RING-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B0A6_LEIMU

TriTrypDb:

LmxM.28.2840

Length:

492

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B0A6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B0A6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	388	392	PF00656	0.706
CLV_C14_Caspase3-7	410	414	PF00656	0.758
CLV_NRD_NRD_1	156	158	PF00675	0.522
CLV_NRD_NRD_1	177	179	PF00675	0.456
CLV_NRD_NRD_1	265	267	PF00675	0.467
CLV_NRD_NRD_1	274	276	PF00675	0.422
CLV_NRD_NRD_1	326	328	PF00675	0.631
CLV_NRD_NRD_1	361	363	PF00675	0.691
CLV_NRD_NRD_1	480	482	PF00675	0.540
CLV_NRD_NRD_1	54	56	PF00675	0.473
CLV_PCSK_FUR_1	275	279	PF00082	0.458
CLV_PCSK_KEX2_1	156	158	PF00082	0.526
CLV_PCSK_KEX2_1	176	178	PF00082	0.353
CLV_PCSK_KEX2_1	274	276	PF00082	0.470
CLV_PCSK_KEX2_1	277	279	PF00082	0.480
CLV_PCSK_KEX2_1	326	328	PF00082	0.586
CLV_PCSK_KEX2_1	363	365	PF00082	0.675
CLV_PCSK_KEX2_1	480	482	PF00082	0.540
CLV_PCSK_KEX2_1	53	55	PF00082	0.476
CLV_PCSK_PC1ET2_1	277	279	PF00082	0.509
CLV_PCSK_PC1ET2_1	363	365	PF00082	0.672
CLV_PCSK_PC7_1	476	482	PF00082	0.549
CLV_PCSK_SKI1_1	163	167	PF00082	0.525
CLV_PCSK_SKI1_1	177	181	PF00082	0.387
CLV_PCSK_SKI1_1	269	273	PF00082	0.359
CLV_PCSK_SKI1_1	451	455	PF00082	0.576
DEG_SPOP_SBC_1	131	135	PF00917	0.539
DEG_SPOP_SBC_1	223	227	PF00917	0.547
DEG_SPOP_SBC_1	229	233	PF00917	0.533
DEG_SPOP_SBC_1	344	348	PF00917	0.687
DEG_SPOP_SBC_1	4	8	PF00917	0.434
DEG_SPOP_SBC_1	455	459	PF00917	0.583
DOC_ANK_TNKS_1	337	344	PF00023	0.503
DOC_CKS1_1	253	258	PF01111	0.516
DOC_MAPK_gen_1	362	373	PF00069	0.700
DOC_MAPK_MEF2A_6	417	425	PF00069	0.614
DOC_MAPK_MEF2A_6	484	492	PF00069	0.642
DOC_MAPK_RevD_3	143	157	PF00069	0.401
DOC_PP2B_LxvP_1	36	39	PF13499	0.465
DOC_USP7_MATH_1	12	16	PF00917	0.549
DOC_USP7_MATH_1	138	142	PF00917	0.700
DOC_USP7_MATH_1	228	232	PF00917	0.691
DOC_USP7_MATH_1	314	318	PF00917	0.683
DOC_USP7_MATH_1	319	323	PF00917	0.674
DOC_USP7_MATH_1	342	346	PF00917	0.770
DOC_USP7_MATH_1	358	362	PF00917	0.694
DOC_USP7_MATH_1	392	396	PF00917	0.672
DOC_USP7_MATH_1	4	8	PF00917	0.604
DOC_USP7_MATH_1	435	439	PF00917	0.762
DOC_USP7_MATH_1	453	457	PF00917	0.582
DOC_USP7_MATH_1	463	467	PF00917	0.722
DOC_WW_Pin1_4	136	141	PF00397	0.676
DOC_WW_Pin1_4	252	257	PF00397	0.499
DOC_WW_Pin1_4	315	320	PF00397	0.673
DOC_WW_Pin1_4	375	380	PF00397	0.666
DOC_WW_Pin1_4	394	399	PF00397	0.702
DOC_WW_Pin1_4	8	13	PF00397	0.552
LIG_14-3-3_CanoR_1	156	166	PF00244	0.582
LIG_14-3-3_CanoR_1	168	173	PF00244	0.531
LIG_14-3-3_CanoR_1	222	230	PF00244	0.578
LIG_14-3-3_CanoR_1	315	319	PF00244	0.655
LIG_14-3-3_CanoR_1	92	98	PF00244	0.543
LIG_Actin_WH2_2	107	125	PF00022	0.536
LIG_BIR_II_1	1	5	PF00653	0.611
LIG_BIR_III_3	1	5	PF00653	0.611
LIG_BRCT_BRCA1_1	488	492	PF00533	0.650
LIG_Clathr_ClatBox_1	59	63	PF01394	0.618
LIG_deltaCOP1_diTrp_1	482	492	PF00928	0.637
LIG_eIF4E_1	440	446	PF01652	0.649
LIG_FHA_1	148	154	PF00498	0.395
LIG_FHA_1	253	259	PF00498	0.518
LIG_FHA_1	274	280	PF00498	0.603
LIG_FHA_1	465	471	PF00498	0.710
LIG_FHA_2	243	249	PF00498	0.462
LIG_FHA_2	259	265	PF00498	0.472
LIG_FHA_2	400	406	PF00498	0.707
LIG_FHA_2	408	414	PF00498	0.747
LIG_FHA_2	431	437	PF00498	0.638
LIG_Integrin_RGD_1	366	368	PF01839	0.678
LIG_LIR_Apic_2	437	443	PF02991	0.668
LIG_LIR_Nem_3	152	158	PF02991	0.566
LIG_LIR_Nem_3	204	210	PF02991	0.549
LIG_MYND_1	443	447	PF01753	0.641
LIG_PDZ_Class_2	487	492	PF00595	0.646
LIG_SH2_CRK	155	159	PF00017	0.491
LIG_SH2_NCK_1	440	444	PF00017	0.648
LIG_SH2_PTP2	449	452	PF00017	0.627
LIG_SH2_SRC	444	447	PF00017	0.612
LIG_SH2_STAT3	250	253	PF00017	0.514
LIG_SH2_STAT5	121	124	PF00017	0.623
LIG_SH2_STAT5	444	447	PF00017	0.635
LIG_SH2_STAT5	449	452	PF00017	0.648
LIG_SUMO_SIM_anti_2	380	386	PF11976	0.800
LIG_SUMO_SIM_anti_2	400	405	PF11976	0.695
LIG_SUMO_SIM_par_1	380	386	PF11976	0.689
LIG_SUMO_SIM_par_1	402	408	PF11976	0.720
LIG_TYR_ITIM	153	158	PF00017	0.407
MOD_CK1_1	133	139	PF00069	0.734
MOD_CK1_1	141	147	PF00069	0.619
MOD_CK1_1	232	238	PF00069	0.568
MOD_CK1_1	3	9	PF00069	0.600
MOD_CK1_1	330	336	PF00069	0.705
MOD_CK1_1	345	351	PF00069	0.666
MOD_CK1_1	456	462	PF00069	0.564
MOD_CK1_1	468	474	PF00069	0.562
MOD_CK1_1	75	81	PF00069	0.638
MOD_CK1_1	90	96	PF00069	0.532
MOD_CK2_1	242	248	PF00069	0.466
MOD_CK2_1	258	264	PF00069	0.529
MOD_CK2_1	285	291	PF00069	0.378
MOD_CK2_1	349	355	PF00069	0.650
MOD_CK2_1	383	389	PF00069	0.724
MOD_CK2_1	435	441	PF00069	0.679
MOD_GlcNHglycan	123	126	PF01048	0.450
MOD_GlcNHglycan	14	17	PF01048	0.432
MOD_GlcNHglycan	2	5	PF01048	0.607
MOD_GlcNHglycan	212	215	PF01048	0.595
MOD_GlcNHglycan	226	229	PF01048	0.594
MOD_GlcNHglycan	347	350	PF01048	0.694
MOD_GlcNHglycan	351	354	PF01048	0.649
MOD_GlcNHglycan	385	388	PF01048	0.732
MOD_GlcNHglycan	393	397	PF01048	0.644
MOD_GlcNHglycan	436	440	PF01048	0.718
MOD_GlcNHglycan	467	470	PF01048	0.776
MOD_GlcNHglycan	77	80	PF01048	0.755
MOD_GSK3_1	132	139	PF00069	0.679
MOD_GSK3_1	224	231	PF00069	0.648
MOD_GSK3_1	269	276	PF00069	0.377
MOD_GSK3_1	3	10	PF00069	0.516
MOD_GSK3_1	315	322	PF00069	0.698
MOD_GSK3_1	345	352	PF00069	0.666
MOD_GSK3_1	383	390	PF00069	0.628
MOD_GSK3_1	451	458	PF00069	0.651
MOD_GSK3_1	464	471	PF00069	0.507
MOD_GSK3_1	87	94	PF00069	0.628
MOD_NEK2_1	210	215	PF00069	0.586
MOD_NEK2_1	258	263	PF00069	0.473
MOD_NEK2_1	295	300	PF00069	0.335
MOD_NEK2_1	5	10	PF00069	0.618
MOD_NEK2_1	87	92	PF00069	0.678
MOD_NEK2_2	321	326	PF00069	0.617
MOD_PIKK_1	109	115	PF00454	0.516
MOD_PIKK_1	138	144	PF00454	0.510
MOD_PIKK_1	258	264	PF00454	0.491
MOD_PIKK_1	28	34	PF00454	0.586
MOD_PIKK_1	468	474	PF00454	0.696
MOD_PK_1	417	423	PF00069	0.497
MOD_PKA_1	177	183	PF00069	0.512
MOD_PKA_2	177	183	PF00069	0.465
MOD_PKA_2	273	279	PF00069	0.560
MOD_PKA_2	307	313	PF00069	0.634
MOD_PKA_2	314	320	PF00069	0.683
MOD_PKA_2	91	97	PF00069	0.602
MOD_PKB_1	168	176	PF00069	0.339
MOD_Plk_1	295	301	PF00069	0.337
MOD_Plk_1	399	405	PF00069	0.718
MOD_Plk_1	435	441	PF00069	0.632
MOD_Plk_2-3	430	436	PF00069	0.592
MOD_Plk_4	399	405	PF00069	0.680
MOD_ProDKin_1	136	142	PF00069	0.674
MOD_ProDKin_1	252	258	PF00069	0.501
MOD_ProDKin_1	315	321	PF00069	0.674
MOD_ProDKin_1	375	381	PF00069	0.667
MOD_ProDKin_1	394	400	PF00069	0.705
MOD_ProDKin_1	8	14	PF00069	0.549
TRG_DiLeu_BaEn_1	441	446	PF01217	0.646
TRG_DiLeu_BaLyEn_6	473	478	PF01217	0.601
TRG_ENDOCYTIC_2	155	158	PF00928	0.494
TRG_ENDOCYTIC_2	286	289	PF00928	0.425
TRG_ER_diArg_1	155	157	PF00400	0.530
TRG_ER_diArg_1	176	178	PF00400	0.568
TRG_ER_diArg_1	325	327	PF00400	0.710
TRG_ER_diArg_1	479	481	PF00400	0.547
TRG_ER_diArg_1	52	55	PF00400	0.500
TRG_NLS_MonoExtC_3	361	366	PF00514	0.693
TRG_NLS_MonoExtN_4	360	367	PF00514	0.694
TRG_Pf-PMV_PEXEL_1	170	174	PF00026	0.433
TRG_Pf-PMV_PEXEL_1	195	199	PF00026	0.495
TRG_Pf-PMV_PEXEL_1	269	273	PF00026	0.400

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYA9	Leptomonas seymouri	50%	100%
A0A1X0NQL1	Trypanosomatidae	28%	100%
A0A3Q8IE22	Leishmania donovani	86%	100%
A0A3R7JYS6	Trypanosoma rangeli	27%	100%
A4HGY7	Leishmania braziliensis	73%	100%
A4I419	Leishmania infantum	82%	100%
Q4Q7X8	Leishmania major	87%	100%