Leucine-rich repeat-containing protein 14

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B0D6_LEIMU

TriTrypDb:

LmxM.29.0110

Length:

427

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 1, no: 8
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	10
GO:0042995	cell projection	2	10
GO:0043226	organelle	2	10
GO:0043227	membrane-bounded organelle	3	10
GO:0110165	cellular anatomical entity	1	10
GO:0120025	plasma membrane bounded cell projection	3	10

Expansion

Sequence features

E9B0D6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B0D6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	110	114	PF00656	0.498
CLV_NRD_NRD_1	148	150	PF00675	0.603
CLV_NRD_NRD_1	186	188	PF00675	0.552
CLV_PCSK_KEX2_1	148	150	PF00082	0.487
CLV_PCSK_KEX2_1	186	188	PF00082	0.552
CLV_PCSK_SKI1_1	186	190	PF00082	0.492
CLV_PCSK_SKI1_1	264	268	PF00082	0.464
DEG_APCC_DBOX_1	82	90	PF00400	0.352
DEG_Nend_UBRbox_2	1	3	PF02207	0.700
DEG_SCF_FBW7_1	368	375	PF00400	0.470
DOC_CDC14_PxL_1	225	233	PF14671	0.483
DOC_CKS1_1	369	374	PF01111	0.554
DOC_MAPK_gen_1	393	403	PF00069	0.524
DOC_MAPK_gen_1	69	77	PF00069	0.574
DOC_MAPK_MEF2A_6	69	77	PF00069	0.565
DOC_PP1_RVXF_1	262	268	PF00149	0.390
DOC_PP1_RVXF_1	391	398	PF00149	0.485
DOC_USP7_MATH_1	133	137	PF00917	0.549
DOC_USP7_MATH_1	142	146	PF00917	0.327
DOC_USP7_MATH_1	247	251	PF00917	0.341
DOC_USP7_MATH_1	32	36	PF00917	0.609
DOC_USP7_MATH_2	289	295	PF00917	0.484
DOC_WW_Pin1_4	124	129	PF00397	0.571
DOC_WW_Pin1_4	166	171	PF00397	0.546
DOC_WW_Pin1_4	26	31	PF00397	0.573
DOC_WW_Pin1_4	368	373	PF00397	0.558
DOC_WW_Pin1_4	407	412	PF00397	0.442
LIG_14-3-3_CanoR_1	153	161	PF00244	0.469
LIG_14-3-3_CanoR_1	186	195	PF00244	0.482
LIG_14-3-3_CanoR_1	258	267	PF00244	0.462
LIG_14-3-3_CanoR_1	405	409	PF00244	0.432
LIG_14-3-3_CanoR_1	72	78	PF00244	0.498
LIG_Actin_WH2_1	264	280	PF00022	0.533
LIG_BRCT_BRCA1_1	393	397	PF00533	0.512
LIG_FHA_1	1	7	PF00498	0.642
LIG_FHA_1	149	155	PF00498	0.486
LIG_FHA_1	231	237	PF00498	0.459
LIG_FHA_1	274	280	PF00498	0.528
LIG_FHA_1	298	304	PF00498	0.513
LIG_FHA_1	319	325	PF00498	0.618
LIG_FHA_1	369	375	PF00498	0.511
LIG_FHA_1	390	396	PF00498	0.504
LIG_FHA_1	65	71	PF00498	0.489
LIG_FHA_1	91	97	PF00498	0.445
LIG_FHA_2	108	114	PF00498	0.484
LIG_FHA_2	230	236	PF00498	0.506
LIG_FHA_2	358	364	PF00498	0.511
LIG_FHA_2	385	391	PF00498	0.494
LIG_FHA_2	74	80	PF00498	0.560
LIG_KLC1_Yacidic_2	350	355	PF13176	0.331
LIG_LIR_Apic_2	196	200	PF02991	0.478
LIG_LIR_Gen_1	291	299	PF02991	0.479
LIG_LIR_Gen_1	394	403	PF02991	0.432
LIG_LIR_LC3C_4	175	178	PF02991	0.420
LIG_LIR_Nem_3	180	184	PF02991	0.538
LIG_LIR_Nem_3	291	295	PF02991	0.467
LIG_LIR_Nem_3	333	337	PF02991	0.474
LIG_LIR_Nem_3	410	415	PF02991	0.536
LIG_NRBOX	116	122	PF00104	0.475
LIG_SH2_CRK	181	185	PF00017	0.545
LIG_SH2_CRK	334	338	PF00017	0.526
LIG_SH2_SRC	353	356	PF00017	0.334
LIG_SH2_SRC	54	57	PF00017	0.449
LIG_SH2_STAT5	12	15	PF00017	0.616
LIG_SH2_STAT5	197	200	PF00017	0.503
LIG_SH2_STAT5	307	310	PF00017	0.525
LIG_SH2_STAT5	353	356	PF00017	0.265
LIG_SH2_STAT5	381	384	PF00017	0.495
LIG_SH2_STAT5	54	57	PF00017	0.604
LIG_SH3_3	162	168	PF00018	0.538
LIG_SH3_3	283	289	PF00018	0.424
LIG_SH3_4	199	206	PF00018	0.546
LIG_SUMO_SIM_anti_2	163	169	PF11976	0.520
LIG_SUMO_SIM_par_1	163	169	PF11976	0.496
LIG_SUMO_SIM_par_1	232	238	PF11976	0.501
LIG_SUMO_SIM_par_1	278	283	PF11976	0.453
LIG_SUMO_SIM_par_1	371	378	PF11976	0.454
LIG_SUMO_SIM_par_1	399	404	PF11976	0.491
LIG_TYR_ITIM	332	337	PF00017	0.550
LIG_WRC_WIRS_1	292	297	PF05994	0.494
MOD_CK1_1	119	125	PF00069	0.509
MOD_CK1_1	237	243	PF00069	0.295
MOD_CK1_1	250	256	PF00069	0.243
MOD_CK1_1	294	300	PF00069	0.488
MOD_CK1_1	333	339	PF00069	0.544
MOD_CK1_1	35	41	PF00069	0.612
MOD_CK1_1	375	381	PF00069	0.445
MOD_CK1_1	407	413	PF00069	0.417
MOD_CK2_1	119	125	PF00069	0.527
MOD_CK2_1	240	246	PF00069	0.524
MOD_CK2_1	257	263	PF00069	0.542
MOD_CK2_1	377	383	PF00069	0.533
MOD_CK2_1	73	79	PF00069	0.450
MOD_GlcNHglycan	121	124	PF01048	0.470
MOD_GlcNHglycan	140	143	PF01048	0.512
MOD_GlcNHglycan	144	147	PF01048	0.486
MOD_GlcNHglycan	155	158	PF01048	0.510
MOD_GlcNHglycan	18	21	PF01048	0.622
MOD_GlcNHglycan	249	252	PF01048	0.482
MOD_GlcNHglycan	281	285	PF01048	0.460
MOD_GlcNHglycan	37	40	PF01048	0.487
MOD_GlcNHglycan	61	64	PF01048	0.553
MOD_GSK3_1	107	114	PF00069	0.533
MOD_GSK3_1	129	136	PF00069	0.468
MOD_GSK3_1	138	145	PF00069	0.524
MOD_GSK3_1	230	237	PF00069	0.437
MOD_GSK3_1	368	375	PF00069	0.504
MOD_GSK3_1	399	406	PF00069	0.482
MOD_GSK3_1	418	425	PF00069	0.500
MOD_N-GLC_1	357	362	PF02516	0.518
MOD_NEK2_1	212	217	PF00069	0.485
MOD_NEK2_1	234	239	PF00069	0.442
MOD_NEK2_1	257	262	PF00069	0.501
MOD_NEK2_1	330	335	PF00069	0.436
MOD_NEK2_1	354	359	PF00069	0.420
MOD_NEK2_1	377	382	PF00069	0.457
MOD_NEK2_1	389	394	PF00069	0.450
MOD_NEK2_1	401	406	PF00069	0.421
MOD_NEK2_1	418	423	PF00069	0.546
MOD_NEK2_1	73	78	PF00069	0.464
MOD_NEK2_2	64	69	PF00069	0.464
MOD_PIKK_1	199	205	PF00454	0.545
MOD_PIKK_1	210	216	PF00454	0.410
MOD_PIKK_1	294	300	PF00454	0.513
MOD_PIKK_1	318	324	PF00454	0.585
MOD_PIKK_1	90	96	PF00454	0.515
MOD_PKA_1	148	154	PF00069	0.473
MOD_PKA_1	186	192	PF00069	0.533
MOD_PKA_2	138	144	PF00069	0.475
MOD_PKA_2	148	154	PF00069	0.409
MOD_PKA_2	186	192	PF00069	0.542
MOD_PKA_2	257	263	PF00069	0.511
MOD_PKA_2	404	410	PF00069	0.461
MOD_Plk_1	357	363	PF00069	0.529
MOD_Plk_1	48	54	PF00069	0.615
MOD_Plk_4	111	117	PF00069	0.542
MOD_Plk_4	172	178	PF00069	0.530
MOD_Plk_4	212	218	PF00069	0.481
MOD_Plk_4	291	297	PF00069	0.469
MOD_Plk_4	32	38	PF00069	0.573
MOD_Plk_4	372	378	PF00069	0.405
MOD_ProDKin_1	124	130	PF00069	0.569
MOD_ProDKin_1	166	172	PF00069	0.549
MOD_ProDKin_1	26	32	PF00069	0.565
MOD_ProDKin_1	368	374	PF00069	0.550
MOD_ProDKin_1	407	413	PF00069	0.451
MOD_SUMO_rev_2	57	62	PF00179	0.537
TRG_DiLeu_BaEn_2	262	268	PF01217	0.253
TRG_DiLeu_BaEn_2	290	296	PF01217	0.502
TRG_DiLeu_BaLyEn_6	226	231	PF01217	0.429
TRG_DiLeu_BaLyEn_6	369	374	PF01217	0.456
TRG_DiLeu_LyEn_5	180	185	PF01217	0.428
TRG_ENDOCYTIC_2	181	184	PF00928	0.556
TRG_ENDOCYTIC_2	334	337	PF00928	0.489
TRG_ENDOCYTIC_2	97	100	PF00928	0.474
TRG_ER_diArg_1	137	140	PF00400	0.572
TRG_ER_diArg_1	185	187	PF00400	0.536
TRG_NES_CRM1_1	270	281	PF08389	0.529

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2N3	Leptomonas seymouri	49%	99%
A0A1X0P2E5	Trypanosomatidae	26%	100%
A0A3Q8IEP2	Leishmania donovani	91%	100%
A4HHV6	Leishmania braziliensis	79%	100%
A4I506	Leishmania infantum	91%	100%
C9ZQF6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	23%	98%
Q4Q7U4	Leishmania major	92%	100%
V5BLE7	Trypanosoma cruzi	26%	100%