_1	275	281	PF00069	0.461
MOD_CK2_1	348	354	PF00069	0.580
MOD_CK2_1	477	483	PF00069	0.404
MOD_CK2_1	539	545	PF00069	0.669
MOD_Cter_Amidation	263	266	PF01082	0.593
MOD_GlcNHglycan	162	165	PF01048	0.567
MOD_GlcNHglycan	277	280	PF01048	0.629
MOD_GlcNHglycan	3	6	PF01048	0.449
MOD_GlcNHglycan	323	326	PF01048	0.601
MOD_GlcNHglycan	351	354	PF01048	0.425
MOD_GlcNHglycan	372	375	PF01048	0.397
MOD_GlcNHglycan	445	448	PF01048	0.730
MOD_GlcNHglycan	453	456	PF01048	0.752
MOD_GlcNHglycan	465	468	PF01048	0.433
MOD_GlcNHglycan	489	492	PF01048	0.273
MOD_GlcNHglycan	569	572	PF01048	0.678
MOD_GlcNHglycan	582	585	PF01048	0.549
MOD_GlcNHglycan	602	605	PF01048	0.574
MOD_GlcNHglycan	608	612	PF01048	0.758
MOD_GlcNHglycan	619	622	PF01048	0.634
MOD_GlcNHglycan	65	68	PF01048	0.420
MOD_GlcNHglycan	96	99	PF01048	0.623
MOD_GSK3_1	105	112	PF00069	0.416
MOD_GSK3_1	121	128	PF00069	0.453
MOD_GSK3_1	183	190	PF00069	0.709
MOD_GSK3_1	224	231	PF00069	0.677
MOD_GSK3_1	271	278	PF00069	0.701
MOD_GSK3_1	317	324	PF00069	0.595
MOD_GSK3_1	335	342	PF00069	0.718
MOD_GSK3_1	345	352	PF00069	0.551
MOD_GSK3_1	370	377	PF00069	0.479
MOD_GSK3_1	456	463	PF00069	0.718
MOD_GSK3_1	498	505	PF00069	0.694
MOD_GSK3_1	600	607	PF00069	0.679
MOD_GSK3_1	633	640	PF00069	0.671
MOD_GSK3_1	90	97	PF00069	0.654
MOD_N-GLC_1	487	492	PF02516	0.282
MOD_N-GLC_1	531	536	PF02516	0.481
MOD_N-GLC_2	118	120	PF02516	0.400
MOD_NEK2_1	1	6	PF00069	0.490
MOD_NEK2_1	185	190	PF00069	0.575
MOD_NEK2_1	272	277	PF00069	0.753
MOD_NEK2_1	369	374	PF00069	0.532
MOD_NEK2_1	477	482	PF00069	0.425
MOD_NEK2_1	617	622	PF00069	0.678
MOD_NEK2_1	90	95	PF00069	0.601
MOD_PIKK_1	264	270	PF00454	0.587
MOD_PKA_1	51	57	PF00069	0.311
MOD_PKA_1	626	632	PF00069	0.616
MOD_PKA_2	264	270	PF00069	0.690
MOD_PKA_2	369	375	PF00069	0.413
MOD_PKA_2	51	57	PF00069	0.475
MOD_PKB_1	380	388	PF00069	0.338
MOD_Plk_1	435	441	PF00069	0.626
MOD_Plk_1	487	493	PF00069	0.482
MOD_Plk_1	531	537	PF00069	0.496
MOD_Plk_2-3	518	524	PF00069	0.399
MOD_Plk_4	148	154	PF00069	0.588
MOD_Plk_4	460	466	PF00069	0.743
MOD_Plk_4	498	504	PF00069	0.553
MOD_ProDKin_1	157	163	PF00069	0.462
MOD_ProDKin_1	168	174	PF00069	0.611
MOD_ProDKin_1	345	351	PF00069	0.768
MOD_ProDKin_1	577	583	PF00069	0.603
MOD_ProDKin_1	612	618	PF00069	0.636
MOD_ProDKin_1	91	97	PF00069	0.595
MOD_SUMO_for_1	236	239	PF00179	0.627
MOD_SUMO_rev_2	360	368	PF00179	0.498
MOD_SUMO_rev_2	393	402	PF00179	0.514
MOD_SUMO_rev_2	454	460	PF00179	0.570
TRG_ENDOCYTIC_2	412	415	PF00928	0.317
TRG_ENDOCYTIC_2	50	53	PF00928	0.433
TRG_ENDOCYTIC_2	556	559	PF00928	0.518
TRG_ER_diArg_1	219	221	PF00400	0.553
TRG_ER_diArg_1	474	477	PF00400	0.487
TRG_Pf-PMV_PEXEL_1	284	289	PF00026	0.421
TRG_Pf-PMV_PEXEL_1	394	398	PF00026	0.554

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7W2	Leptomonas seymouri	39%	88%
A0A1X0P2C9	Trypanosomatidae	33%	100%
A0A3Q8IEK7	Leishmania donovani	89%	100%
A0A3R7MIW1	Trypanosoma rangeli	33%	100%
A4HHX0	Leishmania braziliensis	71%	100%
A4I520	Leishmania infantum	89%	100%
C9ZQH9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
Q4Q7T3	Leishmania major	87%	99%
Q585P3	Trypanosoma brucei brucei (strain 927/4 GUTat10.1)	34%	100%
V5DD36	Trypanosoma cruzi	33%	100%