Putative leucine-rich repeat protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

leucine-rich repeat protein, putative

Species:

Leishmania mexicana

UniProt:

E9B082_LEIMU

TriTrypDb:

LmxM.28.2580

Length:

885

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	10
GO:0042995	cell projection	2	10
GO:0043226	organelle	2	10
GO:0043227	membrane-bounded organelle	3	10
GO:0110165	cellular anatomical entity	1	10
GO:0120025	plasma membrane bounded cell projection	3	10
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

E9B082

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B082

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0019899	enzyme binding	3	1
GO:0019900	kinase binding	4	1
GO:0019901	protein kinase binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	170	174	PF00656	0.568
CLV_C14_Caspase3-7	820	824	PF00656	0.604
CLV_NRD_NRD_1	318	320	PF00675	0.488
CLV_NRD_NRD_1	343	345	PF00675	0.593
CLV_NRD_NRD_1	353	355	PF00675	0.381
CLV_NRD_NRD_1	510	512	PF00675	0.632
CLV_NRD_NRD_1	530	532	PF00675	0.333
CLV_NRD_NRD_1	656	658	PF00675	0.296
CLV_NRD_NRD_1	746	748	PF00675	0.521
CLV_NRD_NRD_1	765	767	PF00675	0.460
CLV_PCSK_KEX2_1	318	320	PF00082	0.488
CLV_PCSK_KEX2_1	353	355	PF00082	0.567
CLV_PCSK_KEX2_1	530	532	PF00082	0.481
CLV_PCSK_KEX2_1	656	658	PF00082	0.319
CLV_PCSK_KEX2_1	765	767	PF00082	0.460
CLV_PCSK_SKI1_1	111	115	PF00082	0.493
CLV_PCSK_SKI1_1	236	240	PF00082	0.555
CLV_PCSK_SKI1_1	28	32	PF00082	0.499
CLV_PCSK_SKI1_1	295	299	PF00082	0.420
CLV_PCSK_SKI1_1	543	547	PF00082	0.294
CLV_PCSK_SKI1_1	65	69	PF00082	0.425
CLV_PCSK_SKI1_1	677	681	PF00082	0.574
CLV_PCSK_SKI1_1	697	701	PF00082	0.560
CLV_PCSK_SKI1_1	720	724	PF00082	0.624
DEG_APCC_DBOX_1	218	226	PF00400	0.460
DEG_APCC_DBOX_1	27	35	PF00400	0.447
DEG_APCC_DBOX_1	294	302	PF00400	0.328
DEG_APCC_DBOX_1	542	550	PF00400	0.474
DEG_APCC_DBOX_1	562	570	PF00400	0.284
DEG_Nend_Nbox_1	1	3	PF02207	0.611
DEG_SPOP_SBC_1	152	156	PF00917	0.615
DEG_SPOP_SBC_1	444	448	PF00917	0.469
DOC_CDC14_PxL_1	188	196	PF14671	0.395
DOC_CKS1_1	1	6	PF01111	0.510
DOC_CKS1_1	358	363	PF01111	0.526
DOC_MAPK_gen_1	111	121	PF00069	0.455
DOC_MAPK_gen_1	318	326	PF00069	0.454
DOC_MAPK_gen_1	334	342	PF00069	0.383
DOC_MAPK_gen_1	530	538	PF00069	0.300
DOC_MAPK_gen_1	653	662	PF00069	0.305
DOC_MAPK_JIP1_4	295	301	PF00069	0.422
DOC_MAPK_MEF2A_6	195	202	PF00069	0.380
DOC_MAPK_MEF2A_6	236	244	PF00069	0.356
DOC_PP1_RVXF_1	115	122	PF00149	0.388
DOC_PP1_RVXF_1	162	168	PF00149	0.559
DOC_PP2B_LxvP_1	189	192	PF13499	0.298
DOC_PP2B_LxvP_1	685	688	PF13499	0.474
DOC_PP4_FxxP_1	257	260	PF00568	0.413
DOC_PP4_FxxP_1	358	361	PF00568	0.575
DOC_USP7_MATH_1	168	172	PF00917	0.706
DOC_USP7_MATH_1	229	233	PF00917	0.387
DOC_USP7_MATH_1	386	390	PF00917	0.465
DOC_USP7_MATH_1	416	420	PF00917	0.547
DOC_USP7_MATH_1	482	486	PF00917	0.567
DOC_USP7_MATH_1	849	853	PF00917	0.712
DOC_USP7_MATH_1	85	89	PF00917	0.469
DOC_WW_Pin1_4	147	152	PF00397	0.649
DOC_WW_Pin1_4	357	362	PF00397	0.697
DOC_WW_Pin1_4	423	428	PF00397	0.703
DOC_WW_Pin1_4	438	443	PF00397	0.666
DOC_WW_Pin1_4	460	465	PF00397	0.623
DOC_WW_Pin1_4	770	775	PF00397	0.659
DOC_WW_Pin1_4	840	845	PF00397	0.702
LIG_14-3-3_CanoR_1	164	168	PF00244	0.659
LIG_14-3-3_CanoR_1	236	241	PF00244	0.510
LIG_14-3-3_CanoR_1	258	264	PF00244	0.377
LIG_14-3-3_CanoR_1	273	277	PF00244	0.444
LIG_14-3-3_CanoR_1	353	362	PF00244	0.565
LIG_14-3-3_CanoR_1	496	505	PF00244	0.569
LIG_14-3-3_CanoR_1	511	517	PF00244	0.603
LIG_14-3-3_CanoR_1	65	70	PF00244	0.423
LIG_14-3-3_CanoR_1	766	774	PF00244	0.465
LIG_14-3-3_CanoR_1	835	841	PF00244	0.732
LIG_Actin_RPEL_3	523	542	PF02755	0.297
LIG_Actin_WH2_2	221	238	PF00022	0.393
LIG_Actin_WH2_2	498	516	PF00022	0.507
LIG_Actin_WH2_2	85	102	PF00022	0.446
LIG_APCC_ABBA_1	323	328	PF00400	0.494
LIG_BIR_III_4	103	107	PF00653	0.375
LIG_BIR_III_4	390	394	PF00653	0.560
LIG_BRCT_BRCA1_1	171	175	PF00533	0.376
LIG_BRCT_BRCA1_1	557	561	PF00533	0.508
LIG_CaM_IQ_9	535	550	PF13499	0.442
LIG_CaM_IQ_9	659	674	PF13499	0.442
LIG_Clathr_ClatBox_1	305	309	PF01394	0.376
LIG_deltaCOP1_diTrp_1	289	300	PF00928	0.408
LIG_EH_1	258	262	PF12763	0.459
LIG_eIF4E_1	123	129	PF01652	0.455
LIG_FHA_1	235	241	PF00498	0.488
LIG_FHA_1	601	607	PF00498	0.696
LIG_FHA_1	700	706	PF00498	0.452
LIG_FHA_1	814	820	PF00498	0.501
LIG_FHA_1	845	851	PF00498	0.748
LIG_FHA_1	861	867	PF00498	0.728
LIG_FHA_2	312	318	PF00498	0.398
LIG_FHA_2	85	91	PF00498	0.383
LIG_GBD_Chelix_1	505	513	PF00786	0.427
LIG_Integrin_isoDGR_2	162	164	PF01839	0.448
LIG_LIR_Apic_2	290	296	PF02991	0.471
LIG_LIR_Apic_2	356	361	PF02991	0.456
LIG_LIR_Gen_1	120	131	PF02991	0.448
LIG_LIR_Gen_1	172	183	PF02991	0.302
LIG_LIR_Gen_1	196	205	PF02991	0.400
LIG_LIR_Gen_1	338	346	PF02991	0.409
LIG_LIR_Gen_1	638	649	PF02991	0.579
LIG_LIR_Gen_1	84	94	PF02991	0.326
LIG_LIR_Gen_1	95	104	PF02991	0.306
LIG_LIR_Nem_3	172	178	PF02991	0.335
LIG_LIR_Nem_3	196	202	PF02991	0.329
LIG_LIR_Nem_3	291	297	PF02991	0.449
LIG_LIR_Nem_3	338	342	PF02991	0.439
LIG_LIR_Nem_3	381	385	PF02991	0.566
LIG_LIR_Nem_3	558	564	PF02991	0.503
LIG_LIR_Nem_3	638	644	PF02991	0.575
LIG_LIR_Nem_3	84	89	PF02991	0.358
LIG_LIR_Nem_3	95	101	PF02991	0.361
LIG_NRBOX	718	724	PF00104	0.559
LIG_PCNA_TLS_4	345	352	PF02747	0.567
LIG_PCNA_yPIPBox_3	631	641	PF02747	0.533
LIG_Pex14_1	293	297	PF04695	0.430
LIG_Pex14_2	257	261	PF04695	0.550
LIG_SH2_CRK	339	343	PF00017	0.614
LIG_SH2_CRK	382	386	PF00017	0.579
LIG_SH2_GRB2like	339	342	PF00017	0.610
LIG_SH2_NCK_1	735	739	PF00017	0.487
LIG_SH2_PTP2	66	69	PF00017	0.341
LIG_SH2_SRC	735	738	PF00017	0.485
LIG_SH2_STAT3	564	567	PF00017	0.523
LIG_SH2_STAT5	199	202	PF00017	0.524
LIG_SH2_STAT5	351	354	PF00017	0.470
LIG_SH2_STAT5	66	69	PF00017	0.341
LIG_SH2_STAT5	98	101	PF00017	0.256
LIG_SH3_3	132	138	PF00018	0.427
LIG_SH3_3	237	243	PF00018	0.354
LIG_SH3_3	394	400	PF00018	0.615
LIG_SH3_3	436	442	PF00018	0.574
LIG_SH3_3	468	474	PF00018	0.644
LIG_SH3_3	835	841	PF00018	0.480
LIG_SUMO_SIM_anti_2	517	524	PF11976	0.574
LIG_SUMO_SIM_anti_2	87	93	PF11976	0.421
LIG_SUMO_SIM_par_1	221	227	PF11976	0.369
LIG_SUMO_SIM_par_1	302	307	PF11976	0.472
LIG_SUMO_SIM_par_1	48	54	PF11976	0.382
LIG_SUMO_SIM_par_1	90	95	PF11976	0.288
LIG_SxIP_EBH_1	150	164	PF03271	0.447
LIG_TRAF2_1	35	38	PF00917	0.462
LIG_TRAF2_1	378	381	PF00917	0.490
LIG_TRAF2_1	515	518	PF00917	0.538
LIG_TRAF2_1	632	635	PF00917	0.582
LIG_TRAF2_1	704	707	PF00917	0.341
LIG_TYR_ITIM	64	69	PF00017	0.346
LIG_UBA3_1	109	114	PF00899	0.462
LIG_WRPW_2	294	297	PF00400	0.424
MOD_CDK_SPK_2	770	775	PF00069	0.464
MOD_CK1_1	122	128	PF00069	0.236
MOD_CK1_1	140	146	PF00069	0.666
MOD_CK1_1	224	230	PF00069	0.394
MOD_CK1_1	419	425	PF00069	0.614
MOD_CK1_1	51	57	PF00069	0.527
MOD_CK1_1	529	535	PF00069	0.297
MOD_CK1_1	600	606	PF00069	0.624
MOD_CK1_1	629	635	PF00069	0.588
MOD_CK1_1	767	773	PF00069	0.588
MOD_CK1_1	852	858	PF00069	0.701
MOD_CK1_1	860	866	PF00069	0.608
MOD_CK1_1	875	881	PF00069	0.497
MOD_CK2_1	311	317	PF00069	0.361
MOD_CK2_1	332	338	PF00069	0.600
MOD_CK2_1	375	381	PF00069	0.622
MOD_CK2_1	386	392	PF00069	0.581
MOD_CK2_1	512	518	PF00069	0.584
MOD_CK2_1	629	635	PF00069	0.545
MOD_CK2_1	701	707	PF00069	0.459
MOD_CK2_1	785	791	PF00069	0.621
MOD_CK2_1	84	90	PF00069	0.530
MOD_GlcNHglycan	142	145	PF01048	0.612
MOD_GlcNHglycan	195	198	PF01048	0.446
MOD_GlcNHglycan	265	268	PF01048	0.532
MOD_GlcNHglycan	277	280	PF01048	0.545
MOD_GlcNHglycan	381	385	PF01048	0.604
MOD_GlcNHglycan	406	409	PF01048	0.598
MOD_GlcNHglycan	464	467	PF01048	0.636
MOD_GlcNHglycan	484	487	PF01048	0.463
MOD_GlcNHglycan	498	501	PF01048	0.439
MOD_GlcNHglycan	53	56	PF01048	0.459
MOD_GlcNHglycan	572	575	PF01048	0.628
MOD_GlcNHglycan	581	584	PF01048	0.416
MOD_GlcNHglycan	599	602	PF01048	0.738
MOD_GlcNHglycan	786	790	PF01048	0.738
MOD_GlcNHglycan	828	831	PF01048	0.584
MOD_GlcNHglycan	872	875	PF01048	0.591
MOD_GlcNHglycan	877	880	PF01048	0.571
MOD_GSK3_1	105	112	PF00069	0.406
MOD_GSK3_1	115	122	PF00069	0.440
MOD_GSK3_1	136	143	PF00069	0.648
MOD_GSK3_1	147	154	PF00069	0.559
MOD_GSK3_1	259	266	PF00069	0.529
MOD_GSK3_1	328	335	PF00069	0.663
MOD_GSK3_1	353	360	PF00069	0.523
MOD_GSK3_1	419	426	PF00069	0.650
MOD_GSK3_1	458	465	PF00069	0.543
MOD_GSK3_1	476	483	PF00069	0.711
MOD_GSK3_1	764	771	PF00069	0.693
MOD_GSK3_1	826	833	PF00069	0.670
MOD_GSK3_1	836	843	PF00069	0.782
MOD_GSK3_1	845	852	PF00069	0.763
MOD_GSK3_1	860	867	PF00069	0.471
MOD_LATS_1	494	500	PF00433	0.525
MOD_N-GLC_1	131	136	PF02516	0.610
MOD_N-GLC_1	181	186	PF02516	0.363
MOD_N-GLC_1	328	333	PF02516	0.490
MOD_N-GLC_1	419	424	PF02516	0.776
MOD_N-GLC_1	42	47	PF02516	0.414
MOD_N-GLC_1	767	772	PF02516	0.588
MOD_NEK2_1	109	114	PF00069	0.462
MOD_NEK2_1	131	136	PF00069	0.503
MOD_NEK2_1	153	158	PF00069	0.714
MOD_NEK2_1	176	181	PF00069	0.333
MOD_NEK2_1	247	252	PF00069	0.345
MOD_NEK2_1	26	31	PF00069	0.466
MOD_NEK2_1	263	268	PF00069	0.466
MOD_NEK2_1	288	293	PF00069	0.464
MOD_NEK2_1	332	337	PF00069	0.564
MOD_NEK2_1	42	47	PF00069	0.456
MOD_NEK2_1	50	55	PF00069	0.417
MOD_NEK2_1	723	728	PF00069	0.438
MOD_NEK2_1	826	831	PF00069	0.594
MOD_NEK2_1	9	14	PF00069	0.389
MOD_NEK2_1	92	97	PF00069	0.284
MOD_NEK2_2	221	226	PF00069	0.432
MOD_PK_1	512	518	PF00069	0.639
MOD_PKA_1	353	359	PF00069	0.566
MOD_PKA_2	140	146	PF00069	0.606
MOD_PKA_2	163	169	PF00069	0.652
MOD_PKA_2	272	278	PF00069	0.561
MOD_PKA_2	353	359	PF00069	0.566
MOD_PKA_2	416	422	PF00069	0.543
MOD_PKA_2	529	535	PF00069	0.411
MOD_PKA_2	764	770	PF00069	0.555
MOD_Plk_1	119	125	PF00069	0.435
MOD_Plk_1	131	137	PF00069	0.410
MOD_Plk_1	26	32	PF00069	0.450
MOD_Plk_1	288	294	PF00069	0.503
MOD_Plk_1	375	381	PF00069	0.672
MOD_Plk_1	9	15	PF00069	0.492
MOD_Plk_2-3	701	707	PF00069	0.345
MOD_Plk_2-3	750	756	PF00069	0.541
MOD_Plk_4	105	111	PF00069	0.372
MOD_Plk_4	124	130	PF00069	0.285
MOD_Plk_4	236	242	PF00069	0.396
MOD_Plk_4	288	294	PF00069	0.530
MOD_Plk_4	473	479	PF00069	0.447
MOD_Plk_4	498	504	PF00069	0.586
MOD_Plk_4	636	642	PF00069	0.491
MOD_Plk_4	65	71	PF00069	0.538
MOD_Plk_4	759	765	PF00069	0.432
MOD_Plk_4	872	878	PF00069	0.754
MOD_ProDKin_1	147	153	PF00069	0.650
MOD_ProDKin_1	357	363	PF00069	0.701
MOD_ProDKin_1	423	429	PF00069	0.701
MOD_ProDKin_1	438	444	PF00069	0.662
MOD_ProDKin_1	460	466	PF00069	0.625
MOD_ProDKin_1	770	776	PF00069	0.660
MOD_ProDKin_1	840	846	PF00069	0.704
MOD_SUMO_rev_2	786	795	PF00179	0.476
TRG_DiLeu_BaEn_1	718	723	PF01217	0.559
TRG_DiLeu_BaEn_2	556	562	PF01217	0.524
TRG_DiLeu_BaEn_4	37	43	PF01217	0.432
TRG_DiLeu_BaEn_4	707	713	PF01217	0.331
TRG_DiLeu_BaLyEn_6	218	223	PF01217	0.412
TRG_DiLeu_BaLyEn_6	300	305	PF01217	0.438
TRG_ENDOCYTIC_2	123	126	PF00928	0.483
TRG_ENDOCYTIC_2	199	202	PF00928	0.469
TRG_ENDOCYTIC_2	339	342	PF00928	0.416
TRG_ENDOCYTIC_2	382	385	PF00928	0.581
TRG_ENDOCYTIC_2	647	650	PF00928	0.547
TRG_ENDOCYTIC_2	66	69	PF00928	0.480
TRG_ENDOCYTIC_2	803	806	PF00928	0.495
TRG_ENDOCYTIC_2	98	101	PF00928	0.277
TRG_ER_diArg_1	318	320	PF00400	0.488
TRG_ER_diArg_1	334	337	PF00400	0.642
TRG_ER_diArg_1	352	354	PF00400	0.547
TRG_ER_diArg_1	530	533	PF00400	0.488
TRG_ER_diArg_1	669	672	PF00400	0.494
TRG_ER_diArg_1	764	766	PF00400	0.462
TRG_NES_CRM1_1	711	725	PF08389	0.333
TRG_Pf-PMV_PEXEL_1	111	115	PF00026	0.424
TRG_Pf-PMV_PEXEL_1	631	635	PF00026	0.452
TRG_Pf-PMV_PEXEL_1	720	725	PF00026	0.540

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0J5	Leptomonas seymouri	52%	100%
A0A0S4IJ40	Bodo saltans	23%	100%
A0A1X0NQK7	Trypanosomatidae	29%	100%
A0A3R7LYV2	Trypanosoma rangeli	29%	100%
A0A3S7X1U4	Leishmania donovani	88%	100%
A4HGW2	Leishmania braziliensis	64%	98%
A4I3Z2	Leishmania infantum	88%	100%
Q4Q803	Leishmania major	86%	100%