LeishMANIAdb
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AB hydrolase-1 domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
AB hydrolase-1 domain-containing protein
Gene product:
Alpha/beta hydrolase family, putative
Species:
Leishmania mexicana
UniProt:
E9B0C6_LEIMU
TriTrypDb:
LmxM.29.0010
Length:
425

Annotations

LeishMANIAdb annotations

Posesses a conserved AB hydrolase domain. Due to the distribution of hydrophilic / hydrophobic amino acids, it likely only has a perimembrane helix, not a full TM one.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 25
NetGPI no yes: 0, no: 25
Cellular components
Term Name Level Count
GO:0016020 membrane 2 5
GO:0110165 cellular anatomical entity 1 5

Expansion

Sequence features

E9B0C6
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B0C6

Function

Biological processes
Term Name Level Count
GO:0006629 lipid metabolic process 3 3
GO:0008152 metabolic process 1 3
GO:0009987 cellular process 1 3
GO:0044237 cellular metabolic process 2 3
GO:0044238 primary metabolic process 2 3
GO:0044255 cellular lipid metabolic process 3 3
GO:0071704 organic substance metabolic process 2 3
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 5
GO:0016298 lipase activity 4 3
GO:0016787 hydrolase activity 2 5
GO:0016788 hydrolase activity, acting on ester bonds 3 3
GO:0034338 short-chain carboxylesterase activity 5 3
GO:0047372 acylglycerol lipase activity 5 3
GO:0052689 carboxylic ester hydrolase activity 4 3

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 251 255 PF00656 0.321
CLV_NRD_NRD_1 281 283 PF00675 0.472
CLV_PCSK_KEX2_1 204 206 PF00082 0.534
CLV_PCSK_KEX2_1 281 283 PF00082 0.489
CLV_PCSK_PC1ET2_1 204 206 PF00082 0.498
CLV_PCSK_SKI1_1 126 130 PF00082 0.509
CLV_PCSK_SKI1_1 189 193 PF00082 0.413
CLV_PCSK_SKI1_1 282 286 PF00082 0.496
CLV_PCSK_SKI1_1 298 302 PF00082 0.435
CLV_PCSK_SKI1_1 321 325 PF00082 0.473
CLV_PCSK_SKI1_1 66 70 PF00082 0.484
DEG_SCF_FBW7_1 169 176 PF00400 0.267
DOC_CDC14_PxL_1 132 140 PF14671 0.272
DOC_CDC14_PxL_1 15 23 PF14671 0.429
DOC_CDC14_PxL_1 287 295 PF14671 0.332
DOC_CDC14_PxL_1 322 330 PF14671 0.332
DOC_CKS1_1 174 179 PF01111 0.291
DOC_CKS1_1 330 335 PF01111 0.302
DOC_MAPK_DCC_7 205 215 PF00069 0.337
DOC_MAPK_DCC_7 96 106 PF00069 0.178
DOC_MAPK_gen_1 126 135 PF00069 0.312
DOC_MAPK_gen_1 204 212 PF00069 0.223
DOC_MAPK_gen_1 23 31 PF00069 0.535
DOC_MAPK_gen_1 96 106 PF00069 0.178
DOC_MAPK_MEF2A_6 126 135 PF00069 0.311
DOC_MAPK_MEF2A_6 23 31 PF00069 0.541
DOC_MAPK_MEF2A_6 321 330 PF00069 0.332
DOC_MAPK_MEF2A_6 99 106 PF00069 0.331
DOC_PP1_RVXF_1 21 27 PF00149 0.494
DOC_PP2B_LxvP_1 133 136 PF13499 0.255
DOC_PP2B_LxvP_1 385 388 PF13499 0.248
DOC_PP2B_PxIxI_1 210 216 PF00149 0.353
DOC_PP4_FxxP_1 330 333 PF00568 0.267
DOC_PP4_FxxP_1 349 352 PF00568 0.124
DOC_USP7_MATH_1 257 261 PF00917 0.199
DOC_USP7_MATH_1 300 304 PF00917 0.302
DOC_USP7_MATH_1 59 63 PF00917 0.200
DOC_WW_Pin1_4 169 174 PF00397 0.242
DOC_WW_Pin1_4 245 250 PF00397 0.251
DOC_WW_Pin1_4 291 296 PF00397 0.233
DOC_WW_Pin1_4 329 334 PF00397 0.283
DOC_WW_Pin1_4 338 343 PF00397 0.284
DOC_WW_Pin1_4 419 424 PF00397 0.270
LIG_14-3-3_CanoR_1 321 326 PF00244 0.324
LIG_14-3-3_CanoR_1 42 47 PF00244 0.310
LIG_Actin_WH2_2 27 44 PF00022 0.250
LIG_deltaCOP1_diTrp_1 344 349 PF00928 0.191
LIG_FHA_1 142 148 PF00498 0.274
LIG_FHA_1 174 180 PF00498 0.291
LIG_FHA_1 183 189 PF00498 0.213
LIG_FHA_1 271 277 PF00498 0.145
LIG_FHA_1 404 410 PF00498 0.324
LIG_FHA_1 83 89 PF00498 0.313
LIG_FHA_2 170 176 PF00498 0.306
LIG_FHA_2 313 319 PF00498 0.252
LIG_FHA_2 330 336 PF00498 0.195
LIG_FHA_2 406 412 PF00498 0.353
LIG_IRF3_LxIS_1 351 357 PF10401 0.196
LIG_LIR_Apic_2 327 333 PF02991 0.294
LIG_LIR_Gen_1 148 155 PF02991 0.340
LIG_LIR_Gen_1 318 326 PF02991 0.281
LIG_LIR_Gen_1 334 343 PF02991 0.165
LIG_LIR_Nem_3 148 153 PF02991 0.314
LIG_LIR_Nem_3 318 322 PF02991 0.280
LIG_LIR_Nem_3 334 340 PF02991 0.169
LIG_LIR_Nem_3 67 71 PF02991 0.232
LIG_MYND_1 291 295 PF01753 0.218
LIG_NRBOX 117 123 PF00104 0.193
LIG_Pex14_1 345 349 PF04695 0.332
LIG_Pex14_2 155 159 PF04695 0.196
LIG_PTB_Apo_2 111 118 PF02174 0.357
LIG_PTB_Phospho_1 111 117 PF10480 0.233
LIG_REV1ctd_RIR_1 44 53 PF16727 0.425
LIG_SH2_NCK_1 415 419 PF00017 0.253
LIG_SH2_NCK_1 79 83 PF00017 0.296
LIG_SH2_SRC 146 149 PF00017 0.332
LIG_SH2_SRC 268 271 PF00017 0.322
LIG_SH2_SRC 79 82 PF00017 0.372
LIG_SH2_STAP1 415 419 PF00017 0.394
LIG_SH2_STAT5 103 106 PF00017 0.215
LIG_SH2_STAT5 117 120 PF00017 0.314
LIG_SH2_STAT5 146 149 PF00017 0.243
LIG_SH2_STAT5 227 230 PF00017 0.266
LIG_SH2_STAT5 395 398 PF00017 0.297
LIG_SH2_STAT5 84 87 PF00017 0.184
LIG_SH3_3 103 109 PF00018 0.327
LIG_SH3_3 243 249 PF00018 0.289
LIG_SH3_3 33 39 PF00018 0.274
LIG_SUMO_SIM_anti_2 241 248 PF11976 0.196
LIG_SUMO_SIM_par_1 33 38 PF11976 0.384
LIG_TYR_ITIM 101 106 PF00017 0.367
LIG_UBA3_1 70 76 PF00899 0.272
LIG_WRC_WIRS_1 43 48 PF05994 0.238
MOD_CDK_SPK_2 173 178 PF00069 0.291
MOD_CDK_SPK_2 419 424 PF00069 0.270
MOD_CDK_SPxxK_3 291 298 PF00069 0.224
MOD_CK1_1 45 51 PF00069 0.290
MOD_CK2_1 169 175 PF00069 0.311
MOD_CK2_1 338 344 PF00069 0.260
MOD_CK2_1 405 411 PF00069 0.325
MOD_CMANNOS 400 403 PF00535 0.513
MOD_GlcNHglycan 109 112 PF01048 0.565
MOD_GlcNHglycan 141 144 PF01048 0.467
MOD_GlcNHglycan 180 183 PF01048 0.463
MOD_GlcNHglycan 302 305 PF01048 0.491
MOD_GlcNHglycan 356 359 PF01048 0.492
MOD_GlcNHglycan 363 366 PF01048 0.493
MOD_GSK3_1 137 144 PF00069 0.212
MOD_GSK3_1 169 176 PF00069 0.256
MOD_GSK3_1 178 185 PF00069 0.244
MOD_GSK3_1 253 260 PF00069 0.239
MOD_GSK3_1 270 277 PF00069 0.285
MOD_GSK3_1 41 48 PF00069 0.539
MOD_NEK2_1 122 127 PF00069 0.365
MOD_NEK2_1 153 158 PF00069 0.320
MOD_NEK2_1 253 258 PF00069 0.258
MOD_NEK2_1 354 359 PF00069 0.280
MOD_NEK2_1 372 377 PF00069 0.171
MOD_NEK2_1 41 46 PF00069 0.468
MOD_NEK2_2 59 64 PF00069 0.181
MOD_PIKK_1 257 263 PF00454 0.190
MOD_PKA_2 41 47 PF00069 0.583
MOD_Plk_1 253 259 PF00069 0.179
MOD_Plk_4 405 411 PF00069 0.268
MOD_Plk_4 42 48 PF00069 0.305
MOD_Plk_4 64 70 PF00069 0.320
MOD_Plk_4 87 93 PF00069 0.265
MOD_ProDKin_1 169 175 PF00069 0.242
MOD_ProDKin_1 245 251 PF00069 0.251
MOD_ProDKin_1 291 297 PF00069 0.233
MOD_ProDKin_1 329 335 PF00069 0.283
MOD_ProDKin_1 338 344 PF00069 0.284
MOD_ProDKin_1 419 425 PF00069 0.285
TRG_DiLeu_BaEn_1 175 180 PF01217 0.332
TRG_DiLeu_BaLyEn_6 10 15 PF01217 0.523
TRG_ENDOCYTIC_2 103 106 PF00928 0.319
TRG_ENDOCYTIC_2 337 340 PF00928 0.237
TRG_Pf-PMV_PEXEL_1 236 241 PF00026 0.478

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P5L7 Leptomonas seymouri 32% 93%
A0A0N1HZ60 Leptomonas seymouri 33% 92%
A0A0N1I523 Leptomonas seymouri 29% 96%
A0A0N1I5Q2 Leptomonas seymouri 31% 84%
A0A0N1I7U8 Leptomonas seymouri 66% 100%
A0A0S4JMS7 Bodo saltans 37% 98%
A0A0S4JTS9 Bodo saltans 37% 99%
A0A1X0NEW5 Trypanosomatidae 43% 100%
A0A1X0NSK7 Trypanosomatidae 43% 100%
A0A1X0NUZ6 Trypanosomatidae 26% 100%
A0A3S5H6J1 Leishmania donovani 31% 90%
A0A3S7X2V6 Leishmania donovani 91% 100%
A0A422NB49 Trypanosoma rangeli 45% 100%
A0A422NQC5 Trypanosoma rangeli 36% 97%
A4H6L0 Leishmania braziliensis 33% 100%
A4HHU6 Leishmania braziliensis 77% 100%
A4HUZ4 Leishmania infantum 31% 90%
A4I4Z6 Leishmania infantum 91% 100%
C9ZPB9 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 39% 100%
E9ANM8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 34% 100%
E9ANM9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 33% 100%
P73879 Synechocystis sp. (strain PCC 6803 / Kazusa) 25% 100%
Q05AK6 Danio rerio 26% 100%
Q0VC00 Bos taurus 25% 100%
Q18610 Caenorhabditis elegans 26% 100%
Q24093 Drosophila melanogaster 24% 100%
Q3T0A0 Bos taurus 27% 100%
Q40863 Picea glauca 30% 93%
Q4Q7V8 Leishmania major 88% 100%
Q4QGZ4 Leishmania major 32% 100%
Q4QGZ5 Leishmania major 31% 100%
Q54H38 Dictyostelium discoideum 29% 100%
Q5F2F2 Mus musculus 26% 93%
Q5RK23 Rattus norvegicus 26% 100%
Q6UXT9 Homo sapiens 25% 91%
Q802V6 Danio rerio 23% 98%
Q8WU67 Homo sapiens 25% 100%
Q91ZH7 Mus musculus 26% 100%
Q96SE0 Homo sapiens 26% 100%
Q9QZC8 Mus musculus 26% 100%
V5AZF4 Trypanosoma cruzi 41% 100%
V5BBC2 Trypanosoma cruzi 36% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS