WD_REPEATS_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

U5 snRNP-specific 40 kDa protein, putative

Species:

Leishmania mexicana

UniProt:

E9B0B8_LEIMU

TriTrypDb:

LmxM.28.2960

Length:

322

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005654	nucleoplasm	2	1
GO:0005681	spliceosomal complex	3	1
GO:0005829	cytosol	2	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0071013	catalytic step 2 spliceosome	3	1
GO:0110165	cellular anatomical entity	1	1
GO:0140513	nuclear protein-containing complex	2	1
GO:1902494	catalytic complex	2	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

E9B0B8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B0B8

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0005488	binding	1	1
GO:0030627	pre-mRNA 5'-splice site binding	6	1
GO:0036002	pre-mRNA binding	5	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	125	129	PF00656	0.450
CLV_PCSK_KEX2_1	144	146	PF00082	0.541
CLV_PCSK_PC1ET2_1	144	146	PF00082	0.541
CLV_PCSK_SKI1_1	211	215	PF00082	0.506
CLV_PCSK_SKI1_1	248	252	PF00082	0.403
DEG_SPOP_SBC_1	230	234	PF00917	0.498
DEG_SPOP_SBC_1	5	9	PF00917	0.579
DOC_MAPK_gen_1	144	151	PF00069	0.458
DOC_MAPK_MEF2A_6	292	301	PF00069	0.446
DOC_USP7_MATH_1	126	130	PF00917	0.474
DOC_USP7_MATH_1	230	234	PF00917	0.501
DOC_USP7_UBL2_3	144	148	PF12436	0.481
LIG_14-3-3_CanoR_1	211	216	PF00244	0.466
LIG_Actin_WH2_2	89	105	PF00022	0.522
LIG_BIR_II_1	1	5	PF00653	0.478
LIG_BRCT_BRCA1_1	128	132	PF00533	0.424
LIG_CSL_BTD_1	255	258	PF09270	0.523
LIG_FHA_1	13	19	PF00498	0.339
LIG_FHA_1	199	205	PF00498	0.428
LIG_FHA_1	218	224	PF00498	0.221
LIG_FHA_1	283	289	PF00498	0.456
LIG_FHA_1	39	45	PF00498	0.415
LIG_FHA_1	78	84	PF00498	0.464
LIG_FHA_2	123	129	PF00498	0.432
LIG_FHA_2	54	60	PF00498	0.376
LIG_FHA_2	90	96	PF00498	0.497
LIG_LIR_Gen_1	164	174	PF02991	0.471
LIG_LIR_Nem_3	16	22	PF02991	0.485
LIG_LIR_Nem_3	164	170	PF02991	0.483
LIG_SH2_GRB2like	19	22	PF00017	0.478
LIG_SH2_STAT5	138	141	PF00017	0.439
LIG_SH2_STAT5	307	310	PF00017	0.494
LIG_SH3_3	260	266	PF00018	0.501
LIG_SUMO_SIM_par_1	271	276	PF11976	0.492
MOD_CK1_1	161	167	PF00069	0.427
MOD_CK1_1	77	83	PF00069	0.435
MOD_CK1_1	9	15	PF00069	0.605
MOD_CK2_1	53	59	PF00069	0.280
MOD_GlcNHglycan	160	163	PF01048	0.456
MOD_GlcNHglycan	196	199	PF01048	0.504
MOD_GlcNHglycan	217	220	PF01048	0.487
MOD_GlcNHglycan	275	278	PF01048	0.484
MOD_GlcNHglycan	294	297	PF01048	0.427
MOD_GlcNHglycan	76	79	PF01048	0.525
MOD_GlcNHglycan	8	11	PF01048	0.518
MOD_GSK3_1	1	8	PF00069	0.533
MOD_GSK3_1	122	129	PF00069	0.466
MOD_GSK3_1	161	168	PF00069	0.381
MOD_GSK3_1	180	187	PF00069	0.512
MOD_GSK3_1	194	201	PF00069	0.431
MOD_GSK3_1	211	218	PF00069	0.245
MOD_N-GLC_1	297	302	PF02516	0.472
MOD_NEK2_1	1	6	PF00069	0.490
MOD_NEK2_1	165	170	PF00069	0.381
MOD_NEK2_1	217	222	PF00069	0.388
MOD_NEK2_1	229	234	PF00069	0.452
MOD_NEK2_1	297	302	PF00069	0.472
MOD_NEK2_1	53	58	PF00069	0.348
MOD_NEK2_2	284	289	PF00069	0.591
MOD_PIKK_1	223	229	PF00454	0.510
MOD_PKA_2	126	132	PF00069	0.447
MOD_PKB_1	101	109	PF00069	0.508
MOD_Plk_1	297	303	PF00069	0.480
MOD_Plk_4	126	132	PF00069	0.431
MOD_Plk_4	199	205	PF00069	0.379
MOD_Plk_4	259	265	PF00069	0.330
MOD_Plk_4	89	95	PF00069	0.451
TRG_DiLeu_BaEn_1	247	252	PF01217	0.521
TRG_DiLeu_BaLyEn_6	155	160	PF01217	0.216
TRG_DiLeu_BaLyEn_6	233	238	PF01217	0.429
TRG_ENDOCYTIC_2	19	22	PF00928	0.478

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5J8	Leptomonas seymouri	63%	100%
A0A1X0NQJ3	Trypanosomatidae	34%	100%
A0A3S7X1X9	Leishmania donovani	91%	72%
A0A422NG23	Trypanosoma rangeli	36%	100%
A4HGZ9	Leishmania braziliensis	87%	100%
A4I431	Leishmania infantum	91%	100%
D0A8X8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	99%
O94620	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	26%	95%
Q4Q7W6	Leishmania major	93%	100%
V5BDN5	Trypanosoma cruzi	37%	100%