DUF4205 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9B0A9_LEIMU

TriTrypDb:

LmxM.28.2870

Length:

250

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B0A9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B0A9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	57	61	PF00656	0.592
CLV_NRD_NRD_1	122	124	PF00675	0.679
CLV_NRD_NRD_1	125	127	PF00675	0.666
CLV_NRD_NRD_1	74	76	PF00675	0.629
CLV_NRD_NRD_1	87	89	PF00675	0.510
CLV_PCSK_KEX2_1	122	124	PF00082	0.679
CLV_PCSK_KEX2_1	74	76	PF00082	0.629
CLV_PCSK_KEX2_1	87	89	PF00082	0.510
CLV_PCSK_SKI1_1	208	212	PF00082	0.543
CLV_PCSK_SKI1_1	225	229	PF00082	0.481
CLV_PCSK_SKI1_1	74	78	PF00082	0.711
DEG_APCC_DBOX_1	74	82	PF00400	0.716
DOC_MAPK_gen_1	22	29	PF00069	0.509
DOC_MAPK_gen_1	87	95	PF00069	0.540
DOC_PP1_RVXF_1	238	245	PF00149	0.480
DOC_USP7_MATH_1	198	202	PF00917	0.570
DOC_USP7_MATH_1	45	49	PF00917	0.529
DOC_USP7_MATH_1	67	71	PF00917	0.516
DOC_WW_Pin1_4	156	161	PF00397	0.622
LIG_14-3-3_CanoR_1	24	28	PF00244	0.571
LIG_BIR_II_1	1	5	PF00653	0.556
LIG_BRCT_BRCA1_1	200	204	PF00533	0.635
LIG_Clathr_ClatBox_1	147	151	PF01394	0.539
LIG_FHA_1	106	112	PF00498	0.556
LIG_FHA_1	181	187	PF00498	0.629
LIG_FHA_1	24	30	PF00498	0.676
LIG_FHA_2	95	101	PF00498	0.635
LIG_GBD_Chelix_1	85	93	PF00786	0.496
LIG_LIR_Nem_3	100	106	PF02991	0.588
LIG_LIR_Nem_3	201	207	PF02991	0.489
LIG_REV1ctd_RIR_1	202	212	PF16727	0.495
LIG_SH2_NCK_1	195	199	PF00017	0.469
LIG_SH2_SRC	195	198	PF00017	0.459
LIG_SH2_STAT5	120	123	PF00017	0.460
LIG_SH3_2	17	22	PF14604	0.535
LIG_SH3_3	14	20	PF00018	0.538
LIG_SUMO_SIM_anti_2	143	149	PF11976	0.512
LIG_SUMO_SIM_anti_2	96	103	PF11976	0.588
LIG_SUMO_SIM_par_1	25	31	PF11976	0.531
LIG_TRAF2_1	48	51	PF00917	0.451
LIG_TYR_ITIM	101	106	PF00017	0.548
MOD_CK1_1	155	161	PF00069	0.583
MOD_CK1_1	164	170	PF00069	0.620
MOD_CK1_1	94	100	PF00069	0.635
MOD_CK2_1	174	180	PF00069	0.573
MOD_CK2_1	45	51	PF00069	0.551
MOD_CK2_1	94	100	PF00069	0.454
MOD_GlcNHglycan	154	157	PF01048	0.621
MOD_GlcNHglycan	213	216	PF01048	0.456
MOD_GlcNHglycan	69	72	PF01048	0.623
MOD_GSK3_1	151	158	PF00069	0.609
MOD_GSK3_1	170	177	PF00069	0.599
MOD_GSK3_1	89	96	PF00069	0.606
MOD_N-GLC_1	60	65	PF02516	0.574
MOD_NEK2_1	141	146	PF00069	0.502
MOD_NEK2_1	152	157	PF00069	0.588
MOD_NEK2_1	38	43	PF00069	0.404
MOD_NEK2_1	89	94	PF00069	0.678
MOD_PIKK_1	170	176	PF00454	0.660
MOD_PIKK_1	187	193	PF00454	0.380
MOD_PKA_2	23	29	PF00069	0.578
MOD_Plk_2-3	54	60	PF00069	0.606
MOD_Plk_4	141	147	PF00069	0.491
MOD_Plk_4	164	170	PF00069	0.602
MOD_Plk_4	174	180	PF00069	0.460
MOD_Plk_4	190	196	PF00069	0.426
MOD_Plk_4	23	29	PF00069	0.578
MOD_ProDKin_1	156	162	PF00069	0.624
MOD_SUMO_for_1	218	221	PF00179	0.536
TRG_DiLeu_BaEn_1	143	148	PF01217	0.503
TRG_ENDOCYTIC_2	103	106	PF00928	0.593
TRG_ER_diArg_1	121	123	PF00400	0.685
TRG_ER_diArg_1	73	75	PF00400	0.642
TRG_ER_diArg_1	87	89	PF00400	0.500
TRG_NES_CRM1_1	137	151	PF08389	0.497
TRG_NLS_MonoExtN_4	123	130	PF00514	0.578
TRG_Pf-PMV_PEXEL_1	87	91	PF00026	0.590

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I6I3	Leptomonas seymouri	50%	96%
A0A3Q8IE62	Leishmania donovani	91%	100%
A4HGZ0	Leishmania braziliensis	84%	100%
A4I422	Leishmania infantum	90%	100%
Q4Q7X5	Leishmania major	91%	100%