TKL protein kinase

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

TKL protein kinase

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9B067_LEIMU

TriTrypDb:

LmxM.28.2450

Length:

814

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 8, no: 2
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10
GO:0005886	plasma membrane	3	1

Expansion

Sequence features

E9B067

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9B067

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	13	15	PF00675	0.712
CLV_NRD_NRD_1	603	605	PF00675	0.479
CLV_NRD_NRD_1	738	740	PF00675	0.613
CLV_NRD_NRD_1	804	806	PF00675	0.425
CLV_PCSK_KEX2_1	13	15	PF00082	0.591
CLV_PCSK_KEX2_1	603	605	PF00082	0.479
CLV_PCSK_KEX2_1	804	806	PF00082	0.411
CLV_PCSK_SKI1_1	313	317	PF00082	0.599
CLV_PCSK_SKI1_1	460	464	PF00082	0.622
CLV_PCSK_SKI1_1	580	584	PF00082	0.482
CLV_PCSK_SKI1_1	777	781	PF00082	0.487
CLV_PCSK_SKI1_1	92	96	PF00082	0.627
DEG_APCC_DBOX_1	516	524	PF00400	0.404
DEG_SPOP_SBC_1	202	206	PF00917	0.523
DEG_SPOP_SBC_1	359	363	PF00917	0.432
DEG_SPOP_SBC_1	365	369	PF00917	0.377
DEG_SPOP_SBC_1	719	723	PF00917	0.531
DOC_CDC14_PxL_1	242	250	PF14671	0.275
DOC_CDC14_PxL_1	85	93	PF14671	0.461
DOC_CKS1_1	427	432	PF01111	0.427
DOC_CKS1_1	546	551	PF01111	0.431
DOC_CKS1_1	755	760	PF01111	0.421
DOC_CYCLIN_RxL_1	774	782	PF00134	0.332
DOC_CYCLIN_RxL_1	89	98	PF00134	0.437
DOC_MAPK_gen_1	517	525	PF00069	0.400
DOC_MAPK_MEF2A_6	22	29	PF00069	0.685
DOC_MAPK_MEF2A_6	241	250	PF00069	0.459
DOC_MAPK_MEF2A_6	31	39	PF00069	0.555
DOC_MAPK_MEF2A_6	313	322	PF00069	0.327
DOC_MAPK_MEF2A_6	517	525	PF00069	0.338
DOC_MAPK_NFAT4_5	313	321	PF00069	0.403
DOC_PP2B_LxvP_1	355	358	PF13499	0.497
DOC_PP2B_LxvP_1	498	501	PF13499	0.341
DOC_PP2B_LxvP_1	523	526	PF13499	0.308
DOC_PP2B_LxvP_1	86	89	PF13499	0.474
DOC_PP4_FxxP_1	240	243	PF00568	0.509
DOC_USP7_MATH_1	112	116	PF00917	0.420
DOC_USP7_MATH_1	154	158	PF00917	0.512
DOC_USP7_MATH_1	200	204	PF00917	0.503
DOC_USP7_MATH_1	222	226	PF00917	0.537
DOC_USP7_MATH_1	359	363	PF00917	0.514
DOC_USP7_MATH_1	364	368	PF00917	0.508
DOC_USP7_MATH_1	412	416	PF00917	0.476
DOC_USP7_MATH_1	492	496	PF00917	0.515
DOC_USP7_MATH_1	554	558	PF00917	0.371
DOC_USP7_MATH_1	633	637	PF00917	0.456
DOC_USP7_MATH_1	718	722	PF00917	0.419
DOC_USP7_UBL2_3	560	564	PF12436	0.443
DOC_WW_Pin1_4	20	25	PF00397	0.599
DOC_WW_Pin1_4	426	431	PF00397	0.441
DOC_WW_Pin1_4	545	550	PF00397	0.378
DOC_WW_Pin1_4	567	572	PF00397	0.504
DOC_WW_Pin1_4	580	585	PF00397	0.385
DOC_WW_Pin1_4	71	76	PF00397	0.440
DOC_WW_Pin1_4	754	759	PF00397	0.368
DOC_WW_Pin1_4	809	814	PF00397	0.714
LIG_14-3-3_CanoR_1	103	111	PF00244	0.338
LIG_14-3-3_CanoR_1	132	140	PF00244	0.496
LIG_14-3-3_CanoR_1	141	150	PF00244	0.358
LIG_14-3-3_CanoR_1	282	292	PF00244	0.414
LIG_14-3-3_CanoR_1	31	35	PF00244	0.593
LIG_14-3-3_CanoR_1	354	358	PF00244	0.363
LIG_14-3-3_CanoR_1	460	465	PF00244	0.435
LIG_14-3-3_CanoR_1	604	610	PF00244	0.317
LIG_14-3-3_CanoR_1	711	719	PF00244	0.440
LIG_14-3-3_CanoR_1	727	737	PF00244	0.431
LIG_14-3-3_CanoR_1	92	97	PF00244	0.346
LIG_Actin_WH2_2	696	713	PF00022	0.421
LIG_Actin_WH2_2	784	801	PF00022	0.464
LIG_BRCT_BRCA1_1	236	240	PF00533	0.513
LIG_BRCT_BRCA1_1	65	69	PF00533	0.433
LIG_Clathr_ClatBox_1	373	377	PF01394	0.226
LIG_deltaCOP1_diTrp_1	477	484	PF00928	0.441
LIG_eIF4E_1	298	304	PF01652	0.428
LIG_eIF4E_1	503	509	PF01652	0.411
LIG_eIF4E_1	515	521	PF01652	0.409
LIG_FHA_1	103	109	PF00498	0.379
LIG_FHA_1	144	150	PF00498	0.474
LIG_FHA_1	387	393	PF00498	0.418
LIG_FHA_1	419	425	PF00498	0.492
LIG_FHA_1	461	467	PF00498	0.420
LIG_FHA_1	563	569	PF00498	0.504
LIG_FHA_1	705	711	PF00498	0.346
LIG_FHA_1	714	720	PF00498	0.444
LIG_FHA_1	72	78	PF00498	0.436
LIG_FHA_1	732	738	PF00498	0.348
LIG_FHA_1	773	779	PF00498	0.440
LIG_FHA_1	783	789	PF00498	0.335
LIG_FHA_1	81	87	PF00498	0.426
LIG_FHA_2	156	162	PF00498	0.537
LIG_FHA_2	389	395	PF00498	0.346
LIG_FHA_2	415	421	PF00498	0.434
LIG_FHA_2	546	552	PF00498	0.388
LIG_FHA_2	615	621	PF00498	0.503
LIG_FHA_2	675	681	PF00498	0.457
LIG_FHA_2	755	761	PF00498	0.436
LIG_FHA_2	93	99	PF00498	0.440
LIG_GBD_Chelix_1	780	788	PF00786	0.443
LIG_Integrin_RGD_1	16	18	PF01839	0.596
LIG_LIR_Apic_2	237	243	PF02991	0.513
LIG_LIR_Apic_2	744	748	PF02991	0.385
LIG_LIR_Apic_2	809	813	PF02991	0.709
LIG_LIR_Gen_1	429	439	PF02991	0.349
LIG_LIR_Gen_1	638	648	PF02991	0.224
LIG_LIR_Gen_1	671	679	PF02991	0.359
LIG_LIR_Gen_1	698	708	PF02991	0.324
LIG_LIR_LC3C_4	179	184	PF02991	0.225
LIG_LIR_Nem_3	208	214	PF02991	0.458
LIG_LIR_Nem_3	429	434	PF02991	0.317
LIG_LIR_Nem_3	475	481	PF02991	0.396
LIG_LIR_Nem_3	495	499	PF02991	0.217
LIG_LIR_Nem_3	527	532	PF02991	0.343
LIG_LIR_Nem_3	583	589	PF02991	0.336
LIG_LIR_Nem_3	638	643	PF02991	0.287
LIG_LIR_Nem_3	671	676	PF02991	0.407
LIG_LIR_Nem_3	698	703	PF02991	0.329
LIG_LIR_Nem_3	741	745	PF02991	0.418
LIG_LIR_Nem_3	773	779	PF02991	0.375
LIG_MLH1_MIPbox_1	65	69	PF16413	0.459
LIG_NRBOX	34	40	PF00104	0.569
LIG_NRBOX	370	376	PF00104	0.241
LIG_PDZ_Class_1	809	814	PF00595	0.714
LIG_Pex14_1	294	298	PF04695	0.439
LIG_Pex14_2	107	111	PF04695	0.377
LIG_Pex14_2	211	215	PF04695	0.455
LIG_PTAP_UEV_1	503	508	PF05743	0.415
LIG_SH2_CRK	431	435	PF00017	0.343
LIG_SH2_CRK	776	780	PF00017	0.311
LIG_SH2_GRB2like	629	632	PF00017	0.406
LIG_SH2_NCK_1	464	468	PF00017	0.335
LIG_SH2_SRC	629	632	PF00017	0.467
LIG_SH2_STAP1	129	133	PF00017	0.505
LIG_SH2_STAP1	345	349	PF00017	0.401
LIG_SH2_STAP1	605	609	PF00017	0.514
LIG_SH2_STAP1	763	767	PF00017	0.233
LIG_SH2_STAT5	298	301	PF00017	0.411
LIG_SH2_STAT5	464	467	PF00017	0.452
LIG_SH2_STAT5	639	642	PF00017	0.332
LIG_SH2_STAT5	68	71	PF00017	0.407
LIG_SH2_STAT5	702	705	PF00017	0.322
LIG_SH2_STAT5	706	709	PF00017	0.296
LIG_SH2_STAT5	745	748	PF00017	0.397
LIG_SH2_STAT5	770	773	PF00017	0.359
LIG_SH2_STAT5	85	88	PF00017	0.427
LIG_SH3_3	18	24	PF00018	0.462
LIG_SH3_3	240	246	PF00018	0.475
LIG_SH3_3	421	427	PF00018	0.493
LIG_SH3_3	433	439	PF00018	0.336
LIG_SH3_3	498	504	PF00018	0.382
LIG_SH3_3	506	512	PF00018	0.413
LIG_SH3_3	543	549	PF00018	0.356
LIG_SUMO_SIM_anti_2	179	184	PF11976	0.383
LIG_SUMO_SIM_anti_2	273	281	PF11976	0.355
LIG_SUMO_SIM_anti_2	367	375	PF11976	0.429
LIG_SUMO_SIM_anti_2	785	790	PF11976	0.299
LIG_SUMO_SIM_par_1	273	281	PF11976	0.366
LIG_SUMO_SIM_par_1	372	377	PF11976	0.256
LIG_SUMO_SIM_par_1	469	475	PF11976	0.418
LIG_SUMO_SIM_par_1	530	536	PF11976	0.329
LIG_SUMO_SIM_par_1	777	782	PF11976	0.288
LIG_SUMO_SIM_par_1	92	98	PF11976	0.416
LIG_TYR_ITSM	427	434	PF00017	0.418
LIG_WW_1	295	298	PF00397	0.448
MOD_CDK_SPxxK_3	754	761	PF00069	0.420
MOD_CK1_1	115	121	PF00069	0.390
MOD_CK1_1	128	134	PF00069	0.485
MOD_CK1_1	155	161	PF00069	0.535
MOD_CK1_1	187	193	PF00069	0.402
MOD_CK1_1	198	204	PF00069	0.451
MOD_CK1_1	206	212	PF00069	0.351
MOD_CK1_1	234	240	PF00069	0.482
MOD_CK1_1	281	287	PF00069	0.458
MOD_CK1_1	308	314	PF00069	0.404
MOD_CK1_1	353	359	PF00069	0.483
MOD_CK1_1	369	375	PF00069	0.340
MOD_CK1_1	414	420	PF00069	0.434
MOD_CK1_1	443	449	PF00069	0.438
MOD_CK1_1	454	460	PF00069	0.408
MOD_CK1_1	502	508	PF00069	0.336
MOD_CK1_1	566	572	PF00069	0.514
MOD_CK1_1	644	650	PF00069	0.449
MOD_CK1_1	723	729	PF00069	0.518
MOD_CK2_1	202	208	PF00069	0.519
MOD_CK2_1	287	293	PF00069	0.431
MOD_CK2_1	453	459	PF00069	0.478
MOD_CK2_1	674	680	PF00069	0.455
MOD_CK2_1	726	732	PF00069	0.524
MOD_GlcNHglycan	154	157	PF01048	0.723
MOD_GlcNHglycan	167	170	PF01048	0.564
MOD_GlcNHglycan	2	5	PF01048	0.781
MOD_GlcNHglycan	200	203	PF01048	0.700
MOD_GlcNHglycan	208	211	PF01048	0.675
MOD_GlcNHglycan	362	365	PF01048	0.718
MOD_GlcNHglycan	368	371	PF01048	0.657
MOD_GlcNHglycan	442	445	PF01048	0.653
MOD_GlcNHglycan	453	456	PF01048	0.677
MOD_GlcNHglycan	504	507	PF01048	0.602
MOD_GlcNHglycan	539	542	PF01048	0.695
MOD_GlcNHglycan	551	555	PF01048	0.547
MOD_GlcNHglycan	556	559	PF01048	0.489
MOD_GlcNHglycan	623	626	PF01048	0.661
MOD_GlcNHglycan	643	646	PF01048	0.515
MOD_GlcNHglycan	716	719	PF01048	0.583
MOD_GSK3_1	102	109	PF00069	0.428
MOD_GSK3_1	128	135	PF00069	0.469
MOD_GSK3_1	150	157	PF00069	0.463
MOD_GSK3_1	194	201	PF00069	0.439
MOD_GSK3_1	202	209	PF00069	0.467
MOD_GSK3_1	222	229	PF00069	0.305
MOD_GSK3_1	280	287	PF00069	0.404
MOD_GSK3_1	360	367	PF00069	0.514
MOD_GSK3_1	410	417	PF00069	0.443
MOD_GSK3_1	418	425	PF00069	0.466
MOD_GSK3_1	462	469	PF00069	0.283
MOD_GSK3_1	488	495	PF00069	0.461
MOD_GSK3_1	533	540	PF00069	0.405
MOD_GSK3_1	541	548	PF00069	0.366
MOD_GSK3_1	550	557	PF00069	0.261
MOD_GSK3_1	562	569	PF00069	0.444
MOD_GSK3_1	59	66	PF00069	0.459
MOD_GSK3_1	604	611	PF00069	0.454
MOD_GSK3_1	635	642	PF00069	0.430
MOD_GSK3_1	668	675	PF00069	0.370
MOD_GSK3_1	710	717	PF00069	0.425
MOD_GSK3_1	719	726	PF00069	0.471
MOD_LATS_1	601	607	PF00433	0.478
MOD_N-GLC_1	112	117	PF02516	0.594
MOD_N-GLC_1	194	199	PF02516	0.573
MOD_N-GLC_1	234	239	PF02516	0.647
MOD_N-GLC_1	284	289	PF02516	0.715
MOD_N-GLC_1	410	415	PF02516	0.650
MOD_N-GLC_1	79	84	PF02516	0.712
MOD_NEK2_1	107	112	PF00069	0.411
MOD_NEK2_1	194	199	PF00069	0.428
MOD_NEK2_1	280	285	PF00069	0.432
MOD_NEK2_1	403	408	PF00069	0.397
MOD_NEK2_1	462	467	PF00069	0.422
MOD_NEK2_1	532	537	PF00069	0.333
MOD_NEK2_1	550	555	PF00069	0.317
MOD_NEK2_1	563	568	PF00069	0.510
MOD_NEK2_1	585	590	PF00069	0.359
MOD_NEK2_1	641	646	PF00069	0.347
MOD_NEK2_1	679	684	PF00069	0.383
MOD_NEK2_1	696	701	PF00069	0.268
MOD_NEK2_1	710	715	PF00069	0.339
MOD_NEK2_1	779	784	PF00069	0.384
MOD_PIKK_1	308	314	PF00454	0.461
MOD_PIKK_1	337	343	PF00454	0.420
MOD_PIKK_1	348	354	PF00454	0.408
MOD_PIKK_1	674	680	PF00454	0.344
MOD_PIKK_1	687	693	PF00454	0.351
MOD_PIKK_1	710	716	PF00454	0.449
MOD_PIKK_1	731	737	PF00454	0.475
MOD_PKA_1	603	609	PF00069	0.304
MOD_PKA_2	102	108	PF00069	0.383
MOD_PKA_2	281	287	PF00069	0.457
MOD_PKA_2	30	36	PF00069	0.359
MOD_PKA_2	337	343	PF00069	0.396
MOD_PKA_2	353	359	PF00069	0.445
MOD_PKA_2	440	446	PF00069	0.461
MOD_PKA_2	603	609	PF00069	0.304
MOD_PKA_2	710	716	PF00069	0.438
MOD_PKA_2	726	732	PF00069	0.460
MOD_Plk_1	112	118	PF00069	0.434
MOD_Plk_1	194	200	PF00069	0.419
MOD_Plk_1	234	240	PF00069	0.496
MOD_Plk_1	284	290	PF00069	0.531
MOD_Plk_1	305	311	PF00069	0.276
MOD_Plk_1	704	710	PF00069	0.318
MOD_Plk_1	763	769	PF00069	0.342
MOD_Plk_2-3	388	394	PF00069	0.421
MOD_Plk_4	115	121	PF00069	0.370
MOD_Plk_4	187	193	PF00069	0.370
MOD_Plk_4	25	31	PF00069	0.668
MOD_Plk_4	369	375	PF00069	0.463
MOD_Plk_4	37	43	PF00069	0.524
MOD_Plk_4	64	70	PF00069	0.452
MOD_Plk_4	741	747	PF00069	0.408
MOD_Plk_4	80	86	PF00069	0.486
MOD_Plk_4	92	98	PF00069	0.292
MOD_ProDKin_1	20	26	PF00069	0.595
MOD_ProDKin_1	426	432	PF00069	0.436
MOD_ProDKin_1	545	551	PF00069	0.377
MOD_ProDKin_1	567	573	PF00069	0.497
MOD_ProDKin_1	580	586	PF00069	0.385
MOD_ProDKin_1	71	77	PF00069	0.441
MOD_ProDKin_1	754	760	PF00069	0.371
MOD_SUMO_rev_2	157	167	PF00179	0.504
TRG_DiLeu_BaEn_1	53	58	PF01217	0.364
TRG_DiLeu_BaEn_4	53	59	PF01217	0.357
TRG_DiLeu_BaLyEn_6	22	27	PF01217	0.699
TRG_ENDOCYTIC_2	431	434	PF00928	0.320
TRG_ENDOCYTIC_2	776	779	PF00928	0.382
TRG_ER_diArg_1	13	16	PF00400	0.497
TRG_ER_diArg_1	603	605	PF00400	0.415
TRG_ER_diArg_1	803	805	PF00400	0.646
TRG_NES_CRM1_1	173	185	PF08389	0.429
TRG_Pf-PMV_PEXEL_1	301	305	PF00026	0.646

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3A4	Leptomonas seymouri	53%	100%
A0A0S4JR51	Bodo saltans	24%	100%
A0A1X0NQP9	Trypanosomatidae	27%	100%
A0A3Q8IB65	Leishmania donovani	89%	100%
A0A3R7KTE0	Trypanosoma rangeli	30%	100%
A4I3X7	Leishmania infantum	89%	100%
D0A945	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
Q4Q818	Leishmania major	90%	100%
V5DCU8	Trypanosoma cruzi	29%	100%