C3H1-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B0B7_LEIMU

TriTrypDb:

LmxM.28.2950

Length:

335

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B0B7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B0B7

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	13
GO:0043167	ion binding	2	13
GO:0043169	cation binding	3	13
GO:0046872	metal ion binding	4	13
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	178	182	PF00656	0.630
CLV_NRD_NRD_1	12	14	PF00675	0.656
CLV_NRD_NRD_1	59	61	PF00675	0.575
CLV_PCSK_FUR_1	9	13	PF00082	0.749
CLV_PCSK_KEX2_1	11	13	PF00082	0.683
CLV_PCSK_KEX2_1	43	45	PF00082	0.499
CLV_PCSK_PC1ET2_1	11	13	PF00082	0.721
CLV_PCSK_PC1ET2_1	43	45	PF00082	0.499
CLV_PCSK_PC7_1	7	13	PF00082	0.740
CLV_PCSK_SKI1_1	216	220	PF00082	0.694
CLV_PCSK_SKI1_1	43	47	PF00082	0.406
CLV_PCSK_SKI1_1	68	72	PF00082	0.532
DEG_Nend_UBRbox_1	1	4	PF02207	0.693
DEG_SPOP_SBC_1	153	157	PF00917	0.303
DOC_ANK_TNKS_1	12	19	PF00023	0.727
DOC_CYCLIN_yCln2_LP_2	218	224	PF00134	0.706
DOC_MAPK_gen_1	43	49	PF00069	0.534
DOC_MAPK_MEF2A_6	216	225	PF00069	0.682
DOC_PP2B_LxvP_1	218	221	PF13499	0.696
DOC_PP2B_LxvP_1	45	48	PF13499	0.374
DOC_USP7_MATH_1	153	157	PF00917	0.605
DOC_USP7_MATH_1	245	249	PF00917	0.520
DOC_USP7_MATH_1	257	261	PF00917	0.670
DOC_USP7_MATH_1	304	308	PF00917	0.690
DOC_USP7_MATH_1	323	327	PF00917	0.649
DOC_USP7_MATH_1	48	52	PF00917	0.473
DOC_USP7_MATH_2	15	21	PF00917	0.755
DOC_WW_Pin1_4	180	185	PF00397	0.606
DOC_WW_Pin1_4	246	251	PF00397	0.736
DOC_WW_Pin1_4	271	276	PF00397	0.623
DOC_WW_Pin1_4	287	292	PF00397	0.597
DOC_WW_Pin1_4	300	305	PF00397	0.608
LIG_14-3-3_CanoR_1	308	318	PF00244	0.595
LIG_BRCT_BRCA1_1	306	310	PF00533	0.719
LIG_EVH1_2	275	279	PF00568	0.690
LIG_EVH1_2	31	35	PF00568	0.555
LIG_FHA_1	112	118	PF00498	0.538
LIG_FHA_1	142	148	PF00498	0.475
LIG_FHA_1	168	174	PF00498	0.483
LIG_FHA_1	217	223	PF00498	0.577
LIG_FHA_1	25	31	PF00498	0.529
LIG_FHA_1	272	278	PF00498	0.681
LIG_FHA_1	312	318	PF00498	0.550
LIG_FHA_2	229	235	PF00498	0.734
LIG_IBAR_NPY_1	322	324	PF08397	0.576
LIG_LIR_Gen_1	132	143	PF02991	0.415
LIG_LIR_Gen_1	191	202	PF02991	0.377
LIG_LIR_Nem_3	132	138	PF02991	0.348
LIG_LIR_Nem_3	191	197	PF02991	0.367
LIG_NRBOX	234	240	PF00104	0.459
LIG_PCNA_yPIPBox_3	227	239	PF02747	0.450
LIG_SH3_3	163	169	PF00018	0.459
LIG_SH3_3	258	264	PF00018	0.701
LIG_SH3_3	270	276	PF00018	0.707
LIG_SH3_3	34	40	PF00018	0.397
LIG_TRAF2_1	231	234	PF00917	0.448
LIG_UBA3_1	235	241	PF00899	0.458
LIG_UBA3_1	34	43	PF00899	0.456
MOD_CDK_SPxxK_3	180	187	PF00069	0.584
MOD_CDK_SPxxK_3	271	278	PF00069	0.704
MOD_CK1_1	112	118	PF00069	0.487
MOD_CK1_1	246	252	PF00069	0.752
MOD_CK1_1	259	265	PF00069	0.712
MOD_CK1_1	309	315	PF00069	0.586
MOD_CK1_1	327	333	PF00069	0.629
MOD_CK2_1	228	234	PF00069	0.684
MOD_CK2_1	328	334	PF00069	0.626
MOD_GlcNHglycan	114	117	PF01048	0.570
MOD_GlcNHglycan	170	173	PF01048	0.497
MOD_GlcNHglycan	177	180	PF01048	0.486
MOD_GlcNHglycan	267	270	PF01048	0.710
MOD_GlcNHglycan	314	317	PF01048	0.638
MOD_GSK3_1	252	259	PF00069	0.725
MOD_GSK3_1	300	307	PF00069	0.619
MOD_GSK3_1	308	315	PF00069	0.526
MOD_GSK3_1	323	330	PF00069	0.531
MOD_GSK3_1	48	55	PF00069	0.457
MOD_N-GLC_1	112	117	PF02516	0.396
MOD_N-GLC_1	324	329	PF02516	0.646
MOD_NEK2_1	265	270	PF00069	0.663
MOD_NEK2_1	284	289	PF00069	0.734
MOD_NEK2_1	306	311	PF00069	0.611
MOD_NEK2_1	52	57	PF00069	0.455
MOD_PIKK_1	252	258	PF00454	0.733
MOD_PKB_1	74	82	PF00069	0.476
MOD_Plk_2-3	234	240	PF00069	0.751
MOD_Plk_4	138	144	PF00069	0.506
MOD_Plk_4	234	240	PF00069	0.673
MOD_Plk_4	328	334	PF00069	0.622
MOD_Plk_4	48	54	PF00069	0.528
MOD_ProDKin_1	180	186	PF00069	0.591
MOD_ProDKin_1	246	252	PF00069	0.737
MOD_ProDKin_1	271	277	PF00069	0.622
MOD_ProDKin_1	287	293	PF00069	0.594
MOD_ProDKin_1	300	306	PF00069	0.664
MOD_SUMO_for_1	212	215	PF00179	0.616
TRG_DiLeu_BaEn_1	234	239	PF01217	0.458
TRG_DiLeu_BaLyEn_6	41	46	PF01217	0.245
TRG_NLS_MonoExtC_3	10	15	PF00514	0.597
TRG_NLS_MonoExtN_4	9	15	PF00514	0.471
TRG_Pf-PMV_PEXEL_1	97	101	PF00026	0.480

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HY30	Leptomonas seymouri	31%	81%
A0A0N1I3L5	Leptomonas seymouri	67%	100%
A0A1X0NQH6	Trypanosomatidae	42%	100%
A0A3R7JXK3	Trypanosoma rangeli	29%	77%
A0A3R7R5S5	Trypanosoma rangeli	31%	76%
A0A3S5IR49	Trypanosoma rangeli	40%	100%
A0A3S7X224	Leishmania donovani	94%	100%
A4HGZ8	Leishmania braziliensis	83%	100%
A4I430	Leishmania infantum	94%	100%
Q4Q7W7	Leishmania major	93%	100%
V5BI47	Trypanosoma cruzi	43%	100%