Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B0A7_LEIMU

TriTrypDb:

LmxM.28.2850

Length:

463

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	1
GO:0042995	cell projection	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0110165	cellular anatomical entity	1	1
GO:0120025	plasma membrane bounded cell projection	3	1

Expansion

Sequence features

E9B0A7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B0A7

Function

Biological processes
Term	Name	Level	Count
GO:0006355	regulation of DNA-templated transcription	6	1
GO:0009889	regulation of biosynthetic process	4	1
GO:0010468	regulation of gene expression	5	1
GO:0010556	regulation of macromolecule biosynthetic process	5	1
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	1
GO:0019222	regulation of metabolic process	3	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0031326	regulation of cellular biosynthetic process	5	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051171	regulation of nitrogen compound metabolic process	4	1
GO:0051252	regulation of RNA metabolic process	5	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0065007	biological regulation	1	1
GO:0080090	regulation of primary metabolic process	4	1
GO:1903506	regulation of nucleic acid-templated transcription	7	1
GO:2001141	regulation of RNA biosynthetic process	6	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	1
GO:0005488	binding	1	1
GO:0005524	ATP binding	5	1
GO:0017076	purine nucleotide binding	4	1
GO:0030554	adenyl nucleotide binding	5	1
GO:0032553	ribonucleotide binding	3	1
GO:0032555	purine ribonucleotide binding	4	1
GO:0032559	adenyl ribonucleotide binding	5	1
GO:0035639	purine ribonucleoside triphosphate binding	4	1
GO:0036094	small molecule binding	2	1
GO:0043167	ion binding	2	1
GO:0043168	anion binding	3	1
GO:0097159	organic cyclic compound binding	2	1
GO:0097367	carbohydrate derivative binding	2	1
GO:1901265	nucleoside phosphate binding	3	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	350	354	PF00656	0.710
CLV_NRD_NRD_1	117	119	PF00675	0.526
CLV_NRD_NRD_1	147	149	PF00675	0.587
CLV_NRD_NRD_1	257	259	PF00675	0.458
CLV_NRD_NRD_1	40	42	PF00675	0.649
CLV_NRD_NRD_1	67	69	PF00675	0.571
CLV_NRD_NRD_1	8	10	PF00675	0.468
CLV_PCSK_KEX2_1	117	119	PF00082	0.508
CLV_PCSK_KEX2_1	147	149	PF00082	0.516
CLV_PCSK_KEX2_1	175	177	PF00082	0.663
CLV_PCSK_KEX2_1	257	259	PF00082	0.458
CLV_PCSK_KEX2_1	321	323	PF00082	0.493
CLV_PCSK_KEX2_1	40	42	PF00082	0.647
CLV_PCSK_KEX2_1	458	460	PF00082	0.671
CLV_PCSK_KEX2_1	7	9	PF00082	0.474
CLV_PCSK_PC1ET2_1	175	177	PF00082	0.685
CLV_PCSK_PC1ET2_1	321	323	PF00082	0.504
CLV_PCSK_PC1ET2_1	458	460	PF00082	0.705
CLV_PCSK_PC7_1	143	149	PF00082	0.580
CLV_PCSK_PC7_1	4	10	PF00082	0.454
CLV_PCSK_SKI1_1	117	121	PF00082	0.642
CLV_PCSK_SKI1_1	147	151	PF00082	0.563
CLV_PCSK_SKI1_1	321	325	PF00082	0.442
CLV_Separin_Metazoa	246	250	PF03568	0.538
DEG_APCC_DBOX_1	116	124	PF00400	0.621
DEG_Nend_UBRbox_2	1	3	PF02207	0.696
DEG_SCF_FBW7_1	274	281	PF00400	0.418
DOC_ANK_TNKS_1	248	255	PF00023	0.528
DOC_CDC14_PxL_1	198	206	PF14671	0.538
DOC_CDC14_PxL_1	432	440	PF14671	0.521
DOC_CKS1_1	130	135	PF01111	0.600
DOC_CYCLIN_RxL_1	114	125	PF00134	0.655
DOC_CYCLIN_RxL_1	157	169	PF00134	0.551
DOC_CYCLIN_yCln2_LP_2	189	195	PF00134	0.491
DOC_CYCLIN_yCln2_LP_2	290	296	PF00134	0.451
DOC_CYCLIN_yCln2_LP_2	311	317	PF00134	0.445
DOC_CYCLIN_yCln2_LP_2	362	368	PF00134	0.705
DOC_MAPK_gen_1	147	153	PF00069	0.556
DOC_MAPK_gen_1	305	315	PF00069	0.440
DOC_MAPK_MEF2A_6	305	313	PF00069	0.505
DOC_PP1_RVXF_1	208	215	PF00149	0.403
DOC_PP2B_LxvP_1	187	190	PF13499	0.516
DOC_PP2B_LxvP_1	290	293	PF13499	0.450
DOC_PP2B_LxvP_1	311	314	PF13499	0.468
DOC_PP4_FxxP_1	98	101	PF00568	0.579
DOC_USP7_MATH_1	155	159	PF00917	0.565
DOC_USP7_MATH_1	16	20	PF00917	0.574
DOC_USP7_MATH_1	217	221	PF00917	0.605
DOC_USP7_MATH_1	23	27	PF00917	0.643
DOC_USP7_MATH_1	368	372	PF00917	0.725
DOC_USP7_UBL2_3	458	462	PF12436	0.724
DOC_WW_Pin1_4	129	134	PF00397	0.459
DOC_WW_Pin1_4	179	184	PF00397	0.587
DOC_WW_Pin1_4	19	24	PF00397	0.682
DOC_WW_Pin1_4	25	30	PF00397	0.712
DOC_WW_Pin1_4	274	279	PF00397	0.659
DOC_WW_Pin1_4	283	288	PF00397	0.692
DOC_WW_Pin1_4	356	361	PF00397	0.589
DOC_WW_Pin1_4	375	380	PF00397	0.729
DOC_WW_Pin1_4	76	81	PF00397	0.724
LIG_14-3-3_CanoR_1	148	154	PF00244	0.542
LIG_14-3-3_CanoR_1	40	48	PF00244	0.637
LIG_Actin_WH2_2	306	323	PF00022	0.529
LIG_APCC_ABBA_1	164	169	PF00400	0.503
LIG_BIR_III_4	353	357	PF00653	0.683
LIG_CSL_BTD_1	311	314	PF09270	0.517
LIG_DLG_GKlike_1	47	54	PF00625	0.551
LIG_FHA_1	161	167	PF00498	0.557
LIG_FHA_1	19	25	PF00498	0.552
LIG_FHA_1	357	363	PF00498	0.749
LIG_FHA_1	409	415	PF00498	0.454
LIG_FHA_2	203	209	PF00498	0.437
LIG_FHA_2	371	377	PF00498	0.717
LIG_FHA_2	411	417	PF00498	0.462
LIG_FHA_2	449	455	PF00498	0.767
LIG_LIR_Apic_2	269	274	PF02991	0.606
LIG_LIR_Apic_2	402	407	PF02991	0.536
LIG_LIR_Gen_1	295	303	PF02991	0.402
LIG_LIR_Gen_1	426	436	PF02991	0.523
LIG_LIR_Gen_1	46	54	PF02991	0.589
LIG_LIR_LC3C_4	263	267	PF02991	0.475
LIG_LIR_Nem_3	295	299	PF02991	0.391
LIG_LIR_Nem_3	310	315	PF02991	0.352
LIG_LIR_Nem_3	46	51	PF02991	0.572
LIG_LYPXL_S_1	405	409	PF13949	0.549
LIG_LYPXL_yS_3	406	409	PF13949	0.521
LIG_NRBOX	222	228	PF00104	0.536
LIG_Rb_LxCxE_1	295	310	PF01857	0.242
LIG_SH2_CRK	332	336	PF00017	0.431
LIG_SH2_PTP2	404	407	PF00017	0.269
LIG_SH2_SRC	404	407	PF00017	0.269
LIG_SH2_STAT5	203	206	PF00017	0.455
LIG_SH2_STAT5	225	228	PF00017	0.421
LIG_SH2_STAT5	271	274	PF00017	0.658
LIG_SH2_STAT5	296	299	PF00017	0.508
LIG_SH2_STAT5	404	407	PF00017	0.397
LIG_SH3_3	127	133	PF00018	0.536
LIG_SH3_3	357	363	PF00018	0.611
LIG_SH3_CIN85_PxpxPR_1	76	81	PF14604	0.646
LIG_SUMO_SIM_anti_2	127	132	PF11976	0.565
LIG_SUMO_SIM_par_1	162	169	PF11976	0.578
LIG_SUMO_SIM_par_1	28	34	PF11976	0.734
LIG_SUMO_SIM_par_1	413	419	PF11976	0.557
LIG_TYR_ITIM	330	335	PF00017	0.441
LIG_WRC_WIRS_1	150	155	PF05994	0.444
LIG_WRC_WIRS_1	48	53	PF05994	0.577
LIG_WW_2	360	363	PF00397	0.476
MOD_CDK_SPK_2	76	81	PF00069	0.646
MOD_CDK_SPxxK_3	375	382	PF00069	0.707
MOD_CK1_1	139	145	PF00069	0.488
MOD_CK1_1	19	25	PF00069	0.502
MOD_CK1_1	283	289	PF00069	0.682
MOD_CK1_1	375	381	PF00069	0.764
MOD_CK1_1	384	390	PF00069	0.717
MOD_CK1_1	43	49	PF00069	0.603
MOD_CK1_1	448	454	PF00069	0.765
MOD_CK2_1	285	291	PF00069	0.607
MOD_CK2_1	370	376	PF00069	0.746
MOD_CK2_1	448	454	PF00069	0.763
MOD_Cter_Amidation	38	41	PF01082	0.640
MOD_GlcNHglycan	138	141	PF01048	0.589
MOD_GlcNHglycan	157	160	PF01048	0.269
MOD_GlcNHglycan	18	21	PF01048	0.603
MOD_GlcNHglycan	25	28	PF01048	0.636
MOD_GlcNHglycan	282	285	PF01048	0.683
MOD_GlcNHglycan	327	330	PF01048	0.579
MOD_GlcNHglycan	35	38	PF01048	0.536
MOD_GlcNHglycan	370	373	PF01048	0.733
MOD_GlcNHglycan	383	386	PF01048	0.745
MOD_GlcNHglycan	399	402	PF01048	0.549
MOD_GlcNHglycan	447	450	PF01048	0.606
MOD_GSK3_1	122	129	PF00069	0.424
MOD_GSK3_1	19	26	PF00069	0.647
MOD_GSK3_1	274	281	PF00069	0.681
MOD_GSK3_1	29	36	PF00069	0.660
MOD_GSK3_1	366	373	PF00069	0.692
MOD_GSK3_1	43	50	PF00069	0.586
MOD_N-GLC_1	260	265	PF02516	0.521
MOD_NEK2_1	109	114	PF00069	0.549
MOD_NEK2_1	126	131	PF00069	0.407
MOD_NEK2_1	33	38	PF00069	0.624
MOD_OFUCOSY	344	349	PF10250	0.554
MOD_PIKK_1	196	202	PF00454	0.516
MOD_PIKK_1	217	223	PF00454	0.557
MOD_PKA_1	40	46	PF00069	0.665
MOD_PKA_2	142	148	PF00069	0.585
MOD_PKA_2	3	9	PF00069	0.538
MOD_PKA_2	381	387	PF00069	0.742
MOD_PKA_2	40	46	PF00069	0.665
MOD_Plk_1	126	132	PF00069	0.399
MOD_Plk_1	260	266	PF00069	0.518
MOD_Plk_4	126	132	PF00069	0.407
MOD_Plk_4	261	267	PF00069	0.522
MOD_Plk_4	307	313	PF00069	0.346
MOD_Plk_4	410	416	PF00069	0.486
MOD_ProDKin_1	129	135	PF00069	0.460
MOD_ProDKin_1	179	185	PF00069	0.582
MOD_ProDKin_1	19	25	PF00069	0.684
MOD_ProDKin_1	274	280	PF00069	0.660
MOD_ProDKin_1	283	289	PF00069	0.675
MOD_ProDKin_1	356	362	PF00069	0.591
MOD_ProDKin_1	375	381	PF00069	0.728
MOD_ProDKin_1	76	82	PF00069	0.723
MOD_SUMO_for_1	174	177	PF00179	0.663
MOD_SUMO_rev_2	70	76	PF00179	0.561
TRG_DiLeu_BaLyEn_6	255	260	PF01217	0.413
TRG_DiLeu_BaLyEn_6	26	31	PF01217	0.562
TRG_ENDOCYTIC_2	296	299	PF00928	0.493
TRG_ENDOCYTIC_2	332	335	PF00928	0.429
TRG_ENDOCYTIC_2	406	409	PF00928	0.521
TRG_ENDOCYTIC_2	428	431	PF00928	0.474
TRG_ER_diArg_1	116	118	PF00400	0.510
TRG_ER_diArg_1	146	148	PF00400	0.569
TRG_ER_diArg_1	256	258	PF00400	0.514
TRG_ER_diArg_1	7	9	PF00400	0.662
TRG_NES_CRM1_1	433	445	PF08389	0.517
TRG_NLS_MonoExtN_4	456	461	PF00514	0.775

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I4Z3	Leptomonas seymouri	45%	98%
A0A0S4IUX7	Bodo saltans	25%	100%
A0A1X0NQH2	Trypanosomatidae	28%	100%
A0A3S7X213	Leishmania donovani	92%	100%
A0A422N0P3	Trypanosoma rangeli	27%	100%
A4HGY8	Leishmania braziliensis	78%	100%
A4I420	Leishmania infantum	93%	100%
D0A8Y9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
Q4Q7X7	Leishmania major	92%	100%
V5ATM8	Trypanosoma cruzi	29%	100%