MATH domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

MATH domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9B0D0_LEIMU

TriTrypDb:

LmxM.29.0050

Length:

762

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B0D0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B0D0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	115	119	PF00656	0.679
CLV_C14_Caspase3-7	126	130	PF00656	0.645
CLV_C14_Caspase3-7	676	680	PF00656	0.403
CLV_NRD_NRD_1	134	136	PF00675	0.497
CLV_NRD_NRD_1	141	143	PF00675	0.478
CLV_NRD_NRD_1	144	146	PF00675	0.477
CLV_NRD_NRD_1	154	156	PF00675	0.332
CLV_NRD_NRD_1	187	189	PF00675	0.498
CLV_NRD_NRD_1	40	42	PF00675	0.483
CLV_NRD_NRD_1	583	585	PF00675	0.470
CLV_NRD_NRD_1	601	603	PF00675	0.347
CLV_NRD_NRD_1	635	637	PF00675	0.458
CLV_PCSK_FUR_1	142	146	PF00082	0.503
CLV_PCSK_KEX2_1	136	138	PF00082	0.494
CLV_PCSK_KEX2_1	141	143	PF00082	0.475
CLV_PCSK_KEX2_1	144	146	PF00082	0.469
CLV_PCSK_KEX2_1	625	627	PF00082	0.487
CLV_PCSK_PC1ET2_1	136	138	PF00082	0.494
CLV_PCSK_PC1ET2_1	141	143	PF00082	0.475
CLV_PCSK_PC1ET2_1	625	627	PF00082	0.571
CLV_PCSK_PC7_1	137	143	PF00082	0.614
CLV_PCSK_PC7_1	621	627	PF00082	0.564
CLV_PCSK_SKI1_1	155	159	PF00082	0.482
CLV_PCSK_SKI1_1	188	192	PF00082	0.541
CLV_PCSK_SKI1_1	356	360	PF00082	0.355
CLV_PCSK_SKI1_1	402	406	PF00082	0.521
CLV_PCSK_SKI1_1	585	589	PF00082	0.451
CLV_PCSK_SKI1_1	65	69	PF00082	0.404
CLV_PCSK_SKI1_1	685	689	PF00082	0.517
CLV_PCSK_SKI1_1	699	703	PF00082	0.430
CLV_PCSK_SKI1_1	92	96	PF00082	0.689
CLV_Separin_Metazoa	35	39	PF03568	0.491
DEG_APCC_KENBOX_2	667	671	PF00400	0.501
DEG_SCF_FBW7_1	196	203	PF00400	0.733
DEG_SCF_FBW7_1	734	740	PF00400	0.662
DEG_SPOP_SBC_1	200	204	PF00917	0.608
DOC_CKS1_1	197	202	PF01111	0.733
DOC_CKS1_1	545	550	PF01111	0.600
DOC_CKS1_1	734	739	PF01111	0.661
DOC_CYCLIN_yClb5_NLxxxL_5	444	453	PF00134	0.390
DOC_MAPK_gen_1	359	367	PF00069	0.360
DOC_MAPK_gen_1	398	406	PF00069	0.437
DOC_MAPK_MEF2A_6	360	369	PF00069	0.370
DOC_MAPK_MEF2A_6	459	466	PF00069	0.285
DOC_MAPK_NFAT4_5	459	467	PF00069	0.271
DOC_MIT_MIM_1	658	668	PF04212	0.565
DOC_PP1_RVXF_1	400	407	PF00149	0.429
DOC_PP2B_LxvP_1	325	328	PF13499	0.548
DOC_PP4_FxxP_1	171	174	PF00568	0.448
DOC_PP4_FxxP_1	234	237	PF00568	0.379
DOC_PP4_FxxP_1	406	409	PF00568	0.381
DOC_USP7_MATH_1	486	490	PF00917	0.384
DOC_USP7_MATH_1	721	725	PF00917	0.621
DOC_USP7_MATH_1	737	741	PF00917	0.508
DOC_USP7_MATH_1	75	79	PF00917	0.593
DOC_USP7_UBL2_3	124	128	PF12436	0.555
DOC_USP7_UBL2_3	356	360	PF12436	0.398
DOC_USP7_UBL2_3	625	629	PF12436	0.577
DOC_USP7_UBL2_3	685	689	PF12436	0.428
DOC_WW_Pin1_4	196	201	PF00397	0.615
DOC_WW_Pin1_4	438	443	PF00397	0.290
DOC_WW_Pin1_4	544	549	PF00397	0.580
DOC_WW_Pin1_4	733	738	PF00397	0.663
LIG_14-3-3_CanoR_1	175	179	PF00244	0.502
LIG_14-3-3_CanoR_1	220	228	PF00244	0.630
LIG_14-3-3_CanoR_1	255	264	PF00244	0.553
LIG_14-3-3_CanoR_1	3	8	PF00244	0.500
LIG_14-3-3_CanoR_1	662	667	PF00244	0.559
LIG_14-3-3_CanoR_1	704	712	PF00244	0.471
LIG_14-3-3_CanoR_1	86	94	PF00244	0.724
LIG_Actin_WH2_2	228	246	PF00022	0.428
LIG_Actin_WH2_2	303	320	PF00022	0.425
LIG_Actin_WH2_2	343	361	PF00022	0.339
LIG_BRCT_BRCA1_1	305	309	PF00533	0.408
LIG_BRCT_BRCA1_1	440	444	PF00533	0.271
LIG_deltaCOP1_diTrp_1	504	509	PF00928	0.271
LIG_FHA_1	230	236	PF00498	0.519
LIG_FHA_1	291	297	PF00498	0.507
LIG_FHA_1	421	427	PF00498	0.376
LIG_FHA_1	467	473	PF00498	0.271
LIG_FHA_1	532	538	PF00498	0.271
LIG_FHA_1	654	660	PF00498	0.502
LIG_FHA_1	66	72	PF00498	0.422
LIG_FHA_1	750	756	PF00498	0.641
LIG_FHA_2	124	130	PF00498	0.662
LIG_FHA_2	193	199	PF00498	0.713
LIG_FHA_2	257	263	PF00498	0.472
LIG_FHA_2	310	316	PF00498	0.530
LIG_FHA_2	455	461	PF00498	0.404
LIG_FHA_2	525	531	PF00498	0.404
LIG_FHA_2	547	553	PF00498	0.616
LIG_FHA_2	592	598	PF00498	0.504
LIG_FHA_2	599	605	PF00498	0.505
LIG_FHA_2	625	631	PF00498	0.578
LIG_FHA_2	64	70	PF00498	0.505
LIG_FHA_2	85	91	PF00498	0.587
LIG_FHA_2	93	99	PF00498	0.554
LIG_GBD_Chelix_1	361	369	PF00786	0.471
LIG_GBD_Chelix_1	694	702	PF00786	0.480
LIG_LIR_Apic_2	232	237	PF02991	0.389
LIG_LIR_Gen_1	17	28	PF02991	0.498
LIG_LIR_Gen_1	335	346	PF02991	0.338
LIG_LIR_Gen_1	375	386	PF02991	0.410
LIG_LIR_Gen_1	418	429	PF02991	0.368
LIG_LIR_Gen_1	443	454	PF02991	0.413
LIG_LIR_Gen_1	495	504	PF02991	0.358
LIG_LIR_Gen_1	506	516	PF02991	0.189
LIG_LIR_Gen_1	610	620	PF02991	0.491
LIG_LIR_Gen_1	724	734	PF02991	0.586
LIG_LIR_Gen_1	752	762	PF02991	0.576
LIG_LIR_Nem_3	17	23	PF02991	0.440
LIG_LIR_Nem_3	375	381	PF02991	0.395
LIG_LIR_Nem_3	418	424	PF02991	0.361
LIG_LIR_Nem_3	443	449	PF02991	0.289
LIG_LIR_Nem_3	506	512	PF02991	0.271
LIG_LIR_Nem_3	610	616	PF02991	0.493
LIG_LIR_Nem_3	62	67	PF02991	0.417
LIG_LIR_Nem_3	724	729	PF02991	0.554
LIG_LIR_Nem_3	752	757	PF02991	0.667
LIG_SH2_CRK	165	169	PF00017	0.478
LIG_SH2_CRK	20	24	PF00017	0.476
LIG_SH2_CRK	64	68	PF00017	0.438
LIG_SH2_STAP1	726	730	PF00017	0.665
LIG_SH2_STAT3	465	468	PF00017	0.286
LIG_SH2_STAT5	465	468	PF00017	0.313
LIG_SH2_STAT5	56	59	PF00017	0.554
LIG_SH3_2	170	175	PF14604	0.575
LIG_SH3_3	167	173	PF00018	0.536
LIG_SH3_3	175	181	PF00018	0.569
LIG_SH3_3	731	737	PF00018	0.618
LIG_SH3_4	356	363	PF00018	0.393
LIG_SH3_CIN85_PxpxPR_1	170	175	PF14604	0.442
LIG_SUMO_SIM_anti_2	364	369	PF11976	0.449
LIG_SUMO_SIM_par_1	236	242	PF11976	0.517
LIG_SUMO_SIM_par_1	538	543	PF11976	0.344
LIG_TYR_ITSM	16	23	PF00017	0.450
LIG_UBA3_1	36	42	PF00899	0.519
LIG_UBA3_1	453	459	PF00899	0.271
LIG_UBA3_1	571	579	PF00899	0.593
LIG_WRC_WIRS_1	421	426	PF05994	0.315
LIG_WW_3	172	176	PF00397	0.573
MOD_CDK_SPxxK_3	544	551	PF00069	0.570
MOD_CK1_1	201	207	PF00069	0.695
MOD_CK1_1	218	224	PF00069	0.565
MOD_CK1_1	239	245	PF00069	0.402
MOD_CK1_1	320	326	PF00069	0.606
MOD_CK1_1	348	354	PF00069	0.481
MOD_CK1_1	430	436	PF00069	0.404
MOD_CK1_1	499	505	PF00069	0.270
MOD_CK1_1	5	11	PF00069	0.522
MOD_CK2_1	192	198	PF00069	0.602
MOD_CK2_1	256	262	PF00069	0.471
MOD_CK2_1	3	9	PF00069	0.539
MOD_CK2_1	454	460	PF00069	0.404
MOD_CK2_1	546	552	PF00069	0.603
MOD_CK2_1	591	597	PF00069	0.560
MOD_CK2_1	624	630	PF00069	0.574
MOD_CK2_1	721	727	PF00069	0.610
MOD_CK2_1	737	743	PF00069	0.539
MOD_GlcNHglycan	248	251	PF01048	0.424
MOD_GlcNHglycan	498	501	PF01048	0.404
MOD_GlcNHglycan	72	75	PF01048	0.457
MOD_GlcNHglycan	77	80	PF01048	0.537
MOD_GSK3_1	118	125	PF00069	0.621
MOD_GSK3_1	192	199	PF00069	0.664
MOD_GSK3_1	200	207	PF00069	0.618
MOD_GSK3_1	215	222	PF00069	0.470
MOD_GSK3_1	291	298	PF00069	0.625
MOD_GSK3_1	454	461	PF00069	0.424
MOD_GSK3_1	492	499	PF00069	0.298
MOD_GSK3_1	63	70	PF00069	0.497
MOD_GSK3_1	658	665	PF00069	0.531
MOD_GSK3_1	721	728	PF00069	0.584
MOD_GSK3_1	733	740	PF00069	0.556
MOD_GSK3_1	745	752	PF00069	0.547
MOD_N-GLC_1	372	377	PF02516	0.418
MOD_N-GLC_1	427	432	PF02516	0.271
MOD_N-GLC_1	84	89	PF02516	0.700
MOD_NEK2_1	14	19	PF00069	0.501
MOD_NEK2_1	216	221	PF00069	0.664
MOD_NEK2_1	309	314	PF00069	0.390
MOD_NEK2_1	317	322	PF00069	0.371
MOD_NEK2_1	36	41	PF00069	0.482
MOD_NEK2_1	449	454	PF00069	0.315
MOD_NEK2_1	466	471	PF00069	0.271
MOD_NEK2_1	476	481	PF00069	0.303
MOD_NEK2_1	63	68	PF00069	0.482
MOD_NEK2_1	673	678	PF00069	0.497
MOD_NEK2_2	15	20	PF00069	0.433
MOD_NEK2_2	174	179	PF00069	0.480
MOD_NEK2_2	420	425	PF00069	0.449
MOD_PIKK_1	262	268	PF00454	0.384
MOD_PIKK_1	492	498	PF00454	0.271
MOD_PIKK_1	499	505	PF00454	0.271
MOD_PIKK_1	624	630	PF00454	0.574
MOD_PIKK_1	678	684	PF00454	0.474
MOD_PIKK_1	705	711	PF00454	0.567
MOD_PK_1	725	731	PF00069	0.640
MOD_PKA_1	155	161	PF00069	0.501
MOD_PKA_1	688	694	PF00069	0.469
MOD_PKA_2	174	180	PF00069	0.505
MOD_PKA_2	2	8	PF00069	0.508
MOD_PKA_2	219	225	PF00069	0.678
MOD_PKA_2	254	260	PF00069	0.571
MOD_PKA_2	607	613	PF00069	0.504
MOD_PKA_2	85	91	PF00069	0.698
MOD_PKB_1	135	143	PF00069	0.619
MOD_PKB_1	619	627	PF00069	0.563
MOD_Plk_1	363	369	PF00069	0.520
MOD_Plk_1	427	433	PF00069	0.271
MOD_Plk_1	486	492	PF00069	0.271
MOD_Plk_1	529	535	PF00069	0.349
MOD_Plk_1	749	755	PF00069	0.645
MOD_Plk_2-3	531	537	PF00069	0.271
MOD_Plk_2-3	745	751	PF00069	0.676
MOD_Plk_4	15	21	PF00069	0.437
MOD_Plk_4	320	326	PF00069	0.461
MOD_Plk_4	345	351	PF00069	0.456
MOD_Plk_4	363	369	PF00069	0.488
MOD_Plk_4	67	73	PF00069	0.429
MOD_Plk_4	725	731	PF00069	0.640
MOD_ProDKin_1	196	202	PF00069	0.616
MOD_ProDKin_1	438	444	PF00069	0.290
MOD_ProDKin_1	544	550	PF00069	0.588
MOD_ProDKin_1	733	739	PF00069	0.662
MOD_SUMO_for_1	587	590	PF00179	0.479
MOD_SUMO_for_1	666	669	PF00179	0.439
MOD_SUMO_rev_2	116	126	PF00179	0.703
MOD_SUMO_rev_2	148	158	PF00179	0.528
MOD_SUMO_rev_2	25	32	PF00179	0.628
MOD_SUMO_rev_2	323	333	PF00179	0.490
MOD_SUMO_rev_2	592	601	PF00179	0.573
MOD_SUMO_rev_2	618	627	PF00179	0.560
MOD_SUMO_rev_2	654	661	PF00179	0.511
MOD_SUMO_rev_2	691	701	PF00179	0.473
TRG_DiLeu_BaEn_1	147	152	PF01217	0.470
TRG_DiLeu_BaEn_1	669	674	PF01217	0.406
TRG_ENDOCYTIC_2	165	168	PF00928	0.550
TRG_ENDOCYTIC_2	20	23	PF00928	0.438
TRG_ENDOCYTIC_2	613	616	PF00928	0.489
TRG_ENDOCYTIC_2	64	67	PF00928	0.435
TRG_ENDOCYTIC_2	726	729	PF00928	0.564
TRG_ER_diArg_1	142	145	PF00400	0.570
TRG_NES_CRM1_1	315	330	PF08389	0.405
TRG_NES_CRM1_1	531	543	PF08389	0.314
TRG_NLS_MonoCore_2	140	145	PF00514	0.558
TRG_NLS_MonoExtC_3	140	145	PF00514	0.558
TRG_NLS_MonoExtC_3	583	588	PF00514	0.433
TRG_NLS_MonoExtN_4	400	406	PF00514	0.442
TRG_NLS_MonoExtN_4	584	589	PF00514	0.433
TRG_Pf-PMV_PEXEL_1	194	198	PF00026	0.734
TRG_Pf-PMV_PEXEL_1	38	43	PF00026	0.458

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PG40	Leptomonas seymouri	89%	100%
A0A1X0P2N7	Trypanosomatidae	59%	100%
A0A3Q8IJ33	Leishmania donovani	100%	100%
A0A3R7ME83	Trypanosoma rangeli	56%	98%
A4HHV0	Leishmania braziliensis	95%	100%
A4I500	Leishmania infantum	99%	100%
C9ZQE9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	99%
Q4Q7V4	Leishmania major	99%	100%
V5BLE1	Trypanosoma cruzi	57%	99%