ADP-ribosylglycohydrolase family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ADP-ribosylglycohydrolase, putative

Species:

Leishmania mexicana

UniProt:

E9B083_LEIMU

TriTrypDb:

LmxM.28.2590

Length:

416

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9B083

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B083

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0016787	hydrolase activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	260	264	PF00656	0.509
CLV_NRD_NRD_1	200	202	PF00675	0.302
CLV_PCSK_KEX2_1	200	202	PF00082	0.302
CLV_PCSK_SKI1_1	369	373	PF00082	0.319
CLV_PCSK_SKI1_1	69	73	PF00082	0.430
CLV_PCSK_SKI1_1	93	97	PF00082	0.554
CLV_Separin_Metazoa	136	140	PF03568	0.463
DOC_CKS1_1	185	190	PF01111	0.443
DOC_CYCLIN_yCln2_LP_2	185	191	PF00134	0.360
DOC_MAPK_MEF2A_6	30	38	PF00069	0.441
DOC_MAPK_MEF2A_6	398	407	PF00069	0.509
DOC_USP7_MATH_1	102	106	PF00917	0.712
DOC_USP7_MATH_1	140	144	PF00917	0.429
DOC_USP7_MATH_1	192	196	PF00917	0.447
DOC_USP7_MATH_1	222	226	PF00917	0.575
DOC_USP7_MATH_1	292	296	PF00917	0.617
DOC_USP7_MATH_1	314	318	PF00917	0.556
DOC_USP7_MATH_2	387	393	PF00917	0.579
DOC_WW_Pin1_4	111	116	PF00397	0.593
DOC_WW_Pin1_4	184	189	PF00397	0.403
DOC_WW_Pin1_4	210	215	PF00397	0.480
DOC_WW_Pin1_4	228	233	PF00397	0.552
DOC_WW_Pin1_4	258	263	PF00397	0.344
DOC_WW_Pin1_4	5	10	PF00397	0.595
DOC_WW_Pin1_4	70	75	PF00397	0.651
DOC_WW_Pin1_4	97	102	PF00397	0.614
LIG_14-3-3_CanoR_1	108	116	PF00244	0.673
LIG_14-3-3_CanoR_1	139	148	PF00244	0.411
LIG_14-3-3_CanoR_1	256	262	PF00244	0.328
LIG_14-3-3_CanoR_1	312	317	PF00244	0.606
LIG_14-3-3_CanoR_1	330	339	PF00244	0.472
LIG_AP2alpha_2	204	206	PF02296	0.481
LIG_BIR_III_4	221	225	PF00653	0.617
LIG_DLG_GKlike_1	312	320	PF00625	0.389
LIG_eIF4E_1	152	158	PF01652	0.511
LIG_FHA_1	128	134	PF00498	0.380
LIG_FHA_1	185	191	PF00498	0.423
LIG_FHA_1	205	211	PF00498	0.195
LIG_FHA_1	245	251	PF00498	0.434
LIG_FHA_1	274	280	PF00498	0.403
LIG_FHA_1	334	340	PF00498	0.396
LIG_FHA_1	400	406	PF00498	0.381
LIG_FHA_2	292	298	PF00498	0.641
LIG_FHA_2	330	336	PF00498	0.527
LIG_FHA_2	61	67	PF00498	0.434
LIG_LIR_Apic_2	411	415	PF02991	0.423
LIG_LIR_Gen_1	204	214	PF02991	0.390
LIG_LIR_Gen_1	245	255	PF02991	0.356
LIG_LIR_Gen_1	81	92	PF02991	0.512
LIG_LIR_Nem_3	128	134	PF02991	0.295
LIG_LIR_Nem_3	20	24	PF02991	0.435
LIG_LIR_Nem_3	204	209	PF02991	0.374
LIG_LIR_Nem_3	245	251	PF02991	0.355
LIG_LIR_Nem_3	81	87	PF02991	0.490
LIG_PCNA_PIPBox_1	53	62	PF02747	0.439
LIG_PCNA_yPIPBox_3	46	60	PF02747	0.504
LIG_SH2_GRB2like	17	20	PF00017	0.397
LIG_SH2_SRC	17	20	PF00017	0.397
LIG_SH2_SRC	202	205	PF00017	0.487
LIG_SH2_STAP1	193	197	PF00017	0.452
LIG_SH2_STAP1	246	250	PF00017	0.351
LIG_SH2_STAT5	134	137	PF00017	0.409
LIG_SH2_STAT5	152	155	PF00017	0.255
LIG_SH2_STAT5	202	205	PF00017	0.487
LIG_SH2_STAT5	246	249	PF00017	0.333
LIG_SH2_STAT5	59	62	PF00017	0.580
LIG_SH3_2	286	291	PF14604	0.456
LIG_SH3_3	109	115	PF00018	0.452
LIG_SH3_3	283	289	PF00018	0.518
LIG_TRAF2_1	63	66	PF00917	0.370
LIG_TRAF2_2	216	221	PF00917	0.563
LIG_WRC_WIRS_1	126	131	PF05994	0.343
LIG_WW_3	90	94	PF00397	0.547
MOD_CK1_1	110	116	PF00069	0.713
MOD_CK1_1	315	321	PF00069	0.638
MOD_CK2_1	228	234	PF00069	0.684
MOD_CK2_1	291	297	PF00069	0.605
MOD_CK2_1	335	341	PF00069	0.561
MOD_CK2_1	60	66	PF00069	0.555
MOD_CK2_1	75	81	PF00069	0.522
MOD_GlcNHglycan	109	112	PF01048	0.693
MOD_GlcNHglycan	142	145	PF01048	0.446
MOD_GlcNHglycan	293	297	PF01048	0.597
MOD_GlcNHglycan	391	394	PF01048	0.396
MOD_GSK3_1	1	8	PF00069	0.587
MOD_GSK3_1	102	109	PF00069	0.706
MOD_GSK3_1	173	180	PF00069	0.428
MOD_GSK3_1	204	211	PF00069	0.448
MOD_GSK3_1	258	265	PF00069	0.335
MOD_GSK3_1	308	315	PF00069	0.592
MOD_GSK3_1	329	336	PF00069	0.524
MOD_GSK3_1	60	67	PF00069	0.444
MOD_NEK2_1	1	6	PF00069	0.574
MOD_NEK2_1	116	121	PF00069	0.640
MOD_NEK2_1	125	130	PF00069	0.481
MOD_NEK2_1	177	182	PF00069	0.395
MOD_NEK2_1	316	321	PF00069	0.642
MOD_NEK2_2	17	22	PF00069	0.397
MOD_PIKK_1	222	228	PF00454	0.565
MOD_PIKK_1	49	55	PF00454	0.515
MOD_PKA_2	107	113	PF00069	0.656
MOD_PKA_2	329	335	PF00069	0.537
MOD_PKA_2	60	66	PF00069	0.364
MOD_Plk_1	146	152	PF00069	0.353
MOD_Plk_1	244	250	PF00069	0.462
MOD_Plk_1	80	86	PF00069	0.468
MOD_Plk_2-3	335	341	PF00069	0.488
MOD_Plk_4	173	179	PF00069	0.363
MOD_Plk_4	180	186	PF00069	0.357
MOD_Plk_4	22	28	PF00069	0.500
MOD_Plk_4	316	322	PF00069	0.403
MOD_ProDKin_1	111	117	PF00069	0.589
MOD_ProDKin_1	184	190	PF00069	0.405
MOD_ProDKin_1	210	216	PF00069	0.494
MOD_ProDKin_1	228	234	PF00069	0.548
MOD_ProDKin_1	258	264	PF00069	0.339
MOD_ProDKin_1	5	11	PF00069	0.592
MOD_ProDKin_1	70	76	PF00069	0.643
MOD_ProDKin_1	97	103	PF00069	0.617
MOD_SUMO_rev_2	392	400	PF00179	0.524
TRG_DiLeu_BaEn_1	173	178	PF01217	0.353
TRG_DiLeu_BaLyEn_6	112	117	PF01217	0.540
TRG_ENDOCYTIC_2	134	137	PF00928	0.420
TRG_ER_diArg_1	199	201	PF00400	0.297
TRG_Pf-PMV_PEXEL_1	325	329	PF00026	0.475

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBW3	Leptomonas seymouri	61%	97%
A0A0S4IN38	Bodo saltans	33%	100%
A0A1X0NQK8	Trypanosomatidae	42%	100%
A0A3Q8IF26	Leishmania donovani	91%	100%
A0A3R7KDQ9	Trypanosoma rangeli	46%	100%
A4HGW3	Leishmania braziliensis	80%	99%
A4I3Z3	Leishmania infantum	92%	100%
D0A963	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
Q4Q802	Leishmania major	90%	100%
V5BC55	Trypanosoma cruzi	44%	100%