Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B080_LEIMU

TriTrypDb:

LmxM.28.2565

Length:

226

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B080

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B080

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	129	133	PF00656	0.792
CLV_C14_Caspase3-7	98	102	PF00656	0.761
CLV_NRD_NRD_1	10	12	PF00675	0.609
CLV_NRD_NRD_1	91	93	PF00675	0.573
CLV_PCSK_KEX2_1	10	12	PF00082	0.582
CLV_PCSK_KEX2_1	125	127	PF00082	0.722
CLV_PCSK_KEX2_1	93	95	PF00082	0.623
CLV_PCSK_PC1ET2_1	125	127	PF00082	0.807
CLV_PCSK_PC1ET2_1	93	95	PF00082	0.623
CLV_PCSK_SKI1_1	37	41	PF00082	0.590
CLV_Separin_Metazoa	117	121	PF03568	0.591
CLV_Separin_Metazoa	205	209	PF03568	0.510
DEG_SCF_SKP2-CKS1_1	70	77	PF00560	0.796
DOC_ANK_TNKS_1	127	134	PF00023	0.506
DOC_CYCLIN_RxL_1	50	62	PF00134	0.555
DOC_MAPK_MEF2A_6	183	192	PF00069	0.393
DOC_MAPK_MEF2A_6	208	216	PF00069	0.506
DOC_PP2B_LxvP_1	134	137	PF13499	0.591
DOC_USP7_MATH_1	105	109	PF00917	0.642
DOC_USP7_MATH_1	137	141	PF00917	0.768
DOC_USP7_MATH_1	173	177	PF00917	0.699
DOC_USP7_MATH_1	184	188	PF00917	0.591
DOC_WW_Pin1_4	112	117	PF00397	0.739
DOC_WW_Pin1_4	140	145	PF00397	0.717
DOC_WW_Pin1_4	22	27	PF00397	0.746
DOC_WW_Pin1_4	71	76	PF00397	0.734
DOC_WW_Pin1_4	78	83	PF00397	0.773
LIG_14-3-3_CanoR_1	126	131	PF00244	0.634
LIG_14-3-3_CanoR_1	160	164	PF00244	0.721
LIG_14-3-3_CanoR_1	27	33	PF00244	0.663
LIG_14-3-3_CanoR_1	37	44	PF00244	0.660
LIG_14-3-3_CanoR_1	50	57	PF00244	0.466
LIG_14-3-3_CanoR_1	92	100	PF00244	0.503
LIG_FHA_1	183	189	PF00498	0.669
LIG_FHA_1	199	205	PF00498	0.375
LIG_FHA_1	23	29	PF00498	0.749
LIG_FHA_1	49	55	PF00498	0.668
LIG_FHA_2	160	166	PF00498	0.508
LIG_FHA_2	67	73	PF00498	0.763
LIG_FHA_2	93	99	PF00498	0.635
LIG_LIR_Gen_1	187	197	PF02991	0.616
LIG_LIR_Nem_3	187	192	PF02991	0.613
LIG_PDZ_Class_2	221	226	PF00595	0.651
LIG_PDZ_Wminus1_1	224	226	PF00595	0.689
LIG_REV1ctd_RIR_1	6	15	PF16727	0.629
LIG_SH2_CRK	12	16	PF00017	0.622
LIG_SH2_NCK_1	12	16	PF00017	0.622
LIG_SH2_PTP2	189	192	PF00017	0.495
LIG_SH2_SRC	99	102	PF00017	0.500
LIG_SH2_STAP1	12	16	PF00017	0.622
LIG_SH2_STAP1	194	198	PF00017	0.528
LIG_SH2_STAT5	12	15	PF00017	0.616
LIG_SH2_STAT5	189	192	PF00017	0.495
LIG_SH2_STAT5	218	221	PF00017	0.501
LIG_SH2_STAT5	99	102	PF00017	0.500
LIG_SH3_3	113	119	PF00018	0.699
LIG_SH3_3	206	212	PF00018	0.527
LIG_UBA3_1	56	63	PF00899	0.518
LIG_WW_3	117	121	PF00397	0.591
MOD_CDK_SPK_2	22	27	PF00069	0.746
MOD_CDK_SPxK_1	71	77	PF00069	0.798
MOD_CK1_1	108	114	PF00069	0.770
MOD_CK1_1	140	146	PF00069	0.697
MOD_CK1_1	176	182	PF00069	0.709
MOD_CK1_1	31	37	PF00069	0.751
MOD_CK1_1	43	49	PF00069	0.499
MOD_CK1_1	66	72	PF00069	0.765
MOD_CK1_1	81	87	PF00069	0.521
MOD_CK2_1	103	109	PF00069	0.651
MOD_CK2_1	70	76	PF00069	0.793
MOD_CK2_1	92	98	PF00069	0.647
MOD_GlcNHglycan	104	108	PF01048	0.800
MOD_GlcNHglycan	134	137	PF01048	0.734
MOD_GlcNHglycan	139	143	PF01048	0.688
MOD_GlcNHglycan	149	152	PF01048	0.626
MOD_GlcNHglycan	37	40	PF01048	0.617
MOD_GlcNHglycan	45	48	PF01048	0.698
MOD_GlcNHglycan	69	72	PF01048	0.650
MOD_GlcNHglycan	78	81	PF01048	0.665
MOD_GlcNHglycan	83	86	PF01048	0.592
MOD_GSK3_1	105	112	PF00069	0.730
MOD_GSK3_1	138	145	PF00069	0.668
MOD_GSK3_1	173	180	PF00069	0.678
MOD_GSK3_1	31	38	PF00069	0.621
MOD_GSK3_1	39	46	PF00069	0.592
MOD_GSK3_1	59	66	PF00069	0.619
MOD_GSK3_1	67	74	PF00069	0.614
MOD_GSK3_1	76	83	PF00069	0.571
MOD_GSK3_1	84	91	PF00069	0.642
MOD_NEK2_1	198	203	PF00069	0.440
MOD_NEK2_1	220	225	PF00069	0.529
MOD_NEK2_1	88	93	PF00069	0.618
MOD_NEK2_2	184	189	PF00069	0.575
MOD_PKA_1	10	16	PF00069	0.592
MOD_PKA_1	92	98	PF00069	0.497
MOD_PKA_2	10	16	PF00069	0.592
MOD_PKA_2	159	165	PF00069	0.719
MOD_PKA_2	49	55	PF00069	0.563
MOD_Plk_4	184	190	PF00069	0.658
MOD_Plk_4	220	226	PF00069	0.545
MOD_ProDKin_1	112	118	PF00069	0.733
MOD_ProDKin_1	140	146	PF00069	0.718
MOD_ProDKin_1	22	28	PF00069	0.746
MOD_ProDKin_1	71	77	PF00069	0.738
MOD_ProDKin_1	78	84	PF00069	0.773
MOD_SUMO_for_1	153	156	PF00179	0.719
MOD_SUMO_rev_2	117	127	PF00179	0.730
MOD_SUMO_rev_2	175	185	PF00179	0.481
TRG_ENDOCYTIC_2	12	15	PF00928	0.620
TRG_ENDOCYTIC_2	189	192	PF00928	0.495
TRG_ER_diArg_1	9	11	PF00400	0.601
TRG_NLS_MonoExtC_3	124	130	PF00514	0.722

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P417	Leptomonas seymouri	42%	100%
A0A3S7X1X0	Leishmania donovani	89%	100%
A4HGW0	Leishmania braziliensis	72%	100%
A4I3Z0	Leishmania infantum	89%	100%
Q4Q805	Leishmania major	91%	100%