LeishMANIAdb
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NARG2_C domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
NARG2_C domain-containing protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania mexicana
UniProt:
E9B0E8_LEIMU
TriTrypDb:
LmxM.29.0240
Length:
583

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0005930 axoneme 2 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

E9B0E8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B0E8

Function

Biological processes
Term Name Level Count
GO:0006508 proteolysis 4 1
GO:0006807 nitrogen compound metabolic process 2 1
GO:0008152 metabolic process 1 1
GO:0016485 protein processing 5 1
GO:0016539 intein-mediated protein splicing 7 1
GO:0019538 protein metabolic process 3 1
GO:0030908 protein splicing 6 1
GO:0043170 macromolecule metabolic process 3 1
GO:0044238 primary metabolic process 2 1
GO:0051604 protein maturation 4 1
GO:0071704 organic substance metabolic process 2 1
GO:1901564 organonitrogen compound metabolic process 3 1
Could not find GO molecular_function term for this entry.

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 98 102 PF00656 0.540
CLV_NRD_NRD_1 171 173 PF00675 0.450
CLV_NRD_NRD_1 191 193 PF00675 0.201
CLV_NRD_NRD_1 209 211 PF00675 0.421
CLV_NRD_NRD_1 330 332 PF00675 0.555
CLV_NRD_NRD_1 373 375 PF00675 0.710
CLV_NRD_NRD_1 543 545 PF00675 0.557
CLV_NRD_NRD_1 566 568 PF00675 0.525
CLV_NRD_NRD_1 86 88 PF00675 0.519
CLV_PCSK_FUR_1 371 375 PF00082 0.516
CLV_PCSK_KEX2_1 171 173 PF00082 0.562
CLV_PCSK_KEX2_1 191 193 PF00082 0.201
CLV_PCSK_KEX2_1 209 211 PF00082 0.340
CLV_PCSK_KEX2_1 247 249 PF00082 0.506
CLV_PCSK_KEX2_1 267 269 PF00082 0.308
CLV_PCSK_KEX2_1 330 332 PF00082 0.509
CLV_PCSK_KEX2_1 362 364 PF00082 0.538
CLV_PCSK_KEX2_1 373 375 PF00082 0.567
CLV_PCSK_KEX2_1 543 545 PF00082 0.545
CLV_PCSK_KEX2_1 565 567 PF00082 0.537
CLV_PCSK_KEX2_1 94 96 PF00082 0.558
CLV_PCSK_PC1ET2_1 171 173 PF00082 0.562
CLV_PCSK_PC1ET2_1 247 249 PF00082 0.506
CLV_PCSK_PC1ET2_1 267 269 PF00082 0.308
CLV_PCSK_PC1ET2_1 362 364 PF00082 0.538
CLV_PCSK_PC1ET2_1 94 96 PF00082 0.558
CLV_PCSK_PC7_1 326 332 PF00082 0.567
CLV_PCSK_SKI1_1 134 138 PF00082 0.609
CLV_PCSK_SKI1_1 164 168 PF00082 0.377
CLV_PCSK_SKI1_1 226 230 PF00082 0.384
CLV_PCSK_SKI1_1 248 252 PF00082 0.559
CLV_PCSK_SKI1_1 271 275 PF00082 0.380
CLV_PCSK_SKI1_1 335 339 PF00082 0.488
CLV_PCSK_SKI1_1 363 367 PF00082 0.514
CLV_PCSK_SKI1_1 54 58 PF00082 0.587
DEG_SCF_FBW7_1 198 205 PF00400 0.523
DEG_SCF_TRCP1_1 426 432 PF00400 0.499
DEG_SPOP_SBC_1 524 528 PF00917 0.619
DOC_CDC14_PxL_1 230 238 PF14671 0.540
DOC_CDC14_PxL_1 532 540 PF14671 0.555
DOC_CKS1_1 136 141 PF01111 0.619
DOC_CKS1_1 199 204 PF01111 0.537
DOC_CYCLIN_RxL_1 330 341 PF00134 0.546
DOC_CYCLIN_yCln2_LP_2 304 310 PF00134 0.596
DOC_MAPK_gen_1 191 198 PF00069 0.390
DOC_MAPK_gen_1 266 276 PF00069 0.419
DOC_MAPK_gen_1 330 340 PF00069 0.478
DOC_MAPK_gen_1 362 370 PF00069 0.642
DOC_MAPK_gen_1 543 554 PF00069 0.611
DOC_MAPK_MEF2A_6 267 276 PF00069 0.391
DOC_MAPK_MEF2A_6 305 312 PF00069 0.573
DOC_MAPK_MEF2A_6 547 556 PF00069 0.571
DOC_MAPK_RevD_3 552 567 PF00069 0.528
DOC_PP2B_LxvP_1 304 307 PF13499 0.597
DOC_PP2B_LxvP_1 495 498 PF13499 0.522
DOC_PP4_FxxP_1 181 184 PF00568 0.388
DOC_PP4_FxxP_1 19 22 PF00568 0.674
DOC_USP7_MATH_1 525 529 PF00917 0.639
DOC_USP7_UBL2_3 31 35 PF12436 0.646
DOC_USP7_UBL2_3 362 366 PF12436 0.635
DOC_WW_Pin1_4 135 140 PF00397 0.608
DOC_WW_Pin1_4 18 23 PF00397 0.535
DOC_WW_Pin1_4 198 203 PF00397 0.408
LIG_14-3-3_CanoR_1 213 223 PF00244 0.528
LIG_14-3-3_CanoR_1 226 231 PF00244 0.297
LIG_14-3-3_CanoR_1 248 257 PF00244 0.550
LIG_14-3-3_CanoR_1 26 34 PF00244 0.690
LIG_14-3-3_CanoR_1 87 96 PF00244 0.459
LIG_APCC_ABBA_1 518 523 PF00400 0.343
LIG_Clathr_ClatBox_1 337 341 PF01394 0.463
LIG_CSL_BTD_1 199 202 PF09270 0.420
LIG_DLG_GKlike_1 95 103 PF00625 0.550
LIG_EH_1 397 401 PF12763 0.294
LIG_FHA_1 199 205 PF00498 0.510
LIG_FHA_1 215 221 PF00498 0.486
LIG_FHA_1 312 318 PF00498 0.530
LIG_FHA_1 63 69 PF00498 0.267
LIG_FHA_2 123 129 PF00498 0.487
LIG_FHA_2 151 157 PF00498 0.411
LIG_FHA_2 390 396 PF00498 0.608
LIG_FHA_2 478 484 PF00498 0.422
LIG_FHA_2 500 506 PF00498 0.545
LIG_HCF-1_HBM_1 259 262 PF13415 0.406
LIG_Integrin_RGD_1 567 569 PF01839 0.558
LIG_LIR_Apic_2 16 22 PF02991 0.681
LIG_LIR_Gen_1 104 113 PF02991 0.432
LIG_LIR_Gen_1 153 162 PF02991 0.420
LIG_LIR_Gen_1 403 409 PF02991 0.587
LIG_LIR_Gen_1 577 583 PF02991 0.615
LIG_LIR_Nem_3 104 109 PF02991 0.398
LIG_LIR_Nem_3 130 136 PF02991 0.578
LIG_LIR_Nem_3 153 157 PF02991 0.370
LIG_LIR_Nem_3 403 407 PF02991 0.570
LIG_LIR_Nem_3 471 477 PF02991 0.433
LIG_LIR_Nem_3 577 582 PF02991 0.549
LIG_LYPXL_S_1 400 404 PF13949 0.472
LIG_MYND_1 3 7 PF01753 0.654
LIG_Pex14_1 473 477 PF04695 0.434
LIG_Pex14_2 400 404 PF04695 0.278
LIG_Pex14_2 74 78 PF04695 0.422
LIG_PTB_Apo_2 395 402 PF02174 0.524
LIG_PTB_Apo_2 72 79 PF02174 0.246
LIG_PTB_Phospho_1 395 401 PF10480 0.523
LIG_SH2_CRK 49 53 PF00017 0.505
LIG_SH2_GRB2like 147 150 PF00017 0.543
LIG_SH2_GRB2like 51 54 PF00017 0.252
LIG_SH2_STAP1 477 481 PF00017 0.487
LIG_SH2_STAT3 147 150 PF00017 0.574
LIG_SH2_STAT5 154 157 PF00017 0.391
LIG_SH2_STAT5 203 206 PF00017 0.585
LIG_SH2_STAT5 235 238 PF00017 0.498
LIG_SH2_STAT5 275 278 PF00017 0.422
LIG_SH2_STAT5 51 54 PF00017 0.422
LIG_SH2_STAT5 537 540 PF00017 0.599
LIG_SH2_STAT5 559 562 PF00017 0.475
LIG_SH3_1 396 402 PF00018 0.338
LIG_SH3_3 133 139 PF00018 0.607
LIG_SH3_3 396 402 PF00018 0.362
LIG_SH3_3 4 10 PF00018 0.701
LIG_SH3_3 451 457 PF00018 0.666
LIG_SH3_3 63 69 PF00018 0.456
LIG_SH3_3 90 96 PF00018 0.522
LIG_SUMO_SIM_anti_2 553 558 PF11976 0.542
LIG_SUMO_SIM_par_1 336 341 PF11976 0.542
LIG_SUMO_SIM_par_1 64 71 PF11976 0.257
LIG_TRAF2_1 504 507 PF00917 0.587
LIG_WRC_WIRS_1 401 406 PF05994 0.576
MOD_CK1_1 214 220 PF00069 0.503
MOD_CK1_1 237 243 PF00069 0.453
MOD_CK1_1 322 328 PF00069 0.539
MOD_CK1_1 429 435 PF00069 0.580
MOD_CK1_1 436 442 PF00069 0.685
MOD_CK1_1 62 68 PF00069 0.281
MOD_CK2_1 150 156 PF00069 0.428
MOD_CK2_1 389 395 PF00069 0.585
MOD_CK2_1 499 505 PF00069 0.534
MOD_CK2_1 555 561 PF00069 0.447
MOD_CK2_1 571 577 PF00069 0.500
MOD_CMANNOS 285 288 PF00535 0.381
MOD_Cter_Amidation 371 374 PF01082 0.509
MOD_Cter_Amidation 541 544 PF01082 0.571
MOD_GlcNHglycan 22 25 PF01048 0.592
MOD_GlcNHglycan 410 413 PF01048 0.703
MOD_GlcNHglycan 426 429 PF01048 0.538
MOD_GlcNHglycan 435 438 PF01048 0.652
MOD_GlcNHglycan 540 543 PF01048 0.609
MOD_GlcNHglycan 548 551 PF01048 0.544
MOD_GSK3_1 198 205 PF00069 0.431
MOD_GSK3_1 275 282 PF00069 0.417
MOD_GSK3_1 322 329 PF00069 0.569
MOD_GSK3_1 353 360 PF00069 0.585
MOD_GSK3_1 429 436 PF00069 0.600
MOD_GSK3_1 473 480 PF00069 0.316
MOD_GSK3_1 523 530 PF00069 0.599
MOD_N-GLC_1 211 216 PF02516 0.542
MOD_N-GLC_1 357 362 PF02516 0.484
MOD_NEK2_1 109 114 PF00069 0.443
MOD_NEK2_1 122 127 PF00069 0.361
MOD_NEK2_1 253 258 PF00069 0.478
MOD_NEK2_1 287 292 PF00069 0.359
MOD_NEK2_1 353 358 PF00069 0.590
MOD_NEK2_1 499 504 PF00069 0.494
MOD_NEK2_1 538 543 PF00069 0.609
MOD_NEK2_2 203 208 PF00069 0.566
MOD_PIKK_1 248 254 PF00454 0.471
MOD_PIKK_1 436 442 PF00454 0.784
MOD_PKA_1 267 273 PF00069 0.547
MOD_PKA_1 87 93 PF00069 0.503
MOD_PKA_2 208 214 PF00069 0.452
MOD_PKA_2 25 31 PF00069 0.643
MOD_PKA_2 267 273 PF00069 0.547
MOD_PKA_2 381 387 PF00069 0.624
MOD_PKA_2 424 430 PF00069 0.752
MOD_PKA_2 546 552 PF00069 0.605
MOD_Plk_1 211 217 PF00069 0.543
MOD_Plk_1 237 243 PF00069 0.450
MOD_Plk_1 279 285 PF00069 0.531
MOD_Plk_1 59 65 PF00069 0.628
MOD_Plk_2-3 555 561 PF00069 0.486
MOD_Plk_4 150 156 PF00069 0.444
MOD_Plk_4 203 209 PF00069 0.449
MOD_Plk_4 237 243 PF00069 0.450
MOD_Plk_4 299 305 PF00069 0.725
MOD_Plk_4 400 406 PF00069 0.544
MOD_Plk_4 415 421 PF00069 0.716
MOD_Plk_4 555 561 PF00069 0.519
MOD_Plk_4 62 68 PF00069 0.367
MOD_Plk_4 95 101 PF00069 0.465
MOD_ProDKin_1 135 141 PF00069 0.601
MOD_ProDKin_1 18 24 PF00069 0.535
MOD_ProDKin_1 198 204 PF00069 0.415
MOD_SUMO_for_1 1 4 PF00179 0.705
MOD_SUMO_for_1 184 187 PF00179 0.452
MOD_SUMO_rev_2 259 269 PF00179 0.429
TRG_DiLeu_BaEn_1 507 512 PF01217 0.387
TRG_DiLeu_BaEn_1 513 518 PF01217 0.440
TRG_DiLeu_BaEn_4 463 469 PF01217 0.526
TRG_DiLeu_BaLyEn_6 268 273 PF01217 0.511
TRG_ENDOCYTIC_2 106 109 PF00928 0.397
TRG_ENDOCYTIC_2 154 157 PF00928 0.388
TRG_ENDOCYTIC_2 401 404 PF00928 0.510
TRG_ENDOCYTIC_2 49 52 PF00928 0.391
TRG_ER_diArg_1 208 210 PF00400 0.521
TRG_ER_diArg_1 213 216 PF00400 0.514
TRG_ER_diArg_1 330 333 PF00400 0.601
TRG_ER_diArg_1 370 373 PF00400 0.682
TRG_ER_diArg_1 543 545 PF00400 0.557
TRG_ER_diArg_1 564 567 PF00400 0.565
TRG_NES_CRM1_1 509 523 PF08389 0.380

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P8C2 Leptomonas seymouri 67% 100%
A0A1X0P2D9 Trypanosomatidae 41% 98%
A0A3S5IRH4 Trypanosoma rangeli 42% 100%
A0A3S7X2Z0 Leishmania donovani 90% 98%
A4HHW8 Leishmania braziliensis 80% 100%
A4I518 Leishmania infantum 90% 98%
C9ZQH7 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 43% 100%
Q4Q7T5 Leishmania major 90% 100%
V5BLG2 Trypanosoma cruzi 45% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS