Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B0E3_LEIMU

TriTrypDb:

LmxM.29.0200

Length:

497

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B0E3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B0E3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	305	309	PF00656	0.551
CLV_C14_Caspase3-7	401	405	PF00656	0.737
CLV_NRD_NRD_1	188	190	PF00675	0.669
CLV_NRD_NRD_1	276	278	PF00675	0.625
CLV_NRD_NRD_1	319	321	PF00675	0.505
CLV_NRD_NRD_1	443	445	PF00675	0.573
CLV_NRD_NRD_1	493	495	PF00675	0.525
CLV_PCSK_KEX2_1	187	189	PF00082	0.588
CLV_PCSK_KEX2_1	276	278	PF00082	0.625
CLV_PCSK_KEX2_1	319	321	PF00082	0.502
CLV_PCSK_KEX2_1	338	340	PF00082	0.515
CLV_PCSK_KEX2_1	484	486	PF00082	0.535
CLV_PCSK_PC1ET2_1	338	340	PF00082	0.515
CLV_PCSK_PC1ET2_1	484	486	PF00082	0.535
CLV_PCSK_SKI1_1	121	125	PF00082	0.586
CLV_PCSK_SKI1_1	236	240	PF00082	0.571
CLV_PCSK_SKI1_1	320	324	PF00082	0.488
CLV_PCSK_SKI1_1	473	477	PF00082	0.459
CLV_PCSK_SKI1_1	485	489	PF00082	0.425
CLV_PCSK_SKI1_1	89	93	PF00082	0.465
CLV_Separin_Metazoa	133	137	PF03568	0.616
DEG_APCC_DBOX_1	443	451	PF00400	0.580
DEG_Kelch_Keap1_1	389	394	PF01344	0.650
DEG_SCF_FBW7_2	275	282	PF00400	0.624
DOC_CDC14_PxL_1	221	229	PF14671	0.553
DOC_CKS1_1	128	133	PF01111	0.567
DOC_CYCLIN_RxL_1	481	492	PF00134	0.501
DOC_CYCLIN_RxL_1	86	93	PF00134	0.481
DOC_CYCLIN_yCln2_LP_2	238	244	PF00134	0.555
DOC_MAPK_MEF2A_6	456	465	PF00069	0.418
DOC_MAPK_NFAT4_5	456	464	PF00069	0.276
DOC_PP2B_LxvP_1	238	241	PF13499	0.454
DOC_PP4_MxPP_1	242	245	PF00568	0.611
DOC_USP7_MATH_1	163	167	PF00917	0.696
DOC_USP7_MATH_1	178	182	PF00917	0.620
DOC_USP7_MATH_1	353	357	PF00917	0.580
DOC_USP7_MATH_1	39	43	PF00917	0.555
DOC_USP7_MATH_1	398	402	PF00917	0.671
DOC_USP7_MATH_1	420	424	PF00917	0.716
DOC_USP7_MATH_1	82	86	PF00917	0.602
DOC_USP7_UBL2_3	473	477	PF12436	0.502
DOC_WW_Pin1_4	127	132	PF00397	0.565
DOC_WW_Pin1_4	253	258	PF00397	0.654
DOC_WW_Pin1_4	275	280	PF00397	0.627
DOC_WW_Pin1_4	78	83	PF00397	0.604
DOC_WW_Pin1_4	9	14	PF00397	0.678
LIG_14-3-3_CanoR_1	319	329	PF00244	0.540
LIG_14-3-3_CanoR_1	331	340	PF00244	0.363
LIG_Actin_WH2_2	458	475	PF00022	0.504
LIG_EH1_1	432	440	PF00400	0.573
LIG_EVH1_1	240	244	PF00568	0.556
LIG_FHA_1	151	157	PF00498	0.645
LIG_FHA_1	17	23	PF00498	0.588
LIG_FHA_1	259	265	PF00498	0.592
LIG_FHA_1	276	282	PF00498	0.403
LIG_FHA_1	332	338	PF00498	0.473
LIG_FHA_1	456	462	PF00498	0.495
LIG_FHA_1	477	483	PF00498	0.463
LIG_FHA_2	1	7	PF00498	0.568
LIG_FHA_2	112	118	PF00498	0.606
LIG_FHA_2	128	134	PF00498	0.576
LIG_FHA_2	232	238	PF00498	0.291
LIG_FHA_2	323	329	PF00498	0.503
LIG_FHA_2	352	358	PF00498	0.499
LIG_FHA_2	366	372	PF00498	0.527
LIG_LIR_Gen_1	209	217	PF02991	0.496
LIG_LIR_Nem_3	209	215	PF02991	0.496
LIG_LIR_Nem_3	260	265	PF02991	0.592
LIG_LIR_Nem_3	288	292	PF02991	0.501
LIG_LIR_Nem_3	32	38	PF02991	0.343
LIG_LIR_Nem_3	369	375	PF02991	0.529
LIG_Pex14_2	212	216	PF04695	0.561
LIG_Pex14_2	476	480	PF04695	0.461
LIG_PTB_Apo_2	109	116	PF02174	0.545
LIG_PTB_Apo_2	210	217	PF02174	0.521
LIG_SH2_NCK_1	208	212	PF00017	0.527
LIG_SH2_SRC	208	211	PF00017	0.494
LIG_SH2_STAP1	208	212	PF00017	0.521
LIG_SH2_STAP1	64	68	PF00017	0.563
LIG_SH2_STAT5	23	26	PF00017	0.450
LIG_SH3_3	10	16	PF00018	0.679
LIG_SH3_3	125	131	PF00018	0.638
LIG_SH3_3	238	244	PF00018	0.449
LIG_SH3_3	382	388	PF00018	0.508
LIG_SH3_3	407	413	PF00018	0.663
LIG_SH3_3	43	49	PF00018	0.447
LIG_SH3_3	71	77	PF00018	0.478
LIG_SUMO_SIM_par_1	152	157	PF11976	0.625
LIG_SUMO_SIM_par_1	175	181	PF11976	0.657
LIG_SUMO_SIM_par_1	2	8	PF11976	0.529
MOD_CK1_1	165	171	PF00069	0.574
MOD_CK1_1	253	259	PF00069	0.563
MOD_CK1_1	351	357	PF00069	0.587
MOD_CK1_1	389	395	PF00069	0.692
MOD_CK1_1	400	406	PF00069	0.621
MOD_CK2_1	127	133	PF00069	0.501
MOD_CK2_1	231	237	PF00069	0.282
MOD_CK2_1	28	34	PF00069	0.582
MOD_CK2_1	285	291	PF00069	0.545
MOD_CK2_1	365	371	PF00069	0.574
MOD_GlcNHglycan	145	148	PF01048	0.495
MOD_GlcNHglycan	164	168	PF01048	0.574
MOD_GlcNHglycan	400	403	PF01048	0.733
MOD_GlcNHglycan	422	425	PF01048	0.683
MOD_GSK3_1	225	232	PF00069	0.370
MOD_GSK3_1	24	31	PF00069	0.373
MOD_GSK3_1	344	351	PF00069	0.491
MOD_GSK3_1	396	403	PF00069	0.669
MOD_GSK3_1	476	483	PF00069	0.535
MOD_GSK3_1	5	12	PF00069	0.602
MOD_GSK3_1	60	67	PF00069	0.372
MOD_GSK3_1	78	85	PF00069	0.556
MOD_N-GLC_1	111	116	PF02516	0.551
MOD_NEK2_1	231	236	PF00069	0.531
MOD_NEK2_1	24	29	PF00069	0.516
MOD_NEK2_1	258	263	PF00069	0.573
MOD_NEK2_1	285	290	PF00069	0.538
MOD_NEK2_1	450	455	PF00069	0.517
MOD_NEK2_1	476	481	PF00069	0.458
MOD_NEK2_1	60	65	PF00069	0.414
MOD_NEK2_1	83	88	PF00069	0.527
MOD_PIKK_1	16	22	PF00454	0.622
MOD_PIKK_1	189	195	PF00454	0.699
MOD_PIKK_1	344	350	PF00454	0.590
MOD_PIKK_1	39	45	PF00454	0.541
MOD_PKA_2	143	149	PF00069	0.600
MOD_PKA_2	330	336	PF00069	0.427
MOD_PKA_2	373	379	PF00069	0.462
MOD_PKA_2	415	421	PF00069	0.476
MOD_PKA_2	455	461	PF00069	0.546
MOD_PKB_1	187	195	PF00069	0.671
MOD_Plk_1	111	117	PF00069	0.536
MOD_Plk_4	18	24	PF00069	0.591
MOD_Plk_4	226	232	PF00069	0.488
MOD_Plk_4	83	89	PF00069	0.486
MOD_ProDKin_1	127	133	PF00069	0.567
MOD_ProDKin_1	253	259	PF00069	0.649
MOD_ProDKin_1	275	281	PF00069	0.622
MOD_ProDKin_1	78	84	PF00069	0.600
MOD_ProDKin_1	9	15	PF00069	0.673
MOD_SUMO_rev_2	29	38	PF00179	0.611
MOD_SUMO_rev_2	468	475	PF00179	0.433
TRG_DiLeu_BaLyEn_6	254	259	PF01217	0.645
TRG_DiLeu_BaLyEn_6	317	322	PF01217	0.289
TRG_ENDOCYTIC_2	208	211	PF00928	0.513
TRG_ENDOCYTIC_2	289	292	PF00928	0.483
TRG_ER_diArg_1	187	189	PF00400	0.643
TRG_ER_diArg_1	275	277	PF00400	0.605
TRG_ER_diArg_1	313	316	PF00400	0.398
TRG_ER_diArg_1	319	321	PF00400	0.440
TRG_Pf-PMV_PEXEL_1	319	324	PF00026	0.535
TRG_Pf-PMV_PEXEL_1	89	93	PF00026	0.477

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDH5	Leptomonas seymouri	66%	84%
A0A0S4JF66	Bodo saltans	27%	98%
A0A1X0P302	Trypanosomatidae	34%	96%
A0A3R7LKS4	Trypanosoma rangeli	35%	97%
A0A3S5H7M2	Leishmania donovani	93%	100%
A4HHW3	Leishmania braziliensis	83%	99%
A4I513	Leishmania infantum	93%	100%
C9ZQG8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	97%
Q4Q7V1	Leishmania major	94%	100%
V5BLF7	Trypanosoma cruzi	34%	89%