2OG-FeII_Oxy_2 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B094_LEIMU

TriTrypDb:

LmxM.28.2710

Length:

280

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005759	mitochondrial matrix	5	11
GO:0031974	membrane-enclosed lumen	2	11
GO:0043233	organelle lumen	3	11
GO:0070013	intracellular organelle lumen	4	11
GO:0110165	cellular anatomical entity	1	11
GO:0005737	cytoplasm	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1

Expansion

Sequence features

E9B094

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B094

Function

Biological processes
Term	Name	Level	Count
GO:0006950	response to stress	2	11
GO:0006974	DNA damage response	4	11
GO:0006996	organelle organization	4	11
GO:0007005	mitochondrion organization	5	11
GO:0007006	mitochondrial membrane organization	5	11
GO:0009987	cellular process	1	11
GO:0016043	cellular component organization	3	11
GO:0033554	cellular response to stress	3	11
GO:0046902	regulation of mitochondrial membrane permeability	4	11
GO:0050896	response to stimulus	1	11
GO:0051716	cellular response to stimulus	2	11
GO:0061024	membrane organization	4	11
GO:0065007	biological regulation	1	11
GO:0065008	regulation of biological quality	2	11
GO:0071840	cellular component organization or biogenesis	2	11
GO:0090559	regulation of membrane permeability	3	11
GO:1902445	regulation of mitochondrial membrane permeability involved in programmed necrotic cell death	5	11
GO:0006082	organic acid metabolic process	3	1
GO:0006629	lipid metabolic process	3	1
GO:0006631	fatty acid metabolic process	4	1
GO:0008152	metabolic process	1	1
GO:0019752	carboxylic acid metabolic process	5	1
GO:0032787	monocarboxylic acid metabolic process	6	1
GO:0043436	oxoacid metabolic process	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044255	cellular lipid metabolic process	3	1
GO:0044281	small molecule metabolic process	2	1
GO:0071704	organic substance metabolic process	2	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	104	108	PF00656	0.552
CLV_C14_Caspase3-7	75	79	PF00656	0.517
CLV_NRD_NRD_1	231	233	PF00675	0.467
CLV_NRD_NRD_1	254	256	PF00675	0.461
CLV_NRD_NRD_1	274	276	PF00675	0.268
CLV_NRD_NRD_1	6	8	PF00675	0.621
CLV_PCSK_KEX2_1	231	233	PF00082	0.467
CLV_PCSK_KEX2_1	254	256	PF00082	0.429
CLV_PCSK_KEX2_1	274	276	PF00082	0.268
CLV_PCSK_KEX2_1	6	8	PF00082	0.590
CLV_PCSK_PC7_1	2	8	PF00082	0.650
CLV_PCSK_SKI1_1	182	186	PF00082	0.328
CLV_PCSK_SKI1_1	2	6	PF00082	0.671
CLV_PCSK_SKI1_1	36	40	PF00082	0.454
CLV_PCSK_SKI1_1	61	65	PF00082	0.365
DEG_Nend_UBRbox_1	1	4	PF02207	0.636
DOC_CYCLIN_yClb5_NLxxxL_5	112	121	PF00134	0.535
DOC_MAPK_gen_1	231	239	PF00069	0.514
DOC_MAPK_gen_1	254	263	PF00069	0.321
DOC_PP1_RVXF_1	145	151	PF00149	0.319
DOC_PP2B_LxvP_1	110	113	PF13499	0.515
DOC_PP4_FxxP_1	66	69	PF00568	0.371
DOC_WW_Pin1_4	239	244	PF00397	0.376
DOC_WW_Pin1_4	248	253	PF00397	0.392
DOC_WW_Pin1_4	264	269	PF00397	0.240
DOC_WW_Pin1_4	38	43	PF00397	0.454
LIG_14-3-3_CanoR_1	167	173	PF00244	0.364
LIG_14-3-3_CanoR_1	182	187	PF00244	0.317
LIG_14-3-3_CanoR_1	232	238	PF00244	0.510
LIG_14-3-3_CanoR_1	73	77	PF00244	0.530
LIG_FHA_1	168	174	PF00498	0.445
LIG_FHA_1	257	263	PF00498	0.322
LIG_FHA_1	45	51	PF00498	0.427
LIG_FHA_2	102	108	PF00498	0.540
LIG_FHA_2	185	191	PF00498	0.433
LIG_FHA_2	54	60	PF00498	0.421
LIG_FHA_2	73	79	PF00498	0.278
LIG_LIR_Apic_2	47	52	PF02991	0.463
LIG_LIR_Apic_2	65	69	PF02991	0.467
LIG_LIR_Gen_1	194	202	PF02991	0.201
LIG_LIR_Gen_1	68	76	PF02991	0.335
LIG_LIR_Gen_1	94	102	PF02991	0.487
LIG_LIR_LC3C_4	236	239	PF02991	0.453
LIG_LIR_Nem_3	194	198	PF02991	0.332
LIG_LIR_Nem_3	250	256	PF02991	0.381
LIG_LIR_Nem_3	68	74	PF02991	0.351
LIG_LIR_Nem_3	90	95	PF02991	0.328
LIG_PALB2_WD40_1	66	74	PF16756	0.343
LIG_PCNA_PIPBox_1	81	90	PF02747	0.400
LIG_Pex14_1	45	49	PF04695	0.445
LIG_Pex14_2	66	70	PF04695	0.370
LIG_SH2_CRK	95	99	PF00017	0.415
LIG_SH2_NCK_1	95	99	PF00017	0.405
LIG_SH2_PTP2	195	198	PF00017	0.456
LIG_SH2_PTP2	206	209	PF00017	0.414
LIG_SH2_PTP2	49	52	PF00017	0.421
LIG_SH2_STAT5	138	141	PF00017	0.377
LIG_SH2_STAT5	195	198	PF00017	0.346
LIG_SH2_STAT5	206	209	PF00017	0.300
LIG_SH2_STAT5	49	52	PF00017	0.421
LIG_SH3_3	137	143	PF00018	0.394
LIG_SH3_3	186	192	PF00018	0.428
LIG_SH3_3	23	29	PF00018	0.468
LIG_SUMO_SIM_anti_2	120	125	PF11976	0.291
LIG_SUMO_SIM_anti_2	194	200	PF11976	0.390
LIG_TRAF2_1	29	32	PF00917	0.537
LIG_TRAF2_1	56	59	PF00917	0.418
MOD_CDK_SPxK_1	239	245	PF00069	0.439
MOD_CDK_SPxK_1	248	254	PF00069	0.362
MOD_CDK_SPxxK_3	248	255	PF00069	0.449
MOD_CK1_1	122	128	PF00069	0.488
MOD_CK1_1	15	21	PF00069	0.431
MOD_CK2_1	184	190	PF00069	0.337
MOD_CK2_1	53	59	PF00069	0.395
MOD_GlcNHglycan	124	127	PF01048	0.432
MOD_GlcNHglycan	155	158	PF01048	0.384
MOD_GSK3_1	12	19	PF00069	0.485
MOD_GSK3_1	163	170	PF00069	0.378
MOD_N-GLC_1	167	172	PF02516	0.333
MOD_NEK2_1	134	139	PF00069	0.346
MOD_NEK2_1	153	158	PF00069	0.405
MOD_NEK2_1	16	21	PF00069	0.264
MOD_NEK2_1	184	189	PF00069	0.337
MOD_NEK2_1	256	261	PF00069	0.394
MOD_NEK2_1	91	96	PF00069	0.348
MOD_PKA_2	166	172	PF00069	0.407
MOD_PKA_2	72	78	PF00069	0.535
MOD_Plk_1	119	125	PF00069	0.416
MOD_Plk_1	256	262	PF00069	0.365
MOD_Plk_2-3	53	59	PF00069	0.427
MOD_Plk_2-3	72	78	PF00069	0.494
MOD_Plk_4	119	125	PF00069	0.454
MOD_Plk_4	12	18	PF00069	0.491
MOD_Plk_4	134	140	PF00069	0.397
MOD_Plk_4	233	239	PF00069	0.496
MOD_ProDKin_1	239	245	PF00069	0.382
MOD_ProDKin_1	248	254	PF00069	0.390
MOD_ProDKin_1	264	270	PF00069	0.243
MOD_ProDKin_1	38	44	PF00069	0.449
MOD_SUMO_rev_2	31	41	PF00179	0.443
MOD_SUMO_rev_2	53	63	PF00179	0.373
TRG_DiLeu_BaEn_1	194	199	PF01217	0.357
TRG_DiLeu_BaEn_1	59	64	PF01217	0.332
TRG_DiLeu_BaEn_4	59	65	PF01217	0.355
TRG_DiLeu_BaLyEn_6	4	9	PF01217	0.680
TRG_ENDOCYTIC_2	195	198	PF00928	0.346
TRG_ENDOCYTIC_2	206	209	PF00928	0.300
TRG_ENDOCYTIC_2	253	256	PF00928	0.373
TRG_ENDOCYTIC_2	88	91	PF00928	0.350
TRG_ENDOCYTIC_2	95	98	PF00928	0.366
TRG_ER_diArg_1	211	214	PF00400	0.444
TRG_ER_diArg_1	230	232	PF00400	0.434
TRG_ER_diArg_1	253	255	PF00400	0.481
TRG_ER_diArg_1	274	277	PF00400	0.474
TRG_ER_diArg_1	5	7	PF00400	0.659
TRG_NES_CRM1_1	228	240	PF08389	0.433
TRG_Pf-PMV_PEXEL_1	6	10	PF00026	0.642

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYL5	Leptomonas seymouri	76%	96%
A0A0S4JCJ0	Bodo saltans	47%	87%
A0A1X0NR19	Trypanosomatidae	60%	100%
A0A3Q8IE10	Leishmania donovani	92%	98%
A4HGX4	Leishmania braziliensis	84%	100%
A4I404	Leishmania infantum	92%	98%
D0A901	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	100%
Q4Q7Z1	Leishmania major	91%	100%
V5B945	Trypanosoma cruzi	56%	100%