G2 M phase-specific E3 ubiquitin- ligase

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B071_LEIMU

TriTrypDb:

LmxM.28.2490

Length:

515

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9B071

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B071

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	123	127	PF00656	0.590
CLV_C14_Caspase3-7	279	283	PF00656	0.608
CLV_C14_Caspase3-7	33	37	PF00656	0.513
CLV_C14_Caspase3-7	395	399	PF00656	0.599
CLV_NRD_NRD_1	201	203	PF00675	0.516
CLV_NRD_NRD_1	214	216	PF00675	0.572
CLV_NRD_NRD_1	489	491	PF00675	0.397
CLV_NRD_NRD_1	53	55	PF00675	0.573
CLV_NRD_NRD_1	76	78	PF00675	0.656
CLV_PCSK_FUR_1	214	218	PF00082	0.558
CLV_PCSK_KEX2_1	201	203	PF00082	0.516
CLV_PCSK_KEX2_1	214	216	PF00082	0.554
CLV_PCSK_KEX2_1	489	491	PF00082	0.397
CLV_PCSK_KEX2_1	53	55	PF00082	0.573
CLV_PCSK_KEX2_1	76	78	PF00082	0.656
CLV_PCSK_PC1ET2_1	216	218	PF00082	0.561
CLV_PCSK_SKI1_1	161	165	PF00082	0.586
CLV_PCSK_SKI1_1	321	325	PF00082	0.556
CLV_PCSK_SKI1_1	464	468	PF00082	0.404
CLV_PCSK_SKI1_1	56	60	PF00082	0.520
CLV_PCSK_SKI1_1	76	80	PF00082	0.492
CLV_Separin_Fungi	453	459	PF03568	0.305
DEG_Nend_UBRbox_2	1	3	PF02207	0.577
DEG_SPOP_SBC_1	373	377	PF00917	0.648
DOC_CYCLIN_RxL_1	458	471	PF00134	0.400
DOC_MAPK_gen_1	309	318	PF00069	0.558
DOC_MAPK_gen_1	500	508	PF00069	0.482
DOC_MAPK_gen_1	53	60	PF00069	0.533
DOC_PP2B_LxvP_1	35	38	PF13499	0.509
DOC_PP2B_PxIxI_1	449	455	PF00149	0.457
DOC_USP7_MATH_1	120	124	PF00917	0.643
DOC_USP7_MATH_1	148	152	PF00917	0.549
DOC_USP7_MATH_1	176	180	PF00917	0.595
DOC_USP7_MATH_1	188	192	PF00917	0.601
DOC_USP7_MATH_1	24	28	PF00917	0.594
DOC_USP7_MATH_1	247	251	PF00917	0.786
DOC_USP7_MATH_1	253	257	PF00917	0.682
DOC_WW_Pin1_4	229	234	PF00397	0.635
DOC_WW_Pin1_4	42	47	PF00397	0.603
DOC_WW_Pin1_4	473	478	PF00397	0.506
DOC_WW_Pin1_4	501	506	PF00397	0.490
LIG_14-3-3_CanoR_1	76	81	PF00244	0.661
LIG_APCC_ABBA_1	58	63	PF00400	0.535
LIG_BIR_III_2	345	349	PF00653	0.644
LIG_BIR_III_4	126	130	PF00653	0.545
LIG_BRCT_BRCA1_1	148	152	PF00533	0.579
LIG_CaM_IQ_9	478	494	PF13499	0.405
LIG_FHA_1	120	126	PF00498	0.607
LIG_FHA_1	469	475	PF00498	0.523
LIG_FHA_1	53	59	PF00498	0.534
LIG_FHA_2	151	157	PF00498	0.438
LIG_FHA_2	162	168	PF00498	0.494
LIG_FHA_2	239	245	PF00498	0.579
LIG_FHA_2	31	37	PF00498	0.649
LIG_FHA_2	315	321	PF00498	0.506
LIG_FHA_2	353	359	PF00498	0.566
LIG_Integrin_isoDGR_2	301	303	PF01839	0.510
LIG_LIR_Nem_3	293	298	PF02991	0.592
LIG_LIR_Nem_3	412	416	PF02991	0.611
LIG_LYPXL_S_1	294	298	PF13949	0.364
LIG_PDZ_Class_1	510	515	PF00595	0.561
LIG_PTAP_UEV_1	37	42	PF05743	0.504
LIG_Rb_LxCxE_1	437	455	PF01857	0.361
LIG_SH2_CRK	495	499	PF00017	0.427
LIG_SH2_STAP1	314	318	PF00017	0.559
LIG_SH3_3	160	166	PF00018	0.584
LIG_SH3_3	266	272	PF00018	0.590
LIG_SH3_3	35	41	PF00018	0.644
LIG_SH3_3	471	477	PF00018	0.512
LIG_SUMO_SIM_par_1	431	437	PF11976	0.398
LIG_SUMO_SIM_par_1	503	509	PF11976	0.562
LIG_TRAF2_1	135	138	PF00917	0.590
LIG_TRAF2_1	3	6	PF00917	0.533
LIG_TRAF2_1	417	420	PF00917	0.492
LIG_WW_3	50	54	PF00397	0.650
MOD_CDK_SPK_2	229	234	PF00069	0.646
MOD_CK1_1	151	157	PF00069	0.601
MOD_CK1_1	232	238	PF00069	0.513
MOD_CK1_1	262	268	PF00069	0.817
MOD_CK1_1	28	34	PF00069	0.693
MOD_CK1_1	385	391	PF00069	0.514
MOD_CK2_1	11	17	PF00069	0.626
MOD_CK2_1	132	138	PF00069	0.583
MOD_CK2_1	150	156	PF00069	0.551
MOD_CK2_1	161	167	PF00069	0.500
MOD_CK2_1	238	244	PF00069	0.618
MOD_CK2_1	260	266	PF00069	0.664
MOD_CK2_1	314	320	PF00069	0.494
MOD_CK2_1	414	420	PF00069	0.494
MOD_CK2_1	473	479	PF00069	0.505
MOD_Cter_Amidation	74	77	PF01082	0.660
MOD_GlcNHglycan	141	144	PF01048	0.597
MOD_GlcNHglycan	148	151	PF01048	0.595
MOD_GlcNHglycan	182	185	PF01048	0.497
MOD_GlcNHglycan	190	193	PF01048	0.551
MOD_GlcNHglycan	223	226	PF01048	0.629
MOD_GlcNHglycan	234	237	PF01048	0.687
MOD_GlcNHglycan	244	247	PF01048	0.662
MOD_GlcNHglycan	249	252	PF01048	0.650
MOD_GlcNHglycan	255	258	PF01048	0.659
MOD_GlcNHglycan	273	276	PF01048	0.575
MOD_GlcNHglycan	38	41	PF01048	0.638
MOD_GlcNHglycan	384	387	PF01048	0.702
MOD_GlcNHglycan	82	85	PF01048	0.677
MOD_GlcNHglycan	97	100	PF01048	0.534
MOD_GSK3_1	115	122	PF00069	0.631
MOD_GSK3_1	146	153	PF00069	0.683
MOD_GSK3_1	176	183	PF00069	0.533
MOD_GSK3_1	221	228	PF00069	0.701
MOD_GSK3_1	238	245	PF00069	0.560
MOD_GSK3_1	24	31	PF00069	0.666
MOD_GSK3_1	76	83	PF00069	0.652
MOD_NEK2_1	29	34	PF00069	0.617
MOD_PIKK_1	76	82	PF00454	0.651
MOD_PKA_1	76	82	PF00069	0.651
MOD_PKA_2	52	58	PF00069	0.580
MOD_PKA_2	76	82	PF00069	0.651
MOD_PKB_1	159	167	PF00069	0.580
MOD_Plk_1	314	320	PF00069	0.574
MOD_Plk_2-3	132	138	PF00069	0.476
MOD_Plk_4	120	126	PF00069	0.646
MOD_Plk_4	494	500	PF00069	0.508
MOD_ProDKin_1	229	235	PF00069	0.637
MOD_ProDKin_1	42	48	PF00069	0.602
MOD_ProDKin_1	473	479	PF00069	0.505
MOD_ProDKin_1	501	507	PF00069	0.487
MOD_SUMO_rev_2	444	453	PF00179	0.325
TRG_DiLeu_BaEn_1	195	200	PF01217	0.519
TRG_DiLeu_BaEn_2	454	460	PF01217	0.405
TRG_DiLeu_BaEn_4	422	428	PF01217	0.601
TRG_DiLeu_BaLyEn_6	194	199	PF01217	0.578
TRG_DiLeu_BaLyEn_6	462	467	PF01217	0.388
TRG_ENDOCYTIC_2	295	298	PF00928	0.362
TRG_ENDOCYTIC_2	495	498	PF00928	0.425
TRG_ER_diArg_1	158	161	PF00400	0.612
TRG_ER_diArg_1	200	202	PF00400	0.515
TRG_ER_diArg_1	214	217	PF00400	0.551
TRG_ER_diArg_1	308	311	PF00400	0.567
TRG_ER_diArg_1	488	490	PF00400	0.397
TRG_ER_diArg_1	499	502	PF00400	0.472
TRG_ER_diArg_1	52	54	PF00400	0.651
TRG_NLS_Bipartite_1	201	219	PF00514	0.516
TRG_NLS_MonoExtC_3	214	219	PF00514	0.565
TRG_NLS_MonoExtN_4	214	219	PF00514	0.565
TRG_Pf-PMV_PEXEL_1	321	325	PF00026	0.536
TRG_Pf-PMV_PEXEL_1	464	468	PF00026	0.485

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PA28	Leptomonas seymouri	44%	100%
A0A3S5H7K0	Leishmania donovani	87%	100%
A4HGV1	Leishmania braziliensis	65%	98%
A4I3Y1	Leishmania infantum	87%	100%
Q4Q814	Leishmania major	84%	99%