Conserved oligomeric Golgi complex subunit 8

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

oligomeric golgi complex component 8, putative

Species:

Leishmania mexicana

UniProt:

E9B0B2_LEIMU

TriTrypDb:

LmxM.28.2900

Length:

531

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	12
GO:0017119	Golgi transport complex	3	12
GO:0032991	protein-containing complex	1	12
GO:0099023	vesicle tethering complex	2	12
GO:0110165	cellular anatomical entity	1	12
GO:0000139	Golgi membrane	5	3
GO:0031090	organelle membrane	3	3
GO:0098588	bounding membrane of organelle	4	3

Expansion

Sequence features

E9B0B2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B0B2

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	12
GO:0008104	protein localization	4	12
GO:0009987	cellular process	1	12
GO:0015031	protein transport	4	12
GO:0033036	macromolecule localization	2	12
GO:0045184	establishment of protein localization	3	12
GO:0051179	localization	1	12
GO:0051234	establishment of localization	2	12
GO:0051641	cellular localization	2	12
GO:0070727	cellular macromolecule localization	3	12
GO:0071702	organic substance transport	4	12
GO:0071705	nitrogen compound transport	4	12
GO:0006891	intra-Golgi vesicle-mediated transport	6	1
GO:0016192	vesicle-mediated transport	4	1
GO:0048193	Golgi vesicle transport	5	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	170	172	PF00675	0.305
CLV_NRD_NRD_1	382	384	PF00675	0.374
CLV_PCSK_KEX2_1	170	172	PF00082	0.305
CLV_PCSK_SKI1_1	180	184	PF00082	0.316
CLV_PCSK_SKI1_1	192	196	PF00082	0.321
CLV_PCSK_SKI1_1	210	214	PF00082	0.343
CLV_PCSK_SKI1_1	239	243	PF00082	0.416
CLV_PCSK_SKI1_1	384	388	PF00082	0.525
CLV_PCSK_SKI1_1	424	428	PF00082	0.426
CLV_PCSK_SKI1_1	48	52	PF00082	0.405
DOC_CDC14_PxL_1	410	418	PF14671	0.574
DOC_CYCLIN_RxL_1	187	199	PF00134	0.440
DOC_CYCLIN_RxL_1	381	391	PF00134	0.513
DOC_CYCLIN_yCln2_LP_2	437	443	PF00134	0.452
DOC_CYCLIN_yCln2_LP_2	504	507	PF00134	0.448
DOC_PP2B_LxvP_1	491	494	PF13499	0.448
DOC_PP2B_LxvP_1	504	507	PF13499	0.623
DOC_USP7_MATH_1	198	202	PF00917	0.321
DOC_USP7_MATH_1	284	288	PF00917	0.456
DOC_USP7_MATH_1	35	39	PF00917	0.316
DOC_USP7_MATH_1	484	488	PF00917	0.651
DOC_USP7_MATH_1	498	502	PF00917	0.714
DOC_USP7_MATH_1	517	521	PF00917	0.692
DOC_USP7_MATH_1	67	71	PF00917	0.446
DOC_USP7_MATH_1	81	85	PF00917	0.412
DOC_WW_Pin1_4	172	177	PF00397	0.426
DOC_WW_Pin1_4	354	359	PF00397	0.439
DOC_WW_Pin1_4	91	96	PF00397	0.452
LIG_14-3-3_CanoR_1	103	107	PF00244	0.456
LIG_14-3-3_CanoR_1	239	248	PF00244	0.400
LIG_14-3-3_CanoR_1	289	298	PF00244	0.420
LIG_14-3-3_CanoR_1	315	325	PF00244	0.463
LIG_14-3-3_CanoR_1	331	335	PF00244	0.379
LIG_APCC_ABBAyCdc20_2	103	109	PF00400	0.305
LIG_Clathr_ClatBox_1	111	115	PF01394	0.305
LIG_Clathr_ClatBox_1	473	477	PF01394	0.526
LIG_EH1_1	443	451	PF00400	0.487
LIG_EH1_1	466	474	PF00400	0.547
LIG_eIF4E_1	163	169	PF01652	0.426
LIG_FHA_1	240	246	PF00498	0.451
LIG_FHA_1	290	296	PF00498	0.352
LIG_FHA_1	355	361	PF00498	0.526
LIG_FHA_1	460	466	PF00498	0.577
LIG_FHA_1	49	55	PF00498	0.420
LIG_FHA_1	500	506	PF00498	0.675
LIG_FHA_1	511	517	PF00498	0.678
LIG_FHA_2	351	357	PF00498	0.603
LIG_FHA_2	40	46	PF00498	0.420
LIG_GBD_Chelix_1	368	376	PF00786	0.379
LIG_LIR_Gen_1	21	31	PF02991	0.407
LIG_LIR_Gen_1	377	387	PF02991	0.376
LIG_LIR_Gen_1	59	67	PF02991	0.452
LIG_LIR_LC3C_4	272	277	PF02991	0.452
LIG_LIR_Nem_3	160	166	PF02991	0.412
LIG_LIR_Nem_3	21	26	PF02991	0.353
LIG_LIR_Nem_3	377	382	PF02991	0.358
LIG_LIR_Nem_3	59	63	PF02991	0.452
LIG_LYPXL_yS_3	439	442	PF13949	0.392
LIG_MAD2	87	95	PF02301	0.452
LIG_Pex14_2	430	434	PF04695	0.350
LIG_SH2_CRK	163	167	PF00017	0.426
LIG_SH2_CRK	205	209	PF00017	0.305
LIG_SH2_PTP2	211	214	PF00017	0.426
LIG_SH2_STAP1	205	209	PF00017	0.308
LIG_SH2_STAT3	128	131	PF00017	0.414
LIG_SH2_STAT3	190	193	PF00017	0.444
LIG_SH2_STAT3	66	69	PF00017	0.374
LIG_SH2_STAT5	128	131	PF00017	0.409
LIG_SH2_STAT5	190	193	PF00017	0.344
LIG_SH2_STAT5	211	214	PF00017	0.321
LIG_SH2_STAT5	335	338	PF00017	0.596
LIG_SH2_STAT5	441	444	PF00017	0.413
LIG_SH3_3	387	393	PF00018	0.481
LIG_SH3_3	473	479	PF00018	0.523
LIG_SH3_3	492	498	PF00018	0.693
LIG_SH3_3	503	509	PF00018	0.673
LIG_SH3_3	513	519	PF00018	0.731
LIG_SUMO_SIM_anti_2	271	277	PF11976	0.414
LIG_SUMO_SIM_par_1	154	161	PF11976	0.275
LIG_SUMO_SIM_par_1	87	94	PF11976	0.426
LIG_TRAF2_1	241	244	PF00917	0.426
LIG_TRAF2_1	393	396	PF00917	0.217
LIG_TYR_ITIM	203	208	PF00017	0.362
LIG_TYR_ITIM	209	214	PF00017	0.426
LIG_TYR_ITIM	437	442	PF00017	0.452
LIG_TYR_ITSM	159	166	PF00017	0.426
LIG_UBA3_1	208	216	PF00899	0.414
LIG_WRC_WIRS_1	376	381	PF05994	0.483
LIG_WRC_WIRS_1	427	432	PF05994	0.443
MOD_CK1_1	175	181	PF00069	0.374
MOD_CK1_1	282	288	PF00069	0.397
MOD_CK1_1	340	346	PF00069	0.622
MOD_CK1_1	378	384	PF00069	0.231
MOD_CK1_1	38	44	PF00069	0.378
MOD_CK1_1	487	493	PF00069	0.650
MOD_CK1_1	53	59	PF00069	0.414
MOD_CK2_1	2	8	PF00069	0.586
MOD_CK2_1	229	235	PF00069	0.337
MOD_CK2_1	38	44	PF00069	0.414
MOD_GlcNHglycan	153	156	PF01048	0.348
MOD_GlcNHglycan	284	287	PF01048	0.364
MOD_GlcNHglycan	4	7	PF01048	0.632
MOD_GlcNHglycan	420	423	PF01048	0.551
MOD_GlcNHglycan	527	530	PF01048	0.737
MOD_GSK3_1	151	158	PF00069	0.409
MOD_GSK3_1	239	246	PF00069	0.436
MOD_GSK3_1	278	285	PF00069	0.300
MOD_GSK3_1	316	323	PF00069	0.467
MOD_GSK3_1	326	333	PF00069	0.449
MOD_GSK3_1	337	344	PF00069	0.523
MOD_GSK3_1	35	42	PF00069	0.408
MOD_GSK3_1	350	357	PF00069	0.410
MOD_GSK3_1	374	381	PF00069	0.244
MOD_N-GLC_1	268	273	PF02516	0.321
MOD_N-GLC_1	337	342	PF02516	0.629
MOD_NEK2_1	1	6	PF00069	0.647
MOD_NEK2_1	183	188	PF00069	0.411
MOD_NEK2_1	325	330	PF00069	0.457
MOD_NEK2_1	342	347	PF00069	0.470
MOD_NEK2_1	375	380	PF00069	0.421
MOD_NEK2_1	415	420	PF00069	0.557
MOD_NEK2_1	50	55	PF00069	0.316
MOD_NEK2_2	330	335	PF00069	0.544
MOD_PIKK_1	459	465	PF00454	0.583
MOD_PIKK_1	58	64	PF00454	0.340
MOD_PKA_2	102	108	PF00069	0.467
MOD_PKA_2	11	17	PF00069	0.404
MOD_PKA_2	317	323	PF00069	0.496
MOD_PKA_2	330	336	PF00069	0.385
MOD_Plk_1	198	204	PF00069	0.393
MOD_Plk_1	220	226	PF00069	0.426
MOD_Plk_1	243	249	PF00069	0.411
MOD_Plk_1	337	343	PF00069	0.607
MOD_Plk_4	102	108	PF00069	0.404
MOD_Plk_4	11	17	PF00069	0.426
MOD_Plk_4	198	204	PF00069	0.451
MOD_Plk_4	243	249	PF00069	0.426
MOD_Plk_4	330	336	PF00069	0.542
MOD_Plk_4	343	349	PF00069	0.583
MOD_Plk_4	415	421	PF00069	0.522
MOD_Plk_4	426	432	PF00069	0.359
MOD_Plk_4	500	506	PF00069	0.570
MOD_ProDKin_1	172	178	PF00069	0.426
MOD_ProDKin_1	354	360	PF00069	0.442
MOD_ProDKin_1	91	97	PF00069	0.452
TRG_DiLeu_BaEn_1	397	402	PF01217	0.485
TRG_DiLeu_BaEn_1	93	98	PF01217	0.426
TRG_DiLeu_BaEn_2	422	428	PF01217	0.525
TRG_DiLeu_BaLyEn_6	411	416	PF01217	0.541
TRG_DiLeu_BaLyEn_6	445	450	PF01217	0.433
TRG_ENDOCYTIC_2	163	166	PF00928	0.426
TRG_ENDOCYTIC_2	205	208	PF00928	0.305
TRG_ENDOCYTIC_2	211	214	PF00928	0.418
TRG_ENDOCYTIC_2	23	26	PF00928	0.322
TRG_ENDOCYTIC_2	439	442	PF00928	0.408
TRG_ER_diArg_1	169	171	PF00400	0.305
TRG_ER_diArg_1	184	187	PF00400	0.305
TRG_NES_CRM1_1	109	122	PF08389	0.426
TRG_NES_CRM1_1	293	304	PF08389	0.161
TRG_Pf-PMV_PEXEL_1	192	196	PF00026	0.374
TRG_Pf-PMV_PEXEL_1	399	404	PF00026	0.509

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKS6	Leptomonas seymouri	68%	88%
A0A0S4IRC0	Bodo saltans	33%	100%
A0A1X0NS75	Trypanosomatidae	39%	100%
A0A3R7LW05	Trypanosoma rangeli	37%	100%
A0A3S7X1Y9	Leishmania donovani	93%	100%
A4HGZ3	Leishmania braziliensis	85%	100%
A4I425	Leishmania infantum	93%	100%
D0A8Y2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
Q2TBH9	Bos taurus	25%	85%
Q4Q7X2	Leishmania major	93%	100%
Q84K25	Arabidopsis thaliana	23%	93%
Q96MW5	Homo sapiens	24%	87%
Q9JJA2	Mus musculus	26%	83%
V5BI51	Trypanosoma cruzi	39%	100%