DUF2231 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Uncharacterised protein family (UPF0220), putative

Species:

Leishmania mexicana

UniProt:

E9B0C9_LEIMU

TriTrypDb:

LmxM.29.0040

Length:

141

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

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Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

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Expansion

Sequence features

E9B0C9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B0C9

Function

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Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0007034	vacuolar transport	4	1
GO:0009987	cellular process	1	1
GO:0016192	vesicle-mediated transport	4	1
GO:0016197	endosomal transport	4	1
GO:0032509	endosome transport via multivesicular body sorting pathway	5	1
GO:0032511	late endosome to vacuole transport via multivesicular body sorting pathway	6	1
GO:0045324	late endosome to vacuole transport	5	1
GO:0046907	intracellular transport	3	1
GO:0051179	localization	1	1

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Could not find GO molecular_function term for this entry.

Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	133	135	PF00675	0.548
CLV_PCSK_KEX2_1	133	135	PF00082	0.545
CLV_PCSK_SKI1_1	75	79	PF00082	0.490
DEG_Nend_UBRbox_3	1	3	PF02207	0.426
DOC_CYCLIN_RxL_1	72	81	PF00134	0.361
DOC_MAPK_gen_1	106	115	PF00069	0.508
DOC_MAPK_MEF2A_6	106	115	PF00069	0.490
DOC_MAPK_MEF2A_6	73	80	PF00069	0.361
DOC_MAPK_NFAT4_5	73	81	PF00069	0.183
DOC_PP1_RVXF_1	73	80	PF00149	0.308

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IM91	Leptomonas seymouri	65%	98%
A0A0S4IVS2	Bodo saltans	27%	91%
A0A1X0P3F9	Trypanosomatidae	43%	100%
A0A3Q8IDZ8	Leishmania donovani	90%	100%
A0A422N652	Trypanosoma rangeli	42%	100%
A4HHU9	Leishmania braziliensis	76%	100%
A4I4Z9	Leishmania infantum	91%	100%
Q4Q7V5	Leishmania major	88%	100%

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