MYND-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9B077_LEIMU

TriTrypDb:

LmxM.28.2550

Length:

1006

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B077

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B077

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	6
GO:0043167	ion binding	2	6
GO:0043169	cation binding	3	6
GO:0046872	metal ion binding	4	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	190	194	PF00656	0.625
CLV_C14_Caspase3-7	273	277	PF00656	0.769
CLV_NRD_NRD_1	126	128	PF00675	0.606
CLV_NRD_NRD_1	130	132	PF00675	0.558
CLV_NRD_NRD_1	491	493	PF00675	0.617
CLV_NRD_NRD_1	527	529	PF00675	0.427
CLV_NRD_NRD_1	560	562	PF00675	0.606
CLV_NRD_NRD_1	824	826	PF00675	0.533
CLV_NRD_NRD_1	878	880	PF00675	0.651
CLV_NRD_NRD_1	890	892	PF00675	0.679
CLV_NRD_NRD_1	914	916	PF00675	0.774
CLV_PCSK_FUR_1	888	892	PF00082	0.755
CLV_PCSK_KEX2_1	126	128	PF00082	0.606
CLV_PCSK_KEX2_1	130	132	PF00082	0.558
CLV_PCSK_KEX2_1	491	493	PF00082	0.617
CLV_PCSK_KEX2_1	527	529	PF00082	0.427
CLV_PCSK_KEX2_1	560	562	PF00082	0.606
CLV_PCSK_KEX2_1	824	826	PF00082	0.533
CLV_PCSK_KEX2_1	877	879	PF00082	0.636
CLV_PCSK_KEX2_1	888	890	PF00082	0.675
CLV_PCSK_KEX2_1	914	916	PF00082	0.774
CLV_PCSK_PC7_1	126	132	PF00082	0.580
CLV_PCSK_PC7_1	556	562	PF00082	0.684
CLV_PCSK_SKI1_1	152	156	PF00082	0.482
CLV_PCSK_SKI1_1	336	340	PF00082	0.639
CLV_PCSK_SKI1_1	486	490	PF00082	0.487
CLV_PCSK_SKI1_1	527	531	PF00082	0.465
CLV_PCSK_SKI1_1	563	567	PF00082	0.656
CLV_PCSK_SKI1_1	666	670	PF00082	0.489
CLV_PCSK_SKI1_1	684	688	PF00082	0.283
CLV_PCSK_SKI1_1	743	747	PF00082	0.686
CLV_PCSK_SKI1_1	75	79	PF00082	0.485
CLV_PCSK_SKI1_1	811	815	PF00082	0.496
CLV_PCSK_SKI1_1	825	829	PF00082	0.501
DEG_APCC_DBOX_1	129	137	PF00400	0.514
DEG_SPOP_SBC_1	287	291	PF00917	0.771
DEG_SPOP_SBC_1	393	397	PF00917	0.627
DEG_SPOP_SBC_1	407	411	PF00917	0.794
DEG_SPOP_SBC_1	588	592	PF00917	0.662
DOC_ANK_TNKS_1	188	195	PF00023	0.618
DOC_ANK_TNKS_1	540	547	PF00023	0.594
DOC_CKS1_1	924	929	PF01111	0.836
DOC_CKS1_1	973	978	PF01111	0.652
DOC_CYCLIN_RxL_1	331	344	PF00134	0.655
DOC_CYCLIN_RxL_1	4	12	PF00134	0.608
DOC_CYCLIN_RxL_1	525	535	PF00134	0.384
DOC_CYCLIN_RxL_1	663	672	PF00134	0.504
DOC_MAPK_gen_1	126	136	PF00069	0.497
DOC_MAPK_gen_1	477	487	PF00069	0.598
DOC_MAPK_gen_1	527	534	PF00069	0.453
DOC_MAPK_gen_1	72	80	PF00069	0.585
DOC_MAPK_gen_1	824	830	PF00069	0.534
DOC_MAPK_MEF2A_6	368	376	PF00069	0.529
DOC_MAPK_MEF2A_6	480	489	PF00069	0.596
DOC_MAPK_MEF2A_6	527	536	PF00069	0.482
DOC_MAPK_NFAT4_5	527	535	PF00069	0.453
DOC_PP2B_LxvP_1	354	357	PF13499	0.625
DOC_PP2B_LxvP_1	376	379	PF13499	0.712
DOC_PP4_FxxP_1	776	779	PF00568	0.559
DOC_USP7_MATH_1	231	235	PF00917	0.679
DOC_USP7_MATH_1	236	240	PF00917	0.625
DOC_USP7_MATH_1	281	285	PF00917	0.791
DOC_USP7_MATH_1	287	291	PF00917	0.682
DOC_USP7_MATH_1	341	345	PF00917	0.603
DOC_USP7_MATH_1	377	381	PF00917	0.692
DOC_USP7_MATH_1	393	397	PF00917	0.632
DOC_USP7_MATH_1	407	411	PF00917	0.693
DOC_USP7_MATH_1	580	584	PF00917	0.494
DOC_USP7_MATH_1	844	848	PF00917	0.575
DOC_USP7_MATH_1	896	900	PF00917	0.737
DOC_USP7_MATH_1	931	935	PF00917	0.574
DOC_WW_Pin1_4	111	116	PF00397	0.634
DOC_WW_Pin1_4	274	279	PF00397	0.831
DOC_WW_Pin1_4	307	312	PF00397	0.747
DOC_WW_Pin1_4	368	373	PF00397	0.702
DOC_WW_Pin1_4	428	433	PF00397	0.727
DOC_WW_Pin1_4	504	509	PF00397	0.755
DOC_WW_Pin1_4	763	768	PF00397	0.702
DOC_WW_Pin1_4	908	913	PF00397	0.789
DOC_WW_Pin1_4	916	921	PF00397	0.834
DOC_WW_Pin1_4	923	928	PF00397	0.655
DOC_WW_Pin1_4	969	974	PF00397	0.639
LIG_14-3-3_CanoR_1	174	181	PF00244	0.526
LIG_14-3-3_CanoR_1	336	341	PF00244	0.729
LIG_14-3-3_CanoR_1	342	346	PF00244	0.650
LIG_14-3-3_CanoR_1	40	50	PF00244	0.446
LIG_14-3-3_CanoR_1	541	545	PF00244	0.524
LIG_14-3-3_CanoR_1	658	664	PF00244	0.538
LIG_14-3-3_CanoR_1	670	678	PF00244	0.448
LIG_14-3-3_CanoR_1	684	692	PF00244	0.529
LIG_14-3-3_CanoR_1	839	843	PF00244	0.339
LIG_14-3-3_CanoR_1	889	895	PF00244	0.642
LIG_Actin_WH2_2	547	565	PF00022	0.682
LIG_APCC_ABBA_1	165	170	PF00400	0.643
LIG_APCC_ABBA_1	387	392	PF00400	0.693
LIG_BIR_II_1	1	5	PF00653	0.592
LIG_BIR_III_2	208	212	PF00653	0.671
LIG_BIR_III_2	451	455	PF00653	0.619
LIG_BIR_III_4	285	289	PF00653	0.838
LIG_BRCT_BRCA1_1	343	347	PF00533	0.639
LIG_BRCT_BRCA1_1	846	850	PF00533	0.488
LIG_EH1_1	661	669	PF00400	0.334
LIG_eIF4E_1	663	669	PF01652	0.510
LIG_FHA_1	308	314	PF00498	0.560
LIG_FHA_1	371	377	PF00498	0.528
LIG_FHA_1	42	48	PF00498	0.362
LIG_FHA_1	520	526	PF00498	0.520
LIG_FHA_1	644	650	PF00498	0.294
LIG_FHA_1	697	703	PF00498	0.507
LIG_FHA_1	754	760	PF00498	0.528
LIG_FHA_2	140	146	PF00498	0.487
LIG_FHA_2	239	245	PF00498	0.727
LIG_FHA_2	289	295	PF00498	0.761
LIG_FHA_2	380	386	PF00498	0.798
LIG_FHA_2	501	507	PF00498	0.715
LIG_FHA_2	571	577	PF00498	0.437
LIG_FHA_2	699	705	PF00498	0.329
LIG_FHA_2	71	77	PF00498	0.402
LIG_FHA_2	908	914	PF00498	0.821
LIG_LIR_Apic_2	773	779	PF02991	0.563
LIG_LIR_Gen_1	48	57	PF02991	0.469
LIG_LIR_Gen_1	936	947	PF02991	0.626
LIG_LIR_Nem_3	48	53	PF02991	0.482
LIG_LIR_Nem_3	535	540	PF02991	0.381
LIG_LIR_Nem_3	936	942	PF02991	0.695
LIG_LIR_Nem_3	995	1001	PF02991	0.521
LIG_LYPXL_S_1	80	84	PF13949	0.479
LIG_LYPXL_yS_3	81	84	PF13949	0.468
LIG_Pex14_2	706	710	PF04695	0.483
LIG_REV1ctd_RIR_1	642	652	PF16727	0.481
LIG_RPA_C_Fungi	487	499	PF08784	0.525
LIG_SH2_CRK	537	541	PF00017	0.490
LIG_SH2_CRK	88	92	PF00017	0.449
LIG_SH2_NCK_1	88	92	PF00017	0.550
LIG_SH2_PTP2	812	815	PF00017	0.471
LIG_SH2_STAT5	132	135	PF00017	0.506
LIG_SH2_STAT5	149	152	PF00017	0.329
LIG_SH2_STAT5	168	171	PF00017	0.549
LIG_SH2_STAT5	315	318	PF00017	0.748
LIG_SH2_STAT5	465	468	PF00017	0.516
LIG_SH2_STAT5	663	666	PF00017	0.542
LIG_SH2_STAT5	812	815	PF00017	0.488
LIG_SH2_STAT5	818	821	PF00017	0.462
LIG_SH3_2	115	120	PF14604	0.661
LIG_SH3_3	112	118	PF00018	0.651
LIG_SH3_3	369	375	PF00018	0.674
LIG_SH3_3	502	508	PF00018	0.628
LIG_SH3_3	582	588	PF00018	0.508
LIG_SH3_3	79	85	PF00018	0.480
LIG_SH3_3	915	921	PF00018	0.838
LIG_SH3_3	970	976	PF00018	0.703
LIG_SH3_5	311	315	PF00018	0.710
LIG_SUMO_SIM_anti_2	198	205	PF11976	0.751
LIG_SUMO_SIM_par_1	373	382	PF11976	0.643
LIG_TRAF2_1	121	124	PF00917	0.648
LIG_TRAF2_1	46	49	PF00917	0.504
LIG_TRAF2_1	630	633	PF00917	0.533
LIG_TRAF2_2	446	451	PF00917	0.670
LIG_WW_3	117	121	PF00397	0.667
MOD_CDC14_SPxK_1	911	914	PF00782	0.777
MOD_CDK_SPK_2	969	974	PF00069	0.531
MOD_CDK_SPxK_1	908	914	PF00069	0.783
MOD_CDK_SPxxK_3	763	770	PF00069	0.704
MOD_CDK_SPxxK_3	908	915	PF00069	0.782
MOD_CK1_1	1000	1006	PF00069	0.551
MOD_CK1_1	298	304	PF00069	0.702
MOD_CK1_1	398	404	PF00069	0.558
MOD_CK1_1	42	48	PF00069	0.541
MOD_CK1_1	657	663	PF00069	0.488
MOD_CK1_1	787	793	PF00069	0.601
MOD_CK1_1	919	925	PF00069	0.803
MOD_CK1_1	934	940	PF00069	0.535
MOD_CK2_1	118	124	PF00069	0.654
MOD_CK2_1	197	203	PF00069	0.646
MOD_CK2_1	238	244	PF00069	0.669
MOD_CK2_1	394	400	PF00069	0.667
MOD_CK2_1	42	48	PF00069	0.486
MOD_CK2_1	500	506	PF00069	0.719
MOD_CK2_1	570	576	PF00069	0.441
MOD_CK2_1	70	76	PF00069	0.401
MOD_CK2_1	868	874	PF00069	0.550
MOD_CK2_1	907	913	PF00069	0.818
MOD_Cter_Amidation	875	878	PF01082	0.687
MOD_DYRK1A_RPxSP_1	368	372	PF00069	0.523
MOD_GlcNHglycan	120	123	PF01048	0.531
MOD_GlcNHglycan	181	184	PF01048	0.550
MOD_GlcNHglycan	232	236	PF01048	0.731
MOD_GlcNHglycan	238	241	PF01048	0.776
MOD_GlcNHglycan	294	298	PF01048	0.689
MOD_GlcNHglycan	397	400	PF01048	0.769
MOD_GlcNHglycan	416	419	PF01048	0.717
MOD_GlcNHglycan	437	440	PF01048	0.560
MOD_GlcNHglycan	44	47	PF01048	0.511
MOD_GlcNHglycan	466	469	PF01048	0.501
MOD_GlcNHglycan	537	540	PF01048	0.421
MOD_GlcNHglycan	542	545	PF01048	0.514
MOD_GlcNHglycan	596	599	PF01048	0.656
MOD_GlcNHglycan	659	662	PF01048	0.514
MOD_GlcNHglycan	747	750	PF01048	0.402
MOD_GlcNHglycan	898	901	PF01048	0.720
MOD_GlcNHglycan	939	942	PF01048	0.727
MOD_GlcNHglycan	963	966	PF01048	0.727
MOD_GlcNHglycan	988	991	PF01048	0.617
MOD_GSK3_1	179	186	PF00069	0.562
MOD_GSK3_1	298	305	PF00069	0.748
MOD_GSK3_1	315	322	PF00069	0.681
MOD_GSK3_1	394	401	PF00069	0.697
MOD_GSK3_1	408	415	PF00069	0.627
MOD_GSK3_1	452	459	PF00069	0.567
MOD_GSK3_1	500	507	PF00069	0.730
MOD_GSK3_1	535	542	PF00069	0.595
MOD_GSK3_1	587	594	PF00069	0.713
MOD_GSK3_1	616	623	PF00069	0.733
MOD_GSK3_1	919	926	PF00069	0.697
MOD_GSK3_1	961	968	PF00069	0.746
MOD_N-GLC_1	301	306	PF02516	0.789
MOD_N-GLC_1	739	744	PF02516	0.445
MOD_N-GLC_2	56	58	PF02516	0.451
MOD_NEK2_1	161	166	PF00069	0.508
MOD_NEK2_1	202	207	PF00069	0.657
MOD_NEK2_1	293	298	PF00069	0.591
MOD_NEK2_1	300	305	PF00069	0.621
MOD_NEK2_1	408	413	PF00069	0.678
MOD_NEK2_1	41	46	PF00069	0.376
MOD_NEK2_1	435	440	PF00069	0.595
MOD_NEK2_1	532	537	PF00069	0.406
MOD_NEK2_1	540	545	PF00069	0.548
MOD_NEK2_1	739	744	PF00069	0.634
MOD_NEK2_1	745	750	PF00069	0.503
MOD_NEK2_1	850	855	PF00069	0.532
MOD_NEK2_1	997	1002	PF00069	0.518
MOD_NEK2_2	2	7	PF00069	0.654
MOD_NEK2_2	679	684	PF00069	0.643
MOD_PIKK_1	315	321	PF00454	0.704
MOD_PIKK_1	379	385	PF00454	0.796
MOD_PIKK_1	850	856	PF00454	0.574
MOD_PK_1	914	920	PF00069	0.780
MOD_PKA_1	890	896	PF00069	0.664
MOD_PKA_1	914	920	PF00069	0.780
MOD_PKA_2	341	347	PF00069	0.610
MOD_PKA_2	39	45	PF00069	0.468
MOD_PKA_2	540	546	PF00069	0.517
MOD_PKA_2	657	663	PF00069	0.525
MOD_PKA_2	669	675	PF00069	0.389
MOD_PKA_2	838	844	PF00069	0.343
MOD_PKA_2	890	896	PF00069	0.682
MOD_PKA_2	914	920	PF00069	0.780
MOD_PKB_1	888	896	PF00069	0.737
MOD_Plk_1	197	203	PF00069	0.646
MOD_Plk_1	696	702	PF00069	0.510
MOD_Plk_2-3	419	425	PF00069	0.670
MOD_Plk_2-3	632	638	PF00069	0.472
MOD_Plk_4	1000	1006	PF00069	0.586
MOD_Plk_4	197	203	PF00069	0.746
MOD_Plk_4	295	301	PF00069	0.769
MOD_Plk_4	398	404	PF00069	0.506
MOD_Plk_4	580	586	PF00069	0.394
MOD_Plk_4	844	850	PF00069	0.420
MOD_Plk_4	868	874	PF00069	0.578
MOD_ProDKin_1	111	117	PF00069	0.637
MOD_ProDKin_1	274	280	PF00069	0.831
MOD_ProDKin_1	307	313	PF00069	0.745
MOD_ProDKin_1	368	374	PF00069	0.703
MOD_ProDKin_1	428	434	PF00069	0.719
MOD_ProDKin_1	504	510	PF00069	0.753
MOD_ProDKin_1	763	769	PF00069	0.700
MOD_ProDKin_1	908	914	PF00069	0.788
MOD_ProDKin_1	916	922	PF00069	0.833
MOD_ProDKin_1	923	929	PF00069	0.656
MOD_ProDKin_1	969	975	PF00069	0.639
TRG_DiLeu_BaLyEn_6	208	213	PF01217	0.797
TRG_DiLeu_BaLyEn_6	645	650	PF01217	0.508
TRG_DiLeu_BaLyEn_6	663	668	PF01217	0.316
TRG_DiLeu_BaLyEn_6	864	869	PF01217	0.594
TRG_DiLeu_BaLyEn_6	95	100	PF01217	0.583
TRG_DiLeu_BaLyEn_6	977	982	PF01217	0.693
TRG_ENDOCYTIC_2	537	540	PF00928	0.480
TRG_ENDOCYTIC_2	81	84	PF00928	0.468
TRG_ENDOCYTIC_2	88	91	PF00928	0.447
TRG_ER_diArg_1	125	127	PF00400	0.573
TRG_ER_diArg_1	130	132	PF00400	0.485
TRG_ER_diArg_1	321	324	PF00400	0.683
TRG_ER_diArg_1	491	493	PF00400	0.606
TRG_ER_diArg_1	527	529	PF00400	0.485
TRG_ER_diArg_1	560	563	PF00400	0.580
TRG_ER_diArg_1	823	825	PF00400	0.527
TRG_ER_diArg_1	865	868	PF00400	0.578
TRG_ER_diArg_1	877	879	PF00400	0.588
TRG_ER_diArg_1	887	890	PF00400	0.676
TRG_Pf-PMV_PEXEL_1	7	12	PF00026	0.601
TRG_Pf-PMV_PEXEL_1	731	735	PF00026	0.506
TRG_Pf-PMV_PEXEL_1	98	102	PF00026	0.610
TRG_Pf-PMV_PEXEL_1	991	995	PF00026	0.695

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1B1	Leptomonas seymouri	54%	100%
A0A3Q8IE47	Leishmania donovani	90%	100%
A4HGV7	Leishmania braziliensis	76%	100%
A4I3Y7	Leishmania infantum	90%	100%
Q4Q808	Leishmania major	88%	100%