Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B0A5_LEIMU

TriTrypDb:

LmxM.28.2830

Length:

944

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B0A5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B0A5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	575	579	PF00656	0.461
CLV_C14_Caspase3-7	889	893	PF00656	0.615
CLV_NRD_NRD_1	122	124	PF00675	0.621
CLV_NRD_NRD_1	149	151	PF00675	0.632
CLV_NRD_NRD_1	237	239	PF00675	0.561
CLV_NRD_NRD_1	307	309	PF00675	0.626
CLV_NRD_NRD_1	319	321	PF00675	0.675
CLV_NRD_NRD_1	425	427	PF00675	0.627
CLV_NRD_NRD_1	491	493	PF00675	0.634
CLV_NRD_NRD_1	696	698	PF00675	0.480
CLV_NRD_NRD_1	710	712	PF00675	0.604
CLV_NRD_NRD_1	757	759	PF00675	0.490
CLV_NRD_NRD_1	939	941	PF00675	0.422
CLV_PCSK_FUR_1	423	427	PF00082	0.546
CLV_PCSK_FUR_1	755	759	PF00082	0.467
CLV_PCSK_KEX2_1	122	124	PF00082	0.621
CLV_PCSK_KEX2_1	237	239	PF00082	0.561
CLV_PCSK_KEX2_1	307	309	PF00082	0.604
CLV_PCSK_KEX2_1	319	321	PF00082	0.617
CLV_PCSK_KEX2_1	425	427	PF00082	0.628
CLV_PCSK_KEX2_1	538	540	PF00082	0.730
CLV_PCSK_KEX2_1	696	698	PF00082	0.487
CLV_PCSK_KEX2_1	710	712	PF00082	0.604
CLV_PCSK_KEX2_1	75	77	PF00082	0.472
CLV_PCSK_KEX2_1	757	759	PF00082	0.502
CLV_PCSK_KEX2_1	939	941	PF00082	0.422
CLV_PCSK_PC1ET2_1	538	540	PF00082	0.730
CLV_PCSK_PC1ET2_1	75	77	PF00082	0.472
CLV_PCSK_PC7_1	935	941	PF00082	0.412
CLV_PCSK_SKI1_1	237	241	PF00082	0.561
CLV_PCSK_SKI1_1	248	252	PF00082	0.524
CLV_PCSK_SKI1_1	308	312	PF00082	0.623
CLV_PCSK_SKI1_1	385	389	PF00082	0.707
CLV_PCSK_SKI1_1	426	430	PF00082	0.654
CLV_PCSK_SKI1_1	467	471	PF00082	0.684
CLV_PCSK_SKI1_1	472	476	PF00082	0.521
CLV_PCSK_SKI1_1	535	539	PF00082	0.699
CLV_PCSK_SKI1_1	635	639	PF00082	0.436
CLV_PCSK_SKI1_1	711	715	PF00082	0.595
CLV_PCSK_SKI1_1	858	862	PF00082	0.717
DEG_APCC_DBOX_1	327	335	PF00400	0.597
DEG_APCC_DBOX_1	471	479	PF00400	0.646
DEG_APCC_DBOX_1	934	942	PF00400	0.603
DEG_Nend_UBRbox_1	1	4	PF02207	0.547
DEG_SCF_FBW7_1	548	554	PF00400	0.518
DEG_SPOP_SBC_1	362	366	PF00917	0.572
DEG_SPOP_SBC_1	570	574	PF00917	0.683
DOC_AGCK_PIF_1	272	277	PF00069	0.587
DOC_CKS1_1	1	6	PF01111	0.616
DOC_CKS1_1	548	553	PF01111	0.556
DOC_CYCLIN_RxL_1	245	252	PF00134	0.669
DOC_CYCLIN_RxL_1	35	43	PF00134	0.514
DOC_CYCLIN_RxL_1	935	944	PF00134	0.462
DOC_MAPK_gen_1	167	176	PF00069	0.667
DOC_MAPK_gen_1	368	375	PF00069	0.624
DOC_MAPK_gen_1	492	498	PF00069	0.633
DOC_MAPK_gen_1	661	671	PF00069	0.432
DOC_MAPK_gen_1	755	764	PF00069	0.721
DOC_MAPK_MEF2A_6	167	176	PF00069	0.680
DOC_MAPK_MEF2A_6	212	221	PF00069	0.564
DOC_MAPK_MEF2A_6	755	764	PF00069	0.721
DOC_MAPK_MEF2A_6	902	910	PF00069	0.648
DOC_MAPK_NFAT4_5	757	765	PF00069	0.654
DOC_PP1_RVXF_1	148	155	PF00149	0.613
DOC_PP1_RVXF_1	930	937	PF00149	0.658
DOC_PP2B_LxvP_1	760	763	PF13499	0.723
DOC_PP4_FxxP_1	187	190	PF00568	0.467
DOC_USP7_MATH_1	177	181	PF00917	0.521
DOC_USP7_MATH_1	203	207	PF00917	0.656
DOC_USP7_MATH_1	215	219	PF00917	0.784
DOC_USP7_MATH_1	268	272	PF00917	0.588
DOC_USP7_MATH_1	310	314	PF00917	0.533
DOC_USP7_MATH_1	362	366	PF00917	0.604
DOC_USP7_MATH_1	387	391	PF00917	0.712
DOC_USP7_MATH_1	418	422	PF00917	0.700
DOC_USP7_MATH_1	444	448	PF00917	0.622
DOC_USP7_MATH_1	518	522	PF00917	0.659
DOC_USP7_MATH_1	562	566	PF00917	0.749
DOC_USP7_MATH_1	569	573	PF00917	0.658
DOC_USP7_MATH_1	606	610	PF00917	0.702
DOC_USP7_MATH_1	753	757	PF00917	0.547
DOC_USP7_MATH_1	763	767	PF00917	0.650
DOC_USP7_MATH_1	825	829	PF00917	0.649
DOC_WW_Pin1_4	185	190	PF00397	0.473
DOC_WW_Pin1_4	213	218	PF00397	0.689
DOC_WW_Pin1_4	278	283	PF00397	0.591
DOC_WW_Pin1_4	516	521	PF00397	0.648
DOC_WW_Pin1_4	547	552	PF00397	0.544
DOC_WW_Pin1_4	553	558	PF00397	0.555
DOC_WW_Pin1_4	765	770	PF00397	0.717
DOC_WW_Pin1_4	8	13	PF00397	0.690
LIG_14-3-3_CanoR_1	368	376	PF00244	0.665
LIG_14-3-3_CanoR_1	407	417	PF00244	0.596
LIG_14-3-3_CanoR_1	492	498	PF00244	0.651
LIG_14-3-3_CanoR_1	510	514	PF00244	0.458
LIG_14-3-3_CanoR_1	757	763	PF00244	0.643
LIG_Actin_RPEL_3	895	914	PF02755	0.545
LIG_APCC_ABBAyCdc20_2	238	244	PF00400	0.602
LIG_APCC_ABBAyCdc20_2	426	432	PF00400	0.656
LIG_CaM_IQ_9	142	158	PF13499	0.575
LIG_Clathr_ClatBox_1	913	917	PF01394	0.665
LIG_deltaCOP1_diTrp_1	841	850	PF00928	0.705
LIG_eIF4E_1	235	241	PF01652	0.681
LIG_FHA_1	140	146	PF00498	0.657
LIG_FHA_1	186	192	PF00498	0.447
LIG_FHA_1	26	32	PF00498	0.579
LIG_FHA_1	375	381	PF00498	0.610
LIG_FHA_1	780	786	PF00498	0.580
LIG_FHA_1	857	863	PF00498	0.689
LIG_FHA_1	929	935	PF00498	0.654
LIG_FHA_2	369	375	PF00498	0.700
LIG_FHA_2	573	579	PF00498	0.534
LIG_FHA_2	60	66	PF00498	0.605
LIG_FHA_2	611	617	PF00498	0.690
LIG_FHA_2	805	811	PF00498	0.453
LIG_GBD_Chelix_1	721	729	PF00786	0.575
LIG_LIR_Apic_2	413	418	PF02991	0.617
LIG_LIR_Gen_1	267	277	PF02991	0.587
LIG_LIR_Gen_1	377	386	PF02991	0.586
LIG_LIR_Gen_1	503	514	PF02991	0.688
LIG_LIR_Gen_1	578	587	PF02991	0.502
LIG_LIR_Gen_1	643	653	PF02991	0.589
LIG_LIR_Gen_1	724	733	PF02991	0.493
LIG_LIR_Gen_1	810	818	PF02991	0.579
LIG_LIR_Nem_3	180	184	PF02991	0.642
LIG_LIR_Nem_3	267	272	PF02991	0.588
LIG_LIR_Nem_3	377	381	PF02991	0.558
LIG_LIR_Nem_3	503	509	PF02991	0.678
LIG_LIR_Nem_3	578	583	PF02991	0.680
LIG_LIR_Nem_3	643	648	PF02991	0.558
LIG_LIR_Nem_3	724	729	PF02991	0.493
LIG_LIR_Nem_3	810	814	PF02991	0.586
LIG_LIR_Nem_3	872	877	PF02991	0.642
LIG_MAD2	212	220	PF02301	0.607
LIG_MYND_1	765	769	PF01753	0.719
LIG_PTAP_UEV_1	3	8	PF05743	0.687
LIG_Rb_pABgroove_1	229	237	PF01858	0.605
LIG_SH2_CRK	181	185	PF00017	0.689
LIG_SH2_CRK	378	382	PF00017	0.563
LIG_SH2_CRK	506	510	PF00017	0.694
LIG_SH2_CRK	645	649	PF00017	0.585
LIG_SH2_NCK_1	378	382	PF00017	0.677
LIG_SH2_NCK_1	430	434	PF00017	0.432
LIG_SH2_SRC	242	245	PF00017	0.664
LIG_SH2_SRC	262	265	PF00017	0.556
LIG_SH2_SRC	926	929	PF00017	0.665
LIG_SH2_STAP1	235	239	PF00017	0.580
LIG_SH2_STAP1	376	380	PF00017	0.637
LIG_SH2_STAP1	430	434	PF00017	0.415
LIG_SH2_STAP1	926	930	PF00017	0.660
LIG_SH2_STAT3	137	140	PF00017	0.589
LIG_SH2_STAT3	323	326	PF00017	0.422
LIG_SH2_STAT3	641	644	PF00017	0.594
LIG_SH2_STAT3	803	806	PF00017	0.427
LIG_SH2_STAT5	262	265	PF00017	0.661
LIG_SH2_STAT5	278	281	PF00017	0.424
LIG_SH2_STAT5	323	326	PF00017	0.527
LIG_SH2_STAT5	376	379	PF00017	0.565
LIG_SH2_STAT5	629	632	PF00017	0.635
LIG_SH2_STAT5	645	648	PF00017	0.503
LIG_SH2_STAT5	652	655	PF00017	0.601
LIG_SH2_STAT5	877	880	PF00017	0.640
LIG_SH3_3	1	7	PF00018	0.790
LIG_SH3_3	205	211	PF00018	0.679
LIG_SH3_3	214	220	PF00018	0.683
LIG_SH3_3	276	282	PF00018	0.536
LIG_SUMO_SIM_par_1	858	863	PF11976	0.692
LIG_TRAF2_1	488	491	PF00917	0.628
LIG_TRAF2_1	499	502	PF00917	0.694
LIG_TRAF2_1	596	599	PF00917	0.649
LIG_UBA3_1	45	50	PF00899	0.364
LIG_UBA3_1	878	883	PF00899	0.648
MOD_CDK_SPK_2	553	558	PF00069	0.522
MOD_CDK_SPxK_1	8	14	PF00069	0.790
MOD_CDK_SPxxK_3	765	772	PF00069	0.712
MOD_CK1_1	405	411	PF00069	0.490
MOD_CK1_1	565	571	PF00069	0.785
MOD_CK1_1	572	578	PF00069	0.482
MOD_CK1_1	609	615	PF00069	0.746
MOD_CK1_1	886	892	PF00069	0.579
MOD_CK2_1	193	199	PF00069	0.739
MOD_CK2_1	570	576	PF00069	0.604
MOD_CK2_1	593	599	PF00069	0.638
MOD_CK2_1	765	771	PF00069	0.643
MOD_CK2_1	799	805	PF00069	0.635
MOD_GlcNHglycan	203	206	PF01048	0.653
MOD_GlcNHglycan	266	269	PF01048	0.600
MOD_GlcNHglycan	345	349	PF01048	0.655
MOD_GlcNHglycan	350	355	PF01048	0.593
MOD_GlcNHglycan	599	603	PF01048	0.699
MOD_GlcNHglycan	607	611	PF01048	0.741
MOD_GlcNHglycan	692	696	PF01048	0.608
MOD_GSK3_1	2	9	PF00069	0.756
MOD_GSK3_1	264	271	PF00069	0.593
MOD_GSK3_1	330	337	PF00069	0.680
MOD_GSK3_1	547	554	PF00069	0.537
MOD_GSK3_1	565	572	PF00069	0.681
MOD_GSK3_1	594	601	PF00069	0.724
MOD_GSK3_1	606	613	PF00069	0.612
MOD_GSK3_1	729	736	PF00069	0.620
MOD_GSK3_1	882	889	PF00069	0.682
MOD_LATS_1	881	887	PF00433	0.640
MOD_NEK2_1	311	316	PF00069	0.647
MOD_NEK2_1	334	339	PF00069	0.691
MOD_NEK2_1	402	407	PF00069	0.709
MOD_NEK2_1	509	514	PF00069	0.639
MOD_NEK2_1	663	668	PF00069	0.682
MOD_NEK2_1	729	734	PF00069	0.676
MOD_PIKK_1	410	416	PF00454	0.478
MOD_PIKK_1	491	497	PF00454	0.629
MOD_PIKK_1	518	524	PF00454	0.736
MOD_PIKK_1	594	600	PF00454	0.710
MOD_PIKK_1	733	739	PF00454	0.595
MOD_PKA_2	491	497	PF00069	0.699
MOD_PKA_2	509	515	PF00069	0.443
MOD_PKA_2	59	65	PF00069	0.681
MOD_PKA_2	663	669	PF00069	0.673
MOD_PKB_1	54	62	PF00069	0.581
MOD_Plk_1	804	810	PF00069	0.549
MOD_Plk_1	886	892	PF00069	0.643
MOD_Plk_2-3	193	199	PF00069	0.568
MOD_Plk_4	376	382	PF00069	0.549
MOD_Plk_4	509	515	PF00069	0.448
MOD_Plk_4	624	630	PF00069	0.579
MOD_Plk_4	886	892	PF00069	0.661
MOD_ProDKin_1	185	191	PF00069	0.472
MOD_ProDKin_1	213	219	PF00069	0.688
MOD_ProDKin_1	278	284	PF00069	0.585
MOD_ProDKin_1	516	522	PF00069	0.648
MOD_ProDKin_1	547	553	PF00069	0.543
MOD_ProDKin_1	765	771	PF00069	0.713
MOD_ProDKin_1	8	14	PF00069	0.691
MOD_SUMO_for_1	49	52	PF00179	0.375
MOD_SUMO_for_1	537	540	PF00179	0.720
MOD_SUMO_rev_2	222	231	PF00179	0.665
MOD_SUMO_rev_2	490	494	PF00179	0.430
MOD_SUMO_rev_2	79	89	PF00179	0.471
TRG_DiLeu_BaEn_4	680	686	PF01217	0.685
TRG_DiLeu_BaLyEn_6	245	250	PF01217	0.666
TRG_DiLeu_BaLyEn_6	769	774	PF01217	0.553
TRG_ENDOCYTIC_2	181	184	PF00928	0.637
TRG_ENDOCYTIC_2	378	381	PF00928	0.566
TRG_ENDOCYTIC_2	506	509	PF00928	0.690
TRG_ENDOCYTIC_2	645	648	PF00928	0.525
TRG_ENDOCYTIC_2	726	729	PF00928	0.581
TRG_ER_diArg_1	318	320	PF00400	0.636
TRG_ER_diArg_1	422	425	PF00400	0.608
TRG_ER_diArg_1	583	586	PF00400	0.426
TRG_ER_diArg_1	648	651	PF00400	0.462
TRG_ER_diArg_1	696	699	PF00400	0.496
TRG_ER_diArg_1	755	758	PF00400	0.657
TRG_ER_diArg_1	781	784	PF00400	0.615
TRG_ER_diArg_1	921	924	PF00400	0.594
TRG_ER_diArg_1	938	940	PF00400	0.599
TRG_NES_CRM1_1	658	673	PF08389	0.419
TRG_NES_CRM1_1	933	944	PF08389	0.607
TRG_Pf-PMV_PEXEL_1	150	155	PF00026	0.610
TRG_Pf-PMV_PEXEL_1	238	243	PF00026	0.535
TRG_Pf-PMV_PEXEL_1	248	252	PF00026	0.514
TRG_Pf-PMV_PEXEL_1	336	341	PF00026	0.656
TRG_Pf-PMV_PEXEL_1	38	43	PF00026	0.511
TRG_Pf-PMV_PEXEL_1	391	395	PF00026	0.550
TRG_Pf-PMV_PEXEL_1	772	777	PF00026	0.547
TRG_Pf-PMV_PEXEL_1	858	863	PF00026	0.692
TRG_Pf-PMV_PEXEL_1	939	944	PF00026	0.430

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PC11	Leptomonas seymouri	33%	100%
A0A3Q8IIE5	Leishmania donovani	86%	100%
A4HGY6	Leishmania braziliensis	70%	100%
A4I418	Leishmania infantum	86%	100%
Q4Q7X9	Leishmania major	86%	100%
V5BDP5	Trypanosoma cruzi	25%	95%