LeishMANIAdb
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Putative heat-shock protein hsp70

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative heat-shock protein hsp70
Gene product:
heat-shock protein hsp70, putative
Species:
Leishmania mexicana
UniProt:
E9B0A0_LEIMU
TriTrypDb:
LmxM.28.2780
Length:
326

Annotations

LeishMANIAdb annotations

ER-associated chaperone protein

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 5
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 3
NetGPI no yes: 0, no: 3
Cellular components
Term Name Level Count
GO:0043226 organelle 2 3
GO:0110165 cellular anatomical entity 1 3

Expansion

Sequence features

E9B0A0
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B0A0

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 4
GO:0005488 binding 1 4
GO:0005524 ATP binding 5 4
GO:0017076 purine nucleotide binding 4 4
GO:0030554 adenyl nucleotide binding 5 4
GO:0032553 ribonucleotide binding 3 4
GO:0032555 purine ribonucleotide binding 4 4
GO:0032559 adenyl ribonucleotide binding 5 4
GO:0035639 purine ribonucleoside triphosphate binding 4 4
GO:0036094 small molecule binding 2 4
GO:0043167 ion binding 2 4
GO:0043168 anion binding 3 4
GO:0044183 protein folding chaperone 1 4
GO:0097159 organic cyclic compound binding 2 4
GO:0097367 carbohydrate derivative binding 2 4
GO:0140657 ATP-dependent activity 1 4
GO:0140662 ATP-dependent protein folding chaperone 2 4
GO:1901265 nucleoside phosphate binding 3 4
GO:1901363 heterocyclic compound binding 2 4

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 105 109 PF00656 0.317
CLV_C14_Caspase3-7 227 231 PF00656 0.469
CLV_PCSK_KEX2_1 172 174 PF00082 0.322
CLV_PCSK_KEX2_1 3 5 PF00082 0.317
CLV_PCSK_KEX2_1 90 92 PF00082 0.317
CLV_PCSK_PC1ET2_1 172 174 PF00082 0.322
CLV_PCSK_PC1ET2_1 3 5 PF00082 0.317
CLV_PCSK_PC1ET2_1 90 92 PF00082 0.317
CLV_PCSK_SKI1_1 122 126 PF00082 0.317
DEG_Nend_UBRbox_2 1 3 PF02207 0.177
DOC_MAPK_gen_1 172 178 PF00069 0.322
DOC_MAPK_gen_1 3 11 PF00069 0.317
DOC_MAPK_gen_1 59 68 PF00069 0.317
DOC_MAPK_MEF2A_6 144 153 PF00069 0.322
DOC_PP2B_PxIxI_1 146 152 PF00149 0.322
DOC_USP7_MATH_1 301 305 PF00917 0.776
DOC_USP7_UBL2_3 168 172 PF12436 0.322
DOC_USP7_UBL2_3 32 36 PF12436 0.317
DOC_WW_Pin1_4 69 74 PF00397 0.317
LIG_BIR_III_4 156 160 PF00653 0.322
LIG_BRCT_BRCA1_1 25 29 PF00533 0.317
LIG_BRCT_BRCA1_1 99 103 PF00533 0.317
LIG_Clathr_ClatBox_1 66 70 PF01394 0.317
LIG_FHA_1 131 137 PF00498 0.322
LIG_FHA_1 150 156 PF00498 0.322
LIG_FHA_1 61 67 PF00498 0.317
LIG_FHA_1 73 79 PF00498 0.317
LIG_FHA_1 84 90 PF00498 0.317
LIG_FHA_2 103 109 PF00498 0.317
LIG_FHA_2 225 231 PF00498 0.322
LIG_FHA_2 261 267 PF00498 0.430
LIG_LIR_Gen_1 283 293 PF02991 0.619
LIG_LIR_Nem_3 100 106 PF02991 0.317
LIG_MLH1_MIPbox_1 25 29 PF16413 0.317
LIG_PCNA_PIPBox_1 22 31 PF02747 0.317
LIG_PCNA_yPIPBox_3 17 29 PF02747 0.443
LIG_PCNA_yPIPBox_3 272 286 PF02747 0.460
LIG_PTB_Apo_2 216 223 PF02174 0.322
LIG_PTB_Phospho_1 216 222 PF10480 0.460
LIG_REV1ctd_RIR_1 26 36 PF16727 0.317
LIG_SH2_SRC 220 223 PF00017 0.460
LIG_SH2_STAP1 220 224 PF00017 0.322
LIG_SH3_3 137 143 PF00018 0.322
LIG_SH3_3 274 280 PF00018 0.427
LIG_SUMO_SIM_anti_2 63 70 PF11976 0.317
LIG_SUMO_SIM_anti_2 8 13 PF11976 0.317
LIG_SUMO_SIM_par_1 63 70 PF11976 0.317
LIG_SxIP_EBH_1 11 20 PF03271 0.317
LIG_SxIP_EBH_1 88 99 PF03271 0.317
LIG_TPR 323 326 PF00515 0.774
LIG_TRAF2_1 164 167 PF00917 0.322
LIG_TRAF2_1 258 261 PF00917 0.381
LIG_TRAF2_1 263 266 PF00917 0.412
LIG_WRC_WIRS_1 131 136 PF05994 0.322
MOD_CK1_1 23 29 PF00069 0.443
MOD_CK1_1 231 237 PF00069 0.445
MOD_CK1_1 304 310 PF00069 0.750
MOD_CK1_1 60 66 PF00069 0.317
MOD_CK2_1 161 167 PF00069 0.322
MOD_CK2_1 183 189 PF00069 0.460
MOD_CK2_1 255 261 PF00069 0.389
MOD_Cter_Amidation 170 173 PF01082 0.322
MOD_GlcNHglycan 135 139 PF01048 0.322
MOD_GlcNHglycan 163 166 PF01048 0.322
MOD_GlcNHglycan 233 236 PF01048 0.409
MOD_GlcNHglycan 302 306 PF01048 0.779
MOD_GlcNHglycan 317 320 PF01048 0.550
MOD_GSK3_1 130 137 PF00069 0.322
MOD_GSK3_1 220 227 PF00069 0.322
MOD_GSK3_1 237 244 PF00069 0.322
MOD_GSK3_1 53 60 PF00069 0.317
MOD_GSK3_1 90 97 PF00069 0.317
MOD_N-GLC_1 161 166 PF02516 0.322
MOD_N-GLC_1 231 236 PF02516 0.460
MOD_N-GLC_1 34 39 PF02516 0.317
MOD_N-GLC_1 91 96 PF02516 0.317
MOD_N-GLC_2 276 278 PF02516 0.185
MOD_NEK2_1 134 139 PF00069 0.322
MOD_NEK2_1 224 229 PF00069 0.322
MOD_NEK2_1 285 290 PF00069 0.536
MOD_NEK2_1 34 39 PF00069 0.317
MOD_NEK2_1 53 58 PF00069 0.317
MOD_NEK2_2 220 225 PF00069 0.322
MOD_PIKK_1 97 103 PF00454 0.317
MOD_PKA_1 90 96 PF00069 0.317
MOD_PKA_2 183 189 PF00069 0.322
MOD_PKA_2 90 96 PF00069 0.317
MOD_Plk_1 149 155 PF00069 0.322
MOD_Plk_1 240 246 PF00069 0.296
MOD_Plk_1 34 40 PF00069 0.317
MOD_Plk_1 91 97 PF00069 0.317
MOD_Plk_2-3 2 8 PF00069 0.443
MOD_Plk_4 20 26 PF00069 0.443
MOD_ProDKin_1 69 75 PF00069 0.317
MOD_SUMO_for_1 198 201 PF00179 0.311
MOD_SUMO_for_1 320 323 PF00179 0.776
MOD_SUMO_rev_2 164 170 PF00179 0.322
MOD_SUMO_rev_2 201 206 PF00179 0.285
TRG_DiLeu_BaEn_1 64 69 PF01217 0.317
TRG_ENDOCYTIC_2 286 289 PF00928 0.575

Homologs

Protein Taxonomy Sequence identity Coverage
A0A1X0NYN5 Trypanosomatidae 60% 83%
A4HGX9 Leishmania braziliensis 83% 100%
A4HIH7 Leishmania braziliensis 43% 100%
A4HIH9 Leishmania braziliensis 43% 100%
P11503 Onchocerca volvulus 77% 100%
P12794 Plasmodium falciparum 60% 100%
P16121 Lupinus polyphyllus 59% 100%
P27894 Leishmania braziliensis 88% 100%
P34934 Sus scrofa 56% 86%
P34935 Sus scrofa 63% 100%
Q03681 Nicotiana tabacum 62% 100%
Q03682 Nicotiana tabacum 62% 100%
Q03686 Nicotiana tabacum 60% 100%
V5B942 Trypanosoma cruzi 84% 71%
V5BZ53 Trypanosoma cruzi 55% 68%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS