Transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B0D2_LEIMU

TriTrypDb:

LmxM.29.0070

Length:

185

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B0D2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B0D2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	14	18	PF00656	0.739
CLV_C14_Caspase3-7	87	91	PF00656	0.549
CLV_PCSK_SKI1_1	117	121	PF00082	0.467
CLV_PCSK_SKI1_1	53	57	PF00082	0.525
DOC_MAPK_gen_1	112	120	PF00069	0.691
DOC_MAPK_MEF2A_6	124	132	PF00069	0.743
DOC_MAPK_MEF2A_6	38	47	PF00069	0.725
DOC_MAPK_MEF2A_6	67	75	PF00069	0.375
DOC_PP1_RVXF_1	51	57	PF00149	0.656
DOC_WW_Pin1_4	48	53	PF00397	0.653
DOC_WW_Pin1_4	98	103	PF00397	0.375
LIG_14-3-3_CanoR_1	179	185	PF00244	0.526
LIG_14-3-3_CanoR_1	53	63	PF00244	0.744
LIG_AP2alpha_2	175	177	PF02296	0.494
LIG_APCC_ABBA_1	126	131	PF00400	0.738
LIG_BIR_III_4	17	21	PF00653	0.773
LIG_BRCT_BRCA1_1	106	110	PF00533	0.428
LIG_BRCT_BRCA1_1	71	75	PF00533	0.428
LIG_EH1_1	78	86	PF00400	0.496
LIG_FHA_1	121	127	PF00498	0.761
LIG_FHA_1	99	105	PF00498	0.345
LIG_FHA_2	12	18	PF00498	0.695
LIG_LIR_Gen_1	107	118	PF02991	0.629
LIG_LIR_Gen_1	127	136	PF02991	0.505
LIG_LIR_Gen_1	92	103	PF02991	0.316
LIG_LIR_Nem_3	107	113	PF02991	0.428
LIG_LIR_Nem_3	127	132	PF02991	0.512
LIG_LIR_Nem_3	92	98	PF02991	0.297
LIG_NRBOX	151	157	PF00104	0.421
LIG_PCNA_yPIPBox_3	166	179	PF02747	0.533
LIG_Pex14_2	106	110	PF04695	0.428
LIG_Pex14_2	75	79	PF04695	0.428
LIG_SH2_PTP2	129	132	PF00017	0.744
LIG_SH2_SRC	129	132	PF00017	0.744
LIG_SH2_SRC	61	64	PF00017	0.736
LIG_SH2_STAT5	129	132	PF00017	0.744
LIG_SH2_STAT5	154	157	PF00017	0.325
LIG_SH2_STAT5	61	64	PF00017	0.687
LIG_SH2_STAT5	97	100	PF00017	0.339
LIG_SH3_3	116	122	PF00018	0.667
LIG_SH3_3	68	74	PF00018	0.425
LIG_SUMO_SIM_anti_2	80	87	PF11976	0.529
LIG_SUMO_SIM_par_1	80	87	PF11976	0.529
LIG_SxIP_EBH_1	53	65	PF03271	0.693
MOD_CDK_SPK_2	48	53	PF00069	0.653
MOD_CK1_1	108	114	PF00069	0.691
MOD_GlcNHglycan	107	110	PF01048	0.375
MOD_GlcNHglycan	32	36	PF01048	0.567
MOD_GlcNHglycan	98	101	PF01048	0.375
MOD_GSK3_1	104	111	PF00069	0.375
MOD_NEK2_1	104	109	PF00069	0.375
MOD_NEK2_1	77	82	PF00069	0.415
MOD_NEK2_1	96	101	PF00069	0.375
MOD_NMyristoyl	1	7	PF02799	0.759
MOD_PIKK_1	162	168	PF00454	0.537
MOD_PIKK_1	54	60	PF00454	0.749
MOD_PKA_2	178	184	PF00069	0.479
MOD_Plk_1	69	75	PF00069	0.342
MOD_Plk_4	80	86	PF00069	0.511
MOD_Plk_4	91	97	PF00069	0.394
MOD_ProDKin_1	48	54	PF00069	0.652
MOD_ProDKin_1	98	104	PF00069	0.375
MOD_SUMO_for_1	37	40	PF00179	0.734
TRG_DiLeu_BaEn_2	130	136	PF01217	0.731
TRG_ENDOCYTIC_2	129	132	PF00928	0.744
TRG_ENDOCYTIC_2	141	144	PF00928	0.710
TRG_ER_diArg_1	24	27	PF00400	0.681

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0P2B5	Trypanosomatidae	69%	68%
A0A3Q8IEJ7	Leishmania donovani	98%	100%
A4HHV2	Leishmania braziliensis	94%	100%
A4I502	Leishmania infantum	98%	100%
C9ZQF1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	59%	66%
Q4Q7U9	Leishmania major	97%	100%