FoP_duplication domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B0D4_LEIMU

TriTrypDb:

LmxM.29.0090

Length:

228

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B0D4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B0D4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	108	110	PF00675	0.428
CLV_NRD_NRD_1	123	125	PF00675	0.509
CLV_NRD_NRD_1	128	130	PF00675	0.454
CLV_NRD_NRD_1	134	136	PF00675	0.495
CLV_NRD_NRD_1	150	152	PF00675	0.554
CLV_NRD_NRD_1	170	172	PF00675	0.520
CLV_NRD_NRD_1	20	22	PF00675	0.414
CLV_NRD_NRD_1	32	34	PF00675	0.497
CLV_NRD_NRD_1	43	45	PF00675	0.497
CLV_NRD_NRD_1	50	52	PF00675	0.403
CLV_NRD_NRD_1	69	71	PF00675	0.524
CLV_NRD_NRD_1	81	83	PF00675	0.492
CLV_NRD_NRD_1	9	11	PF00675	0.527
CLV_NRD_NRD_1	90	92	PF00675	0.527
CLV_NRD_NRD_1	98	100	PF00675	0.434
CLV_PCSK_FUR_1	17	21	PF00082	0.511
CLV_PCSK_FUR_1	29	33	PF00082	0.471
CLV_PCSK_FUR_1	79	83	PF00082	0.578
CLV_PCSK_FUR_1	96	100	PF00082	0.480
CLV_PCSK_KEX2_1	108	110	PF00082	0.428
CLV_PCSK_KEX2_1	123	125	PF00082	0.509
CLV_PCSK_KEX2_1	128	130	PF00082	0.454
CLV_PCSK_KEX2_1	134	136	PF00082	0.495
CLV_PCSK_KEX2_1	150	152	PF00082	0.554
CLV_PCSK_KEX2_1	169	171	PF00082	0.526
CLV_PCSK_KEX2_1	19	21	PF00082	0.415
CLV_PCSK_KEX2_1	31	33	PF00082	0.485
CLV_PCSK_KEX2_1	43	45	PF00082	0.488
CLV_PCSK_KEX2_1	50	52	PF00082	0.393
CLV_PCSK_KEX2_1	69	71	PF00082	0.524
CLV_PCSK_KEX2_1	8	10	PF00082	0.533
CLV_PCSK_KEX2_1	81	83	PF00082	0.492
CLV_PCSK_KEX2_1	90	92	PF00082	0.527
CLV_PCSK_KEX2_1	98	100	PF00082	0.434
CLV_PCSK_PC7_1	119	125	PF00082	0.596
CLV_PCSK_PC7_1	86	92	PF00082	0.559
CLV_PCSK_PC7_1	94	100	PF00082	0.501
CLV_PCSK_SKI1_1	86	90	PF00082	0.598
DEG_APCC_DBOX_1	7	15	PF00400	0.518
DOC_USP7_MATH_1	194	198	PF00917	0.583
DOC_USP7_MATH_1	199	203	PF00917	0.614
LIG_14-3-3_CanoR_1	195	199	PF00244	0.534
LIG_14-3-3_CanoR_1	44	54	PF00244	0.580
LIG_14-3-3_CanoR_1	81	89	PF00244	0.556
LIG_FHA_2	213	219	PF00498	0.590
LIG_FHA_2	50	56	PF00498	0.581
LIG_Integrin_RGD_1	119	121	PF01839	0.593
LIG_LIR_Apic_2	36	42	PF02991	0.611
LIG_LIR_Nem_3	110	115	PF02991	0.462
LIG_SH2_CRK	39	43	PF00017	0.601
LIG_SH2_STAT5	45	48	PF00017	0.576
LIG_TRAF2_1	215	218	PF00917	0.588
MOD_CK1_1	206	212	PF00069	0.587
MOD_CK2_1	212	218	PF00069	0.602
MOD_CK2_1	49	55	PF00069	0.579
MOD_Cter_Amidation	121	124	PF01082	0.589
MOD_Cter_Amidation	126	129	PF01082	0.549
MOD_Cter_Amidation	167	170	PF01082	0.587
MOD_GlcNHglycan	173	176	PF01048	0.659
MOD_GlcNHglycan	22	25	PF01048	0.520
MOD_GSK3_1	199	206	PF00069	0.542
MOD_GSK3_1	45	52	PF00069	0.574
MOD_NEK2_1	140	145	PF00069	0.660
MOD_PIKK_1	194	200	PF00454	0.534
MOD_PIKK_1	203	209	PF00454	0.517
MOD_PIKK_1	59	65	PF00454	0.571
MOD_PKA_1	20	26	PF00069	0.518
MOD_PKA_1	81	87	PF00069	0.598
MOD_PKA_2	140	146	PF00069	0.663
MOD_PKA_2	163	169	PF00069	0.646
MOD_PKA_2	194	200	PF00069	0.556
MOD_PKA_2	20	26	PF00069	0.518
MOD_PKA_2	49	55	PF00069	0.535
MOD_PKA_2	81	87	PF00069	0.598
MOD_PKB_1	169	177	PF00069	0.658
MOD_PKB_1	79	87	PF00069	0.559
TRG_ER_diArg_1	123	125	PF00400	0.568
TRG_ER_diArg_1	128	130	PF00400	0.513
TRG_ER_diArg_1	134	137	PF00400	0.474
TRG_ER_diArg_1	138	141	PF00400	0.541
TRG_ER_diArg_1	150	152	PF00400	0.554
TRG_ER_diArg_1	169	171	PF00400	0.549
TRG_ER_diArg_1	17	20	PF00400	0.427
TRG_ER_diArg_1	31	33	PF00400	0.467
TRG_ER_diArg_1	42	44	PF00400	0.494
TRG_ER_diArg_1	50	53	PF00400	0.424
TRG_ER_diArg_1	68	70	PF00400	0.500
TRG_ER_diArg_1	78	81	PF00400	0.518
TRG_ER_diArg_1	8	10	PF00400	0.533
TRG_ER_diArg_1	89	91	PF00400	0.513
TRG_ER_diArg_1	97	99	PF00400	0.427
TRG_Pf-PMV_PEXEL_1	12	16	PF00026	0.504

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X2W4	Leishmania donovani	91%	100%
A4HHV4	Leishmania braziliensis	61%	93%
A4I504	Leishmania infantum	89%	100%
Q4Q7U6	Leishmania major	94%	100%