Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9B093_LEIMU

TriTrypDb:

LmxM.28.2700

Length:

463

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B093

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B093

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	429	433	PF00656	0.666
CLV_NRD_NRD_1	144	146	PF00675	0.784
CLV_NRD_NRD_1	193	195	PF00675	0.724
CLV_NRD_NRD_1	233	235	PF00675	0.631
CLV_NRD_NRD_1	262	264	PF00675	0.700
CLV_NRD_NRD_1	295	297	PF00675	0.700
CLV_NRD_NRD_1	423	425	PF00675	0.673
CLV_PCSK_KEX2_1	144	146	PF00082	0.784
CLV_PCSK_KEX2_1	192	194	PF00082	0.732
CLV_PCSK_KEX2_1	233	235	PF00082	0.631
CLV_PCSK_KEX2_1	262	264	PF00082	0.705
CLV_PCSK_KEX2_1	423	425	PF00082	0.673
CLV_PCSK_PC7_1	419	425	PF00082	0.490
CLV_PCSK_SKI1_1	174	178	PF00082	0.699
DEG_APCC_DBOX_1	14	22	PF00400	0.600
DEG_APCC_DBOX_1	192	200	PF00400	0.722
DEG_APCC_DBOX_1	423	431	PF00400	0.668
DEG_SCF_FBW7_2	163	169	PF00400	0.675
DEG_SPOP_SBC_1	205	209	PF00917	0.673
DEG_SPOP_SBC_1	370	374	PF00917	0.721
DOC_CKS1_1	163	168	PF01111	0.675
DOC_CKS1_1	175	180	PF01111	0.578
DOC_PP2B_LxvP_1	149	152	PF13499	0.529
DOC_PP2B_LxvP_1	402	405	PF13499	0.687
DOC_PP4_FxxP_1	380	383	PF00568	0.693
DOC_USP7_MATH_1	154	158	PF00917	0.785
DOC_USP7_MATH_1	205	209	PF00917	0.680
DOC_USP7_MATH_1	258	262	PF00917	0.619
DOC_USP7_MATH_1	370	374	PF00917	0.675
DOC_USP7_MATH_1	68	72	PF00917	0.605
DOC_USP7_UBL2_3	121	125	PF12436	0.671
DOC_WW_Pin1_4	114	119	PF00397	0.637
DOC_WW_Pin1_4	125	130	PF00397	0.582
DOC_WW_Pin1_4	162	167	PF00397	0.713
DOC_WW_Pin1_4	174	179	PF00397	0.582
DOC_WW_Pin1_4	274	279	PF00397	0.700
DOC_WW_Pin1_4	301	306	PF00397	0.552
DOC_WW_Pin1_4	384	389	PF00397	0.566
DOC_WW_Pin1_4	418	423	PF00397	0.677
DOC_WW_Pin1_4	45	50	PF00397	0.444
LIG_14-3-3_CanoR_1	144	149	PF00244	0.778
LIG_14-3-3_CanoR_1	156	164	PF00244	0.701
LIG_14-3-3_CanoR_1	192	197	PF00244	0.726
LIG_14-3-3_CanoR_1	206	212	PF00244	0.590
LIG_14-3-3_CanoR_1	262	270	PF00244	0.688
LIG_14-3-3_CanoR_1	282	289	PF00244	0.530
LIG_14-3-3_CanoR_1	455	463	PF00244	0.647
LIG_14-3-3_CanoR_1	84	88	PF00244	0.576
LIG_BIR_II_1	1	5	PF00653	0.668
LIG_BIR_III_4	285	289	PF00653	0.554
LIG_deltaCOP1_diTrp_1	413	416	PF00928	0.660
LIG_FHA_1	1	7	PF00498	0.484
LIG_FHA_1	175	181	PF00498	0.611
LIG_FHA_1	275	281	PF00498	0.683
LIG_FHA_1	398	404	PF00498	0.632
LIG_FHA_1	46	52	PF00498	0.441
LIG_FHA_1	98	104	PF00498	0.518
LIG_FHA_2	100	106	PF00498	0.446
LIG_FHA_2	251	257	PF00498	0.688
LIG_FHA_2	387	393	PF00498	0.588
LIG_GBD_Chelix_1	95	103	PF00786	0.556
LIG_LIR_Apic_2	378	383	PF02991	0.692
LIG_LIR_LC3C_4	400	404	PF02991	0.560
LIG_SH2_STAT3	439	442	PF00017	0.661
LIG_SH2_STAT5	164	167	PF00017	0.708
LIG_SH2_STAT5	50	53	PF00017	0.582
LIG_SH2_STAT5	55	58	PF00017	0.512
LIG_SH2_STAT5	78	81	PF00017	0.654
LIG_SH3_3	160	166	PF00018	0.750
LIG_SH3_3	172	178	PF00018	0.672
LIG_SH3_3	362	368	PF00018	0.625
LIG_SH3_3	380	386	PF00018	0.620
LIG_SUMO_SIM_par_1	2	7	PF11976	0.483
LIG_SUMO_SIM_par_1	99	105	PF11976	0.568
LIG_TRAF2_1	11	14	PF00917	0.614
MOD_CDC14_SPxK_1	421	424	PF00782	0.664
MOD_CDK_SPK_2	162	167	PF00069	0.713
MOD_CDK_SPK_2	418	423	PF00069	0.677
MOD_CDK_SPxK_1	418	424	PF00069	0.677
MOD_CDK_SPxxK_3	114	121	PF00069	0.614
MOD_CDK_SPxxK_3	45	52	PF00069	0.435
MOD_CK1_1	117	123	PF00069	0.588
MOD_CK1_1	157	163	PF00069	0.549
MOD_CK1_1	195	201	PF00069	0.674
MOD_CK1_1	204	210	PF00069	0.606
MOD_CK1_1	261	267	PF00069	0.698
MOD_CK1_1	281	287	PF00069	0.583
MOD_CK1_1	299	305	PF00069	0.547
MOD_CK1_1	307	313	PF00069	0.668
MOD_CK1_1	326	332	PF00069	0.579
MOD_CK1_1	357	363	PF00069	0.749
MOD_CK1_1	372	378	PF00069	0.574
MOD_CK2_1	372	378	PF00069	0.680
MOD_CK2_1	68	74	PF00069	0.624
MOD_CMANNOS	411	414	PF00535	0.705
MOD_Cter_Amidation	142	145	PF01082	0.521
MOD_Cter_Amidation	294	297	PF01082	0.695
MOD_GlcNHglycan	159	162	PF01048	0.583
MOD_GlcNHglycan	188	191	PF01048	0.734
MOD_GlcNHglycan	203	206	PF01048	0.569
MOD_GlcNHglycan	313	316	PF01048	0.692
MOD_GlcNHglycan	323	326	PF01048	0.628
MOD_GlcNHglycan	356	359	PF01048	0.707
MOD_GlcNHglycan	374	377	PF01048	0.544
MOD_GlcNHglycan	70	73	PF01048	0.634
MOD_GSK3_1	170	177	PF00069	0.581
MOD_GSK3_1	188	195	PF00069	0.704
MOD_GSK3_1	201	208	PF00069	0.589
MOD_GSK3_1	257	264	PF00069	0.695
MOD_GSK3_1	274	281	PF00069	0.551
MOD_GSK3_1	299	306	PF00069	0.715
MOD_GSK3_1	307	314	PF00069	0.641
MOD_GSK3_1	317	324	PF00069	0.580
MOD_GSK3_1	79	86	PF00069	0.654
MOD_N-GLC_1	258	263	PF02516	0.610
MOD_N-GLC_1	326	331	PF02516	0.681
MOD_NEK2_1	188	193	PF00069	0.679
MOD_NEK2_1	79	84	PF00069	0.654
MOD_PIKK_1	228	234	PF00454	0.690
MOD_PK_1	296	302	PF00069	0.559
MOD_PK_1	58	64	PF00069	0.617
MOD_PKA_1	144	150	PF00069	0.661
MOD_PKA_1	192	198	PF00069	0.679
MOD_PKA_1	262	268	PF00069	0.699
MOD_PKA_1	296	302	PF00069	0.692
MOD_PKA_2	144	150	PF00069	0.661
MOD_PKA_2	192	198	PF00069	0.727
MOD_PKA_2	205	211	PF00069	0.593
MOD_PKA_2	261	267	PF00069	0.665
MOD_PKA_2	281	287	PF00069	0.535
MOD_PKA_2	454	460	PF00069	0.653
MOD_PKA_2	79	85	PF00069	0.570
MOD_PKB_1	255	263	PF00069	0.694
MOD_PKB_1	309	317	PF00069	0.737
MOD_Plk_4	74	80	PF00069	0.602
MOD_ProDKin_1	114	120	PF00069	0.637
MOD_ProDKin_1	125	131	PF00069	0.584
MOD_ProDKin_1	162	168	PF00069	0.709
MOD_ProDKin_1	174	180	PF00069	0.583
MOD_ProDKin_1	274	280	PF00069	0.701
MOD_ProDKin_1	301	307	PF00069	0.553
MOD_ProDKin_1	384	390	PF00069	0.564
MOD_ProDKin_1	418	424	PF00069	0.677
MOD_ProDKin_1	45	51	PF00069	0.436
TRG_ENDOCYTIC_2	243	246	PF00928	0.738
TRG_ER_diArg_1	144	146	PF00400	0.778
TRG_ER_diArg_1	15	18	PF00400	0.605
TRG_ER_diArg_1	192	194	PF00400	0.686
TRG_ER_diArg_1	308	311	PF00400	0.747
TRG_ER_diArg_1	416	419	PF00400	0.651
TRG_ER_diArg_1	422	424	PF00400	0.653

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IID2	Leishmania donovani	88%	100%
A4HGX3	Leishmania braziliensis	58%	95%
A4I403	Leishmania infantum	88%	100%
Q4Q7Z2	Leishmania major	88%	100%