Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B0B1_LEIMU

TriTrypDb:

LmxM.28.2890

Length:

385

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B0B1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B0B1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	354	358	PF00656	0.489
CLV_NRD_NRD_1	180	182	PF00675	0.463
CLV_NRD_NRD_1	273	275	PF00675	0.411
CLV_NRD_NRD_1	98	100	PF00675	0.545
CLV_PCSK_FUR_1	55	59	PF00082	0.612
CLV_PCSK_KEX2_1	125	127	PF00082	0.537
CLV_PCSK_KEX2_1	180	182	PF00082	0.463
CLV_PCSK_KEX2_1	273	275	PF00082	0.411
CLV_PCSK_KEX2_1	57	59	PF00082	0.610
CLV_PCSK_KEX2_1	98	100	PF00082	0.605
CLV_PCSK_PC1ET2_1	125	127	PF00082	0.506
CLV_PCSK_PC1ET2_1	57	59	PF00082	0.610
CLV_PCSK_SKI1_1	208	212	PF00082	0.603
CLV_PCSK_SKI1_1	214	218	PF00082	0.519
CLV_PCSK_SKI1_1	273	277	PF00082	0.430
DEG_SPOP_SBC_1	5	9	PF00917	0.561
DOC_USP7_MATH_1	179	183	PF00917	0.584
DOC_USP7_MATH_1	240	244	PF00917	0.420
DOC_USP7_MATH_1	344	348	PF00917	0.617
DOC_USP7_MATH_1	351	355	PF00917	0.577
DOC_USP7_MATH_2	14	20	PF00917	0.551
DOC_WW_Pin1_4	361	366	PF00397	0.666
DOC_WW_Pin1_4	368	373	PF00397	0.629
DOC_WW_Pin1_4	9	14	PF00397	0.560
LIG_14-3-3_CanoR_1	180	184	PF00244	0.526
LIG_14-3-3_CanoR_1	189	193	PF00244	0.457
LIG_14-3-3_CanoR_1	299	305	PF00244	0.466
LIG_14-3-3_CanoR_1	51	59	PF00244	0.611
LIG_BIR_II_1	1	5	PF00653	0.583
LIG_BIR_III_4	357	361	PF00653	0.577
LIG_BRCT_BRCA1_1	317	321	PF00533	0.356
LIG_Clathr_ClatBox_1	172	176	PF01394	0.465
LIG_FHA_1	167	173	PF00498	0.499
LIG_FHA_1	295	301	PF00498	0.418
LIG_FHA_1	368	374	PF00498	0.589
LIG_FHA_1	51	57	PF00498	0.570
LIG_FHA_2	262	268	PF00498	0.514
LIG_FHA_2	301	307	PF00498	0.484
LIG_LIR_Gen_1	142	151	PF02991	0.493
LIG_LIR_Gen_1	318	328	PF02991	0.392
LIG_LIR_Gen_1	69	78	PF02991	0.454
LIG_LIR_Nem_3	142	146	PF02991	0.493
LIG_LIR_Nem_3	153	157	PF02991	0.364
LIG_LIR_Nem_3	269	275	PF02991	0.464
LIG_LIR_Nem_3	287	293	PF02991	0.451
LIG_LIR_Nem_3	303	307	PF02991	0.459
LIG_LIR_Nem_3	318	324	PF02991	0.312
LIG_LIR_Nem_3	69	75	PF02991	0.511
LIG_Pex14_2	272	276	PF04695	0.313
LIG_RPA_C_Fungi	46	58	PF08784	0.597
LIG_SH2_CRK	162	166	PF00017	0.405
LIG_SH2_CRK	293	297	PF00017	0.454
LIG_SH2_NCK_1	187	191	PF00017	0.483
LIG_SH2_NCK_1	293	297	PF00017	0.454
LIG_SH2_NCK_1	78	82	PF00017	0.455
LIG_SH2_SRC	143	146	PF00017	0.314
LIG_SH2_SRC	38	41	PF00017	0.384
LIG_SH2_STAP1	143	147	PF00017	0.482
LIG_SH2_STAP1	317	321	PF00017	0.377
LIG_SH2_STAP1	34	38	PF00017	0.657
LIG_SH2_STAP1	78	82	PF00017	0.542
LIG_SH2_STAT3	317	320	PF00017	0.377
LIG_SH2_STAT3	34	37	PF00017	0.544
LIG_SH2_STAT5	290	293	PF00017	0.379
LIG_SH2_STAT5	34	37	PF00017	0.544
LIG_SH2_STAT5	67	70	PF00017	0.462
LIG_SH2_STAT5	78	81	PF00017	0.517
LIG_SH3_2	121	126	PF14604	0.717
LIG_SH3_3	118	124	PF00018	0.708
LIG_SH3_3	359	365	PF00018	0.595
LIG_SH3_3	369	375	PF00018	0.644
LIG_SH3_3	53	59	PF00018	0.496
LIG_SUMO_SIM_anti_2	129	136	PF11976	0.528
LIG_SUMO_SIM_par_1	145	150	PF11976	0.418
LIG_SUMO_SIM_par_1	242	249	PF11976	0.392
LIG_TYR_ITIM	291	296	PF00017	0.434
LIG_WRC_WIRS_1	321	326	PF05994	0.305
LIG_WW_3	12	16	PF00397	0.566
MOD_CDC14_SPxK_1	12	15	PF00782	0.502
MOD_CDK_SPxK_1	9	15	PF00069	0.500
MOD_CK1_1	19	25	PF00069	0.513
MOD_CK1_1	363	369	PF00069	0.585
MOD_CK1_1	76	82	PF00069	0.636
MOD_CK1_1	9	15	PF00069	0.584
MOD_CK1_1	91	97	PF00069	0.473
MOD_CK2_1	18	24	PF00069	0.567
MOD_CK2_1	261	267	PF00069	0.477
MOD_CK2_1	300	306	PF00069	0.483
MOD_CK2_1	59	65	PF00069	0.523
MOD_GlcNHglycan	18	21	PF01048	0.505
MOD_GlcNHglycan	353	356	PF01048	0.533
MOD_GlcNHglycan	79	82	PF01048	0.524
MOD_GlcNHglycan	8	11	PF01048	0.619
MOD_GlcNHglycan	90	93	PF01048	0.548
MOD_GSK3_1	18	25	PF00069	0.567
MOD_GSK3_1	363	370	PF00069	0.591
MOD_GSK3_1	5	12	PF00069	0.531
MOD_GSK3_1	73	80	PF00069	0.539
MOD_N-GLC_1	5	10	PF02516	0.603
MOD_NEK2_1	300	305	PF00069	0.412
MOD_NEK2_1	77	82	PF00069	0.523
MOD_PIKK_1	32	38	PF00454	0.542
MOD_PKA_2	179	185	PF00069	0.539
MOD_PKA_2	188	194	PF00069	0.457
MOD_PKA_2	300	306	PF00069	0.466
MOD_PKA_2	50	56	PF00069	0.595
MOD_Plk_1	199	205	PF00069	0.362
MOD_Plk_1	315	321	PF00069	0.377
MOD_Plk_1	73	79	PF00069	0.569
MOD_Plk_2-3	263	269	PF00069	0.464
MOD_Plk_4	150	156	PF00069	0.384
MOD_Plk_4	188	194	PF00069	0.360
MOD_Plk_4	240	246	PF00069	0.536
MOD_Plk_4	344	350	PF00069	0.489
MOD_Plk_4	73	79	PF00069	0.521
MOD_ProDKin_1	361	367	PF00069	0.669
MOD_ProDKin_1	368	374	PF00069	0.628
MOD_ProDKin_1	9	15	PF00069	0.562
MOD_SUMO_rev_2	145	154	PF00179	0.403
TRG_DiLeu_BaEn_1	206	211	PF01217	0.416
TRG_DiLeu_BaEn_2	149	155	PF01217	0.475
TRG_DiLeu_BaEn_2	305	311	PF01217	0.485
TRG_DiLeu_BaLyEn_6	205	210	PF01217	0.419
TRG_DiLeu_BaLyEn_6	225	230	PF01217	0.342
TRG_ENDOCYTIC_2	143	146	PF00928	0.612
TRG_ENDOCYTIC_2	162	165	PF00928	0.311
TRG_ENDOCYTIC_2	293	296	PF00928	0.472
TRG_ENDOCYTIC_2	304	307	PF00928	0.416
TRG_ER_diArg_1	109	112	PF00400	0.396
TRG_ER_diArg_1	211	214	PF00400	0.426
TRG_ER_diArg_1	272	274	PF00400	0.433
TRG_ER_diArg_1	334	337	PF00400	0.491
TRG_ER_diArg_1	97	99	PF00400	0.647

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5J9	Leptomonas seymouri	48%	100%
A0A3S7X1Y7	Leishmania donovani	86%	100%
A4HGZ2	Leishmania braziliensis	71%	100%
A4I424	Leishmania infantum	86%	100%
Q4Q7X3	Leishmania major	85%	100%