Rubis-subs-bind domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Rubisco LSMT substrate-binding, putative

Species:

Leishmania mexicana

UniProt:

E9B0E1_LEIMU

TriTrypDb:

LmxM.29.0170

Length:

623

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B0E1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B0E1

Function

Biological processes
Term	Name	Level	Count
GO:0008152	metabolic process	1	11
GO:0032259	methylation	2	11
GO:0006479	protein methylation	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008213	protein alkylation	5	1
GO:0009987	cellular process	1	1
GO:0018022	peptidyl-lysine methylation	5	1
GO:0018026	peptidyl-lysine monomethylation	6	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018205	peptidyl-lysine modification	6	1
GO:0019538	protein metabolic process	3	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0043414	macromolecule methylation	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0008168	methyltransferase activity	4	11
GO:0016740	transferase activity	2	11
GO:0016741	transferase activity, transferring one-carbon groups	3	11
GO:0008170	N-methyltransferase activity	5	1
GO:0008276	protein methyltransferase activity	3	1
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	5	1
GO:0016278	lysine N-methyltransferase activity	6	1
GO:0016279	protein-lysine N-methyltransferase activity	4	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	158	162	PF00656	0.527
CLV_C14_Caspase3-7	169	173	PF00656	0.559
CLV_C14_Caspase3-7	81	85	PF00656	0.471
CLV_MEL_PAP_1	602	608	PF00089	0.344
CLV_NRD_NRD_1	266	268	PF00675	0.483
CLV_NRD_NRD_1	274	276	PF00675	0.497
CLV_NRD_NRD_1	28	30	PF00675	0.503
CLV_NRD_NRD_1	392	394	PF00675	0.396
CLV_NRD_NRD_1	487	489	PF00675	0.352
CLV_NRD_NRD_1	493	495	PF00675	0.337
CLV_NRD_NRD_1	535	537	PF00675	0.326
CLV_PCSK_FUR_1	264	268	PF00082	0.239
CLV_PCSK_KEX2_1	266	268	PF00082	0.483
CLV_PCSK_KEX2_1	27	29	PF00082	0.358
CLV_PCSK_KEX2_1	274	276	PF00082	0.497
CLV_PCSK_KEX2_1	303	305	PF00082	0.426
CLV_PCSK_KEX2_1	487	489	PF00082	0.354
CLV_PCSK_KEX2_1	493	495	PF00082	0.341
CLV_PCSK_KEX2_1	535	537	PF00082	0.326
CLV_PCSK_KEX2_1	609	611	PF00082	0.273
CLV_PCSK_PC1ET2_1	27	29	PF00082	0.358
CLV_PCSK_PC1ET2_1	303	305	PF00082	0.426
CLV_PCSK_PC1ET2_1	609	611	PF00082	0.288
CLV_PCSK_PC7_1	262	268	PF00082	0.388
CLV_PCSK_PC7_1	605	611	PF00082	0.269
CLV_PCSK_SKI1_1	130	134	PF00082	0.383
CLV_PCSK_SKI1_1	166	170	PF00082	0.648
CLV_PCSK_SKI1_1	177	181	PF00082	0.514
CLV_PCSK_SKI1_1	237	241	PF00082	0.477
CLV_PCSK_SKI1_1	266	270	PF00082	0.413
CLV_PCSK_SKI1_1	488	492	PF00082	0.401
CLV_PCSK_SKI1_1	494	498	PF00082	0.378
DEG_APCC_DBOX_1	202	210	PF00400	0.389
DEG_APCC_DBOX_1	604	612	PF00400	0.469
DEG_APCC_DBOX_1	67	75	PF00400	0.446
DOC_CYCLIN_RxL_1	262	270	PF00134	0.476
DOC_CYCLIN_yCln2_LP_2	448	454	PF00134	0.441
DOC_MAPK_gen_1	493	499	PF00069	0.466
DOC_MAPK_gen_1	593	602	PF00069	0.404
DOC_MAPK_MEF2A_6	596	604	PF00069	0.494
DOC_MAPK_RevD_3	289	304	PF00069	0.406
DOC_PP1_RVXF_1	104	110	PF00149	0.417
DOC_PP1_RVXF_1	175	181	PF00149	0.481
DOC_PP1_RVXF_1	27	34	PF00149	0.381
DOC_PP1_RVXF_1	612	619	PF00149	0.335
DOC_PP2B_LxvP_1	207	210	PF13499	0.382
DOC_PP2B_LxvP_1	452	455	PF13499	0.580
DOC_PP2B_LxvP_1	497	500	PF13499	0.509
DOC_USP7_MATH_1	122	126	PF00917	0.555
DOC_USP7_MATH_1	154	158	PF00917	0.677
DOC_USP7_MATH_1	199	203	PF00917	0.464
DOC_USP7_MATH_1	232	236	PF00917	0.461
DOC_USP7_MATH_1	302	306	PF00917	0.565
DOC_USP7_MATH_1	335	339	PF00917	0.498
DOC_USP7_MATH_1	480	484	PF00917	0.636
DOC_USP7_MATH_1	550	554	PF00917	0.531
DOC_WW_Pin1_4	117	122	PF00397	0.523
DOC_WW_Pin1_4	541	546	PF00397	0.564
LIG_14-3-3_CanoR_1	156	160	PF00244	0.548
LIG_14-3-3_CanoR_1	166	171	PF00244	0.587
LIG_14-3-3_CanoR_1	266	276	PF00244	0.487
LIG_14-3-3_CanoR_1	57	63	PF00244	0.545
LIG_14-3-3_CterR_2	621	623	PF00244	0.424
LIG_Actin_WH2_2	595	611	PF00022	0.521
LIG_AP2alpha_2	97	99	PF02296	0.430
LIG_BIR_II_1	1	5	PF00653	0.561
LIG_BRCT_BRCA1_1	211	215	PF00533	0.400
LIG_BRCT_BRCA1_1	3	7	PF00533	0.360
LIG_BRCT_BRCA1_1	342	346	PF00533	0.440
LIG_BRCT_BRCA1_1	359	363	PF00533	0.215
LIG_Clathr_ClatBox_1	71	75	PF01394	0.449
LIG_deltaCOP1_diTrp_1	172	180	PF00928	0.419
LIG_FHA_1	136	142	PF00498	0.407
LIG_FHA_1	314	320	PF00498	0.402
LIG_FHA_1	386	392	PF00498	0.486
LIG_FHA_1	401	407	PF00498	0.484
LIG_FHA_1	6	12	PF00498	0.596
LIG_FHA_2	129	135	PF00498	0.545
LIG_FHA_2	156	162	PF00498	0.702
LIG_FHA_2	167	173	PF00498	0.631
LIG_FHA_2	279	285	PF00498	0.481
LIG_FHA_2	409	415	PF00498	0.441
LIG_FHA_2	567	573	PF00498	0.484
LIG_FHA_2	574	580	PF00498	0.456
LIG_FHA_2	59	65	PF00498	0.545
LIG_FHA_2	76	82	PF00498	0.464
LIG_GBD_Chelix_1	310	318	PF00786	0.321
LIG_LIR_Apic_2	58	63	PF02991	0.489
LIG_LIR_Gen_1	527	537	PF02991	0.460
LIG_LIR_Gen_1	78	88	PF02991	0.381
LIG_LIR_Nem_3	263	268	PF02991	0.363
LIG_LIR_Nem_3	418	423	PF02991	0.330
LIG_LIR_Nem_3	78	83	PF02991	0.366
LIG_LYPXL_yS_3	276	279	PF13949	0.339
LIG_NRBOX	216	222	PF00104	0.280
LIG_NRBOX	235	241	PF00104	0.392
LIG_NRBOX	514	520	PF00104	0.486
LIG_SH2_CRK	423	427	PF00017	0.326
LIG_SH2_CRK	435	439	PF00017	0.338
LIG_SH2_NCK_1	136	140	PF00017	0.457
LIG_SH2_STAP1	253	257	PF00017	0.348
LIG_SH2_STAP1	495	499	PF00017	0.388
LIG_SH2_STAT5	110	113	PF00017	0.370
LIG_SH2_STAT5	30	33	PF00017	0.404
LIG_SH3_1	274	280	PF00018	0.316
LIG_SH3_1	536	542	PF00018	0.508
LIG_SH3_3	274	280	PF00018	0.344
LIG_SH3_3	536	542	PF00018	0.508
LIG_SH3_3	92	98	PF00018	0.455
LIG_SUMO_SIM_par_1	70	75	PF11976	0.425
LIG_TRFH_1	437	441	PF08558	0.447
MOD_CK1_1	124	130	PF00069	0.550
MOD_CK1_1	152	158	PF00069	0.684
MOD_CK1_1	190	196	PF00069	0.504
MOD_CK1_1	202	208	PF00069	0.469
MOD_CK1_1	465	471	PF00069	0.732
MOD_CK1_1	479	485	PF00069	0.437
MOD_CK1_1	544	550	PF00069	0.462
MOD_CK1_1	565	571	PF00069	0.540
MOD_CK2_1	145	151	PF00069	0.658
MOD_CK2_1	278	284	PF00069	0.535
MOD_CK2_1	566	572	PF00069	0.494
MOD_CK2_1	573	579	PF00069	0.459
MOD_CK2_1	58	64	PF00069	0.494
MOD_CK2_1	75	81	PF00069	0.269
MOD_Cter_Amidation	533	536	PF01082	0.222
MOD_GlcNHglycan	1	4	PF01048	0.716
MOD_GlcNHglycan	126	129	PF01048	0.509
MOD_GlcNHglycan	151	155	PF01048	0.663
MOD_GlcNHglycan	341	345	PF01048	0.469
MOD_GlcNHglycan	463	467	PF01048	0.694
MOD_GlcNHglycan	470	473	PF01048	0.692
MOD_GlcNHglycan	477	481	PF01048	0.589
MOD_GSK3_1	1	8	PF00069	0.615
MOD_GSK3_1	117	124	PF00069	0.485
MOD_GSK3_1	145	152	PF00069	0.641
MOD_GSK3_1	168	175	PF00069	0.539
MOD_GSK3_1	353	360	PF00069	0.457
MOD_GSK3_1	468	475	PF00069	0.694
MOD_GSK3_1	476	483	PF00069	0.618
MOD_GSK3_1	562	569	PF00069	0.466
MOD_LATS_1	164	170	PF00433	0.564
MOD_N-GLC_1	145	150	PF02516	0.614
MOD_N-GLC_1	18	23	PF02516	0.449
MOD_N-GLC_1	385	390	PF02516	0.370
MOD_NEK2_1	1	6	PF00069	0.700
MOD_NEK2_1	216	221	PF00069	0.329
MOD_NEK2_1	314	319	PF00069	0.465
MOD_NEK2_1	419	424	PF00069	0.345
MOD_NEK2_2	137	142	PF00069	0.481
MOD_PIKK_1	302	308	PF00454	0.469
MOD_PKA_2	155	161	PF00069	0.476
MOD_PKA_2	202	208	PF00069	0.442
MOD_Plk_1	145	151	PF00069	0.574
MOD_Plk_1	260	266	PF00069	0.456
MOD_Plk_1	480	486	PF00069	0.480
MOD_Plk_1	573	579	PF00069	0.534
MOD_Plk_2-3	573	579	PF00069	0.524
MOD_Plk_2-3	75	81	PF00069	0.466
MOD_Plk_4	202	208	PF00069	0.430
MOD_Plk_4	216	222	PF00069	0.292
MOD_Plk_4	314	320	PF00069	0.393
MOD_Plk_4	550	556	PF00069	0.546
MOD_ProDKin_1	117	123	PF00069	0.526
MOD_ProDKin_1	541	547	PF00069	0.564
MOD_SUMO_rev_2	587	595	PF00179	0.496
TRG_DiLeu_BaEn_1	243	248	PF01217	0.378
TRG_DiLeu_BaEn_2	44	50	PF01217	0.528
TRG_DiLeu_BaLyEn_6	264	269	PF01217	0.486
TRG_ENDOCYTIC_2	253	256	PF00928	0.427
TRG_ENDOCYTIC_2	276	279	PF00928	0.339
TRG_ENDOCYTIC_2	423	426	PF00928	0.329
TRG_ENDOCYTIC_2	435	438	PF00928	0.333
TRG_ENDOCYTIC_2	537	540	PF00928	0.532
TRG_ER_diArg_1	262	265	PF00400	0.470
TRG_ER_diArg_1	266	268	PF00400	0.481
TRG_ER_diArg_1	273	275	PF00400	0.496
TRG_ER_diArg_1	28	30	PF00400	0.382
TRG_ER_diArg_1	487	489	PF00400	0.447
TRG_ER_diArg_1	492	494	PF00400	0.434
TRG_ER_diArg_1	535	537	PF00400	0.527
TRG_ER_diArg_1	67	70	PF00400	0.415
TRG_NES_CRM1_1	287	299	PF08389	0.389
TRG_Pf-PMV_PEXEL_1	286	290	PF00026	0.434
TRG_Pf-PMV_PEXEL_1	77	81	PF00026	0.368

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8B9	Leptomonas seymouri	60%	99%
A0A0S4JJX6	Bodo saltans	35%	90%
A0A1X0P2C3	Trypanosomatidae	42%	100%
A0A3Q8IFL1	Leishmania donovani	93%	100%
A0A422N122	Trypanosoma rangeli	44%	100%
A4HHW1	Leishmania braziliensis	80%	100%
A4I511	Leishmania infantum	92%	100%
C9ZQG5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
Q4Q7U0	Leishmania major	92%	100%
V5AWY0	Trypanosoma cruzi	44%	100%