Putative sodium/sulphate symporter

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Low-affinity phosphate transporter PHO91

Species:

Leishmania mexicana

UniProt:

E9B0B5_LEIMU

TriTrypDb:

LmxM.28.2930

Length:

734

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10
GO:0000331	contractile vacuole	6	1
GO:0005773	vacuole	5	1
GO:0005777	peroxisome	6	1
GO:0020015	glycosome	7	1
GO:0031410	cytoplasmic vesicle	6	1
GO:0031982	vesicle	4	1
GO:0042579	microbody	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0097708	intracellular vesicle	5	1

Expansion

Sequence features

E9B0B5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B0B5

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	1
GO:0006793	phosphorus metabolic process	3	1
GO:0006797	polyphosphate metabolic process	4	1
GO:0006810	transport	3	4
GO:0006811	monoatomic ion transport	4	1
GO:0006817	phosphate ion transport	7	1
GO:0006820	monoatomic anion transport	5	1
GO:0006873	intracellular monoatomic ion homeostasis	4	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	4
GO:0015698	inorganic anion transport	6	1
GO:0019725	cellular homeostasis	2	1
GO:0030002	intracellular monoatomic anion homeostasis	5	1
GO:0030643	intracellular phosphate ion homeostasis	7	1
GO:0034220	monoatomic ion transmembrane transport	3	1
GO:0042592	homeostatic process	3	1
GO:0043436	oxoacid metabolic process	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044281	small molecule metabolic process	2	1
GO:0048878	chemical homeostasis	4	1
GO:0050801	monoatomic ion homeostasis	5	1
GO:0051179	localization	1	4
GO:0051234	establishment of localization	2	4
GO:0055062	phosphate ion homeostasis	8	1
GO:0055081	monoatomic anion homeostasis	6	1
GO:0055082	intracellular chemical homeostasis	3	1
GO:0055085	transmembrane transport	2	4
GO:0065007	biological regulation	1	1
GO:0065008	regulation of biological quality	2	1
GO:0071704	organic substance metabolic process	2	1
GO:0072502	obsolete cellular trivalent inorganic anion homeostasis	6	1
GO:0072506	obsolete trivalent inorganic anion homeostasis	7	1
GO:0098656	monoatomic anion transmembrane transport	4	1
GO:0098771	inorganic ion homeostasis	6	1

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	7
GO:0022857	transmembrane transporter activity	2	7
GO:0005315	inorganic phosphate transmembrane transporter activity	4	1
GO:0015291	secondary active transmembrane transporter activity	4	1
GO:0015318	inorganic molecular entity transmembrane transporter activity	3	1
GO:0022804	active transmembrane transporter activity	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	122	126	PF00656	0.763
CLV_C14_Caspase3-7	604	608	PF00656	0.365
CLV_NRD_NRD_1	187	189	PF00675	0.348
CLV_NRD_NRD_1	236	238	PF00675	0.351
CLV_NRD_NRD_1	87	89	PF00675	0.456
CLV_NRD_NRD_1	92	94	PF00675	0.496
CLV_PCSK_KEX2_1	142	144	PF00082	0.471
CLV_PCSK_KEX2_1	23	25	PF00082	0.356
CLV_PCSK_KEX2_1	5	7	PF00082	0.407
CLV_PCSK_KEX2_1	92	94	PF00082	0.507
CLV_PCSK_PC1ET2_1	142	144	PF00082	0.471
CLV_PCSK_PC1ET2_1	23	25	PF00082	0.356
CLV_PCSK_PC1ET2_1	5	7	PF00082	0.407
CLV_PCSK_PC7_1	88	94	PF00082	0.487
CLV_PCSK_SKI1_1	142	146	PF00082	0.425
CLV_PCSK_SKI1_1	163	167	PF00082	0.436
CLV_PCSK_SKI1_1	189	193	PF00082	0.359
CLV_PCSK_SKI1_1	216	220	PF00082	0.402
CLV_PCSK_SKI1_1	225	229	PF00082	0.415
CLV_PCSK_SKI1_1	23	27	PF00082	0.364
CLV_PCSK_SKI1_1	237	241	PF00082	0.387
CLV_PCSK_SKI1_1	260	264	PF00082	0.347
CLV_PCSK_SKI1_1	701	705	PF00082	0.264
CLV_PCSK_SKI1_1	71	75	PF00082	0.485
DEG_APCC_DBOX_1	142	150	PF00400	0.589
DEG_APCC_DBOX_1	213	221	PF00400	0.576
DEG_APCC_DBOX_1	224	232	PF00400	0.576
DEG_APCC_DBOX_1	381	389	PF00400	0.282
DEG_Nend_UBRbox_1	1	4	PF02207	0.637
DOC_CKS1_1	656	661	PF01111	0.157
DOC_CYCLIN_RxL_1	160	171	PF00134	0.635
DOC_CYCLIN_RxL_1	222	232	PF00134	0.640
DOC_MAPK_DCC_7	494	504	PF00069	0.510
DOC_MAPK_gen_1	142	149	PF00069	0.640
DOC_MAPK_gen_1	223	231	PF00069	0.591
DOC_MAPK_gen_1	237	243	PF00069	0.584
DOC_MAPK_gen_1	5	13	PF00069	0.684
DOC_MAPK_gen_1	71	81	PF00069	0.658
DOC_MAPK_HePTP_8	340	352	PF00069	0.464
DOC_MAPK_MEF2A_6	223	231	PF00069	0.569
DOC_MAPK_MEF2A_6	343	352	PF00069	0.464
DOC_MAPK_MEF2A_6	74	81	PF00069	0.671
DOC_PP1_RVXF_1	462	468	PF00149	0.327
DOC_PP1_RVXF_1	641	647	PF00149	0.343
DOC_PP4_FxxP_1	239	242	PF00568	0.641
DOC_PP4_FxxP_1	646	649	PF00568	0.282
DOC_USP7_MATH_1	114	118	PF00917	0.754
DOC_USP7_MATH_1	399	403	PF00917	0.319
DOC_USP7_MATH_1	514	518	PF00917	0.357
DOC_USP7_MATH_1	588	592	PF00917	0.264
DOC_USP7_MATH_1	677	681	PF00917	0.319
DOC_USP7_MATH_1	689	693	PF00917	0.464
DOC_USP7_UBL2_3	189	193	PF12436	0.559
DOC_WW_Pin1_4	158	163	PF00397	0.615
DOC_WW_Pin1_4	443	448	PF00397	0.302
DOC_WW_Pin1_4	606	611	PF00397	0.304
DOC_WW_Pin1_4	648	653	PF00397	0.268
DOC_WW_Pin1_4	655	660	PF00397	0.262
LIG_14-3-3_CanoR_1	188	194	PF00244	0.581
LIG_14-3-3_CanoR_1	216	221	PF00244	0.557
LIG_14-3-3_CanoR_1	377	385	PF00244	0.264
LIG_Actin_WH2_2	22	37	PF00022	0.605
LIG_BRCT_BRCA1_1	231	235	PF00533	0.631
LIG_deltaCOP1_diTrp_1	254	259	PF00928	0.598
LIG_EH1_1	629	637	PF00400	0.319
LIG_FHA_1	106	112	PF00498	0.792
LIG_FHA_1	113	119	PF00498	0.692
LIG_FHA_1	203	209	PF00498	0.569
LIG_FHA_1	294	300	PF00498	0.326
LIG_FHA_1	306	312	PF00498	0.274
LIG_FHA_1	330	336	PF00498	0.477
LIG_FHA_1	46	52	PF00498	0.636
LIG_FHA_1	517	523	PF00498	0.485
LIG_FHA_1	528	534	PF00498	0.279
LIG_FHA_1	543	549	PF00498	0.343
LIG_FHA_1	611	617	PF00498	0.306
LIG_FHA_1	623	629	PF00498	0.347
LIG_FHA_1	713	719	PF00498	0.333
LIG_FHA_1	724	730	PF00498	0.309
LIG_FHA_2	324	330	PF00498	0.510
LIG_FHA_2	363	369	PF00498	0.319
LIG_FHA_2	415	421	PF00498	0.464
LIG_FHA_2	507	513	PF00498	0.514
LIG_FHA_2	602	608	PF00498	0.365
LIG_GBD_Chelix_1	525	533	PF00786	0.383
LIG_LIR_Apic_2	236	242	PF02991	0.633
LIG_LIR_Apic_2	417	422	PF02991	0.464
LIG_LIR_Apic_2	532	537	PF02991	0.460
LIG_LIR_Apic_2	720	724	PF02991	0.320
LIG_LIR_Apic_2	726	731	PF02991	0.314
LIG_LIR_Gen_1	244	252	PF02991	0.675
LIG_LIR_Gen_1	42	52	PF02991	0.551
LIG_LIR_Gen_1	55	65	PF02991	0.553
LIG_LIR_Gen_1	565	575	PF02991	0.464
LIG_LIR_Gen_1	608	619	PF02991	0.377
LIG_LIR_LC3C_4	613	617	PF02991	0.361
LIG_LIR_Nem_3	14	18	PF02991	0.568
LIG_LIR_Nem_3	21	25	PF02991	0.544
LIG_LIR_Nem_3	244	249	PF02991	0.628
LIG_LIR_Nem_3	42	47	PF02991	0.530
LIG_LIR_Nem_3	461	465	PF02991	0.290
LIG_LIR_Nem_3	498	504	PF02991	0.510
LIG_LIR_Nem_3	55	61	PF02991	0.543
LIG_LIR_Nem_3	565	570	PF02991	0.464
LIG_LIR_Nem_3	608	614	PF02991	0.377
LIG_LIR_Nem_3	679	684	PF02991	0.319
LIG_NRBOX	143	149	PF00104	0.659
LIG_NRBOX	223	229	PF00104	0.641
LIG_NRBOX	573	579	PF00104	0.319
LIG_Pex14_1	15	19	PF04695	0.557
LIG_Pex14_1	259	263	PF04695	0.461
LIG_Pex14_1	572	576	PF04695	0.319
LIG_Pex14_1	721	725	PF04695	0.305
LIG_Pex14_2	235	239	PF04695	0.609
LIG_PTB_Apo_2	38	45	PF02174	0.500
LIG_SH2_CRK	22	26	PF00017	0.558
LIG_SH2_CRK	246	250	PF00017	0.632
LIG_SH2_GRB2like	246	249	PF00017	0.685
LIG_SH2_NCK_1	246	250	PF00017	0.685
LIG_SH2_PTP2	261	264	PF00017	0.375
LIG_SH2_PTP2	501	504	PF00017	0.535
LIG_SH2_PTP2	728	731	PF00017	0.396
LIG_SH2_SRC	246	249	PF00017	0.685
LIG_SH2_STAP1	246	250	PF00017	0.646
LIG_SH2_STAP1	370	374	PF00017	0.305
LIG_SH2_STAT5	19	22	PF00017	0.518
LIG_SH2_STAT5	261	264	PF00017	0.375
LIG_SH2_STAT5	386	389	PF00017	0.319
LIG_SH2_STAT5	501	504	PF00017	0.535
LIG_SH2_STAT5	611	614	PF00017	0.319
LIG_SH2_STAT5	697	700	PF00017	0.464
LIG_SH2_STAT5	728	731	PF00017	0.367
LIG_SH3_1	74	80	PF00018	0.731
LIG_SH3_3	115	121	PF00018	0.772
LIG_SH3_3	312	318	PF00018	0.322
LIG_SH3_3	319	325	PF00018	0.495
LIG_SH3_3	401	407	PF00018	0.313
LIG_SH3_3	470	476	PF00018	0.342
LIG_SH3_3	489	495	PF00018	0.189
LIG_SH3_3	497	503	PF00018	0.464
LIG_SH3_3	646	652	PF00018	0.282
LIG_SH3_3	653	659	PF00018	0.147
LIG_SH3_3	74	80	PF00018	0.648
LIG_SUMO_SIM_anti_2	519	525	PF11976	0.438
LIG_SUMO_SIM_anti_2	613	619	PF11976	0.320
LIG_SUMO_SIM_anti_2	708	715	PF11976	0.375
LIG_SUMO_SIM_par_1	145	152	PF11976	0.721
LIG_SUMO_SIM_par_1	227	232	PF11976	0.596
LIG_SUMO_SIM_par_1	291	296	PF11976	0.403
LIG_SUMO_SIM_par_1	475	481	PF11976	0.375
LIG_SUMO_SIM_par_1	521	527	PF11976	0.323
LIG_SUMO_SIM_par_1	661	666	PF11976	0.295
LIG_TRAF2_1	104	107	PF00917	0.767
LIG_TRAF2_1	510	513	PF00917	0.565
LIG_TYR_ITIM	20	25	PF00017	0.548
LIG_TYR_ITIM	499	504	PF00017	0.535
LIG_UBA3_1	593	602	PF00899	0.335
LIG_UBA3_1	635	643	PF00899	0.321
LIG_Vh1_VBS_1	617	635	PF01044	0.313
LIG_WRC_WIRS_1	624	629	PF05994	0.464
LIG_WRPW_2	493	496	PF00400	0.448
MOD_CDK_SPK_2	158	163	PF00069	0.615
MOD_CK1_1	112	118	PF00069	0.767
MOD_CK1_1	37	43	PF00069	0.586
MOD_CK1_1	458	464	PF00069	0.290
MOD_CK1_1	516	522	PF00069	0.496
MOD_CK1_1	527	533	PF00069	0.263
MOD_CK1_1	600	606	PF00069	0.365
MOD_CK2_1	323	329	PF00069	0.510
MOD_CK2_1	362	368	PF00069	0.301
MOD_CK2_1	414	420	PF00069	0.464
MOD_CK2_1	506	512	PF00069	0.535
MOD_Cter_Amidation	3	6	PF01082	0.413
MOD_GlcNHglycan	189	192	PF01048	0.404
MOD_GlcNHglycan	329	332	PF01048	0.314
MOD_GlcNHglycan	457	460	PF01048	0.535
MOD_GlcNHglycan	516	519	PF01048	0.335
MOD_GlcNHglycan	526	529	PF01048	0.418
MOD_GlcNHglycan	665	668	PF01048	0.301
MOD_GlcNHglycan	670	673	PF01048	0.314
MOD_GlcNHglycan	97	100	PF01048	0.567
MOD_GSK3_1	105	112	PF00069	0.734
MOD_GSK3_1	212	219	PF00069	0.576
MOD_GSK3_1	293	300	PF00069	0.319
MOD_GSK3_1	323	330	PF00069	0.476
MOD_GSK3_1	443	450	PF00069	0.319
MOD_GSK3_1	597	604	PF00069	0.296
MOD_GSK3_1	606	613	PF00069	0.256
MOD_GSK3_1	622	629	PF00069	0.345
MOD_GSK3_1	708	715	PF00069	0.403
MOD_NEK2_1	110	115	PF00069	0.772
MOD_NEK2_1	212	217	PF00069	0.605
MOD_NEK2_1	293	298	PF00069	0.334
MOD_NEK2_1	305	310	PF00069	0.285
MOD_NEK2_1	362	367	PF00069	0.343
MOD_NEK2_1	391	396	PF00069	0.336
MOD_NEK2_1	524	529	PF00069	0.404
MOD_NEK2_1	542	547	PF00069	0.175
MOD_NEK2_1	601	606	PF00069	0.264
MOD_NEK2_1	668	673	PF00069	0.319
MOD_NEK2_1	705	710	PF00069	0.295
MOD_NEK2_1	712	717	PF00069	0.295
MOD_PIKK_1	149	155	PF00454	0.678
MOD_PKA_1	94	100	PF00069	0.732
MOD_PKA_2	187	193	PF00069	0.578
MOD_PKA_2	34	40	PF00069	0.623
MOD_PKA_2	376	382	PF00069	0.250
MOD_PKA_2	588	594	PF00069	0.266
MOD_PKB_1	214	222	PF00069	0.574
MOD_Plk_1	229	235	PF00069	0.625
MOD_Plk_4	119	125	PF00069	0.730
MOD_Plk_4	216	222	PF00069	0.573
MOD_Plk_4	370	376	PF00069	0.332
MOD_Plk_4	381	387	PF00069	0.229
MOD_Plk_4	458	464	PF00069	0.276
MOD_Plk_4	610	616	PF00069	0.340
MOD_Plk_4	623	629	PF00069	0.319
MOD_Plk_4	658	664	PF00069	0.282
MOD_Plk_4	683	689	PF00069	0.464
MOD_Plk_4	705	711	PF00069	0.305
MOD_Plk_4	717	723	PF00069	0.344
MOD_ProDKin_1	158	164	PF00069	0.611
MOD_ProDKin_1	443	449	PF00069	0.302
MOD_ProDKin_1	606	612	PF00069	0.304
MOD_ProDKin_1	648	654	PF00069	0.268
MOD_ProDKin_1	655	661	PF00069	0.262
MOD_SUMO_for_1	52	55	PF00179	0.629
MOD_SUMO_rev_2	230	239	PF00179	0.560
TRG_DiLeu_BaEn_1	106	111	PF01217	0.714
TRG_DiLeu_BaEn_1	68	73	PF01217	0.644
TRG_DiLeu_BaLyEn_6	404	409	PF01217	0.319
TRG_ENDOCYTIC_2	197	200	PF00928	0.613
TRG_ENDOCYTIC_2	22	25	PF00928	0.546
TRG_ENDOCYTIC_2	246	249	PF00928	0.632
TRG_ENDOCYTIC_2	261	264	PF00928	0.343
TRG_ENDOCYTIC_2	501	504	PF00928	0.535
TRG_ENDOCYTIC_2	611	614	PF00928	0.319
TRG_ER_diArg_1	214	217	PF00400	0.502
TRG_ER_diArg_1	222	225	PF00400	0.549
TRG_ER_diArg_1	91	93	PF00400	0.649
TRG_NES_CRM1_1	175	185	PF08389	0.605
TRG_NLS_Bipartite_1	5	27	PF00514	0.597
TRG_NLS_MonoExtC_3	191	196	PF00514	0.575
TRG_NLS_MonoExtN_4	189	196	PF00514	0.568
TRG_NLS_MonoExtN_4	92	97	PF00514	0.754
TRG_Pf-PMV_PEXEL_1	163	168	PF00026	0.415
TRG_Pf-PMV_PEXEL_1	225	230	PF00026	0.417
TRG_Pf-PMV_PEXEL_1	416	420	PF00026	0.305

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HWP2	Leptomonas seymouri	80%	99%
A0A1X0NQK1	Trypanosomatidae	65%	100%
A0A3Q8IB88	Leishmania donovani	95%	100%
A0A422NG32	Trypanosoma rangeli	72%	100%
A4HGZ6	Leishmania braziliensis	90%	100%
A4I428	Leishmania infantum	96%	100%
D0A8X9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	63%	100%
P27514	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	33%	82%
Q21339	Caenorhabditis elegans	26%	100%
Q4Q7W9	Leishmania major	95%	100%