LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania mexicana
UniProt:
E9B0E4_LEIMU
TriTrypDb:
LmxM.29.0205
Length:
119

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0016020 membrane 2 10
GO:0110165 cellular anatomical entity 1 10

Expansion

Sequence features

E9B0E4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B0E4

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 117 119 PF00675 0.456
CLV_NRD_NRD_1 32 34 PF00675 0.449
CLV_PCSK_KEX2_1 32 34 PF00082 0.434
CLV_PCSK_SKI1_1 32 36 PF00082 0.435
DEG_Nend_Nbox_1 1 3 PF02207 0.653
DOC_CKS1_1 59 64 PF01111 0.511
DOC_CYCLIN_yCln2_LP_2 22 28 PF00134 0.598
DOC_CYCLIN_yCln2_LP_2 59 65 PF00134 0.623
DOC_MAPK_gen_1 32 40 PF00069 0.656
DOC_USP7_MATH_1 75 79 PF00917 0.407
DOC_WW_Pin1_4 58 63 PF00397 0.506
LIG_14-3-3_CanoR_1 16 22 PF00244 0.666
LIG_14-3-3_CanoR_1 32 40 PF00244 0.564
LIG_BRCT_BRCA1_1 30 34 PF00533 0.694
LIG_BRCT_BRCA1_1 43 47 PF00533 0.447
LIG_FHA_1 33 39 PF00498 0.610
LIG_FHA_1 50 56 PF00498 0.312
LIG_LIR_Gen_1 53 63 PF02991 0.474
LIG_LIR_Nem_3 53 59 PF02991 0.456
LIG_LIR_Nem_3 92 97 PF02991 0.335
LIG_MYND_1 10 14 PF01753 0.686
LIG_NRBOX 54 60 PF00104 0.447
LIG_SH3_3 59 65 PF00018 0.594
MOD_CK1_1 18 24 PF00069 0.598
MOD_CK1_1 42 48 PF00069 0.417
MOD_CK1_1 50 56 PF00069 0.360
MOD_CK2_1 109 115 PF00069 0.536
MOD_GlcNHglycan 77 80 PF01048 0.595
MOD_GSK3_1 28 35 PF00069 0.662
MOD_GSK3_1 41 48 PF00069 0.258
MOD_GSK3_1 71 78 PF00069 0.412
MOD_GSK3_1 85 92 PF00069 0.472
MOD_N-GLC_1 89 94 PF02516 0.586
MOD_N-GLC_2 17 19 PF02516 0.340
MOD_NEK2_1 27 32 PF00069 0.653
MOD_NEK2_1 39 44 PF00069 0.376
MOD_NEK2_1 47 52 PF00069 0.281
MOD_NEK2_1 89 94 PF00069 0.395
MOD_OFUCOSY 43 49 PF10250 0.447
MOD_PIKK_1 109 115 PF00454 0.647
MOD_PKA_1 32 38 PF00069 0.660
MOD_PKA_2 15 21 PF00069 0.682
MOD_PKA_2 32 38 PF00069 0.604
MOD_Plk_4 42 48 PF00069 0.376
MOD_ProDKin_1 58 64 PF00069 0.505
TRG_ER_diArg_1 32 34 PF00400 0.669

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IMG4 Leptomonas seymouri 70% 100%
A0A0S4JM96 Bodo saltans 58% 100%
A0A1X0P2D6 Trypanosomatidae 61% 100%
A0A3S7X310 Leishmania donovani 93% 100%
A0A422N153 Trypanosoma rangeli 64% 100%
A4HHW4 Leishmania braziliensis 90% 100%
A4I514 Leishmania infantum 93% 100%
C9ZQG9 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 56% 100%
Q4Q7V0 Leishmania major 91% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS