Molybdenum cofactor biosynthesis protein,putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

molybdenum cofactor biosynthesis protein, putative

Species:

Leishmania mexicana

UniProt:

E9B087_LEIMU

TriTrypDb:

LmxM.28.2640

Length:

761

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B087

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B087

Function

Biological processes
Term	Name	Level	Count
GO:0006777	Mo-molybdopterin cofactor biosynthetic process	5	6
GO:0006793	phosphorus metabolic process	3	6
GO:0006796	phosphate-containing compound metabolic process	4	6
GO:0006807	nitrogen compound metabolic process	2	6
GO:0008152	metabolic process	1	6
GO:0009058	biosynthetic process	2	6
GO:0009987	cellular process	1	6
GO:0018130	heterocycle biosynthetic process	4	6
GO:0019637	organophosphate metabolic process	3	6
GO:0019720	Mo-molybdopterin cofactor metabolic process	4	6
GO:0032324	molybdopterin cofactor biosynthetic process	4	6
GO:0043545	molybdopterin cofactor metabolic process	3	6
GO:0044237	cellular metabolic process	2	6
GO:0044249	cellular biosynthetic process	3	6
GO:0046483	heterocycle metabolic process	3	6
GO:0051189	prosthetic group metabolic process	2	6
GO:0071704	organic substance metabolic process	2	6
GO:0090407	organophosphate biosynthetic process	4	6
GO:1901360	organic cyclic compound metabolic process	3	6
GO:1901362	organic cyclic compound biosynthetic process	4	6
GO:1901564	organonitrogen compound metabolic process	3	6
GO:1901566	organonitrogen compound biosynthetic process	4	6
GO:1901576	organic substance biosynthetic process	3	6

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0016829	lyase activity	2	1
GO:0016830	carbon-carbon lyase activity	3	1
GO:0016849	phosphorus-oxygen lyase activity	3	1
GO:0061798	GTP 3',8'-cyclase activity	4	1
GO:0061799	cyclic pyranopterin monophosphate synthase activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	288	292	PF00656	0.706
CLV_NRD_NRD_1	277	279	PF00675	0.744
CLV_NRD_NRD_1	318	320	PF00675	0.718
CLV_NRD_NRD_1	404	406	PF00675	0.730
CLV_NRD_NRD_1	428	430	PF00675	0.786
CLV_NRD_NRD_1	501	503	PF00675	0.713
CLV_NRD_NRD_1	575	577	PF00675	0.732
CLV_NRD_NRD_1	605	607	PF00675	0.610
CLV_NRD_NRD_1	615	617	PF00675	0.632
CLV_NRD_NRD_1	664	666	PF00675	0.720
CLV_NRD_NRD_1	698	700	PF00675	0.625
CLV_NRD_NRD_1	745	747	PF00675	0.721
CLV_NRD_NRD_1	76	78	PF00675	0.415
CLV_NRD_NRD_1	96	98	PF00675	0.415
CLV_PCSK_KEX2_1	167	169	PF00082	0.415
CLV_PCSK_KEX2_1	273	275	PF00082	0.746
CLV_PCSK_KEX2_1	277	279	PF00082	0.701
CLV_PCSK_KEX2_1	310	312	PF00082	0.639
CLV_PCSK_KEX2_1	318	320	PF00082	0.632
CLV_PCSK_KEX2_1	404	406	PF00082	0.700
CLV_PCSK_KEX2_1	428	430	PF00082	0.786
CLV_PCSK_KEX2_1	499	501	PF00082	0.721
CLV_PCSK_KEX2_1	526	528	PF00082	0.705
CLV_PCSK_KEX2_1	533	535	PF00082	0.654
CLV_PCSK_KEX2_1	587	589	PF00082	0.709
CLV_PCSK_KEX2_1	663	665	PF00082	0.720
CLV_PCSK_KEX2_1	698	700	PF00082	0.668
CLV_PCSK_KEX2_1	75	77	PF00082	0.415
CLV_PCSK_KEX2_1	754	756	PF00082	0.712
CLV_PCSK_KEX2_1	759	761	PF00082	0.658
CLV_PCSK_KEX2_1	95	97	PF00082	0.415
CLV_PCSK_PC1ET2_1	167	169	PF00082	0.415
CLV_PCSK_PC1ET2_1	273	275	PF00082	0.746
CLV_PCSK_PC1ET2_1	310	312	PF00082	0.639
CLV_PCSK_PC1ET2_1	499	501	PF00082	0.721
CLV_PCSK_PC1ET2_1	526	528	PF00082	0.705
CLV_PCSK_PC1ET2_1	533	535	PF00082	0.654
CLV_PCSK_PC1ET2_1	587	589	PF00082	0.584
CLV_PCSK_PC1ET2_1	754	756	PF00082	0.712
CLV_PCSK_PC1ET2_1	759	761	PF00082	0.658
CLV_PCSK_PC7_1	755	761	PF00082	0.707
CLV_PCSK_PC7_1	91	97	PF00082	0.415
CLV_PCSK_SKI1_1	2	6	PF00082	0.692
CLV_PCSK_SKI1_1	234	238	PF00082	0.624
CLV_PCSK_SKI1_1	435	439	PF00082	0.732
CLV_PCSK_SKI1_1	747	751	PF00082	0.721
CLV_PCSK_SKI1_1	77	81	PF00082	0.415
CLV_PCSK_SKI1_1	91	95	PF00082	0.253
DEG_APCC_KENBOX_2	638	642	PF00400	0.545
DEG_Nend_UBRbox_1	1	4	PF02207	0.621
DEG_SCF_FBW7_1	335	340	PF00400	0.549
DEG_SCF_FBW7_1	613	618	PF00400	0.550
DEG_SCF_FBW7_1	7	13	PF00400	0.706
DEG_SPOP_SBC_1	474	478	PF00917	0.727
DOC_ANK_TNKS_1	325	332	PF00023	0.547
DOC_CKS1_1	4	9	PF01111	0.688
DOC_CKS1_1	63	68	PF01111	0.375
DOC_CYCLIN_yCln2_LP_2	327	330	PF00134	0.694
DOC_CYCLIN_yCln2_LP_2	4	10	PF00134	0.689
DOC_MAPK_FxFP_2	61	64	PF00069	0.375
DOC_MAPK_gen_1	587	596	PF00069	0.662
DOC_PP2B_LxvP_1	327	330	PF13499	0.796
DOC_PP2B_LxvP_1	80	83	PF13499	0.415
DOC_PP4_FxxP_1	61	64	PF00568	0.375
DOC_USP7_MATH_1	103	107	PF00917	0.375
DOC_USP7_MATH_1	22	26	PF00917	0.667
DOC_USP7_MATH_1	222	226	PF00917	0.791
DOC_USP7_MATH_1	337	341	PF00917	0.641
DOC_USP7_MATH_1	350	354	PF00917	0.686
DOC_USP7_MATH_1	408	412	PF00917	0.674
DOC_USP7_MATH_1	431	435	PF00917	0.705
DOC_USP7_MATH_1	437	441	PF00917	0.690
DOC_USP7_MATH_1	443	447	PF00917	0.620
DOC_USP7_MATH_1	518	522	PF00917	0.690
DOC_USP7_MATH_1	580	584	PF00917	0.565
DOC_USP7_MATH_1	597	601	PF00917	0.632
DOC_USP7_MATH_1	615	619	PF00917	0.545
DOC_USP7_UBL2_3	373	377	PF12436	0.626
DOC_USP7_UBL2_3	587	591	PF12436	0.584
DOC_USP7_UBL2_3	667	671	PF12436	0.730
DOC_USP7_UBL2_3	747	751	PF12436	0.729
DOC_WW_Pin1_4	10	15	PF00397	0.667
DOC_WW_Pin1_4	234	239	PF00397	0.611
DOC_WW_Pin1_4	3	8	PF00397	0.727
DOC_WW_Pin1_4	333	338	PF00397	0.760
DOC_WW_Pin1_4	346	351	PF00397	0.569
DOC_WW_Pin1_4	611	616	PF00397	0.700
DOC_WW_Pin1_4	62	67	PF00397	0.443
LIG_14-3-3_CanoR_1	345	350	PF00244	0.627
LIG_14-3-3_CanoR_1	442	450	PF00244	0.565
LIG_14-3-3_CanoR_1	619	627	PF00244	0.705
LIG_14-3-3_CanoR_1	69	75	PF00244	0.415
LIG_14-3-3_CanoR_1	95	101	PF00244	0.415
LIG_BRCT_BRCA1_1	70	74	PF00533	0.415
LIG_deltaCOP1_diTrp_1	690	696	PF00928	0.731
LIG_Dynein_DLC8_1	524	530	PF01221	0.665
LIG_FHA_1	173	179	PF00498	0.617
LIG_FHA_1	394	400	PF00498	0.722
LIG_FHA_1	407	413	PF00498	0.574
LIG_FHA_1	41	47	PF00498	0.415
LIG_FHA_2	139	145	PF00498	0.415
LIG_FHA_2	261	267	PF00498	0.552
LIG_FHA_2	283	289	PF00498	0.702
LIG_FHA_2	550	556	PF00498	0.675
LIG_FHA_2	724	730	PF00498	0.728
LIG_GSK3_LRP6_1	10	15	PF00069	0.522
LIG_LIR_Gen_1	109	116	PF02991	0.415
LIG_LIR_Gen_1	141	150	PF02991	0.517
LIG_LIR_Gen_1	173	182	PF02991	0.635
LIG_LIR_Nem_3	109	113	PF02991	0.415
LIG_LIR_Nem_3	141	146	PF02991	0.517
LIG_LIR_Nem_3	173	177	PF02991	0.596
LIG_MYND_1	740	744	PF01753	0.516
LIG_NRP_CendR_1	759	761	PF00754	0.726
LIG_Pex14_1	692	696	PF04695	0.735
LIG_RPA_C_Fungi	660	672	PF08784	0.683
LIG_SH2_CRK	110	114	PF00017	0.415
LIG_SH2_CRK	143	147	PF00017	0.415
LIG_SH2_STAP1	110	114	PF00017	0.415
LIG_SH2_STAT5	114	117	PF00017	0.415
LIG_SH2_STAT5	33	36	PF00017	0.415
LIG_SH2_STAT5	535	538	PF00017	0.727
LIG_SH3_1	326	332	PF00018	0.695
LIG_SH3_2	675	680	PF14604	0.694
LIG_SH3_2	741	746	PF14604	0.709
LIG_SH3_3	179	185	PF00018	0.747
LIG_SH3_3	18	24	PF00018	0.564
LIG_SH3_3	210	216	PF00018	0.747
LIG_SH3_3	326	332	PF00018	0.760
LIG_SH3_3	4	10	PF00018	0.642
LIG_SH3_3	672	678	PF00018	0.690
LIG_SH3_3	737	743	PF00018	0.706
LIG_SH3_3	76	82	PF00018	0.447
LIG_SUMO_SIM_anti_2	25	31	PF11976	0.649
LIG_TRAF2_1	258	261	PF00917	0.782
LIG_TRAF2_1	418	421	PF00917	0.700
LIG_TRAF2_1	464	467	PF00917	0.697
LIG_TRAF2_1	470	473	PF00917	0.650
LIG_TRAF2_1	485	488	PF00917	0.592
LIG_TRAF2_1	559	562	PF00917	0.637
LIG_TRAF2_1	635	638	PF00917	0.691
LIG_TRAF2_1	716	719	PF00917	0.659
LIG_WW_2	740	743	PF00397	0.519
LIG_WW_3	81	85	PF00397	0.415
MOD_CDK_SPK_2	611	616	PF00069	0.700
MOD_CDK_SPxK_1	611	617	PF00069	0.702
MOD_CDK_SPxxK_3	62	69	PF00069	0.375
MOD_CK1_1	193	199	PF00069	0.583
MOD_CK1_1	225	231	PF00069	0.746
MOD_CK1_1	339	345	PF00069	0.727
MOD_CK1_1	351	357	PF00069	0.591
MOD_CK1_1	376	382	PF00069	0.789
MOD_CK1_1	512	518	PF00069	0.657
MOD_CK1_1	521	527	PF00069	0.636
MOD_CK1_1	618	624	PF00069	0.588
MOD_CK1_1	697	703	PF00069	0.720
MOD_CK2_1	103	109	PF00069	0.375
MOD_CK2_1	155	161	PF00069	0.415
MOD_CK2_1	177	183	PF00069	0.635
MOD_CK2_1	221	227	PF00069	0.571
MOD_CK2_1	24	30	PF00069	0.650
MOD_CK2_1	260	266	PF00069	0.553
MOD_CK2_1	303	309	PF00069	0.650
MOD_CK2_1	353	359	PF00069	0.703
MOD_CK2_1	408	414	PF00069	0.621
MOD_CK2_1	443	449	PF00069	0.685
MOD_CK2_1	631	637	PF00069	0.702
MOD_CK2_1	723	729	PF00069	0.727
MOD_Cter_Amidation	524	527	PF01082	0.719
MOD_Cter_Amidation	585	588	PF01082	0.730
MOD_Cter_Amidation	604	607	PF01082	0.539
MOD_DYRK1A_RPxSP_1	234	238	PF00069	0.556
MOD_GlcNHglycan	16	19	PF01048	0.649
MOD_GlcNHglycan	188	191	PF01048	0.718
MOD_GlcNHglycan	192	195	PF01048	0.693
MOD_GlcNHglycan	204	207	PF01048	0.747
MOD_GlcNHglycan	208	211	PF01048	0.727
MOD_GlcNHglycan	224	227	PF01048	0.614
MOD_GlcNHglycan	244	247	PF01048	0.727
MOD_GlcNHglycan	266	272	PF01048	0.679
MOD_GlcNHglycan	291	295	PF01048	0.780
MOD_GlcNHglycan	350	353	PF01048	0.705
MOD_GlcNHglycan	355	358	PF01048	0.676
MOD_GlcNHglycan	386	389	PF01048	0.702
MOD_GlcNHglycan	439	442	PF01048	0.733
MOD_GlcNHglycan	445	448	PF01048	0.699
MOD_GlcNHglycan	457	460	PF01048	0.661
MOD_GlcNHglycan	523	526	PF01048	0.753
MOD_GlcNHglycan	569	572	PF01048	0.684
MOD_GlcNHglycan	603	606	PF01048	0.716
MOD_GlcNHglycan	620	623	PF01048	0.562
MOD_GlcNHglycan	631	636	PF01048	0.623
MOD_GSK3_1	186	193	PF00069	0.808
MOD_GSK3_1	202	209	PF00069	0.638
MOD_GSK3_1	216	223	PF00069	0.714
MOD_GSK3_1	225	232	PF00069	0.751
MOD_GSK3_1	252	259	PF00069	0.558
MOD_GSK3_1	333	340	PF00069	0.680
MOD_GSK3_1	346	353	PF00069	0.624
MOD_GSK3_1	473	480	PF00069	0.824
MOD_GSK3_1	509	516	PF00069	0.702
MOD_GSK3_1	521	528	PF00069	0.569
MOD_GSK3_1	597	604	PF00069	0.618
MOD_GSK3_1	6	13	PF00069	0.704
MOD_GSK3_1	611	618	PF00069	0.591
MOD_N-GLC_1	431	436	PF02516	0.734
MOD_NEK2_1	136	141	PF00069	0.375
MOD_NEK2_1	186	191	PF00069	0.714
MOD_NEK2_1	40	45	PF00069	0.415
MOD_NEK2_2	138	143	PF00069	0.415
MOD_NEK2_2	70	75	PF00069	0.415
MOD_PIKK_1	252	258	PF00454	0.561
MOD_PIKK_1	525	531	PF00454	0.763
MOD_PKA_1	501	507	PF00069	0.714
MOD_PKA_1	95	101	PF00069	0.415
MOD_PKA_2	303	309	PF00069	0.626
MOD_PKA_2	501	507	PF00069	0.714
MOD_PKA_2	615	621	PF00069	0.658
MOD_PKA_2	68	74	PF00069	0.415
MOD_PKA_2	697	703	PF00069	0.665
MOD_PKA_2	95	101	PF00069	0.415
MOD_PKB_1	343	351	PF00069	0.698
MOD_Plk_1	108	114	PF00069	0.415
MOD_Plk_1	431	437	PF00069	0.731
MOD_Plk_2-3	155	161	PF00069	0.415
MOD_Plk_2-3	260	266	PF00069	0.586
MOD_Plk_4	108	114	PF00069	0.421
MOD_Plk_4	138	144	PF00069	0.490
MOD_Plk_4	24	30	PF00069	0.650
MOD_Plk_4	376	382	PF00069	0.687
MOD_Plk_4	54	60	PF00069	0.415
MOD_ProDKin_1	10	16	PF00069	0.669
MOD_ProDKin_1	234	240	PF00069	0.612
MOD_ProDKin_1	3	9	PF00069	0.730
MOD_ProDKin_1	333	339	PF00069	0.758
MOD_ProDKin_1	346	352	PF00069	0.570
MOD_ProDKin_1	611	617	PF00069	0.702
MOD_ProDKin_1	62	68	PF00069	0.443
MOD_SUMO_rev_2	449	459	PF00179	0.629
TRG_ENDOCYTIC_2	110	113	PF00928	0.415
TRG_ENDOCYTIC_2	143	146	PF00928	0.523
TRG_ER_diArg_1	276	278	PF00400	0.749
TRG_ER_diArg_1	317	319	PF00400	0.708
TRG_ER_diArg_1	404	406	PF00400	0.700
TRG_ER_diArg_1	428	430	PF00400	0.779
TRG_ER_diArg_1	433	436	PF00400	0.831
TRG_ER_diArg_1	500	502	PF00400	0.613
TRG_ER_diArg_1	663	665	PF00400	0.680
TRG_ER_diArg_1	698	701	PF00400	0.664
TRG_ER_diArg_1	74	77	PF00400	0.415
TRG_ER_diArg_1	94	97	PF00400	0.415
TRG_NES_CRM1_1	130	144	PF08389	0.415
TRG_NLS_Bipartite_1	606	620	PF00514	0.745
TRG_NLS_MonoCore_2	497	502	PF00514	0.723
TRG_NLS_MonoExtC_3	497	502	PF00514	0.616
TRG_NLS_MonoExtC_3	745	750	PF00514	0.726
TRG_NLS_MonoExtN_4	498	503	PF00514	0.722
TRG_NLS_MonoExtN_4	615	620	PF00514	0.744
TRG_NLS_MonoExtN_4	743	750	PF00514	0.713
TRG_Pf-PMV_PEXEL_1	310	314	PF00026	0.640
TRG_Pf-PMV_PEXEL_1	534	538	PF00026	0.714

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IDC7	Leishmania donovani	87%	100%
A4HGW7	Leishmania braziliensis	67%	100%
A4I3Z7	Leishmania infantum	87%	85%
Q4Q7Z8	Leishmania major	85%	100%