Putative membrane-bound acid phosphatase

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

membrane-bound acid phosphatase, putative

Species:

Leishmania mexicana

UniProt:

E9B088_LEIMU

TriTrypDb:

LmxM.28.2650

Length:

550

Annotations

LeishMANIAdb annotations

An extensively expanded family of exophosphatase enzymes presumed to be active at acidic pH

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 1
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 60

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 7

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 14

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 34, no: 3
NetGPI	no	yes: 0, no: 37

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	28
GO:0110165	cellular anatomical entity	1	28

Expansion

Sequence features

E9B088

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B088

Function

Biological processes
Term	Name	Level	Count
GO:0006793	phosphorus metabolic process	3	4
GO:0006796	phosphate-containing compound metabolic process	4	4
GO:0008152	metabolic process	1	4
GO:0009987	cellular process	1	4
GO:0016311	dephosphorylation	5	4
GO:0044237	cellular metabolic process	2	4

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	6
GO:0003993	acid phosphatase activity	6	2
GO:0016787	hydrolase activity	2	6
GO:0016788	hydrolase activity, acting on ester bonds	3	6
GO:0016791	phosphatase activity	5	6
GO:0042578	phosphoric ester hydrolase activity	4	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	16	18	PF00675	0.603
CLV_NRD_NRD_1	395	397	PF00675	0.529
CLV_PCSK_KEX2_1	16	18	PF00082	0.635
CLV_PCSK_KEX2_1	395	397	PF00082	0.514
CLV_Separin_Metazoa	544	548	PF03568	0.551
DOC_CKS1_1	33	38	PF01111	0.402
DOC_MAPK_gen_1	16	24	PF00069	0.300
DOC_MAPK_MEF2A_6	16	24	PF00069	0.516
DOC_PP1_RVXF_1	394	401	PF00149	0.369
DOC_PP2B_LxvP_1	457	460	PF13499	0.409
DOC_PP4_FxxP_1	164	167	PF00568	0.202
DOC_PP4_FxxP_1	76	79	PF00568	0.173
DOC_PP4_MxPP_1	324	327	PF00568	0.331
DOC_USP7_MATH_1	141	145	PF00917	0.264
DOC_USP7_MATH_1	178	182	PF00917	0.392
DOC_USP7_MATH_1	264	268	PF00917	0.295
DOC_USP7_MATH_1	34	38	PF00917	0.646
DOC_WW_Pin1_4	32	37	PF00397	0.605
DOC_WW_Pin1_4	354	359	PF00397	0.294
DOC_WW_Pin1_4	69	74	PF00397	0.417
LIG_14-3-3_CanoR_1	121	129	PF00244	0.269
LIG_14-3-3_CanoR_1	294	298	PF00244	0.239
LIG_14-3-3_CanoR_1	395	401	PF00244	0.293
LIG_14-3-3_CanoR_1	95	103	PF00244	0.331
LIG_Actin_WH2_2	234	251	PF00022	0.292
LIG_APCC_Cbox_2	189	195	PF00515	0.230
LIG_BRCT_BRCA1_1	264	268	PF00533	0.431
LIG_deltaCOP1_diTrp_1	254	260	PF00928	0.279
LIG_FHA_1	213	219	PF00498	0.363
LIG_FHA_1	294	300	PF00498	0.292
LIG_FHA_1	367	373	PF00498	0.350
LIG_FHA_1	383	389	PF00498	0.339
LIG_FHA_1	414	420	PF00498	0.371
LIG_FHA_1	428	434	PF00498	0.270
LIG_FHA_1	63	69	PF00498	0.385
LIG_FHA_2	121	127	PF00498	0.264
LIG_FHA_2	313	319	PF00498	0.313
LIG_FHA_2	99	105	PF00498	0.381
LIG_HP1_1	167	171	PF01393	0.193
LIG_LIR_Apic_2	163	167	PF02991	0.340
LIG_LIR_Gen_1	165	176	PF02991	0.332
LIG_LIR_Gen_1	194	203	PF02991	0.354
LIG_LIR_Nem_3	165	171	PF02991	0.279
LIG_LIR_Nem_3	194	198	PF02991	0.349
LIG_LIR_Nem_3	392	397	PF02991	0.285
LIG_PCNA_PIPBox_1	85	94	PF02747	0.304
LIG_PCNA_yPIPBox_3	183	192	PF02747	0.293
LIG_Pex14_1	168	172	PF04695	0.341
LIG_Pex14_1	206	210	PF04695	0.415
LIG_Pex14_2	164	168	PF04695	0.342
LIG_Pex14_2	362	366	PF04695	0.389
LIG_SH2_NCK_1	328	332	PF00017	0.255
LIG_SH2_NCK_1	449	453	PF00017	0.248
LIG_SH2_PTP2	19	22	PF00017	0.370
LIG_SH2_SRC	225	228	PF00017	0.315
LIG_SH2_SRC	262	265	PF00017	0.396
LIG_SH2_STAP1	113	117	PF00017	0.274
LIG_SH2_STAP1	172	176	PF00017	0.311
LIG_SH2_STAP1	214	218	PF00017	0.335
LIG_SH2_STAP1	328	332	PF00017	0.255
LIG_SH2_STAT5	162	165	PF00017	0.333
LIG_SH2_STAT5	172	175	PF00017	0.283
LIG_SH2_STAT5	19	22	PF00017	0.365
LIG_SH2_STAT5	191	194	PF00017	0.372
LIG_SH2_STAT5	210	213	PF00017	0.326
LIG_SH2_STAT5	214	217	PF00017	0.352
LIG_SH2_STAT5	397	400	PF00017	0.316
LIG_SH2_STAT5	455	458	PF00017	0.329
LIG_SH3_3	100	106	PF00018	0.295
LIG_SH3_3	28	34	PF00018	0.358
LIG_SH3_3	430	436	PF00018	0.428
LIG_SUMO_SIM_anti_2	114	120	PF11976	0.167
LIG_SUMO_SIM_anti_2	516	521	PF11976	0.411
LIG_TRAF2_1	424	427	PF00917	0.438
LIG_TRAF2_2	354	359	PF00917	0.348
LIG_WRC_WIRS_1	161	166	PF05994	0.353
LIG_WRC_WIRS_1	88	93	PF05994	0.322
MOD_CDK_SPxK_1	32	38	PF00069	0.406
MOD_CK1_1	120	126	PF00069	0.312
MOD_CK1_1	212	218	PF00069	0.347
MOD_CK1_1	37	43	PF00069	0.425
MOD_CK1_1	490	496	PF00069	0.478
MOD_CK2_1	113	119	PF00069	0.305
MOD_CK2_1	120	126	PF00069	0.291
MOD_GlcNHglycan	130	133	PF01048	0.463
MOD_GlcNHglycan	180	183	PF01048	0.629
MOD_GlcNHglycan	228	231	PF01048	0.444
MOD_GlcNHglycan	302	305	PF01048	0.505
MOD_GlcNHglycan	341	344	PF01048	0.552
MOD_GlcNHglycan	413	419	PF01048	0.551
MOD_GlcNHglycan	443	446	PF01048	0.532
MOD_GlcNHglycan	457	460	PF01048	0.524
MOD_GlcNHglycan	467	470	PF01048	0.543
MOD_GlcNHglycan	478	481	PF01048	0.645
MOD_GlcNHglycan	489	492	PF01048	0.665
MOD_GlcNHglycan	57	60	PF01048	0.544
MOD_GSK3_1	113	120	PF00069	0.229
MOD_GSK3_1	149	156	PF00069	0.313
MOD_GSK3_1	209	216	PF00069	0.330
MOD_GSK3_1	262	269	PF00069	0.336
MOD_GSK3_1	362	369	PF00069	0.383
MOD_GSK3_1	455	462	PF00069	0.403
MOD_GSK3_1	483	490	PF00069	0.508
MOD_GSK3_1	509	516	PF00069	0.308
MOD_GSK3_1	55	62	PF00069	0.359
MOD_GSK3_1	87	94	PF00069	0.342
MOD_N-GLC_1	141	146	PF02516	0.479
MOD_N-GLC_1	212	217	PF02516	0.574
MOD_N-GLC_1	483	488	PF02516	0.577
MOD_N-GLC_1	63	68	PF02516	0.547
MOD_N-GLC_2	387	389	PF02516	0.504
MOD_NEK2_1	125	130	PF00069	0.240
MOD_NEK2_1	160	165	PF00069	0.347
MOD_NEK2_1	171	176	PF00069	0.380
MOD_NEK2_1	300	305	PF00069	0.307
MOD_NEK2_1	441	446	PF00069	0.368
MOD_NEK2_1	91	96	PF00069	0.315
MOD_OFUCOSY	464	471	PF10250	0.653
MOD_OGLYCOS	69	74	PF02709	0.476
MOD_PIKK_1	153	159	PF00454	0.426
MOD_PIKK_1	162	168	PF00454	0.370
MOD_PIKK_1	459	465	PF00454	0.431
MOD_PKA_2	120	126	PF00069	0.269
MOD_PKA_2	293	299	PF00069	0.398
MOD_PKA_2	37	43	PF00069	0.358
MOD_PKB_1	93	101	PF00069	0.355
MOD_Plk_1	113	119	PF00069	0.250
MOD_Plk_1	125	131	PF00069	0.248
MOD_Plk_1	141	147	PF00069	0.321
MOD_Plk_1	305	311	PF00069	0.284
MOD_Plk_1	414	420	PF00069	0.347
MOD_Plk_1	427	433	PF00069	0.372
MOD_Plk_1	483	489	PF00069	0.364
MOD_Plk_1	536	542	PF00069	0.667
MOD_Plk_1	63	69	PF00069	0.329
MOD_Plk_1	98	104	PF00069	0.285
MOD_Plk_4	113	119	PF00069	0.293
MOD_Plk_4	513	519	PF00069	0.320
MOD_Plk_4	6	12	PF00069	0.468
MOD_Plk_4	87	93	PF00069	0.279
MOD_Plk_4	98	104	PF00069	0.288
MOD_ProDKin_1	32	38	PF00069	0.604
MOD_ProDKin_1	354	360	PF00069	0.296
MOD_ProDKin_1	69	75	PF00069	0.382
TRG_DiLeu_BaLyEn_6	142	147	PF01217	0.278
TRG_ENDOCYTIC_2	19	22	PF00928	0.347
TRG_ENDOCYTIC_2	245	248	PF00928	0.360
TRG_ENDOCYTIC_2	256	259	PF00928	0.300
TRG_ENDOCYTIC_2	297	300	PF00928	0.381
TRG_ER_diArg_1	15	17	PF00400	0.487
TRG_ER_diArg_1	394	396	PF00400	0.326
TRG_ER_diArg_1	92	95	PF00400	0.308

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5Y5	Leptomonas seymouri	43%	96%
A0A0N1I756	Leptomonas seymouri	35%	100%
A0A0N1PEH4	Leptomonas seymouri	32%	100%
A0A0S4IRF5	Bodo saltans	23%	82%
A0A0S4IUV8	Bodo saltans	23%	100%
A0A0S4IV77	Bodo saltans	33%	100%
A0A0S4JEA9	Bodo saltans	24%	100%
A0A0S4JJK3	Bodo saltans	29%	100%
A0A0S4JW09	Bodo saltans	26%	100%
A0A1X0NNY4	Trypanosomatidae	36%	99%
A0A1X0NQL4	Trypanosomatidae	29%	100%
A0A1X0NY34	Trypanosomatidae	25%	100%
A0A1X0P7V5	Trypanosomatidae	39%	100%
A0A3Q8IR23	Leishmania donovani	45%	96%
A0A3R7KSH4	Trypanosoma rangeli	25%	100%
A0A3R7MEN7	Trypanosoma rangeli	41%	100%
A0A3R7MHJ7	Trypanosoma rangeli	29%	100%
A0A3S5H827	Leishmania donovani	36%	100%
A0A3S7WXU0	Leishmania donovani	43%	100%
A0A3S7X1W4	Leishmania donovani	87%	100%
A4HCZ0	Leishmania braziliensis	41%	100%
A4HGW8	Leishmania braziliensis	72%	100%
A4HPC1	Leishmania braziliensis	35%	100%
A4HPC5	Leishmania braziliensis	45%	100%
A4HQG6	Leishmania braziliensis	34%	100%
A4HQG9	Leishmania braziliensis	34%	100%
A4I0H5	Leishmania infantum	43%	100%
A4I3Z8	Leishmania infantum	87%	100%
A4ICA5	Leishmania infantum	33%	82%
A4ICG3	Leishmania infantum	36%	100%
A4ICG5	Leishmania infantum	46%	96%
B1H1P9	Xenopus laevis	27%	100%
D0A3E0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
D0A947	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	23%	100%
D0A948	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	23%	100%
D0A9J5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9AT34	Leishmania mexicana (strain MHOM/GT/2001/U1103)	36%	100%
E9AT36	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	100%
E9AWD7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	42%	100%
P11117	Homo sapiens	27%	100%
P20611	Rattus norvegicus	26%	100%
P24638	Mus musculus	27%	100%
Q0P5F0	Bos taurus	26%	100%
Q4Q0A9	Leishmania major	26%	100%
Q4Q1G2	Leishmania major	45%	100%
Q4Q1G4	Leishmania major	36%	100%
Q4Q7Z7	Leishmania major	85%	100%
Q4QB35	Leishmania major	42%	100%
Q4R5N9	Macaca fascicularis	27%	100%
Q5NVF6	Pongo abelii	27%	100%
V5BCI2	Trypanosoma cruzi	25%	100%
V5BIM1	Trypanosoma cruzi	23%	100%
V5BK91	Trypanosoma cruzi	37%	100%
V5BL75	Trypanosoma cruzi	28%	100%