Nsp1_C domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Nucleoporin NUP140

Species:

Leishmania mexicana

UniProt:

E9B0C4_LEIMU

TriTrypDb:

LmxM.28.3010

Length:

879

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 3
NetGPI	no	yes: 0, no: 3

Cellular components
Term	Name	Level	Count
GO:0005643	nuclear pore	3	1
GO:0032991	protein-containing complex	1	1
GO:0140513	nuclear protein-containing complex	2	1

Expansion

Sequence features

E9B0C4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B0C4

Function

Biological processes
Term	Name	Level	Count
GO:0006405	RNA export from nucleus	5	1
GO:0006406	mRNA export from nucleus	6	1
GO:0006810	transport	3	1
GO:0006913	nucleocytoplasmic transport	5	1
GO:0009987	cellular process	1	1
GO:0015931	nucleobase-containing compound transport	5	1
GO:0046907	intracellular transport	3	1
GO:0050657	nucleic acid transport	6	1
GO:0050658	RNA transport	4	1
GO:0051028	mRNA transport	5	1
GO:0051168	nuclear export	6	1
GO:0051169	nuclear transport	4	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051236	establishment of RNA localization	3	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	5	9	PF00656	0.656
CLV_C14_Caspase3-7	85	89	PF00656	0.643
CLV_NRD_NRD_1	106	108	PF00675	0.605
CLV_NRD_NRD_1	159	161	PF00675	0.614
CLV_NRD_NRD_1	29	31	PF00675	0.608
CLV_NRD_NRD_1	34	36	PF00675	0.528
CLV_NRD_NRD_1	43	45	PF00675	0.422
CLV_PCSK_KEX2_1	100	102	PF00082	0.730
CLV_PCSK_KEX2_1	106	108	PF00082	0.712
CLV_PCSK_KEX2_1	159	161	PF00082	0.610
CLV_PCSK_KEX2_1	29	31	PF00082	0.529
CLV_PCSK_PC1ET2_1	100	102	PF00082	0.695
CLV_PCSK_SKI1_1	160	164	PF00082	0.689
CLV_PCSK_SKI1_1	218	222	PF00082	0.582
CLV_PCSK_SKI1_1	280	284	PF00082	0.564
CLV_PCSK_SKI1_1	342	346	PF00082	0.581
CLV_PCSK_SKI1_1	438	442	PF00082	0.585
CLV_PCSK_SKI1_1	500	504	PF00082	0.588
CLV_PCSK_SKI1_1	562	566	PF00082	0.584
CLV_PCSK_SKI1_1	624	628	PF00082	0.581
CLV_PCSK_SKI1_1	686	690	PF00082	0.581
CLV_PCSK_SKI1_1	853	857	PF00082	0.757
DEG_SPOP_SBC_1	111	115	PF00917	0.771
DEG_SPOP_SBC_1	788	792	PF00917	0.550
DOC_PP4_FxxP_1	154	157	PF00568	0.590
DOC_PP4_MxPP_1	1	4	PF00568	0.553
DOC_USP7_MATH_1	105	109	PF00917	0.698
DOC_USP7_MATH_1	110	114	PF00917	0.613
DOC_USP7_MATH_1	147	151	PF00917	0.759
DOC_USP7_MATH_1	200	204	PF00917	0.576
DOC_USP7_MATH_1	214	218	PF00917	0.602
DOC_USP7_MATH_1	262	266	PF00917	0.580
DOC_USP7_MATH_1	276	280	PF00917	0.516
DOC_USP7_MATH_1	324	328	PF00917	0.536
DOC_USP7_MATH_1	338	342	PF00917	0.599
DOC_USP7_MATH_1	386	390	PF00917	0.787
DOC_USP7_MATH_1	420	424	PF00917	0.784
DOC_USP7_MATH_1	434	438	PF00917	0.586
DOC_USP7_MATH_1	48	52	PF00917	0.620
DOC_USP7_MATH_1	482	486	PF00917	0.745
DOC_USP7_MATH_1	496	500	PF00917	0.577
DOC_USP7_MATH_1	544	548	PF00917	0.746
DOC_USP7_MATH_1	558	562	PF00917	0.574
DOC_USP7_MATH_1	606	610	PF00917	0.754
DOC_USP7_MATH_1	620	624	PF00917	0.575
DOC_USP7_MATH_1	668	672	PF00917	0.741
DOC_USP7_MATH_1	682	686	PF00917	0.573
DOC_USP7_MATH_1	730	734	PF00917	0.727
DOC_USP7_MATH_1	76	80	PF00917	0.700
DOC_USP7_MATH_1	764	768	PF00917	0.778
DOC_USP7_MATH_1	789	793	PF00917	0.553
DOC_USP7_MATH_1	815	819	PF00917	0.558
DOC_USP7_MATH_1	834	838	PF00917	0.663
DOC_USP7_MATH_1	94	98	PF00917	0.393
DOC_WW_Pin1_4	121	126	PF00397	0.784
DOC_WW_Pin1_4	205	210	PF00397	0.595
DOC_WW_Pin1_4	267	272	PF00397	0.600
DOC_WW_Pin1_4	329	334	PF00397	0.602
DOC_WW_Pin1_4	391	396	PF00397	0.728
DOC_WW_Pin1_4	425	430	PF00397	0.594
DOC_WW_Pin1_4	487	492	PF00397	0.685
DOC_WW_Pin1_4	549	554	PF00397	0.608
DOC_WW_Pin1_4	611	616	PF00397	0.612
DOC_WW_Pin1_4	673	678	PF00397	0.608
DOC_WW_Pin1_4	72	77	PF00397	0.607
DOC_WW_Pin1_4	735	740	PF00397	0.644
DOC_WW_Pin1_4	769	774	PF00397	0.632
LIG_14-3-3_CanoR_1	159	163	PF00244	0.765
LIG_Actin_WH2_2	20	37	PF00022	0.618
LIG_BRCT_BRCA1_1	191	195	PF00533	0.671
LIG_BRCT_BRCA1_1	201	205	PF00533	0.526
LIG_BRCT_BRCA1_1	253	257	PF00533	0.713
LIG_BRCT_BRCA1_1	263	267	PF00533	0.564
LIG_BRCT_BRCA1_1	315	319	PF00533	0.706
LIG_BRCT_BRCA1_1	325	329	PF00533	0.794
LIG_BRCT_BRCA1_1	377	381	PF00533	0.695
LIG_BRCT_BRCA1_1	387	391	PF00533	0.704
LIG_BRCT_BRCA1_1	411	415	PF00533	0.725
LIG_BRCT_BRCA1_1	421	425	PF00533	0.717
LIG_BRCT_BRCA1_1	473	477	PF00533	0.678
LIG_BRCT_BRCA1_1	483	487	PF00533	0.702
LIG_BRCT_BRCA1_1	535	539	PF00533	0.680
LIG_BRCT_BRCA1_1	545	549	PF00533	0.701
LIG_BRCT_BRCA1_1	597	601	PF00533	0.681
LIG_BRCT_BRCA1_1	607	611	PF00533	0.705
LIG_BRCT_BRCA1_1	659	663	PF00533	0.671
LIG_BRCT_BRCA1_1	669	673	PF00533	0.699
LIG_BRCT_BRCA1_1	721	725	PF00533	0.658
LIG_BRCT_BRCA1_1	731	735	PF00533	0.687
LIG_BRCT_BRCA1_1	755	759	PF00533	0.701
LIG_BRCT_BRCA1_1	765	769	PF00533	0.710
LIG_BRCT_BRCA1_1	789	793	PF00533	0.603
LIG_BRCT_BRCA1_1	817	821	PF00533	0.728
LIG_BRCT_BRCA1_2	191	197	PF00533	0.596
LIG_BRCT_BRCA1_2	253	259	PF00533	0.595
LIG_BRCT_BRCA1_2	315	321	PF00533	0.589
LIG_BRCT_BRCA1_2	377	383	PF00533	0.644
LIG_BRCT_BRCA1_2	411	417	PF00533	0.651
LIG_BRCT_BRCA1_2	473	479	PF00533	0.602
LIG_BRCT_BRCA1_2	535	541	PF00533	0.606
LIG_BRCT_BRCA1_2	597	603	PF00533	0.605
LIG_BRCT_BRCA1_2	659	665	PF00533	0.597
LIG_BRCT_BRCA1_2	721	727	PF00533	0.580
LIG_BRCT_BRCA1_2	755	761	PF00533	0.630
LIG_BRCT_BRCA1_2	789	795	PF00533	0.603
LIG_CaM_IQ_9	21	37	PF13499	0.613
LIG_EH1_1	77	85	PF00400	0.669
LIG_FHA_1	116	122	PF00498	0.625
LIG_FHA_1	16	22	PF00498	0.680
LIG_FHA_2	17	23	PF00498	0.544
LIG_FHA_2	65	71	PF00498	0.715
LIG_LIR_Gen_1	869	878	PF02991	0.726
LIG_LIR_Nem_3	869	874	PF02991	0.733
LIG_NRBOX	60	66	PF00104	0.676
LIG_Pex14_2	835	839	PF04695	0.764
LIG_SH2_NCK_1	137	141	PF00017	0.585
LIG_SH2_SRC	137	140	PF00017	0.784
MOD_CK1_1	113	119	PF00069	0.769
MOD_CK1_1	124	130	PF00069	0.608
MOD_CK1_1	814	820	PF00069	0.748
MOD_CK1_1	823	829	PF00069	0.609
MOD_CK1_1	833	839	PF00069	0.473
MOD_CK1_1	869	875	PF00069	0.580
MOD_CK2_1	106	112	PF00069	0.711
MOD_CK2_1	16	22	PF00069	0.680
MOD_CK2_1	48	54	PF00069	0.622
MOD_GlcNHglycan	108	111	PF01048	0.705
MOD_GlcNHglycan	164	167	PF01048	0.622
MOD_GlcNHglycan	202	205	PF01048	0.777
MOD_GlcNHglycan	264	267	PF01048	0.602
MOD_GlcNHglycan	326	329	PF01048	0.784
MOD_GlcNHglycan	388	391	PF01048	0.752
MOD_GlcNHglycan	422	425	PF01048	0.793
MOD_GlcNHglycan	484	487	PF01048	0.751
MOD_GlcNHglycan	546	549	PF01048	0.751
MOD_GlcNHglycan	608	611	PF01048	0.755
MOD_GlcNHglycan	670	673	PF01048	0.750
MOD_GlcNHglycan	732	735	PF01048	0.738
MOD_GlcNHglycan	766	769	PF01048	0.784
MOD_GlcNHglycan	803	806	PF01048	0.739
MOD_GlcNHglycan	813	816	PF01048	0.597
MOD_GlcNHglycan	817	820	PF01048	0.539
MOD_GlcNHglycan	822	825	PF01048	0.459
MOD_GlcNHglycan	832	835	PF01048	0.465
MOD_GlcNHglycan	836	839	PF01048	0.489
MOD_GlcNHglycan	853	856	PF01048	0.505
MOD_GlcNHglycan	863	866	PF01048	0.589
MOD_GSK3_1	106	113	PF00069	0.615
MOD_GSK3_1	12	19	PF00069	0.669
MOD_GSK3_1	158	165	PF00069	0.735
MOD_GSK3_1	214	221	PF00069	0.698
MOD_GSK3_1	276	283	PF00069	0.779
MOD_GSK3_1	338	345	PF00069	0.733
MOD_GSK3_1	434	441	PF00069	0.592
MOD_GSK3_1	496	503	PF00069	0.604
MOD_GSK3_1	558	565	PF00069	0.592
MOD_GSK3_1	620	627	PF00069	0.589
MOD_GSK3_1	682	689	PF00069	0.589
MOD_GSK3_1	72	79	PF00069	0.578
MOD_GSK3_1	811	818	PF00069	0.750
MOD_GSK3_1	830	837	PF00069	0.460
MOD_GSK3_1	847	854	PF00069	0.485
MOD_GSK3_1	866	873	PF00069	0.453
MOD_N-GLC_1	95	100	PF02516	0.678
MOD_NEK2_1	56	61	PF00069	0.623
MOD_NEK2_1	82	87	PF00069	0.673
MOD_NEK2_1	866	871	PF00069	0.740
MOD_PIKK_1	95	101	PF00454	0.688
MOD_PKA_1	100	106	PF00069	0.743
MOD_PKA_2	100	106	PF00069	0.630
MOD_PKA_2	158	164	PF00069	0.691
MOD_Plk_1	49	55	PF00069	0.624
MOD_Plk_4	124	130	PF00069	0.673
MOD_Plk_4	817	823	PF00069	0.549
MOD_ProDKin_1	121	127	PF00069	0.783
MOD_ProDKin_1	205	211	PF00069	0.596
MOD_ProDKin_1	267	273	PF00069	0.601
MOD_ProDKin_1	329	335	PF00069	0.602
MOD_ProDKin_1	391	397	PF00069	0.722
MOD_ProDKin_1	425	431	PF00069	0.595
MOD_ProDKin_1	487	493	PF00069	0.686
MOD_ProDKin_1	549	555	PF00069	0.609
MOD_ProDKin_1	611	617	PF00069	0.612
MOD_ProDKin_1	673	679	PF00069	0.610
MOD_ProDKin_1	72	78	PF00069	0.608
MOD_ProDKin_1	735	741	PF00069	0.643
MOD_ProDKin_1	769	775	PF00069	0.631
TRG_ER_diArg_1	29	31	PF00400	0.608

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IH13	Leishmania donovani	56%	90%
Q4Q7W0	Leishmania major	59%	100%