Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9B086_LEIMU

TriTrypDb:

LmxM.28.2630

Length:

441

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B086

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B086

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	151	155	PF00656	0.611
CLV_C14_Caspase3-7	39	43	PF00656	0.503
CLV_C14_Caspase3-7	51	55	PF00656	0.460
CLV_C14_Caspase3-7	92	96	PF00656	0.588
CLV_NRD_NRD_1	139	141	PF00675	0.849
CLV_NRD_NRD_1	348	350	PF00675	0.653
CLV_NRD_NRD_1	357	359	PF00675	0.612
CLV_PCSK_KEX2_1	138	140	PF00082	0.848
CLV_PCSK_KEX2_1	163	165	PF00082	0.748
CLV_PCSK_KEX2_1	348	350	PF00082	0.653
CLV_PCSK_KEX2_1	357	359	PF00082	0.612
CLV_PCSK_PC1ET2_1	138	140	PF00082	0.778
CLV_PCSK_PC1ET2_1	163	165	PF00082	0.711
CLV_PCSK_PC7_1	344	350	PF00082	0.636
CLV_PCSK_SKI1_1	387	391	PF00082	0.720
CLV_PCSK_SKI1_1	426	430	PF00082	0.699
DEG_APCC_DBOX_1	290	298	PF00400	0.646
DEG_SCF_FBW7_1	232	237	PF00400	0.713
DEG_SCF_FBW7_1	389	394	PF00400	0.712
DEG_SPOP_SBC_1	297	301	PF00917	0.687
DOC_CDC14_PxL_1	247	255	PF14671	0.510
DOC_CKS1_1	231	236	PF01111	0.718
DOC_CKS1_1	306	311	PF01111	0.685
DOC_CKS1_1	379	384	PF01111	0.589
DOC_MAPK_DCC_7	238	247	PF00069	0.723
DOC_MAPK_gen_1	348	355	PF00069	0.518
DOC_MAPK_HePTP_8	235	247	PF00069	0.720
DOC_MAPK_MEF2A_6	238	247	PF00069	0.723
DOC_MAPK_RevD_3	336	349	PF00069	0.623
DOC_PP1_RVXF_1	349	356	PF00149	0.519
DOC_PP2B_LxvP_1	179	182	PF13499	0.722
DOC_PP2B_LxvP_1	240	243	PF13499	0.726
DOC_PP4_FxxP_1	231	234	PF00568	0.718
DOC_USP7_MATH_1	133	137	PF00917	0.701
DOC_USP7_MATH_1	212	216	PF00917	0.549
DOC_USP7_MATH_1	298	302	PF00917	0.714
DOC_USP7_MATH_1	391	395	PF00917	0.669
DOC_WW_Pin1_4	128	133	PF00397	0.732
DOC_WW_Pin1_4	230	235	PF00397	0.721
DOC_WW_Pin1_4	305	310	PF00397	0.755
DOC_WW_Pin1_4	324	329	PF00397	0.691
DOC_WW_Pin1_4	332	337	PF00397	0.585
DOC_WW_Pin1_4	375	380	PF00397	0.749
DOC_WW_Pin1_4	387	392	PF00397	0.675
DOC_WW_Pin1_4	71	76	PF00397	0.537
LIG_14-3-3_CanoR_1	120	126	PF00244	0.647
LIG_14-3-3_CanoR_1	262	267	PF00244	0.702
LIG_14-3-3_CanoR_1	296	306	PF00244	0.685
LIG_14-3-3_CanoR_1	426	431	PF00244	0.641
LIG_14-3-3_CanoR_1	47	56	PF00244	0.512
LIG_AP2alpha_2	220	222	PF02296	0.727
LIG_BIR_III_2	205	209	PF00653	0.537
LIG_BIR_III_2	24	28	PF00653	0.664
LIG_BIR_III_2	42	46	PF00653	0.501
LIG_EVH1_1	179	183	PF00568	0.627
LIG_EVH1_2	382	386	PF00568	0.590
LIG_FHA_1	13	19	PF00498	0.736
LIG_FHA_1	174	180	PF00498	0.567
LIG_FHA_1	235	241	PF00498	0.748
LIG_FHA_2	282	288	PF00498	0.757
LIG_FHA_2	328	334	PF00498	0.692
LIG_FHA_2	388	394	PF00498	0.713
LIG_FHA_2	429	435	PF00498	0.696
LIG_Integrin_RGD_1	395	397	PF01839	0.706
LIG_LIR_Gen_1	61	69	PF02991	0.690
LIG_LIR_Nem_3	61	65	PF02991	0.685
LIG_MAD2	351	359	PF02301	0.587
LIG_SH2_CRK	326	330	PF00017	0.693
LIG_SH2_STAP1	62	66	PF00017	0.695
LIG_SH2_STAT5	307	310	PF00017	0.683
LIG_SH3_2	382	387	PF14604	0.560
LIG_SH3_3	129	135	PF00018	0.672
LIG_SH3_3	177	183	PF00018	0.666
LIG_SH3_3	20	26	PF00018	0.719
LIG_SH3_3	246	252	PF00018	0.721
LIG_SH3_3	322	328	PF00018	0.613
LIG_SH3_3	376	382	PF00018	0.619
LIG_SH3_3	403	409	PF00018	0.636
LIG_SH3_3	72	78	PF00018	0.757
LIG_SUMO_SIM_par_1	327	333	PF11976	0.693
LIG_SUMO_SIM_par_1	426	431	PF11976	0.644
LIG_TRAF2_1	183	186	PF00917	0.711
LIG_TRAF2_1	285	288	PF00917	0.762
LIG_TYR_ITIM	324	329	PF00017	0.691
MOD_CDK_SPxK_1	305	311	PF00069	0.756
MOD_CK1_1	124	130	PF00069	0.615
MOD_CK1_1	155	161	PF00069	0.621
MOD_CK1_1	28	34	PF00069	0.712
MOD_CK1_1	281	287	PF00069	0.692
MOD_CK1_1	299	305	PF00069	0.798
MOD_CK1_1	3	9	PF00069	0.651
MOD_CK1_1	327	333	PF00069	0.693
MOD_CK1_1	36	42	PF00069	0.752
MOD_CK1_1	378	384	PF00069	0.622
MOD_CK1_1	88	94	PF00069	0.693
MOD_CK2_1	141	147	PF00069	0.602
MOD_CK2_1	281	287	PF00069	0.758
MOD_CK2_1	387	393	PF00069	0.717
MOD_DYRK1A_RPxSP_1	387	391	PF00069	0.720
MOD_GlcNHglycan	135	138	PF01048	0.714
MOD_GlcNHglycan	222	225	PF01048	0.623
MOD_GlcNHglycan	280	283	PF01048	0.823
MOD_GlcNHglycan	317	320	PF01048	0.637
MOD_GlcNHglycan	35	38	PF01048	0.634
MOD_GlcNHglycan	359	362	PF01048	0.737
MOD_GlcNHglycan	398	404	PF01048	0.680
MOD_GlcNHglycan	412	415	PF01048	0.693
MOD_GlcNHglycan	51	54	PF01048	0.615
MOD_GSK3_1	124	131	PF00069	0.784
MOD_GSK3_1	148	155	PF00069	0.607
MOD_GSK3_1	230	237	PF00069	0.717
MOD_GSK3_1	278	285	PF00069	0.646
MOD_GSK3_1	28	35	PF00069	0.699
MOD_GSK3_1	297	304	PF00069	0.644
MOD_GSK3_1	374	381	PF00069	0.700
MOD_GSK3_1	387	394	PF00069	0.712
MOD_GSK3_1	83	90	PF00069	0.773
MOD_N-GLC_1	302	307	PF02516	0.678
MOD_NEK2_1	374	379	PF00069	0.701
MOD_PIKK_1	407	413	PF00454	0.760
MOD_PKA_1	357	363	PF00069	0.693
MOD_PKA_2	141	147	PF00069	0.572
MOD_PKA_2	173	179	PF00069	0.570
MOD_PKA_2	206	212	PF00069	0.768
MOD_PKA_2	357	363	PF00069	0.734
MOD_PKA_2	88	94	PF00069	0.756
MOD_Plk_1	168	174	PF00069	0.653
MOD_Plk_1	302	308	PF00069	0.677
MOD_Plk_4	262	268	PF00069	0.704
MOD_Plk_4	302	308	PF00069	0.820
MOD_Plk_4	36	42	PF00069	0.733
MOD_ProDKin_1	128	134	PF00069	0.729
MOD_ProDKin_1	230	236	PF00069	0.720
MOD_ProDKin_1	305	311	PF00069	0.756
MOD_ProDKin_1	324	330	PF00069	0.691
MOD_ProDKin_1	332	338	PF00069	0.583
MOD_ProDKin_1	375	381	PF00069	0.749
MOD_ProDKin_1	387	393	PF00069	0.673
MOD_ProDKin_1	71	77	PF00069	0.534
TRG_DiLeu_BaEn_1	423	428	PF01217	0.685
TRG_DiLeu_BaEn_1	435	440	PF01217	0.633
TRG_DiLeu_LyEn_5	423	428	PF01217	0.685
TRG_ENDOCYTIC_2	326	329	PF00928	0.693
TRG_ENDOCYTIC_2	62	65	PF00928	0.697
TRG_ER_diArg_1	139	141	PF00400	0.849
TRG_ER_diArg_1	348	351	PF00400	0.656
TRG_ER_diArg_1	357	359	PF00400	0.612
TRG_NLS_MonoExtC_3	137	142	PF00514	0.778
TRG_NLS_MonoExtN_4	135	142	PF00514	0.647
TRG_NLS_MonoExtN_4	160	167	PF00514	0.713

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H7K1	Leishmania donovani	85%	95%
A4HGW6	Leishmania braziliensis	56%	100%
Q4Q7Z9	Leishmania major	85%	100%