Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B070_LEIMU

TriTrypDb:

LmxM.28.2480

Length:

303

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

E9B070

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B070

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	178	180	PF00675	0.844
CLV_NRD_NRD_1	272	274	PF00675	0.569
CLV_NRD_NRD_1	45	47	PF00675	0.759
CLV_PCSK_KEX2_1	271	273	PF00082	0.556
CLV_PCSK_KEX2_1	45	47	PF00082	0.759
DEG_SPOP_SBC_1	170	174	PF00917	0.435
DOC_MAPK_MEF2A_6	295	303	PF00069	0.593
DOC_USP7_MATH_1	120	124	PF00917	0.493
DOC_USP7_MATH_1	170	174	PF00917	0.476
DOC_USP7_MATH_1	213	217	PF00917	0.574
DOC_USP7_MATH_1	263	267	PF00917	0.452
DOC_USP7_MATH_1	37	41	PF00917	0.480
DOC_WW_Pin1_4	100	105	PF00397	0.445
DOC_WW_Pin1_4	150	155	PF00397	0.574
DOC_WW_Pin1_4	171	176	PF00397	0.516
DOC_WW_Pin1_4	181	186	PF00397	0.499
DOC_WW_Pin1_4	70	75	PF00397	0.513
DOC_WW_Pin1_4	79	84	PF00397	0.477
LIG_14-3-3_CanoR_1	119	128	PF00244	0.533
LIG_14-3-3_CanoR_1	9	17	PF00244	0.611
LIG_BRCT_BRCA1_1	245	249	PF00533	0.238
LIG_FHA_1	101	107	PF00498	0.638
LIG_FHA_1	128	134	PF00498	0.567
LIG_FHA_1	16	22	PF00498	0.505
LIG_FHA_1	199	205	PF00498	0.473
LIG_FHA_1	210	216	PF00498	0.491
LIG_FHA_1	26	32	PF00498	0.367
LIG_FHA_2	200	206	PF00498	0.624
LIG_FHA_2	295	301	PF00498	0.745
LIG_FHA_2	37	43	PF00498	0.551
LIG_Integrin_isoDGR_2	43	45	PF01839	0.755
LIG_LIR_Apic_2	82	88	PF02991	0.417
LIG_LIR_Nem_3	246	252	PF02991	0.382
LIG_LIR_Nem_3	288	294	PF02991	0.598
LIG_PDZ_Class_2	298	303	PF00595	0.784
LIG_Pex14_2	243	247	PF04695	0.324
LIG_PTB_Apo_2	86	93	PF02174	0.420
LIG_PTB_Phospho_1	86	92	PF10480	0.422
LIG_SH2_NCK_1	85	89	PF00017	0.488
LIG_SH3_3	28	34	PF00018	0.452
LIG_SH3_3	283	289	PF00018	0.752
LIG_SH3_3	53	59	PF00018	0.471
LIG_UBA3_1	163	169	PF00899	0.468
LIG_WRC_WIRS_1	240	245	PF05994	0.523
MOD_CDK_SPK_2	79	84	PF00069	0.421
MOD_CDK_SPxxK_3	181	188	PF00069	0.494
MOD_CK1_1	168	174	PF00069	0.485
MOD_CK1_1	217	223	PF00069	0.646
MOD_CK2_1	199	205	PF00069	0.487
MOD_CK2_1	222	228	PF00069	0.578
MOD_CK2_1	36	42	PF00069	0.549
MOD_Cter_Amidation	43	46	PF01082	0.755
MOD_GlcNHglycan	11	14	PF01048	0.473
MOD_GlcNHglycan	122	125	PF01048	0.629
MOD_GlcNHglycan	146	149	PF01048	0.625
MOD_GlcNHglycan	217	220	PF01048	0.794
MOD_GlcNHglycan	225	228	PF01048	0.721
MOD_GlcNHglycan	236	239	PF01048	0.579
MOD_GlcNHglycan	265	268	PF01048	0.566
MOD_GlcNHglycan	28	31	PF01048	0.293
MOD_GlcNHglycan	66	69	PF01048	0.772
MOD_GlcNHglycan	79	82	PF01048	0.709
MOD_GSK3_1	165	172	PF00069	0.587
MOD_GSK3_1	209	216	PF00069	0.576
MOD_GSK3_1	218	225	PF00069	0.575
MOD_GSK3_1	234	241	PF00069	0.333
MOD_GSK3_1	64	71	PF00069	0.535
MOD_LATS_1	117	123	PF00433	0.431
MOD_N-GLC_1	213	218	PF02516	0.742
MOD_NEK2_1	243	248	PF00069	0.303
MOD_NEK2_1	25	30	PF00069	0.530
MOD_NEK2_1	294	299	PF00069	0.802
MOD_PIKK_1	95	101	PF00454	0.609
MOD_PKA_2	118	124	PF00069	0.534
MOD_PKA_2	294	300	PF00069	0.802
MOD_Plk_4	15	21	PF00069	0.413
MOD_Plk_4	243	249	PF00069	0.259
MOD_ProDKin_1	100	106	PF00069	0.447
MOD_ProDKin_1	150	156	PF00069	0.572
MOD_ProDKin_1	171	177	PF00069	0.517
MOD_ProDKin_1	181	187	PF00069	0.500
MOD_ProDKin_1	70	76	PF00069	0.514
MOD_ProDKin_1	79	85	PF00069	0.477
MOD_SUMO_for_1	83	86	PF00179	0.503
TRG_DiLeu_LyEn_5	159	164	PF01217	0.417
TRG_ENDOCYTIC_2	291	294	PF00928	0.597
TRG_ER_diArg_1	271	273	PF00400	0.756
TRG_ER_diArg_1	45	47	PF00400	0.559

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X1W1	Leishmania donovani	77%	100%
A4HGV0	Leishmania braziliensis	56%	100%
A4I3Y0	Leishmania infantum	77%	100%
Q4Q815	Leishmania major	74%	100%