Protein YIPF

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Protein YIPF

Gene product:

Yip1 domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9B0D9_LEIMU

TriTrypDb:

LmxM.29.0140

Length:

346

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005794	Golgi apparatus	5	12
GO:0016020	membrane	2	12
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043231	intracellular membrane-bounded organelle	4	12
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

E9B0D9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B0D9

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	12
GO:0016192	vesicle-mediated transport	4	12
GO:0051179	localization	1	12
GO:0051234	establishment of localization	2	12

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	12
GO:0005515	protein binding	2	12
GO:0019899	enzyme binding	3	12
GO:0031267	small GTPase binding	5	12
GO:0051020	GTPase binding	4	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	179	181	PF00675	0.303
CLV_PCSK_SKI1_1	127	131	PF00082	0.284
DEG_APCC_DBOX_1	126	134	PF00400	0.498
DEG_SIAH_1	21	29	PF03145	0.550
DEG_SPOP_SBC_1	296	300	PF00917	0.143
DOC_CYCLIN_yClb5_NLxxxL_5	249	258	PF00134	0.466
DOC_CYCLIN_yCln2_LP_2	184	190	PF00134	0.423
DOC_MAPK_MEF2A_6	316	324	PF00069	0.466
DOC_USP7_MATH_1	100	104	PF00917	0.697
DOC_USP7_MATH_1	199	203	PF00917	0.356
DOC_USP7_MATH_1	28	32	PF00917	0.679
DOC_USP7_MATH_1	4	8	PF00917	0.636
DOC_WW_Pin1_4	18	23	PF00397	0.559
DOC_WW_Pin1_4	76	81	PF00397	0.690
LIG_14-3-3_CanoR_1	132	138	PF00244	0.512
LIG_Actin_WH2_2	117	134	PF00022	0.485
LIG_AP2alpha_2	12	14	PF02296	0.602
LIG_BIR_II_1	1	5	PF00653	0.608
LIG_BIR_III_1	1	5	PF00653	0.621
LIG_BIR_III_3	1	5	PF00653	0.621
LIG_BRCT_BRCA1_1	335	339	PF00533	0.282
LIG_deltaCOP1_diTrp_1	315	325	PF00928	0.463
LIG_EVH1_2	67	71	PF00568	0.558
LIG_FHA_1	124	130	PF00498	0.488
LIG_FHA_1	195	201	PF00498	0.309
LIG_FHA_1	257	263	PF00498	0.438
LIG_FHA_1	297	303	PF00498	0.305
LIG_FHA_1	77	83	PF00498	0.764
LIG_FHA_2	167	173	PF00498	0.620
LIG_FHA_2	255	261	PF00498	0.454
LIG_FHA_2	310	316	PF00498	0.514
LIG_FHA_2	49	55	PF00498	0.689
LIG_IBAR_NPY_1	3	5	PF08397	0.615
LIG_LIR_Apic_2	110	116	PF02991	0.614
LIG_LIR_Apic_2	16	22	PF02991	0.616
LIG_LIR_Gen_1	192	201	PF02991	0.249
LIG_LIR_Gen_1	228	239	PF02991	0.392
LIG_LIR_Gen_1	285	296	PF02991	0.362
LIG_LIR_Gen_1	298	309	PF02991	0.204
LIG_LIR_Gen_1	49	59	PF02991	0.657
LIG_LIR_Nem_3	109	115	PF02991	0.545
LIG_LIR_Nem_3	183	188	PF02991	0.439
LIG_LIR_Nem_3	192	198	PF02991	0.285
LIG_LIR_Nem_3	228	234	PF02991	0.392
LIG_LIR_Nem_3	285	291	PF02991	0.362
LIG_LIR_Nem_3	298	304	PF02991	0.194
LIG_LIR_Nem_3	334	340	PF02991	0.276
LIG_LIR_Nem_3	49	55	PF02991	0.727
LIG_PALB2_WD40_1	314	322	PF16756	0.514
LIG_PDZ_Class_2	341	346	PF00595	0.284
LIG_Pex14_1	113	117	PF04695	0.487
LIG_Pex14_1	220	224	PF04695	0.212
LIG_Pex14_1	297	301	PF04695	0.264
LIG_Pex14_2	117	121	PF04695	0.473
LIG_Pex14_2	293	297	PF04695	0.320
LIG_Pex14_2	325	329	PF04695	0.367
LIG_Pex14_2	337	341	PF04695	0.255
LIG_REV1ctd_RIR_1	339	346	PF16727	0.374
LIG_SH2_CRK	19	23	PF00017	0.583
LIG_SH2_CRK	231	235	PF00017	0.411
LIG_SH2_CRK	237	241	PF00017	0.348
LIG_SH2_NCK_1	19	23	PF00017	0.763
LIG_SH2_NCK_1	231	235	PF00017	0.325
LIG_SH2_NCK_1	52	56	PF00017	0.650
LIG_SH2_STAP1	222	226	PF00017	0.251
LIG_SH2_STAP1	231	235	PF00017	0.282
LIG_SH2_STAP1	267	271	PF00017	0.249
LIG_SH2_STAT5	210	213	PF00017	0.316
LIG_SH2_STAT5	235	238	PF00017	0.253
LIG_SH2_STAT5	301	304	PF00017	0.283
LIG_SH2_STAT5	340	343	PF00017	0.252
LIG_SH2_STAT5	52	55	PF00017	0.653
LIG_SH3_3	136	142	PF00018	0.534
LIG_SH3_3	84	90	PF00018	0.674
LIG_SUMO_SIM_anti_2	197	202	PF11976	0.342
LIG_SUMO_SIM_anti_2	273	279	PF11976	0.392
LIG_SUMO_SIM_par_1	196	202	PF11976	0.344
LIG_TRAF2_1	170	173	PF00917	0.639
LIG_TYR_ITIM	229	234	PF00017	0.392
LIG_TYR_ITSM	297	304	PF00017	0.342
LIG_UBA3_1	204	212	PF00899	0.325
LIG_UBA3_1	302	311	PF00899	0.325
MOD_CK1_1	103	109	PF00069	0.706
MOD_CK1_1	225	231	PF00069	0.228
MOD_CK1_1	31	37	PF00069	0.703
MOD_CK1_1	7	13	PF00069	0.689
MOD_CK2_1	166	172	PF00069	0.640
MOD_CK2_1	309	315	PF00069	0.514
MOD_CK2_1	48	54	PF00069	0.740
MOD_CMANNOS	307	310	PF00535	0.223
MOD_GlcNHglycan	30	33	PF01048	0.510
MOD_GlcNHglycan	48	51	PF01048	0.504
MOD_GlcNHglycan	6	9	PF01048	0.467
MOD_GlcNHglycan	75	79	PF01048	0.452
MOD_GSK3_1	100	107	PF00069	0.643
MOD_GSK3_1	190	197	PF00069	0.262
MOD_GSK3_1	199	206	PF00069	0.230
MOD_GSK3_1	208	215	PF00069	0.154
MOD_GSK3_1	254	261	PF00069	0.428
MOD_GSK3_1	31	38	PF00069	0.739
MOD_GSK3_1	46	53	PF00069	0.684
MOD_GSK3_1	76	83	PF00069	0.662
MOD_N-GLC_1	153	158	PF02516	0.453
MOD_N-GLC_1	212	217	PF02516	0.500
MOD_NEK2_1	131	136	PF00069	0.490
MOD_NEK2_1	153	158	PF00069	0.661
MOD_NEK2_1	194	199	PF00069	0.297
MOD_NEK2_1	258	263	PF00069	0.476
MOD_NEK2_1	309	314	PF00069	0.461
MOD_NEK2_1	331	336	PF00069	0.283
MOD_NEK2_2	265	270	PF00069	0.249
MOD_PIKK_1	101	107	PF00454	0.700
MOD_PIKK_1	214	220	PF00454	0.188
MOD_PKA_2	131	137	PF00069	0.494
MOD_Plk_1	153	159	PF00069	0.638
MOD_Plk_1	166	172	PF00069	0.679
MOD_Plk_1	222	228	PF00069	0.240
MOD_Plk_2-3	167	173	PF00069	0.645
MOD_Plk_4	133	139	PF00069	0.518
MOD_Plk_4	190	196	PF00069	0.272
MOD_Plk_4	265	271	PF00069	0.288
MOD_Plk_4	297	303	PF00069	0.297
MOD_ProDKin_1	18	24	PF00069	0.560
MOD_ProDKin_1	76	82	PF00069	0.693
TRG_DiLeu_BaEn_2	314	320	PF01217	0.514
TRG_ENDOCYTIC_2	118	121	PF00928	0.481
TRG_ENDOCYTIC_2	185	188	PF00928	0.412
TRG_ENDOCYTIC_2	231	234	PF00928	0.392
TRG_ENDOCYTIC_2	237	240	PF00928	0.332
TRG_ENDOCYTIC_2	267	270	PF00928	0.292
TRG_ENDOCYTIC_2	301	304	PF00928	0.308
TRG_ENDOCYTIC_2	52	55	PF00928	0.771

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PG17	Leptomonas seymouri	62%	95%
A0A0S4JRK9	Bodo saltans	61%	100%
A0A1X0P3E9	Trypanosomatidae	50%	95%
A0A3Q8IBR6	Leishmania donovani	96%	100%
A0A422N136	Trypanosoma rangeli	48%	99%
A4HHV9	Leishmania braziliensis	90%	100%
A4I509	Leishmania infantum	96%	100%
C9ZQG2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	97%
Q4Q7U1	Leishmania major	94%	100%
Q54TS4	Dictyostelium discoideum	30%	100%
Q5RBL0	Pongo abelii	29%	100%
Q6P6G5	Rattus norvegicus	27%	100%
Q91VU1	Mus musculus	28%	100%
Q9UTD3	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	25%	100%
Q9Y548	Homo sapiens	28%	100%
V5BLF2	Trypanosoma cruzi	49%	100%