RanBP2-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B0E6_LEIMU

TriTrypDb:

LmxM.29.0220

Length:

386

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B0E6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B0E6

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	5
GO:0043167	ion binding	2	5
GO:0043169	cation binding	3	5
GO:0046872	metal ion binding	4	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	282	286	PF00656	0.770
CLV_C14_Caspase3-7	295	299	PF00656	0.675
CLV_C14_Caspase3-7	42	46	PF00656	0.578
CLV_NRD_NRD_1	163	165	PF00675	0.534
CLV_NRD_NRD_1	27	29	PF00675	0.446
CLV_PCSK_KEX2_1	105	107	PF00082	0.513
CLV_PCSK_KEX2_1	163	165	PF00082	0.534
CLV_PCSK_KEX2_1	27	29	PF00082	0.544
CLV_PCSK_PC1ET2_1	105	107	PF00082	0.559
CLV_PCSK_SKI1_1	134	138	PF00082	0.502
CLV_PCSK_SKI1_1	193	197	PF00082	0.768
CLV_Separin_Metazoa	135	139	PF03568	0.287
DEG_Nend_UBRbox_3	1	3	PF02207	0.638
DEG_SCF_FBW7_1	241	248	PF00400	0.740
DEG_SPOP_SBC_1	339	343	PF00917	0.652
DOC_CKS1_1	251	256	PF01111	0.758
DOC_CYCLIN_RxL_1	193	202	PF00134	0.767
DOC_MAPK_DCC_7	266	275	PF00069	0.724
DOC_MAPK_gen_1	114	123	PF00069	0.574
DOC_MAPK_MEF2A_6	266	275	PF00069	0.735
DOC_PP1_RVXF_1	161	168	PF00149	0.679
DOC_PP2B_LxvP_1	215	218	PF13499	0.610
DOC_USP7_MATH_1	141	145	PF00917	0.560
DOC_USP7_MATH_1	276	280	PF00917	0.649
DOC_WW_Pin1_4	176	181	PF00397	0.700
DOC_WW_Pin1_4	237	242	PF00397	0.819
DOC_WW_Pin1_4	245	250	PF00397	0.685
DOC_WW_Pin1_4	298	303	PF00397	0.639
LIG_14-3-3_CanoR_1	120	124	PF00244	0.564
LIG_14-3-3_CanoR_1	138	146	PF00244	0.277
LIG_14-3-3_CanoR_1	149	155	PF00244	0.487
LIG_14-3-3_CanoR_1	210	215	PF00244	0.351
LIG_14-3-3_CanoR_1	5	15	PF00244	0.392
LIG_APCC_ABBA_1	55	60	PF00400	0.495
LIG_BRCT_BRCA1_1	126	130	PF00533	0.574
LIG_Clathr_ClatBox_1	71	75	PF01394	0.547
LIG_eIF4E_1	325	331	PF01652	0.515
LIG_eIF4E_1	68	74	PF01652	0.335
LIG_FHA_1	230	236	PF00498	0.450
LIG_FHA_1	298	304	PF00498	0.732
LIG_FHA_1	36	42	PF00498	0.506
LIG_FHA_1	52	58	PF00498	0.382
LIG_FHA_2	120	126	PF00498	0.563
LIG_FHA_2	40	46	PF00498	0.572
LIG_LIR_Apic_2	248	254	PF02991	0.603
LIG_LIR_Apic_2	322	328	PF02991	0.632
LIG_LIR_Apic_2	60	64	PF02991	0.508
LIG_LIR_Gen_1	125	131	PF02991	0.579
LIG_LIR_Gen_1	32	41	PF02991	0.296
LIG_LIR_Nem_3	125	129	PF02991	0.581
LIG_LIR_Nem_3	32	36	PF02991	0.597
LIG_LIR_Nem_3	365	371	PF02991	0.626
LIG_MYND_1	328	332	PF01753	0.508
LIG_PTB_Apo_2	79	86	PF02174	0.577
LIG_SH2_CRK	126	130	PF00017	0.574
LIG_SH2_CRK	251	255	PF00017	0.528
LIG_SH2_CRK	61	65	PF00017	0.348
LIG_SH2_CRK	68	72	PF00017	0.325
LIG_SH2_GRB2like	214	217	PF00017	0.611
LIG_SH2_NCK_1	251	255	PF00017	0.528
LIG_SH2_NCK_1	325	329	PF00017	0.630
LIG_SH2_NCK_1	61	65	PF00017	0.589
LIG_SH2_SRC	214	217	PF00017	0.611
LIG_SH2_SRC	325	328	PF00017	0.630
LIG_SH2_STAP1	126	130	PF00017	0.574
LIG_SH2_STAP1	83	87	PF00017	0.567
LIG_SH2_STAT3	93	96	PF00017	0.398
LIG_SH2_STAT5	214	217	PF00017	0.611
LIG_SH2_STAT5	3	6	PF00017	0.620
LIG_SH2_STAT5	58	61	PF00017	0.565
LIG_SH3_3	174	180	PF00018	0.615
LIG_SH3_3	191	197	PF00018	0.555
LIG_SH3_3	266	272	PF00018	0.778
LIG_SUMO_SIM_par_1	70	75	PF11976	0.545
LIG_TYR_ITIM	124	129	PF00017	0.581
LIG_TYR_ITIM	366	371	PF00017	0.618
LIG_UBA3_1	175	181	PF00899	0.616
LIG_UBA3_1	99	105	PF00899	0.509
LIG_WRC_WIRS_1	143	148	PF05994	0.589
LIG_WW_2	271	274	PF00397	0.704
MOD_CDK_SPK_2	176	181	PF00069	0.623
MOD_CDK_SPK_2	241	246	PF00069	0.721
MOD_CK1_1	240	246	PF00069	0.730
MOD_CK1_1	252	258	PF00069	0.641
MOD_CK1_1	286	292	PF00069	0.766
MOD_CK1_1	301	307	PF00069	0.652
MOD_CK1_1	341	347	PF00069	0.803
MOD_CK1_1	354	360	PF00069	0.574
MOD_CK2_1	119	125	PF00069	0.564
MOD_CK2_1	141	147	PF00069	0.579
MOD_CK2_1	176	182	PF00069	0.708
MOD_CK2_1	199	205	PF00069	0.737
MOD_CK2_1	276	282	PF00069	0.610
MOD_GlcNHglycan	139	142	PF01048	0.544
MOD_GlcNHglycan	189	192	PF01048	0.773
MOD_GlcNHglycan	201	204	PF01048	0.651
MOD_GlcNHglycan	218	221	PF01048	0.345
MOD_GlcNHglycan	254	257	PF01048	0.526
MOD_GlcNHglycan	266	269	PF01048	0.545
MOD_GlcNHglycan	289	292	PF01048	0.790
MOD_GlcNHglycan	307	312	PF01048	0.528
MOD_GlcNHglycan	346	350	PF01048	0.633
MOD_GSK3_1	137	144	PF00069	0.580
MOD_GSK3_1	225	232	PF00069	0.503
MOD_GSK3_1	233	240	PF00069	0.654
MOD_GSK3_1	241	248	PF00069	0.682
MOD_GSK3_1	276	283	PF00069	0.661
MOD_GSK3_1	297	304	PF00069	0.690
MOD_GSK3_1	31	38	PF00069	0.543
MOD_GSK3_1	334	341	PF00069	0.805
MOD_N-GLC_1	258	263	PF02516	0.748
MOD_NEK2_1	124	129	PF00069	0.420
MOD_NEK2_1	137	142	PF00069	0.415
MOD_NEK2_1	186	191	PF00069	0.724
MOD_NEK2_1	198	203	PF00069	0.607
MOD_NEK2_1	297	302	PF00069	0.771
MOD_NEK2_1	50	55	PF00069	0.553
MOD_NEK2_2	225	230	PF00069	0.644
MOD_PIKK_1	283	289	PF00454	0.740
MOD_PIKK_1	31	37	PF00454	0.307
MOD_PKA_2	119	125	PF00069	0.564
MOD_PKA_2	137	143	PF00069	0.277
MOD_PKA_2	15	21	PF00069	0.578
MOD_Plk_1	124	130	PF00069	0.415
MOD_Plk_1	31	37	PF00069	0.307
MOD_Plk_2-3	39	45	PF00069	0.569
MOD_Plk_4	119	125	PF00069	0.564
MOD_Plk_4	150	156	PF00069	0.543
MOD_Plk_4	210	216	PF00069	0.416
MOD_ProDKin_1	176	182	PF00069	0.708
MOD_ProDKin_1	237	243	PF00069	0.822
MOD_ProDKin_1	245	251	PF00069	0.686
MOD_ProDKin_1	298	304	PF00069	0.638
MOD_SUMO_rev_2	9	13	PF00179	0.387
TRG_DiLeu_BaEn_2	31	37	PF01217	0.501
TRG_ENDOCYTIC_2	126	129	PF00928	0.581
TRG_ENDOCYTIC_2	368	371	PF00928	0.733
TRG_ENDOCYTIC_2	68	71	PF00928	0.340
TRG_ER_diArg_1	163	166	PF00400	0.692
TRG_ER_diArg_1	26	28	PF00400	0.437
TRG_NES_CRM1_1	94	108	PF08389	0.499
TRG_Pf-PMV_PEXEL_1	156	161	PF00026	0.622

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IE12	Leishmania donovani	89%	100%
A4HHW6	Leishmania braziliensis	71%	100%
A4I516	Leishmania infantum	89%	100%
Q4Q7T7	Leishmania major	86%	100%