Putative mitotic cyclin

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

mitotic cyclin, putative

Species:

Leishmania mexicana

UniProt:

E9B0D3_LEIMU

TriTrypDb:

LmxM.29.0080

Length:

420

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0000307	cyclin-dependent protein kinase holoenzyme complex	7	1
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0061695	transferase complex, transferring phosphorus-containing groups	4	1
GO:0110165	cellular anatomical entity	1	1
GO:1902494	catalytic complex	2	1
GO:1902554	serine/threonine protein kinase complex	6	1
GO:1902911	protein kinase complex	5	1
GO:1990234	transferase complex	3	1

Expansion

Sequence features

E9B0D3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B0D3

Function

Biological processes
Term	Name	Level	Count
GO:0000079	regulation of cyclin-dependent protein serine/threonine kinase activity	6	1
GO:0001932	regulation of protein phosphorylation	7	1
GO:0009987	cellular process	1	1
GO:0019220	regulation of phosphate metabolic process	6	1
GO:0019222	regulation of metabolic process	3	1
GO:0022402	cell cycle process	2	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0031399	regulation of protein modification process	6	1
GO:0042325	regulation of phosphorylation	7	1
GO:0043549	regulation of kinase activity	5	1
GO:0044770	cell cycle phase transition	3	1
GO:0044772	mitotic cell cycle phase transition	4	1
GO:0045859	regulation of protein kinase activity	6	1
GO:0050789	regulation of biological process	2	1
GO:0050790	regulation of catalytic activity	3	1
GO:0050794	regulation of cellular process	3	1
GO:0051171	regulation of nitrogen compound metabolic process	4	1
GO:0051174	regulation of phosphorus metabolic process	5	1
GO:0051246	regulation of protein metabolic process	5	1
GO:0051338	regulation of transferase activity	4	1
GO:0051726	regulation of cell cycle	4	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0065007	biological regulation	1	1
GO:0065009	regulation of molecular function	2	1
GO:0071900	regulation of protein serine/threonine kinase activity	7	1
GO:0080090	regulation of primary metabolic process	4	1
GO:1903047	mitotic cell cycle process	3	1
GO:1904029	regulation of cyclin-dependent protein kinase activity	5	1

Molecular functions
Term	Name	Level	Count
GO:0016538	cyclin-dependent protein serine/threonine kinase regulator activity	5	1
GO:0019207	kinase regulator activity	3	1
GO:0019887	protein kinase regulator activity	4	1
GO:0030234	enzyme regulator activity	2	1
GO:0098772	molecular function regulator activity	1	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	131	135	PF00656	0.292
CLV_NRD_NRD_1	140	142	PF00675	0.511
CLV_NRD_NRD_1	283	285	PF00675	0.581
CLV_NRD_NRD_1	417	419	PF00675	0.496
CLV_NRD_NRD_1	72	74	PF00675	0.493
CLV_PCSK_KEX2_1	283	285	PF00082	0.576
CLV_PCSK_KEX2_1	359	361	PF00082	0.385
CLV_PCSK_KEX2_1	417	419	PF00082	0.496
CLV_PCSK_KEX2_1	72	74	PF00082	0.557
CLV_PCSK_PC1ET2_1	359	361	PF00082	0.333
CLV_PCSK_SKI1_1	283	287	PF00082	0.559
CLV_PCSK_SKI1_1	359	363	PF00082	0.379
CLV_PCSK_SKI1_1	388	392	PF00082	0.450
CLV_PCSK_SKI1_1	42	46	PF00082	0.526
CLV_PCSK_SKI1_1	51	55	PF00082	0.469
CLV_PCSK_SKI1_1	73	77	PF00082	0.508
DEG_APCC_DBOX_1	264	272	PF00400	0.439
DOC_CYCLIN_yCln2_LP_2	19	25	PF00134	0.471
DOC_MAPK_gen_1	51	61	PF00069	0.322
DOC_MAPK_MEF2A_6	218	225	PF00069	0.386
DOC_MAPK_MEF2A_6	89	97	PF00069	0.298
DOC_USP7_MATH_1	203	207	PF00917	0.414
DOC_USP7_UBL2_3	355	359	PF12436	0.570
DOC_USP7_UBL2_3	47	51	PF12436	0.349
DOC_WW_Pin1_4	349	354	PF00397	0.551
LIG_14-3-3_CanoR_1	218	224	PF00244	0.430
LIG_14-3-3_CanoR_1	265	275	PF00244	0.412
LIG_14-3-3_CanoR_1	333	338	PF00244	0.444
LIG_14-3-3_CanoR_1	89	94	PF00244	0.351
LIG_14-3-3_CterR_2	417	420	PF00244	0.627
LIG_Actin_WH2_2	126	143	PF00022	0.290
LIG_Actin_WH2_2	75	91	PF00022	0.290
LIG_BIR_II_1	1	5	PF00653	0.451
LIG_BRCT_BRCA1_1	16	20	PF00533	0.477
LIG_eIF4E_1	181	187	PF01652	0.378
LIG_EVH1_1	400	404	PF00568	0.616
LIG_EVH1_2	403	407	PF00568	0.613
LIG_FHA_1	172	178	PF00498	0.308
LIG_FHA_1	267	273	PF00498	0.419
LIG_FHA_1	320	326	PF00498	0.380
LIG_FHA_1	372	378	PF00498	0.590
LIG_FHA_1	74	80	PF00498	0.278
LIG_FHA_1	90	96	PF00498	0.268
LIG_FHA_2	295	301	PF00498	0.421
LIG_FHA_2	325	331	PF00498	0.327
LIG_FHA_2	391	397	PF00498	0.647
LIG_GBD_Chelix_1	176	184	PF00786	0.458
LIG_IRF3_LxIS_1	365	372	PF10401	0.578
LIG_LIR_Apic_2	36	41	PF02991	0.471
LIG_LIR_Gen_1	219	225	PF02991	0.402
LIG_LIR_Gen_1	250	261	PF02991	0.317
LIG_LIR_Gen_1	303	310	PF02991	0.366
LIG_LIR_Gen_1	312	321	PF02991	0.357
LIG_LIR_Gen_1	330	338	PF02991	0.225
LIG_LIR_Gen_1	43	53	PF02991	0.336
LIG_LIR_Nem_3	165	170	PF02991	0.304
LIG_LIR_Nem_3	219	223	PF02991	0.404
LIG_LIR_Nem_3	250	256	PF02991	0.313
LIG_LIR_Nem_3	303	307	PF02991	0.364
LIG_LIR_Nem_3	312	317	PF02991	0.363
LIG_LIR_Nem_3	330	334	PF02991	0.259
LIG_PCNA_PIPBox_1	232	241	PF02747	0.444
LIG_Pex14_2	256	260	PF04695	0.378
LIG_PTB_Apo_2	175	182	PF02174	0.304
LIG_PTB_Phospho_1	175	181	PF10480	0.304
LIG_SH2_CRK	335	339	PF00017	0.444
LIG_SH2_PTP2	304	307	PF00017	0.387
LIG_SH2_SRC	170	173	PF00017	0.394
LIG_SH2_SRC	38	41	PF00017	0.438
LIG_SH2_STAT5	103	106	PF00017	0.349
LIG_SH2_STAT5	170	173	PF00017	0.382
LIG_SH2_STAT5	181	184	PF00017	0.252
LIG_SH2_STAT5	304	307	PF00017	0.383
LIG_SH2_STAT5	337	340	PF00017	0.418
LIG_SH2_STAT5	413	416	PF00017	0.599
LIG_SH3_1	398	404	PF00018	0.571
LIG_SH3_3	398	404	PF00018	0.630
LIG_SUMO_SIM_anti_2	2	10	PF11976	0.455
LIG_SUMO_SIM_anti_2	206	211	PF11976	0.380
LIG_SUMO_SIM_anti_2	219	227	PF11976	0.364
LIG_SUMO_SIM_anti_2	57	63	PF11976	0.320
LIG_SUMO_SIM_par_1	142	148	PF11976	0.331
LIG_SUMO_SIM_par_1	203	208	PF11976	0.372
LIG_TRAF2_1	158	161	PF00917	0.362
LIG_UBA3_1	44	51	PF00899	0.331
LIG_WRC_WIRS_1	163	168	PF05994	0.262
MOD_CDC14_SPxK_1	352	355	PF00782	0.650
MOD_CDK_SPxK_1	349	355	PF00069	0.555
MOD_CK1_1	12	18	PF00069	0.484
MOD_CK1_1	227	233	PF00069	0.412
MOD_CK1_1	289	295	PF00069	0.424
MOD_CK1_1	309	315	PF00069	0.190
MOD_CK1_1	336	342	PF00069	0.369
MOD_CK1_1	57	63	PF00069	0.374
MOD_CK2_1	192	198	PF00069	0.418
MOD_CK2_1	294	300	PF00069	0.433
MOD_CK2_1	324	330	PF00069	0.328
MOD_CK2_1	390	396	PF00069	0.635
MOD_GlcNHglycan	239	242	PF01048	0.614
MOD_GlcNHglycan	311	314	PF01048	0.586
MOD_GlcNHglycan	370	374	PF01048	0.392
MOD_GSK3_1	288	295	PF00069	0.429
MOD_GSK3_1	6	13	PF00069	0.442
MOD_N-GLC_1	246	251	PF02516	0.467
MOD_NEK2_1	192	197	PF00069	0.440
MOD_NEK2_1	239	244	PF00069	0.396
MOD_NEK2_1	245	250	PF00069	0.457
MOD_NEK2_1	255	260	PF00069	0.309
MOD_NEK2_1	286	291	PF00069	0.356
MOD_NEK2_1	369	374	PF00069	0.563
MOD_NEK2_1	382	387	PF00069	0.511
MOD_NEK2_1	407	412	PF00069	0.618
MOD_NEK2_1	62	67	PF00069	0.279
MOD_NEK2_1	88	93	PF00069	0.286
MOD_NEK2_1	99	104	PF00069	0.270
MOD_NEK2_2	162	167	PF00069	0.266
MOD_PIKK_1	192	198	PF00454	0.492
MOD_PIKK_1	224	230	PF00454	0.233
MOD_PIKK_1	289	295	PF00454	0.465
MOD_PIKK_1	319	325	PF00454	0.381
MOD_PIKK_1	371	377	PF00454	0.592
MOD_PKA_2	300	306	PF00069	0.363
MOD_PKA_2	407	413	PF00069	0.587
MOD_PKA_2	88	94	PF00069	0.361
MOD_Plk_1	57	63	PF00069	0.391
MOD_Plk_4	162	168	PF00069	0.295
MOD_Plk_4	172	178	PF00069	0.317
MOD_Plk_4	219	225	PF00069	0.423
MOD_Plk_4	248	254	PF00069	0.409
MOD_Plk_4	267	273	PF00069	0.341
MOD_Plk_4	300	306	PF00069	0.376
MOD_Plk_4	333	339	PF00069	0.418
MOD_Plk_4	40	46	PF00069	0.436
MOD_Plk_4	62	68	PF00069	0.274
MOD_Plk_4	99	105	PF00069	0.391
MOD_ProDKin_1	349	355	PF00069	0.555
MOD_SUMO_for_1	128	131	PF00179	0.290
MOD_SUMO_for_1	34	37	PF00179	0.509
MOD_SUMO_rev_2	352	361	PF00179	0.539
MOD_SUMO_rev_2	36	44	PF00179	0.442
TRG_DiLeu_BaEn_1	357	362	PF01217	0.592
TRG_DiLeu_LyEn_5	357	362	PF01217	0.592
TRG_ENDOCYTIC_2	181	184	PF00928	0.306
TRG_ENDOCYTIC_2	304	307	PF00928	0.387
TRG_ENDOCYTIC_2	335	338	PF00928	0.444
TRG_ER_diArg_1	283	285	PF00400	0.388
TRG_ER_diArg_1	417	419	PF00400	0.696
TRG_ER_diArg_1	72	74	PF00400	0.335
TRG_NES_CRM1_1	136	148	PF08389	0.309
TRG_Pf-PMV_PEXEL_1	141	145	PF00026	0.561
TRG_Pf-PMV_PEXEL_1	77	81	PF00026	0.531

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8P2	Leptomonas seymouri	80%	100%
A0A0S4JZZ8	Bodo saltans	45%	99%
A0A1X0P2F8	Trypanosomatidae	45%	100%
A0A3Q8IHJ8	Leishmania donovani	97%	100%
A4HHV3	Leishmania braziliensis	90%	100%
A4I503	Leishmania infantum	96%	100%
C9ZQF2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	93%
Q4Q7U8	Leishmania major	95%	100%