Malate dehydrogenase

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cytosolic malate dehydrogenase, putative

Species:

Leishmania mexicana

UniProt:

E9B0A8_LEIMU

TriTrypDb:

LmxM.28.2860

Length:

324

Annotations

LeishMANIAdb annotations

A group of metabolic enzymes without any likely TM segment. Very conserved in Eukaryota.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 4
Forrest at al. (procyclic)	no	yes: 4
Silverman et al.	no	yes: 2
Pissara et al.	no	yes: 8

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 4

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

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Cellular components
Term	Name	Level	Count
GO:0005829	cytosol	2	1
GO:0110165	cellular anatomical entity	1	1

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Expansion

Sequence features

E9B0A8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B0A8

PDB structure(s): 4h7p_A , 4h7p_B , 4i1i_A , 4i1i_B

Function

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Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	11
GO:0006099	tricarboxylic acid cycle	3	10
GO:0006107	oxaloacetate metabolic process	7	1
GO:0006108	malate metabolic process	7	11
GO:0006734	NADH metabolic process	2	1
GO:0008152	metabolic process	1	11
GO:0009987	cellular process	1	11
GO:0019752	carboxylic acid metabolic process	5	11
GO:0043436	oxoacid metabolic process	4	11
GO:0043648	dicarboxylic acid metabolic process	6	11

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Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	1
GO:0003824	catalytic activity	1	11
GO:0005488	binding	1	1
GO:0016491	oxidoreductase activity	2	11
GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	3	11
GO:0016615	malate dehydrogenase activity	4	11
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	4	11
GO:0030060	L-malate dehydrogenase activity	5	11
GO:0036094	small molecule binding	2	1
GO:0097159	organic cyclic compound binding	2	1

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	168	170	PF00675	0.455
CLV_NRD_NRD_1	91	93	PF00675	0.338
CLV_NRD_NRD_1	96	98	PF00675	0.242
CLV_PCSK_KEX2_1	91	93	PF00082	0.214
CLV_PCSK_SKI1_1	106	110	PF00082	0.295
CLV_PCSK_SKI1_1	150	154	PF00082	0.423
CLV_PCSK_SKI1_1	25	29	PF00082	0.455
CLV_PCSK_SKI1_1	74	78	PF00082	0.353
CLV_PCSK_SKI1_1	98	102	PF00082	0.295
DEG_APCC_DBOX_1	96	104	PF00400	0.455

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6H7	Leptomonas seymouri	27%	100%
A0A0N1HYD1	Leptomonas seymouri	28%	100%
A0A0S4IRB3	Bodo saltans	63%	98%
A0A1X0NQI1	Trypanosomatidae	60%	98%
A0A1X0P752	Trypanosomatidae	29%	100%
A0A3Q8IH05	Leishmania donovani	95%	100%
A0A3Q8IKK8	Leishmania donovani	29%	98%
A0A3R7MEL1	Trypanosoma rangeli	55%	97%
A0A3S7WVE3	Leishmania donovani	28%	100%
A0A422NMV1	Trypanosoma rangeli	28%	100%

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