Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B092_LEIMU

TriTrypDb:

LmxM.28.2690

Length:

374

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 10, no: 0
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

E9B092

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B092

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	237	241	PF00656	0.320
CLV_NRD_NRD_1	3	5	PF00675	0.705
CLV_NRD_NRD_1	311	313	PF00675	0.436
CLV_NRD_NRD_1	327	329	PF00675	0.446
CLV_NRD_NRD_1	339	341	PF00675	0.306
CLV_PCSK_KEX2_1	3	5	PF00082	0.725
CLV_PCSK_KEX2_1	327	329	PF00082	0.502
CLV_PCSK_KEX2_1	338	340	PF00082	0.324
CLV_PCSK_SKI1_1	193	197	PF00082	0.639
CLV_PCSK_SKI1_1	353	357	PF00082	0.496
CLV_PCSK_SKI1_1	358	362	PF00082	0.374
CLV_PCSK_SKI1_1	42	46	PF00082	0.441
CLV_PCSK_SKI1_1	6	10	PF00082	0.672
DEG_APCC_DBOX_1	327	335	PF00400	0.713
DEG_SPOP_SBC_1	118	122	PF00917	0.537
DEG_SPOP_SBC_1	233	237	PF00917	0.534
DOC_CYCLIN_RxL_1	3	11	PF00134	0.575
DOC_MAPK_DCC_7	275	283	PF00069	0.438
DOC_MAPK_gen_1	275	283	PF00069	0.438
DOC_MAPK_MEF2A_6	277	285	PF00069	0.454
DOC_PP1_RVXF_1	132	139	PF00149	0.319
DOC_PP4_FxxP_1	360	363	PF00568	0.767
DOC_USP7_MATH_1	118	122	PF00917	0.534
DOC_USP7_MATH_1	233	237	PF00917	0.458
DOC_USP7_MATH_1	247	251	PF00917	0.415
DOC_USP7_MATH_1	261	265	PF00917	0.354
DOC_USP7_MATH_1	297	301	PF00917	0.473
DOC_USP7_MATH_1	354	358	PF00917	0.674
DOC_USP7_MATH_1	88	92	PF00917	0.525
DOC_USP7_MATH_1	93	97	PF00917	0.520
DOC_WW_Pin1_4	102	107	PF00397	0.412
DOC_WW_Pin1_4	111	116	PF00397	0.552
DOC_WW_Pin1_4	160	165	PF00397	0.342
DOC_WW_Pin1_4	293	298	PF00397	0.480
LIG_14-3-3_CanoR_1	207	216	PF00244	0.446
LIG_14-3-3_CanoR_1	328	336	PF00244	0.683
LIG_14-3-3_CanoR_1	339	345	PF00244	0.691
LIG_BIR_II_1	1	5	PF00653	0.684
LIG_BRCT_BRCA1_1	173	177	PF00533	0.247
LIG_BRCT_BRCA1_1	299	303	PF00533	0.402
LIG_BRCT_BRCA1_1	356	360	PF00533	0.674
LIG_BRCT_BRCA1_1	64	68	PF00533	0.437
LIG_deltaCOP1_diTrp_1	46	52	PF00928	0.390
LIG_FHA_1	189	195	PF00498	0.369
LIG_FHA_1	208	214	PF00498	0.224
LIG_FHA_1	237	243	PF00498	0.475
LIG_FHA_2	174	180	PF00498	0.452
LIG_FHA_2	198	204	PF00498	0.422
LIG_FHA_2	206	212	PF00498	0.382
LIG_FHA_2	61	67	PF00498	0.413
LIG_LIR_Apic_2	102	106	PF02991	0.373
LIG_LIR_Apic_2	357	363	PF02991	0.746
LIG_LIR_Gen_1	291	299	PF02991	0.284
LIG_LIR_Gen_1	300	311	PF02991	0.340
LIG_LIR_Gen_1	66	77	PF02991	0.390
LIG_LIR_Nem_3	132	138	PF02991	0.427
LIG_LIR_Nem_3	182	188	PF02991	0.416
LIG_LIR_Nem_3	291	295	PF02991	0.284
LIG_LIR_Nem_3	300	306	PF02991	0.340
LIG_LIR_Nem_3	66	72	PF02991	0.385
LIG_Pex14_1	135	139	PF04695	0.339
LIG_Pex14_1	47	51	PF04695	0.263
LIG_Pex14_1	64	68	PF04695	0.421
LIG_Pex14_2	138	142	PF04695	0.259
LIG_SH2_CRK	185	189	PF00017	0.388
LIG_SH2_SRC	267	270	PF00017	0.407
LIG_SH2_STAP1	131	135	PF00017	0.357
LIG_SH2_STAP1	209	213	PF00017	0.431
LIG_SH2_STAT5	131	134	PF00017	0.438
LIG_SH2_STAT5	185	188	PF00017	0.378
LIG_SH2_STAT5	209	212	PF00017	0.469
LIG_SH2_STAT5	267	270	PF00017	0.432
LIG_SH2_STAT5	349	352	PF00017	0.647
LIG_SH3_1	348	354	PF00018	0.641
LIG_SH3_2	351	356	PF14604	0.700
LIG_SH3_3	158	164	PF00018	0.444
LIG_SH3_3	348	354	PF00018	0.637
LIG_SH3_3	360	366	PF00018	0.753
LIG_SUMO_SIM_anti_2	15	21	PF11976	0.571
LIG_TYR_ITIM	183	188	PF00017	0.370
LIG_UBA3_1	284	290	PF00899	0.478
MOD_CK1_1	120	126	PF00069	0.499
MOD_CK1_1	236	242	PF00069	0.507
MOD_CK1_1	96	102	PF00069	0.546
MOD_CK2_1	173	179	PF00069	0.400
MOD_CK2_1	205	211	PF00069	0.377
MOD_CK2_1	60	66	PF00069	0.345
MOD_CK2_1	96	102	PF00069	0.451
MOD_GlcNHglycan	125	128	PF01048	0.683
MOD_GlcNHglycan	179	182	PF01048	0.546
MOD_GlcNHglycan	219	223	PF01048	0.577
MOD_GlcNHglycan	229	232	PF01048	0.672
MOD_GlcNHglycan	31	34	PF01048	0.625
MOD_GlcNHglycan	371	374	PF01048	0.537
MOD_GSK3_1	107	114	PF00069	0.555
MOD_GSK3_1	117	124	PF00069	0.449
MOD_GSK3_1	171	178	PF00069	0.400
MOD_GSK3_1	179	186	PF00069	0.362
MOD_GSK3_1	193	200	PF00069	0.304
MOD_GSK3_1	201	208	PF00069	0.435
MOD_GSK3_1	232	239	PF00069	0.480
MOD_GSK3_1	284	291	PF00069	0.417
MOD_GSK3_1	293	300	PF00069	0.342
MOD_GSK3_1	340	347	PF00069	0.744
MOD_GSK3_1	354	361	PF00069	0.560
MOD_GSK3_1	365	372	PF00069	0.660
MOD_GSK3_1	60	67	PF00069	0.280
MOD_GSK3_1	75	82	PF00069	0.363
MOD_GSK3_1	8	15	PF00069	0.577
MOD_N-GLC_1	129	134	PF02516	0.486
MOD_N-GLC_1	197	202	PF02516	0.543
MOD_N-GLC_1	247	252	PF02516	0.645
MOD_N-GLC_1	297	302	PF02516	0.402
MOD_N-GLC_1	314	319	PF02516	0.503
MOD_N-GLC_1	329	334	PF02516	0.510
MOD_NEK2_1	117	122	PF00069	0.533
MOD_NEK2_1	177	182	PF00069	0.369
MOD_NEK2_1	183	188	PF00069	0.342
MOD_NEK2_1	234	239	PF00069	0.400
MOD_NEK2_1	284	289	PF00069	0.501
MOD_NEK2_1	31	36	PF00069	0.487
MOD_NEK2_1	321	326	PF00069	0.660
MOD_NEK2_1	344	349	PF00069	0.673
MOD_NEK2_1	79	84	PF00069	0.374
MOD_NEK2_1	8	13	PF00069	0.581
MOD_NEK2_2	129	134	PF00069	0.322
MOD_NEK2_2	64	69	PF00069	0.331
MOD_PIKK_1	108	114	PF00454	0.523
MOD_PIKK_1	137	143	PF00454	0.262
MOD_PIKK_1	154	160	PF00454	0.366
MOD_PKB_1	338	346	PF00069	0.721
MOD_Plk_1	297	303	PF00069	0.402
MOD_Plk_1	329	335	PF00069	0.710
MOD_Plk_4	179	185	PF00069	0.400
MOD_Plk_4	262	268	PF00069	0.241
MOD_Plk_4	297	303	PF00069	0.402
MOD_Plk_4	340	346	PF00069	0.719
MOD_Plk_4	64	70	PF00069	0.378
MOD_Plk_4	75	81	PF00069	0.387
MOD_Plk_4	8	14	PF00069	0.562
MOD_ProDKin_1	102	108	PF00069	0.412
MOD_ProDKin_1	111	117	PF00069	0.552
MOD_ProDKin_1	160	166	PF00069	0.338
MOD_ProDKin_1	293	299	PF00069	0.480
TRG_DiLeu_BaEn_1	179	184	PF01217	0.317
TRG_ENDOCYTIC_2	185	188	PF00928	0.363
TRG_ENDOCYTIC_2	349	352	PF00928	0.713
TRG_ER_diArg_1	3	6	PF00400	0.671
TRG_ER_diArg_1	326	328	PF00400	0.709
TRG_ER_diArg_1	338	340	PF00400	0.508
TRG_ER_diArg_1	366	369	PF00400	0.781

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3M3	Leptomonas seymouri	49%	99%
A0A1X0NQJ6	Trypanosomatidae	36%	100%
A0A3S7X1V5	Leishmania donovani	87%	100%
A0A422MSP0	Trypanosoma rangeli	35%	100%
A4HGX2	Leishmania braziliensis	69%	100%
A4I402	Leishmania infantum	88%	100%
D0A972	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
Q4Q7Z3	Leishmania major	83%	99%
V5AWR0	Trypanosoma cruzi	34%	100%