Putative sodium/sulphate symporter

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Low-affinity phosphate transporter PHO91

Species:

Leishmania mexicana

UniProt:

E9B0B5_LEIMU

TriTrypDb:

LmxM.28.2930

Length:

734

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

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Cellular components
Term	Name	Level	Count
GO:0000331	contractile vacuole	6	1
GO:0005773	vacuole	5	1
GO:0005777	peroxisome	6	1
GO:0016020	membrane	2	10
GO:0020015	glycosome	7	1
GO:0031410	cytoplasmic vesicle	6	1
GO:0031982	vesicle	4	1
GO:0042579	microbody	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1

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Expansion

Sequence features

E9B0B5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B0B5

Function

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Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	1
GO:0006793	phosphorus metabolic process	3	1
GO:0006797	polyphosphate metabolic process	4	1
GO:0006810	transport	3	4
GO:0006811	monoatomic ion transport	4	1
GO:0006817	phosphate ion transport	7	1
GO:0006820	monoatomic anion transport	5	1
GO:0006873	intracellular monoatomic ion homeostasis	4	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	4

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Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	7
GO:0005315	inorganic phosphate transmembrane transporter activity	4	1
GO:0015291	secondary active transmembrane transporter activity	4	1
GO:0015318	inorganic molecular entity transmembrane transporter activity	3	1
GO:0022804	active transmembrane transporter activity	3	1
GO:0022857	transmembrane transporter activity	2	7

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	122	126	PF00656	0.763
CLV_C14_Caspase3-7	604	608	PF00656	0.365
CLV_NRD_NRD_1	187	189	PF00675	0.348
CLV_NRD_NRD_1	236	238	PF00675	0.351
CLV_NRD_NRD_1	87	89	PF00675	0.456
CLV_NRD_NRD_1	92	94	PF00675	0.496
CLV_PCSK_KEX2_1	142	144	PF00082	0.471
CLV_PCSK_KEX2_1	23	25	PF00082	0.356
CLV_PCSK_KEX2_1	5	7	PF00082	0.407
CLV_PCSK_KEX2_1	92	94	PF00082	0.507

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HWP2	Leptomonas seymouri	80%	99%
A0A1X0NQK1	Trypanosomatidae	65%	100%
A0A3Q8IB88	Leishmania donovani	95%	100%
A0A422NG32	Trypanosoma rangeli	72%	100%
A4HGZ6	Leishmania braziliensis	90%	100%
A4I428	Leishmania infantum	96%	100%
D0A8X9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	63%	100%
P27514	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	33%	82%
Q21339	Caenorhabditis elegans	26%	100%
Q4Q7W9	Leishmania major	95%	100%

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