Beta-lactamase domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

beta-lactamase, putative

Species:

Leishmania mexicana

UniProt:

E9B0A2_LEIMU

TriTrypDb:

LmxM.28.2800

Length:

498

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B0A2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B0A2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	357	361	PF00656	0.433
CLV_NRD_NRD_1	496	498	PF00675	0.691
CLV_PCSK_KEX2_1	318	320	PF00082	0.447
CLV_PCSK_KEX2_1	481	483	PF00082	0.663
CLV_PCSK_KEX2_1	496	498	PF00082	0.498
CLV_PCSK_PC1ET2_1	318	320	PF00082	0.447
CLV_PCSK_PC1ET2_1	481	483	PF00082	0.649
CLV_PCSK_SKI1_1	135	139	PF00082	0.364
CLV_PCSK_SKI1_1	162	166	PF00082	0.330
CLV_PCSK_SKI1_1	240	244	PF00082	0.410
CLV_PCSK_SKI1_1	277	281	PF00082	0.415
CLV_PCSK_SKI1_1	349	353	PF00082	0.310
CLV_PCSK_SKI1_1	362	366	PF00082	0.310
CLV_PCSK_SKI1_1	394	398	PF00082	0.513
CLV_PCSK_SKI1_1	447	451	PF00082	0.528
CLV_PCSK_SKI1_1	478	482	PF00082	0.652
CLV_PCSK_SKI1_1	53	57	PF00082	0.422
DOC_ANK_TNKS_1	318	325	PF00023	0.202
DOC_CDC14_PxL_1	145	153	PF14671	0.447
DOC_CKS1_1	140	145	PF01111	0.372
DOC_CYCLIN_RxL_1	346	357	PF00134	0.310
DOC_CYCLIN_yCln2_LP_2	111	117	PF00134	0.310
DOC_CYCLIN_yCln2_LP_2	120	126	PF00134	0.310
DOC_CYCLIN_yCln2_LP_2	365	371	PF00134	0.185
DOC_CYCLIN_yCln2_LP_2	392	398	PF00134	0.291
DOC_MAPK_gen_1	11	18	PF00069	0.519
DOC_MAPK_MEF2A_6	11	18	PF00069	0.596
DOC_PP1_RVXF_1	13	19	PF00149	0.578
DOC_PP1_RVXF_1	275	282	PF00149	0.406
DOC_PP2B_LxvP_1	120	123	PF13499	0.310
DOC_PP2B_LxvP_1	340	343	PF13499	0.310
DOC_PP4_FxxP_1	280	283	PF00568	0.447
DOC_PP4_FxxP_1	304	307	PF00568	0.310
DOC_PP4_FxxP_1	317	320	PF00568	0.310
DOC_SPAK_OSR1_1	431	435	PF12202	0.490
DOC_USP7_MATH_1	283	287	PF00917	0.330
DOC_USP7_MATH_1	405	409	PF00917	0.350
DOC_WW_Pin1_4	139	144	PF00397	0.372
DOC_WW_Pin1_4	187	192	PF00397	0.474
DOC_WW_Pin1_4	211	216	PF00397	0.410
DOC_WW_Pin1_4	232	237	PF00397	0.389
LIG_14-3-3_CanoR_1	162	168	PF00244	0.402
LIG_14-3-3_CanoR_1	237	243	PF00244	0.244
LIG_14-3-3_CanoR_1	248	258	PF00244	0.350
LIG_14-3-3_CanoR_1	410	417	PF00244	0.418
LIG_Actin_WH2_2	164	180	PF00022	0.309
LIG_BIR_II_1	1	5	PF00653	0.721
LIG_BIR_III_2	401	405	PF00653	0.465
LIG_Clathr_ClatBox_1	352	356	PF01394	0.330
LIG_eIF4E_1	347	353	PF01652	0.330
LIG_FHA_1	117	123	PF00498	0.340
LIG_FHA_1	166	172	PF00498	0.360
LIG_FHA_1	241	247	PF00498	0.457
LIG_FHA_1	391	397	PF00498	0.421
LIG_FHA_2	355	361	PF00498	0.433
LIG_FHA_2	488	494	PF00498	0.701
LIG_Integrin_isoDGR_2	372	374	PF01839	0.333
LIG_LIR_Apic_2	278	283	PF02991	0.466
LIG_LIR_Apic_2	289	294	PF02991	0.305
LIG_LIR_Apic_2	295	300	PF02991	0.206
LIG_LIR_Apic_2	302	307	PF02991	0.257
LIG_LIR_Apic_2	315	320	PF02991	0.150
LIG_LIR_Gen_1	142	151	PF02991	0.334
LIG_LIR_Nem_3	142	148	PF02991	0.284
LIG_LIR_Nem_3	17	21	PF02991	0.542
LIG_LIR_Nem_3	345	350	PF02991	0.309
LIG_LIR_Nem_3	486	492	PF02991	0.602
LIG_Rb_LxCxE_1	190	203	PF01857	0.185
LIG_SH2_CRK	117	121	PF00017	0.310
LIG_SH2_CRK	291	295	PF00017	0.310
LIG_SH2_CRK	347	351	PF00017	0.330
LIG_SH2_NCK_1	202	206	PF00017	0.387
LIG_SH2_NCK_1	341	345	PF00017	0.433
LIG_SH2_SRC	341	344	PF00017	0.387
LIG_SH2_SRC	383	386	PF00017	0.515
LIG_SH2_STAT5	128	131	PF00017	0.330
LIG_SH2_STAT5	147	150	PF00017	0.330
LIG_SH2_STAT5	231	234	PF00017	0.276
LIG_SH2_STAT5	383	386	PF00017	0.515
LIG_SH2_STAT5	488	491	PF00017	0.532
LIG_SH3_3	453	459	PF00018	0.631
LIG_SH3_5	343	347	PF00018	0.330
LIG_SUMO_SIM_anti_2	254	260	PF11976	0.314
LIG_SUMO_SIM_par_1	319	325	PF11976	0.447
LIG_SUMO_SIM_par_1	349	354	PF11976	0.330
LIG_SUMO_SIM_par_1	54	59	PF11976	0.491
LIG_TYR_ITIM	115	120	PF00017	0.330
LIG_UBA3_1	440	447	PF00899	0.409
LIG_WRC_WIRS_1	164	169	PF05994	0.387
MOD_CDK_SPK_2	232	237	PF00069	0.447
MOD_CK1_1	163	169	PF00069	0.367
MOD_CK1_1	252	258	PF00069	0.333
MOD_CK1_1	271	277	PF00069	0.355
MOD_CK1_1	286	292	PF00069	0.330
MOD_CK1_1	354	360	PF00069	0.387
MOD_CK1_1	424	430	PF00069	0.414
MOD_CK1_1	59	65	PF00069	0.462
MOD_CK2_1	487	493	PF00069	0.671
MOD_CK2_1	51	57	PF00069	0.413
MOD_GlcNHglycan	1	4	PF01048	0.601
MOD_GlcNHglycan	63	66	PF01048	0.456
MOD_GlcNHglycan	90	93	PF01048	0.339
MOD_GSK3_1	118	125	PF00069	0.310
MOD_GSK3_1	153	160	PF00069	0.418
MOD_GSK3_1	210	217	PF00069	0.359
MOD_GSK3_1	232	239	PF00069	0.385
MOD_GSK3_1	271	278	PF00069	0.368
MOD_GSK3_1	405	412	PF00069	0.388
MOD_GSK3_1	472	479	PF00069	0.663
MOD_GSK3_1	483	490	PF00069	0.707
MOD_N-GLC_1	249	254	PF02516	0.250
MOD_N-GLC_1	334	339	PF02516	0.314
MOD_N-GLC_1	435	440	PF02516	0.480
MOD_NEK2_1	165	170	PF00069	0.364
MOD_NEK2_1	242	247	PF00069	0.408
MOD_NEK2_1	390	395	PF00069	0.421
MOD_NEK2_1	476	481	PF00069	0.447
MOD_NEK2_1	56	61	PF00069	0.439
MOD_NEK2_2	405	410	PF00069	0.391
MOD_OFUCOSY	419	425	PF10250	0.454
MOD_PIKK_1	262	268	PF00454	0.430
MOD_PIKK_1	64	70	PF00454	0.480
MOD_PKA_2	236	242	PF00069	0.373
MOD_PKA_2	409	415	PF00069	0.416
MOD_PKA_2	93	99	PF00069	0.447
MOD_Plk_1	435	441	PF00069	0.460
MOD_Plk_1	472	478	PF00069	0.704
MOD_Plk_1	56	62	PF00069	0.502
MOD_Plk_4	292	298	PF00069	0.413
MOD_Plk_4	354	360	PF00069	0.430
MOD_ProDKin_1	139	145	PF00069	0.372
MOD_ProDKin_1	187	193	PF00069	0.474
MOD_ProDKin_1	211	217	PF00069	0.410
MOD_ProDKin_1	232	238	PF00069	0.389
TRG_DiLeu_BaLyEn_6	188	193	PF01217	0.185
TRG_ENDOCYTIC_2	117	120	PF00928	0.310
TRG_ENDOCYTIC_2	202	205	PF00928	0.312
TRG_ENDOCYTIC_2	341	344	PF00928	0.352
TRG_ENDOCYTIC_2	347	350	PF00928	0.305
TRG_ENDOCYTIC_2	376	379	PF00928	0.491
TRG_ER_diArg_1	11	14	PF00400	0.585
TRG_ER_diArg_1	496	498	PF00400	0.641
TRG_NLS_MonoExtN_4	478	485	PF00514	0.621
TRG_Pf-PMV_PEXEL_1	98	103	PF00026	0.466

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HWQ0	Leptomonas seymouri	72%	96%
A0A0S4J446	Bodo saltans	46%	94%
A0A1X0NQV6	Trypanosomatidae	59%	96%
A0A3Q8IDD8	Leishmania donovani	94%	100%
A4HGY3	Leishmania braziliensis	88%	100%
A4I415	Leishmania infantum	94%	100%
D0A8Z4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	57%	100%
Q4Q7Y2	Leishmania major	94%	100%
V5ATN3	Trypanosoma cruzi	57%	100%